ES2260244T3 - Compuesto de succinamida heterociclicos condensados y analogos de los mismos, moduladores de la funcion del receptor nuclear de hormona. - Google Patents

Compuesto de succinamida heterociclicos condensados y analogos de los mismos, moduladores de la funcion del receptor nuclear de hormona.

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Publication number
ES2260244T3
ES2260244T3 ES01948503T ES01948503T ES2260244T3 ES 2260244 T3 ES2260244 T3 ES 2260244T3 ES 01948503 T ES01948503 T ES 01948503T ES 01948503 T ES01948503 T ES 01948503T ES 2260244 T3 ES2260244 T3 ES 2260244T3
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substituted
aryl
alkyl
arylalkyl
heterocycle
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Mark E. Salvati
James Aaron Balog
Dacia A. Pickering
Soren Giese
Aberra Fura
Wenying Li
Ramesh N. Patel
Ronald L. Hanson
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

Un compuesto de la siguiente fórmula (I) o una sal o hidrato del mismo: (Ver fórmula) en la que los símbolos tienen los siguientes significados y, para cada aparición, se seleccionan independientemente entre: G es un grupo arilo o heterociclo, siendo dicho grupo mono- o policíclico, y está opcionalmente sustituido en una o más posiciones; L es un enlace, (CR7R7")n (donde n es 1 y cada uno de R7 y R7'' es independientemente H, alquilo o alquilo sustituido), o -CH2-NH-; cada uno de A1 y A2 es independientemente CR7 donde R7 (i) es hidrógeno, alquilo o alquilo sustituido, arilalquilo o arilalquilo sustituido, alquenilo o alquenilo sustituido, arilo o arilo sustituido, heterociclo o heterociclo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, donde, para cada uno los sustituyentes son uno o más grupos seleccionados entre V1, o (ii) forma, junto con R7 de un grupo W, un anillo heterocíclico; V1 es OH, CN, halo, -O-arilo, -O-arilo sustituido, -O-heterociclo, -O-heterociclo sustituido, -O-CO-alquilo, -OCO-alquilo sustituido, -O-(alquilsililo), -O-arilalquilo, -O-arilalquilo sustituido, -O-CO-arilalquilo, -O-CO-arilalquilo sustituido, -O-CO-arilo, -O-CO-arilo sustituido, -O-CO-heterociclo, -O-CO-heterociclo sustituido, S-(aril opcionalmente sustituido)-NH-CO-(alquilo opcionalmente sustituido), -SO-(aril opcionalmente sustituido)-NH-CO-(alquilo opcionalmente sustituido), -SO2-(aril opcionalmente sustituido)-NH-CO-(alquilo opcionalmente sustituido), -NHSO2-arilo, -NH-SO2-arilo sustituido, -NH-CO-O-(arilalquil opcionalmente sustituido), -NH-CO-O-alquilo, -NH-COO-alquilo sustituido, -NH-CO-alquilo, -NH-CO-alquilo sustituido, -NH-CO-arilo, -NH-CO-arilo sustituido, -NH-CO(arilalquilo opcionalmente sustituido), -NH-CO-(alquil opcionalmente sustituido)-O-(arilo opcionalmente sustituido), -N(alquil opcionalmente sustituido)(arilo opcionalmente sustituido), -N(alquil opcionalmente sustituido)(arilalquilo opcionalmente sustituido), -COH, -COOH, -CO-O-alquilo, -CO-O-alquilo sustituido, -CO-O-arilalquilo opcionalmente sustituido, -CO-arilo, -CO-arilo sustituido, -O-CO-NH-arilo, -O-CO-NH-arilo sustituido, -CO-NH-arilo, -CONH-arilo sustituido, -CO-NH-arilaquilo, -CO-NH-arilalquilo sustituido, u-O-(aril opcionalmente sustituido)-NH-CO(alquilo opcionalmente sustituido); Y es -O-, -SO-, -N(V2), -CH2-N(V2)-, -CO-N(alquil)-, -CH2-S-, o -CH2-SO2; V2 es hidrógeno, alquilo, arilalquilo, -CO-alquilo, -CO-O-arilo, o -CO-O-arilalquilo; Z1 y Z2 son O; Q1 y Q2 son H; W es CR7R7''-CR7R7'', CR7R7''-C=O, NR9-CR7R7'', N=CR8, N=N, NR9-NR9'', cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, o arilo o arilo sustituido, donde, cuando W no es NR9-CR7R7'', N=CR8, N=N, NR9-NR9'', o heterociclo o heterociclo sustituido, entonces Y debe ser -O-, -CH2S-, -SO-, -CH2-SO2-, N(V2)- o -CH2-N(V2), cada uno de R1 y R1" es independientemente H, alquilo o alquilo sustituido, cicloalquilo o cicloalquilo sustituido, cicloalquenilo o cicloalquenilo sustituido, heterociclo o heterociclo sustituido, cicloalquilalquilo o cicloalquilalquilo sustituido, cicloalquenilalquilo o cicloalquenilalquilo sustituido, heterocicloalquilo o heterocicloalquilo sustituido, arilo o arilo sustituido, arilalquilo o arilalquilo sustituido.
ES01948503T 2000-09-19 2001-06-20 Compuesto de succinamida heterociclicos condensados y analogos de los mismos, moduladores de la funcion del receptor nuclear de hormona. Expired - Lifetime ES2260244T3 (es)

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US23351900P 2000-09-19 2000-09-19
US233519P 2000-09-19
US28473001P 2001-04-18 2001-04-18
US28443801P 2001-04-18 2001-04-18
US284730P 2001-04-18
US284438P 2001-04-18

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Publication number Priority date Publication date Assignee Title
JP2004509072A (ja) 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1854798A3 (en) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002364082A1 (en) * 2001-12-19 2003-07-09 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
TWI263640B (en) * 2001-12-19 2006-10-11 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
MXPA05001631A (es) 2002-08-12 2005-08-19 Takeda Pharmaceutical Derivado de benceno fusionado y su uso.
EP1636167A2 (en) * 2003-06-10 2006-03-22 SmithKline Beecham Corporation 1-aminonaphthalenes as modulators of androgen, glucocorticoid, mineralocorticoid and progesterone receptors
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
CA2617256C (en) * 2005-08-01 2014-07-15 Takeda Pharmaceutical Company Limited Cyclic amine compound
EP2039695A4 (en) * 2006-07-11 2010-09-15 Takeda Pharmaceutical BICYCLIC HETEROCYLIC COMPOUND AND ITS USE
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
JPWO2011007819A1 (ja) 2009-07-17 2012-12-27 塩野義製薬株式会社 ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US11649234B2 (en) 2018-06-14 2023-05-16 The University Of Florida Research Foundation, Inc. Nonmuscle myosin II inhibitors for substance use relapse
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
WO2022061226A1 (en) * 2020-09-19 2022-03-24 Augusta University Research Institute, Inc. Compositions and methods for inhibiting trem-1
CN115340483A (zh) * 2022-08-31 2022-11-15 南京吉星生物技术开发有限公司 一种萘基吡咯啉二酮化合物及其制备方法与它的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3261845A (en) * 1964-07-14 1966-07-19 Dow Chemical Co N-phenyl derivatives of 3,6-epoxyhexahydrophthalimide
JPS5046697A (es) * 1973-08-20 1975-04-25
US5539126A (en) * 1994-04-20 1996-07-23 Bristol-Myers Squibb Company Method for preparing homochiral maleimide intermediates, via silylation techniques
WO1996019458A2 (en) * 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
AU728178B2 (en) * 1996-06-27 2001-01-04 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
WO1998049555A1 (en) * 1997-04-29 1998-11-05 The Salk Institute For Biological Studies Methods for identifying ligands for nuclear hormone receptors
US7101681B1 (en) * 1997-11-21 2006-09-05 Amgen, Inc. Nuclear hormone receptor drug screens
WO2001019831A1 (en) * 1999-09-10 2001-03-22 Novo Nordisk A/S MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法

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