ES2284653T3 - Purificacion de insulina utilizando tecnologia de lecho movil simulado. - Google Patents

Purificacion de insulina utilizando tecnologia de lecho movil simulado. Download PDF

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Publication number
ES2284653T3
ES2284653T3 ES01941486T ES01941486T ES2284653T3 ES 2284653 T3 ES2284653 T3 ES 2284653T3 ES 01941486 T ES01941486 T ES 01941486T ES 01941486 T ES01941486 T ES 01941486T ES 2284653 T3 ES2284653 T3 ES 2284653T3
Authority
ES
Spain
Prior art keywords
insulin
fraction
component
simulated mobile
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01941486T
Other languages
English (en)
Inventor
Nien-Hwa Linda Wang
Yi Xie
Sungyong Mun
Jin-Hyun Kim
Benjamin J Hritzko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of ES2284653T3 publication Critical patent/ES2284653T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedimiento para separar cromatográficamente insulina de uno o más componentes que comprende a) proporcionar un lecho fluidizado simulado que comprende un primer anillo, una fase estacionaria, y una primera corriente de desorbente; b) proporcionar una corriente de alimentación que comprende insulina y un primer componente o fracción; c) introducir la primera corriente de desorbente y la corriente de alimentación en el primer anillo bajo condiciones de frente estacionario para separar la insulina del primer componente o fracción; y d) extraer del primer anillo la insulina sustancialmente separada del primer componente o fracción.
ES01941486T 2000-05-16 2001-05-16 Purificacion de insulina utilizando tecnologia de lecho movil simulado. Expired - Lifetime ES2284653T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20470100P 2000-05-16 2000-05-16

Publications (1)

Publication Number Publication Date
ES2284653T3 true ES2284653T3 (es) 2007-11-16

Family

ID=22759061

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01941486T Expired - Lifetime ES2284653T3 (es) 2000-05-16 2001-05-16 Purificacion de insulina utilizando tecnologia de lecho movil simulado.

Country Status (6)

Country Link
EP (1) EP1349866B1 (es)
AT (1) ATE358679T1 (es)
AU (1) AU2001274837A1 (es)
DE (1) DE60127713T2 (es)
ES (1) ES2284653T3 (es)
WO (1) WO2001087924A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005026486A1 (de) * 2005-06-09 2006-12-14 Bayer Technology Services Gmbh Ein chromatographisches quasi-kontinuierliches Verfahren und entsprechende Vorrichtung zur Trennung von binären und Mehrstoffgemischen
CN102271775A (zh) * 2008-12-08 2011-12-07 诺沃-诺迪斯克有限公司 多肽的逆流提纯
CA2873141C (en) 2009-12-30 2018-05-29 Adam Kelliher Simulated moving bed chromatographic separation process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
JP6303017B2 (ja) 2014-01-07 2018-03-28 ノヴァセプ プロセスＮｏｖａｓｅｐ Ｐｒｏｃｅｓｓ 芳香族アミノ酸を精製する方法

Also Published As

Publication number Publication date
EP1349866A2 (en) 2003-10-08
WO2001087924A3 (en) 2003-08-07
AU2001274837A1 (en) 2001-11-26
EP1349866B1 (en) 2007-04-04
DE60127713D1 (de) 2007-05-16
ATE358679T1 (de) 2007-04-15
WO2001087924A2 (en) 2001-11-22
DE60127713T2 (de) 2007-12-27

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