ES228514A3 - Procedimiento para la preparación de compuestos esteroidales que contengan un grupo cetólico de cadena lateral - Google Patents

Info

Publication number

ES228514A3

ES228514A3 ES228514A ES228514A ES228514A3 ES 228514 A3 ES228514 A3 ES 228514A3 ES 228514 A ES228514 A ES 228514A ES 228514 A ES228514 A ES 228514A ES 228514 A3 ES228514 A3 ES 228514A3

Authority

ES

Spain

Prior art keywords

pregnen

delta

ethylenedioxy

group

acetoxy

Prior art date

1956-05-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

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• 238000000034 method Methods 0.000 title abstract 2
• -1 steroid compounds Chemical class 0.000 title abstract 2
• RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 6
• FCYQTGCEDUOHLT-LEKSSAKUSA-N 1-[(8s,9s,10r,13s,14s,17s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C1C=C2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 FCYQTGCEDUOHLT-LEKSSAKUSA-N 0.000 abstract 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
• 239000002253 acid Substances 0.000 abstract 2
• SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 abstract 2
• 229960003387 progesterone Drugs 0.000 abstract 2
• 239000000186 progesterone Substances 0.000 abstract 2
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 2
• JRMAQQQTXDJDNC-UHFFFAOYSA-M 2-ethoxy-2-oxoacetate Chemical compound CCOC(=O)C([O-])=O JRMAQQQTXDJDNC-UHFFFAOYSA-M 0.000 abstract 1
• MWFMGBPGAXYFAR-UHFFFAOYSA-N 2-hydroxy-2-methylpropanenitrile Chemical compound CC(C)(O)C#N MWFMGBPGAXYFAR-UHFFFAOYSA-N 0.000 abstract 1
• DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
• 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
• 230000002378 acidificating effect Effects 0.000 abstract 1
• 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
• 239000003054 catalyst Substances 0.000 abstract 1
• 238000003776 cleavage reaction Methods 0.000 abstract 1
• 150000001875 compounds Chemical class 0.000 abstract 1
• 125000004494 ethyl ester group Chemical group 0.000 abstract 1
• 159000000011 group IA salts Chemical class 0.000 abstract 1
• 230000026045 iodination Effects 0.000 abstract 1
• 238000006192 iodination reaction Methods 0.000 abstract 1
• 125000000468 ketone group Chemical group 0.000 abstract 1
• 235000011056 potassium acetate Nutrition 0.000 abstract 1
• 230000007017 scission Effects 0.000 abstract 1
• QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
• 230000003637 steroidlike Effects 0.000 abstract 1
• 230000009466 transformation Effects 0.000 abstract 1