ES2292452T3 - Dispositivo de enfriamiento dinamico de tejidos biologicos en cirugia laser. - Google Patents

Dispositivo de enfriamiento dinamico de tejidos biologicos en cirugia laser. Download PDF

Info

Publication number: ES2292452T3
Authority: ES; Spain
Prior art keywords: biological tissue; period; heat; cryogenic liquid; cooling
Prior art date: 1999-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES00946769T

Other languages

English (en)

Spanish (es)

Inventor

Sam Tannenbaum

Nelson Stuart

Thomas Milner

Anvari Bahman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of California Berkeley

University of California San Diego UCSD

Original Assignee

University of California Berkeley

University of California San Diego UCSD

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-28

Filing date

2000-05-30

Publication date

2008-03-16

2000-05-30 Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley

2008-03-16 Application granted granted Critical

2008-03-16 Publication of ES2292452T3 publication Critical patent/ES2292452T3/es

2020-05-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B18/0218—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3203—Fluid jet cutting instruments
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00029—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00458—Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/02—Radiation therapy using microwaves
- A61N5/04—Radiators for near-field treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Optics & Photonics (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Medical Informatics (AREA)
Molecular Biology (AREA)
Radiology & Medical Imaging (AREA)
Pathology (AREA)
Biophysics (AREA)
Electromagnetism (AREA)
Laser Surgery Devices (AREA)
Radiation-Therapy Devices (AREA)

ES00946769T 1999-05-28 2000-05-30 Dispositivo de enfriamiento dinamico de tejidos biologicos en cirugia laser. Expired - Lifetime ES2292452T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/322,311 US6248103B1 (en)	1994-04-05	1999-05-28	Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses
US322311		1999-05-28

Publications (1)

Publication Number	Publication Date
ES2292452T3 true ES2292452T3 (es)	2008-03-16

Family

ID=23254321

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES00946769T Expired - Lifetime ES2292452T3 (es)	1999-05-28	2000-05-30	Dispositivo de enfriamiento dinamico de tejidos biologicos en cirugia laser.

Country Status (6)

Country	Link
US (1)	US6248103B1 (de)
EP (1)	EP1180982B1 (de)
AT (1)	ATE367126T1 (de)
DE (1)	DE60035582T2 (de)
ES (1)	ES2292452T3 (de)
WO (1)	WO2001013811A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7006874B2 (en) *	1996-01-05	2006-02-28	Thermage, Inc.	Treatment apparatus with electromagnetic energy delivery device and non-volatile memory
US7267675B2 (en)	1996-01-05	2007-09-11	Thermage, Inc.	RF device with thermo-electric cooler
US6350276B1 (en)	1996-01-05	2002-02-26	Thermage, Inc.	Tissue remodeling apparatus containing cooling fluid
US7115123B2 (en)	1996-01-05	2006-10-03	Thermage, Inc.	Handpiece with electrode and non-volatile memory
US7473251B2 (en)	1996-01-05	2009-01-06	Thermage, Inc.	Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient
US7229436B2 (en)	1996-01-05	2007-06-12	Thermage, Inc.	Method and kit for treatment of tissue
US7141049B2 (en)	1999-03-09	2006-11-28	Thermage, Inc.	Handpiece for treatment of tissue
US7189230B2 (en) *	1996-01-05	2007-03-13	Thermage, Inc.	Method for treating skin and underlying tissue
US7452358B2 (en) *	1996-01-05	2008-11-18	Thermage, Inc.	RF electrode assembly for handpiece
US7022121B2 (en)	1999-03-09	2006-04-04	Thermage, Inc.	Handpiece for treatment of tissue
US6077294A (en) *	1998-06-11	2000-06-20	Cynosure, Inc.	Method for non-invasive wrinkle removal and skin treatment
US6059820A (en)	1998-10-16	2000-05-09	Paradigm Medical Corporation	Tissue cooling rod for laser surgery
US20020156471A1 (en) *	1999-03-09	2002-10-24	Stern Roger A.	Method for treatment of tissue
EP1455668A2 (de) *	1999-06-30	2004-09-15	Thermage, Inc.	Flüssigskeitsgekükltes rf-handstück
US6451007B1 (en) *	1999-07-29	2002-09-17	Dale E. Koop	Thermal quenching of tissue
US6816820B1 (en) *	1999-09-24	2004-11-09	Moldflow Ireland, Ltd.	Method and apparatus for modeling injection of a fluid in a mold cavity
US6771678B1 (en) *	2000-06-13	2004-08-03	International Business Machines Corporation	Laser system and method of operation having improved signal continuity and safety
US20040082940A1 (en) *	2002-10-22	2004-04-29	Michael Black	Dermatological apparatus and method
US20030216719A1 (en) *	2001-12-12	2003-11-20	Len Debenedictis	Method and apparatus for treating skin using patterns of optical energy
AU2003230808A1 (en) *	2002-04-05	2003-10-27	Candela Corporation	High fluence rate activation of photosensitizers for dermatological applications
AU2003245573A1 (en)	2002-06-19	2004-01-06	Palomar Medical Technologies, Inc.	Method and apparatus for treatment of cutaneous and subcutaneous conditions
US20040048842A1 (en) *	2002-09-10	2004-03-11	Mcmillan Kathleen	Method of treating skin disorders
AU2004211184A1 (en) *	2003-02-05	2004-08-26	Moldflow Ireland Ltd.	Apparatus and methods for performing process simulation using a hybrid model
EP1603730A2 (de) *	2003-03-03	2005-12-14	Moldflow Ireland Ltd	Vorrichtung und verfahren zur vorhersage der eigenschaften von bearbeitetem material
JP4340459B2 (ja) *	2003-03-14	2009-10-07	株式会社日立ディスプレイズ	表示装置の製造方法
EP1613202B1 (de) *	2003-03-27	2011-02-09	The General Hospital Corporation	Gerät für die dermatologische behandlung und fraktionale oberflächenerneuerung der haut
GB0315974D0 (en) *	2003-07-08	2003-08-13	Coolanalgesia Ltd	Cooling device for pain relief
US20050137658A1 (en) *	2003-12-17	2005-06-23	Hennings David R.	Treatment of superficial pigmented and vascular lesions of the skin
US7413572B2 (en)	2004-06-14	2008-08-19	Reliant Technologies, Inc.	Adaptive control of optical pulses for laser medicine
US8308717B2 (en)	2004-06-21	2012-11-13	Seilex Ltd	Thermal energy applicator
US7780656B2 (en) *	2004-12-10	2010-08-24	Reliant Technologies, Inc.	Patterned thermal treatment using patterned cryogen spray and irradiation by light
US8277495B2 (en) *	2005-01-13	2012-10-02	Candela Corporation	Method and apparatus for treating a diseased nail
US7856985B2 (en)	2005-04-22	2010-12-28	Cynosure, Inc.	Method of treatment body tissue using a non-uniform laser beam
US20060287662A1 (en) *	2005-05-26	2006-12-21	Ntk Enterprises, Inc.	Device, system, and method for epithelium protection during cornea reshaping
US20070176262A1 (en) *	2005-08-11	2007-08-02	Ernest Sirkin	Series connection of a diode laser bar
US20070173799A1 (en) *	2005-09-01	2007-07-26	Hsia James C	Treatment of fatty tissue adjacent an eye
US9028469B2 (en) *	2005-09-28	2015-05-12	Candela Corporation	Method of treating cellulite
US20070083190A1 (en) *	2005-10-11	2007-04-12	Yacov Domankevitz	Compression device for a laser handpiece
US20070142885A1 (en) *	2005-11-29	2007-06-21	Reliant Technologies, Inc.	Method and Apparatus for Micro-Needle Array Electrode Treatment of Tissue
US7891362B2 (en) *	2005-12-23	2011-02-22	Candela Corporation	Methods for treating pigmentary and vascular abnormalities in a dermal region
US20070173912A1 (en) *	2006-01-20	2007-07-26	Somnuk Amornsiripanitch	Phototherapy with specific infrared light for treating skin disorders
US7691099B2 (en)	2006-07-12	2010-04-06	Ntk Enterprises, Inc.	Deuterated ocular solutions for LTK and other surgical eye procedures
US7586957B2 (en)	2006-08-02	2009-09-08	Cynosure, Inc	Picosecond laser apparatus and methods for its operation and use
US20080221649A1 (en) *	2007-03-09	2008-09-11	Agustina Echague	Method of sequentially treating tissue
US8603081B2 (en) *	2007-08-23	2013-12-10	Ntk Enterprises, Inc.	System and method for defining and controlling LTK and other surgical eye procedures to produce little or no stromal collagen shrinkage
US20090192438A1 (en) *	2008-01-25	2009-07-30	Jones Dennis R	Use of Iontophoresis or Electrotherapy and Ultrasound to Deliver Melanin for Skin Rejuvenation
US20090246270A1 (en) *	2008-01-31	2009-10-01	Jones Dennis R	Use of Iontophoresis or Electrotherapy and Ultrasound to Deliver Agents for Skin Rejuvenation.
US8357150B2 (en)	2009-07-20	2013-01-22	Syneron Medical Ltd.	Method and apparatus for fractional skin treatment
ES2407531T3 (es) *	2009-04-22	2013-06-12	Radiancy Inc.	Dispositivo de tratamiento cutáneo que utiliza luz y temperatura
SG179201A1 (en)	2009-09-24	2012-05-30	Sanofi Aventis Us Llc	Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof
RU2424009C1 (ru) *	2009-11-24	2011-07-20	Учреждение Российской академии наук Институт общей физики им. П.А. Прохорова РАН (ИОФ РАН)	Устройство для проведения внутритканевой лазерной гипертермии и фотодинамической терапии и способ их осуществления
US20110190745A1 (en) *	2009-12-04	2011-08-04	Uebelhoer Nathan S	Treatment of sweat glands
RU2437691C2 (ru) *	2010-01-26	2011-12-27	Общество с ограниченной ответственностью "Научно-производственное предприятие Волоконно-Оптического и Лазерного Оборудования" (ООО "НПП ВОЛО")	Устройство управления температурой поверхностного слоя кожи и подкожных слоев биоткани
KR101269970B1 (ko) *	2010-11-15	2013-05-31	주식회사 루트로닉	피부 치료용 광학장치 및 이의 제어방법
KR101256119B1 (ko) *	2011-03-25	2013-04-23	주식회사 루트로닉	레이저 치료장치 및 이의 제어방법
WO2013158299A1 (en)	2012-04-18	2013-10-24	Cynosure, Inc.	Picosecond laser apparatus and methods for treating target tissues with same
US9101743B2 (en) *	2012-05-02	2015-08-11	Elwha, Llc	Fluid spraying apparatuses, and related systems and methods
US9022999B2 (en) *	2012-05-02	2015-05-05	Elwha, Llc	Fluid spraying apparatuses, and related systems and methods
WO2013176857A1 (en) *	2012-05-23	2013-11-28	Elwha Llc	Fluid spraying apparatuses, and related systems and methods
US20140081356A1 (en) *	2012-09-20	2014-03-20	Georgia Tech Research Corporation	Thermal capacitors for minimizing complications and side effects from thermal medicine
EP2973894A2 (de)	2013-03-15	2016-01-20	Cynosure, Inc.	Optische picosekunden-strahlungssysteme und verfahren zur verwendung
CN112042066A (zh)	2018-02-26	2020-12-04	赛诺秀股份有限公司	调q倾腔亚纳秒激光器
WO2021087264A1 (en) *	2019-10-31	2021-05-06	Musc Foundation For Research Development	Ultrasound-based shunt flow detection
JP7634810B2 (ja) *	2020-06-05	2025-02-25	レセンスメディカル、インコーポレイテッド	レーザ外科デバイス及びその外科的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5057104A (en)	1989-05-30	1991-10-15	Cyrus Chess	Method and apparatus for treating cutaneous vascular lesions
US5344418A (en)	1991-12-12	1994-09-06	Shahriar Ghaffari	Optical system for treatment of vascular lesions
JP3263275B2 (ja) *	1994-04-05	2002-03-04	ザリージェンツオブザユニバーシティオブカリフォルニア	生体組織のレーザー処理のための装置並びに火焔状斑点母斑のレーザー処理装置
US5979454A (en) *	1995-05-15	1999-11-09	The Regents Of The University Of California	Method and apparatus for causing rapid and deep spatially selective coagulation during thermally mediated therapeutic procedures
US5820626A (en)	1996-07-30	1998-10-13	Laser Aesthetics, Inc.	Cooling laser handpiece with refillable coolant reservoir
US5810801A (en)	1997-02-05	1998-09-22	Candela Corporation	Method and apparatus for treating wrinkles in skin using radiation

1999
- 1999-05-28 US US09/322,311 patent/US6248103B1/en not_active Expired - Lifetime
2000
- 2000-05-30 ES ES00946769T patent/ES2292452T3/es not_active Expired - Lifetime
- 2000-05-30 WO PCT/US2000/014955 patent/WO2001013811A1/en not_active Ceased
- 2000-05-30 DE DE60035582T patent/DE60035582T2/de not_active Expired - Lifetime
- 2000-05-30 AT AT00946769T patent/ATE367126T1/de not_active IP Right Cessation
- 2000-05-30 EP EP00946769A patent/EP1180982B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1180982A1 (de)	2002-02-27
DE60035582D1 (de)	2007-08-30
EP1180982B1 (de)	2007-07-18
ATE367126T1 (de)	2007-08-15
DE60035582T2 (de)	2008-04-03
WO2001013811A1 (en)	2001-03-01
US6248103B1 (en)	2001-06-19

Publication	Publication Date	Title
ES2292452T3 (es)	2008-03-16	Dispositivo de enfriamiento dinamico de tejidos biologicos en cirugia laser.
US5814040A (en)	1998-09-29	Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery
ES2230570T3 (es)	2005-05-01	Eliminacion del bello por fototermolisis selectiva con un laser de alejandrita.
ES2326256T3 (es)	2009-10-06	Varilla de enfriamiento de tejidos por cirugia laser.
US6436094B1 (en)	2002-08-20	Electromagnetic and laser treatment and cooling device
Nelson et al.	1996	Dynamic epidermal cooling in conjunction with laser‐induced photothermolysis of port wine stain blood vessels
AU742982B2 (en)	2002-01-17	Pulsed filament lamp for dermatological treatment
US5968034A (en)	1999-10-19	Pulsed filament lamp for dermatological treatment
US5853407A (en)	1998-12-29	Method and apparatus for hair removal
Sturesson et al.	1996	Mathematical modelling of dynamic cooling and pre-heating, used to increase the depth of selective damage to blood vessels in laser treatment of port wine stains
Hammes et al.	2005	Evaluation of different temperatures in cold air cooling with pulsed‐dye laser treatment of facial telangiectasia
CN102427773B (zh)	2016-02-03	除脂方法和设备
Das et al.	2016	Cooling devices in laser therapy
JP2014503255A (ja)	2014-02-13	温熱処置による非侵襲的な脂肪低減
Cassuto et al.	2000	Treatment of facial telangiectasias with a diode-pumped Nd: YAG Laser at 532nm
US20150258347A1 (en)	2015-09-17	Tissue treatment and modification device
WO2010017556A1 (en)	2010-02-11	Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue
Sadick et al.	2004	Effective epilation of white and blond hair using combined radiofrequency and optical energy
Sadick et al.	2016	Minimally invasive radiofrequency devices
Tunnell et al.	2000	Epidermal protection with cryogen spray cooling during high fluence pulsed dye laser irradiation: an ex vivo study
Svaasand et al.	2004	Increase of dermal blood volume fraction reduces the threshold for laser‐induced purpura: implications for port wine stain laser treatment
Svaasand et al.	2003	Cooling efficiency of cryogen spray during laser therapy of skin
US20050065503A1 (en)	2005-03-24	Method and apparatus for reducing the appearance of skin markings
ES2345544T3 (es)	2010-09-27	Dispositivo de tratamiento terapeutico con fuentes de luz incoherente.
Košir et al.	2023	Dry Molecular Cooling (DMC™) in Laser Aesthetics and Dermatology