ES2305567T3 - Formulaciones de tramadol de liberacion sostenida con una eficacia de 24 horas. - Google Patents

Formulaciones de tramadol de liberacion sostenida con una eficacia de 24 horas. Download PDF

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Publication number
ES2305567T3
ES2305567T3 ES03809237T ES03809237T ES2305567T3 ES 2305567 T3 ES2305567 T3 ES 2305567T3 ES 03809237 T ES03809237 T ES 03809237T ES 03809237 T ES03809237 T ES 03809237T ES 2305567 T3 ES2305567 T3 ES 2305567T3
Authority
ES
Spain
Prior art keywords
hours
release
formulations
effectiveness
sustained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03809237T
Other languages
English (en)
Inventor
Vincent Lenaerts
Patricia Laure Ouadji-Njiki
Jonathan Bacon
Rachid Ouzerourou
Sonia Gervais
Miloud Rahmouni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharm Barbados Ltd
Labopharm Inc
Paladin Labs Europe Ltd
Original Assignee
Labopharm Barbados Ltd
Labopharm Inc
Paladin Labs Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Barbados Ltd, Labopharm Inc, Paladin Labs Europe Ltd filed Critical Labopharm Barbados Ltd
Application granted granted Critical
Publication of ES2305567T3 publication Critical patent/ES2305567T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cereal-Derived Products (AREA)

Abstract

Formulación de dosificación sólida que comprende: un núcleo que comprende un principio farmacéutico activo (API) y una matriz y un recubrimiento que comprende una mezcla física de acetato de polivinilo y polivinilpirrolidona y un principio farmacéutico activo, en la que el principio farmacéutico activo y la matriz del núcleo están asociados de manera que la liberación del principio farmacéutico desde la matriz del núcleo es controlada, de manera que la liberación desde la formulación del principio activo dispuesto en el núcleo resulta más lenta que la liberación del principio farmacéutico activo dispuesto en la matriz del recubrimiento, en la que el principio farmacéutico activo del núcleo y del recubrimiento es el mismo y es tramadol o un estereoisómero o su sal farmacéuticamente aceptable.
ES03809237T 2002-10-25 2003-10-27 Formulaciones de tramadol de liberacion sostenida con una eficacia de 24 horas. Expired - Lifetime ES2305567T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50906202P 2002-10-25 2002-10-25
US51037803P 2003-10-10 2003-10-10

Publications (1)

Publication Number Publication Date
ES2305567T3 true ES2305567T3 (es) 2008-11-01

Family

ID=35044187

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03809237T Expired - Lifetime ES2305567T3 (es) 2002-10-25 2003-10-27 Formulaciones de tramadol de liberacion sostenida con una eficacia de 24 horas.

Country Status (11)

Country Link
US (1) US7988998B2 (es)
EP (1) EP1594460B1 (es)
AT (1) ATE390128T1 (es)
BR (1) BR0315659A (es)
DE (1) DE60320039T2 (es)
DK (1) DK1594460T3 (es)
ES (1) ES2305567T3 (es)
MX (1) MXPA05004412A (es)
NZ (1) NZ539870A (es)
SI (1) SI1594460T1 (es)
TW (1) TWI319713B (es)

Families Citing this family (13)

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US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
WO2007048219A2 (en) * 2005-09-09 2007-05-03 Labopharm Inc. Sustained drug release composition
PT1931346E (pt) * 2005-09-09 2012-08-14 Angelini Labopharm Llc Composição de trazodona para administração uma vez por dia
JP5453280B2 (ja) * 2007-10-16 2014-03-26 ラボファーム インコーポレイテッド アセトアミノフェンおよびトラマドールを持続的に放出するための二層組成物
US8486448B2 (en) 2007-12-17 2013-07-16 Paladin Labs Inc. Misuse preventative, controlled release formulation
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
ES2509497T3 (es) 2008-12-16 2014-10-17 Paladin Labs Inc. Formulación de liberación controlada para evitar un uso indebido
US8623409B1 (en) 2010-10-20 2014-01-07 Tris Pharma Inc. Clonidine formulation
KR102380825B1 (ko) * 2015-05-29 2022-04-01 삼성전자주식회사 반도체 발광다이오드 칩 및 이를 구비한 발광장치
ES2862209T3 (es) 2017-07-20 2021-10-07 Intas Pharmaceuticals Ltd Composiciones orales sólidas de liberación prolongada no pulsátil que contienen betahistina
US11918689B1 (en) 2020-07-28 2024-03-05 Tris Pharma Inc Liquid clonidine extended release composition

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TWI319713B (en) 2010-01-21
EP1594460B1 (en) 2008-03-26
BR0315659A (pt) 2005-09-20
SI1594460T1 (sl) 2008-08-31
US20090047345A9 (en) 2009-02-19
HK1101355A1 (en) 2007-10-18
US7988998B2 (en) 2011-08-02
ATE390128T1 (de) 2008-04-15
EP1594460A2 (en) 2005-11-16
MXPA05004412A (es) 2005-11-23
DE60320039T2 (de) 2009-05-14
NZ539870A (en) 2007-11-30
US20070003618A1 (en) 2007-01-04
DE60320039D1 (de) 2008-05-08
DK1594460T3 (da) 2008-07-28

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