ES2325977T3 - Fibrillas de colageno obtenidas por biotecnologia. - Google Patents

Fibrillas de colageno obtenidas por biotecnologia. Download PDF

Info

Publication number: ES2325977T3
Authority: ES; Spain
Prior art keywords: collagen; chains; solution; agent; coagulation
Prior art date: 1999-09-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES00967071T

Other languages

English (en)

Spanish (es)

Inventor

Nathaniel Bachrach

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organogenesis Inc

Original Assignee

Organogenesis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-28

Publication date

2009-09-28

2000-09-28 Application filed by Organogenesis Inc filed Critical Organogenesis Inc

2009-09-28 Application granted granted Critical

2009-09-28 Publication of ES2325977T3 publication Critical patent/ES2325977T3/es

2020-09-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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229940124597 therapeutic agent Drugs 0.000 description 1
230000017423 tissue regeneration Effects 0.000 description 1
210000000515 tooth Anatomy 0.000 description 1
238000012549 training Methods 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
239000002699 waste material Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Oral & Maxillofacial Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Materials For Medical Uses (AREA)
Prostheses (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ES00967071T 1999-09-28 2000-09-28 Fibrillas de colageno obtenidas por biotecnologia. Expired - Lifetime ES2325977T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US15614499P	1999-09-28	1999-09-28
US156144P		1999-09-28

Publications (1)

Publication Number	Publication Date
ES2325977T3 true ES2325977T3 (es)	2009-09-28

Family

ID=22558293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES00967071T Expired - Lifetime ES2325977T3 (es)	1999-09-28	2000-09-28	Fibrillas de colageno obtenidas por biotecnologia.

Country Status (7)

Country	Link
EP (1)	EP1216296B1 (de)
AT (1)	ATE428768T1 (de)
AU (1)	AU7732600A (de)
CA (1)	CA2386217C (de)
DE (1)	DE60042027D1 (de)
ES (1)	ES2325977T3 (de)
WO (1)	WO2001023529A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030114061A1 (en) *	2001-12-13	2003-06-19	Kazuhisa Matsuda	Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same
WO2004078120A2 (en) *	2003-02-28	2004-09-16	Fibrogen, Inc.	Collagen compositions and biomaterials
US8263109B2 (en)	2005-05-09	2012-09-11	Boston Scientific Scimed, Inc.	Injectable bulking compositions
GB2463811B (en) *	2005-05-16	2010-05-05	Purdue Research Foundation	Engineered extracellular matrices
US8518436B2 (en)	2005-05-16	2013-08-27	Purdue Research Foundation	Engineered extracellular matrices
US20070269476A1 (en)	2006-05-16	2007-11-22	Voytik-Harbin Sherry L	Engineered extracellular matrices control stem cell behavior
US8084055B2 (en)	2006-09-21	2011-12-27	Purdue Research Foundation	Collagen preparation and method of isolation
WO2009076441A1 (en)	2007-12-10	2009-06-18	Purdue Research Foundation	Collagen-based matrices with stem cells
US9782457B2 (en) *	2011-10-07	2017-10-10	Tissue Repair Company	Flowable formulations for tissue repair and regeneration
US10137223B2 (en)	2013-03-14	2018-11-27	Lifenet Health	Aligned fiber and method of use thereof
US9878071B2 (en)	2013-10-16	2018-01-30	Purdue Research Foundation	Collagen compositions and methods of use
ES3027646T3 (en)	2014-08-27	2025-06-16	Purdue Research Foundation	Collagen-based therapeutic delivery systems
US9238090B1 (en)	2014-12-24	2016-01-19	Fettech, Llc	Tissue-based compositions
US11919941B2 (en)	2015-04-21	2024-03-05	Purdue Research Foundation	Cell-collagen-silica composites and methods of making and using the same
CN110446500B (zh)	2017-01-31	2024-11-26	格尼菲斯公司	用于基质制备的方法和组合物
US11739291B2 (en)	2017-04-25	2023-08-29	Purdue Research Foundation	3-dimensional (3D) tissue-engineered muscle for tissue restoration
EP3624730A4 (de)	2017-05-16	2021-04-14	Embody Inc.	Biopolymerzusammensetzungen, gerüste und vorrichtungen
WO2019084209A1 (en)	2017-10-24	2019-05-02	Embody Llc	BIOPOLYMER SCAFFOLDING IMPLANTS AND METHODS OF MAKING SAME
JP7686561B2 (ja)	2019-02-01	2025-06-02	エンボディ，インコーポレイテッド	マイクロフルイディック押出
AT523123B1 (de) *	2019-11-04	2021-10-15	3D Spine Matrix Biotechnologie Gmbh	Herstellung und verwendung von verdichtetem kollagen
EP4096635A4 (de)	2020-01-27	2024-02-21	GeniPhys, Inc.	Biologischer füllstoff zur wiederherstellung und regeneration von gewebe
MX2023002670A (es) *	2020-09-08	2023-05-08	Genentech Inc	Sistemas y procedimientos para producir composiciones farmaceuticas usando bombas peristalticas y amortiguadores.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1214505B (it) *	1987-03-12	1990-01-18	Gentili Ist Spa	Procedimento per la preparazione di collageno e prodotti cosi'ottenuto.
BR9609393A (pt) *	1995-06-07	1999-12-21	Organogenesis Inc	Composição injetável de colágeno; segmentos de fibra de colágeno reconstituìdos.

2000
- 2000-09-28 WO PCT/US2000/026766 patent/WO2001023529A1/en not_active Ceased
- 2000-09-28 ES ES00967071T patent/ES2325977T3/es not_active Expired - Lifetime
- 2000-09-28 AU AU77326/00A patent/AU7732600A/en not_active Abandoned
- 2000-09-28 EP EP00967071A patent/EP1216296B1/de not_active Expired - Lifetime
- 2000-09-28 AT AT00967071T patent/ATE428768T1/de not_active IP Right Cessation
- 2000-09-28 DE DE60042027T patent/DE60042027D1/de not_active Expired - Lifetime
- 2000-09-28 CA CA2386217A patent/CA2386217C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1216296A1 (de)	2002-06-26
CA2386217A1 (en)	2001-04-05
EP1216296B1 (de)	2009-04-15
AU7732600A (en)	2001-04-30
DE60042027D1 (de)	2009-05-28
WO2001023529A1 (en)	2001-04-05
ATE428768T1 (de)	2009-05-15
CA2386217C (en)	2011-04-26

Publication	Publication Date	Title
ES2325977T3 (es)	2009-09-28	Fibrillas de colageno obtenidas por biotecnologia.
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Rieu et al.	2019	Topotactic fibrillogenesis of freeze-cast microridged collagen scaffolds for 3D cell culture
Wallace et al.	2003	Collagen gel systems for sustained delivery and tissue engineering
AU722322B2 (en)	2000-07-27	Reconstituted collagen fiber segment compositions and methods of preparation thereof
DE69819329T2 (de)	2004-05-13	Kollagen-polysaccharid matrize zur wiederherstellung von knochen und knorpel
JP4137382B2 (ja)	2008-08-20	膠原組織組成物
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JP7384767B2 (ja)	2023-11-21	コラーゲンに基づく治療送達系
US20080131473A1 (en)	2008-06-05	Cell-Independent Fabrication of Tissue Equivalents
EA019118B1 (ru)	2014-01-30	Способ желатинизации фиброина шелка и регулирования времени желатинизации, способ инкапсуляции по меньшей мере одного компонента в фиброин шелка (варианты)
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