ES232836A1 - Procedure for the obtaining of derivatives of 3,5-dicetopirazolidina (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of derivatives of 3,5-dicetopirazolidina (Machine-translation by Google Translate, not legally binding)

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Publication number
ES232836A1
ES232836A1 ES0232836A ES232836A ES232836A1 ES 232836 A1 ES232836 A1 ES 232836A1 ES 0232836 A ES0232836 A ES 0232836A ES 232836 A ES232836 A ES 232836A ES 232836 A1 ES232836 A1 ES 232836A1
Authority
ES
Spain
Prior art keywords
formula
alkyl
meaning
hydrazine
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0232836A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH3895456A external-priority patent/CH372058A/en
Priority claimed from CH4007156A external-priority patent/CH372059A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES232836A1 publication Critical patent/ES232836A1/en
Expired legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Process for obtaining 3,5-diketopyrazolidine derivatives of the formula I ** (See formula) ** where R 1 signifies hydrogen or an alkyl or acyl residue, R 2 an alkyl radical and R 3 and R 4 alkyl, aryl, aralkyl, alkaryl or cycloalkyl radicals, characterized in that an (N-alkyl-piperidyl4) -hydrazine of the formula II is obtained ** (See formula) ** where R1 and R2 have the meaning described above, a) condensing a hydrazine derivative of formula III ** (See formula) ** where R has the meaning described above and X means hydrogen or an acyl residue, but where R1 and X can not both be hydrogen or both acyl residues, with an N-alkyl-4-piperidone of formula IV ** (See formula) ** where R2 has the meaning indicated above, and the hydrazone thus obtained, which in the case of representing R1 an alkyl group and X hydrogen can be acylated, if necessary in a known manner, is reduced and the reaction product is dissociated if necessary an optionally existing acyl group, or b) hydrazine or a hydrazine derivative of the formula III is reacted with a 4-halogen-N-alkylpiperidine of the formula V ** (See formula) ** where R2 has the above-mentioned meaning and Hal means a halogen, and the acyl group, if any, is dissociated from the reaction product or c) chloroamine is reacted with a 4-amino-n-alkylpiperidine of formula VI ** (See formula) ** wherein R2 has the above-indicated meaning, and the reaction product, if appropriate, is acylated or alkylated, and the hydrazine of the formula II obtained therefrom is reacted with a malonic acid derivative of the formula VII ** (See formula) ** where R3 and R4 have the meaning indicated above and Y and Z represent halogen, an -O-alkyl group, -NH2 or the acid group, after which an existing acyl group is dissociated, if appropriate. (Machine-translation by Google Translate, not legally binding)
ES0232836A 1956-01-07 1957-01-05 Procedure for the obtaining of derivatives of 3,5-dicetopirazolidina (Machine-translation by Google Translate, not legally binding) Expired ES232836A1 (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
CH2864256 1956-01-07
CH2968256 1956-02-08
CH3262656 1956-04-26
CH3380356 1956-05-31
CH3461756 1956-06-22
CH3787756 1956-09-27
CH3787656 1956-09-27
CH3793156 1956-09-28
CH3895456A CH372058A (en) 1956-01-07 1956-10-26 Process for the preparation of the hitherto unknown 1- (N-methyl-piperidyl-4 ') -3,5-diketo-4,4-dimethyl-pyrazolidine
CH3988756 1956-11-22
CH4007156A CH372059A (en) 1956-01-07 1956-11-28 Process for the preparation of new 3,5-diketopyrazolidines
CH4007256 1956-11-28

Publications (1)

Publication Number Publication Date
ES232836A1 true ES232836A1 (en) 1957-10-16

Family

ID=38526755

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0232836A Expired ES232836A1 (en) 1956-01-07 1957-01-05 Procedure for the obtaining of derivatives of 3,5-dicetopirazolidina (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES232836A1 (en)

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