ES2329453T3 - Cebado ex-vivo para generar linfocitos t citotoxicos especificos del ligando cd40 para tratar enfermedades autoinmunitarias y alergicas. - Google Patents

Cebado ex-vivo para generar linfocitos t citotoxicos especificos del ligando cd40 para tratar enfermedades autoinmunitarias y alergicas. Download PDF

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Publication number
ES2329453T3
ES2329453T3 ES02769746T ES02769746T ES2329453T3 ES 2329453 T3 ES2329453 T3 ES 2329453T3 ES 02769746 T ES02769746 T ES 02769746T ES 02769746 T ES02769746 T ES 02769746T ES 2329453 T3 ES2329453 T3 ES 2329453T3
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Prior art keywords
cytotoxy
autoimmunitary
vival
priming
lymphocytes
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Expired - Lifetime
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ES02769746T
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Inventor
Zeling Cai
Michael R Jackson
Per A Peterson
Weixing Shi
Yan Kong
Juli Degraw
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Janssen Pharmaceuticals Inc
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Ortho McNeil Janssen Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0634—Cells from the blood or the immune system
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Abstract

Células T CD8+ purificadas que son específicamente citotóxicas para una célula diana, donde la célula diana tiene sobre su superficie uno o más epítopos de células T auto-antigénicos presentes sobre la proteína ligando CD40 asociada con las moléculas del MHC de Clase I y donde las células T CD8+ han sido activadas selectivamente por interacción con moléculas del MHC de Clase I asociadas con dichos epítopos de las células T, para su uso en el tratamiento de enfermedades autoinmunitarias, incluyendo diabetes, artritis reumatoide, LES, esclerosis múltiple y psoriasis, y enfermedades alérgicas, incluyendo anafilaxis generalizada, rinitis alérgica, alergias alimentarias y asma alérgica.
ES02769746T 2001-05-15 2002-05-13 Cebado ex-vivo para generar linfocitos t citotoxicos especificos del ligando cd40 para tratar enfermedades autoinmunitarias y alergicas. Expired - Lifetime ES2329453T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29130001P 2001-05-15 2001-05-15

Publications (1)

Publication Number Publication Date
ES2329453T3 true ES2329453T3 (es) 2009-11-26

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ES02769746T Expired - Lifetime ES2329453T3 (es) 2001-05-15 2002-05-13 Cebado ex-vivo para generar linfocitos t citotoxicos especificos del ligando cd40 para tratar enfermedades autoinmunitarias y alergicas.

Country Status (11)

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US (10) US7811816B2 (es)
EP (4) EP1407004B1 (es)
JP (2) JP2005516581A (es)
AT (1) ATE438710T1 (es)
AU (1) AU2002308732A1 (es)
CA (1) CA2447593C (es)
DE (1) DE60233231D1 (es)
ES (1) ES2329453T3 (es)
MX (1) MXPA03010507A (es)
PT (1) PT1407004E (es)
WO (1) WO2002092773A2 (es)

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US8133972B2 (en) 2012-03-13
US7842501B2 (en) 2010-11-30
US7811816B2 (en) 2010-10-12
EP1407004A2 (en) 2004-04-14
EP2330187B1 (en) 2016-07-27
EP2330187A2 (en) 2011-06-08
EP2107110A3 (en) 2011-10-26
US8133728B2 (en) 2012-03-13
ATE438710T1 (de) 2009-08-15
US20110065187A1 (en) 2011-03-17
JP2009165482A (ja) 2009-07-30
EP1407004B1 (en) 2009-08-05
US20110015370A1 (en) 2011-01-20
CA2447593C (en) 2014-07-08
US20110021747A1 (en) 2011-01-27
WO2002092773A2 (en) 2002-11-21
MXPA03010507A (es) 2005-07-25
CA2447593A1 (en) 2002-11-21
US8133726B2 (en) 2012-03-13
EP2687593A1 (en) 2014-01-22
WO2002092773A3 (en) 2003-11-06
JP2005516581A (ja) 2005-06-09
US20070098734A1 (en) 2007-05-03
JP5247547B2 (ja) 2013-07-24
US20110020309A1 (en) 2011-01-27
DE60233231D1 (de) 2009-09-17
EP2107110A2 (en) 2009-10-07
US20110027301A1 (en) 2011-02-03
US8106153B2 (en) 2012-01-31
US8084253B2 (en) 2011-12-27
US20090202506A1 (en) 2009-08-13
AU2002308732A1 (en) 2002-11-25
US8084256B2 (en) 2011-12-27
US20110065186A1 (en) 2011-03-17
US20030170212A1 (en) 2003-09-11
US20110065180A1 (en) 2011-03-17
PT1407004E (pt) 2009-08-31
EP1407004A4 (en) 2004-07-21
EP2330187A3 (en) 2011-09-21

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