ES2335995T3 - Combinaciones de agentes vasoactivos, su uso en el campo farmaceutico y cosmetico, formulaciones que las contienen. - Google Patents
Combinaciones de agentes vasoactivos, su uso en el campo farmaceutico y cosmetico, formulaciones que las contienen. Download PDFInfo
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- ES2335995T3 ES2335995T3 ES04740699T ES04740699T ES2335995T3 ES 2335995 T3 ES2335995 T3 ES 2335995T3 ES 04740699 T ES04740699 T ES 04740699T ES 04740699 T ES04740699 T ES 04740699T ES 2335995 T3 ES2335995 T3 ES 2335995T3
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- visnadine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composición farmacéutica, cosmética, dietética o nutracéutica que comprende: - visnadina; - amentoflavona; - extracto de Centella asiatica en forma libre o complejada con fosfolípidos.
Description
Combinaciones de agentes vasoactivos, su uso en
el campo farmacéutico y cosmético, y formulaciones que las
contienen.
Esta invención se refiere a combinaciones de
sustancias vasoactivas que actúan a nivel venoso o arterial con
inhibidores de la fosfodiesterasa, incluyendo la
c-GMP fosfodiesterasa V.
\vskip1.000000\baselineskip
La visnadina es una cumarina que se encuentra
principalmente en las semillas de Ammi visnaga, una planta
usada tradicionalmente para tratar trastornos anginoides. El
compuesto se ha usado en el campo farmacéutico como dilatador
coronario.
También se ha demostrado que este compuesto,
cuando se aplica por vía tópica, tiene una fuerte acción
vasocinética sobre las arteriolas y arterias precapilares, y
aumenta el flujo sanguíneo y la perfusión de tejidos (documento EP
0418806). El suministro de sangre al tejido implica una mejor
nutrición y la eliminación de desechos metabólicos, con beneficios
consiguientes para la zona tratada. La visnadina también tiene una
actividad antifosfodiesterasa.
La amentoflavona es una biflavona presente en
cantidades moderadas en numerosas plantas, tales como Gingko
biloba, Brakeringea zanguebarica y Taxus sp.
Las saponinas del castaño de Indias o
Centella asiatica actúan sobre el sistema venoso y linfático,
en el que realizan una acción antiedematosa que facilita el drenaje
linfático.
\vskip1.000000\baselineskip
La invención se refiere a composiciones
farmacéuticas, dietéticas, cosméticas o nutracéuticas que
comprenden:
- -
- visnadina;
- -
- amentoflavona; extracto de Centella asiatica en forma libre o complejada con fosfolípidos.
\vskip1.000000\baselineskip
La combinación de sustancias vasoactivas según
la invención, que actúan simultáneamente a nivel arterial y venoso
y sobre el drenaje linfático, reduce el edema por estasis, que es
uno de los primeros síntomas de la insuficiencia venosa crónica,
con consecuencias patológicas que oscilan desde celulitis hasta
úlceras crurales de diversas etiologías. Las señales de alerta de
deficiencia circulatoria de las extremidades inferiores incluyen
temperatura de la piel por debajo de la normal, una sensación de
pesadez en las piernas y síndromes acroasfícticos con dolor
periférico. Se han hecho diversos intentos por tratar estos
síntomas, pero con un éxito moderado.
Ahora se ha descubierto sorprendentemente que
las formulaciones según la invención, que contienen compuestos con
diferentes mecanismos de acción, previenen la degeneración tisular y
vascular periférica.
El caso más común es la celulitis o
paniculopatía degenerativa. Antes de la formación de dolorosos
nódulos fibrosos o depósitos de grasa debido a la degeneración de
los adipocitos, la celulitis está provocada por la filtración de
fluidos y proteína al interior de los espacios perivasculares como
resultado de la insuficiencia venosa. El edema resultante, debido a
la compresión mecánica, reduce la libre circulación del torrente
circulatorio arterial. En estas circunstancias los adipocitos
acumulan grasa, aumentan de tamaño y quitan espacio a otras
células. El tratamiento con formulaciones anticelulíticas debe
comenzar en este momento si quiere conseguirse el máximo éxito. La
asociación según la invención permite tratar el estado en la fase
prepatológica, con el fin de evitar que progrese hasta daño
periférico. Las mismas formulaciones también pueden usarse
satisfactoriamente incluso cuando el trastorno ha pasado a ser
crónico, para eliminar sensaciones dolorosas y reducir masas
adiposas no deseadas con tratamientos a largo plazo, por medio de
la estimulación de lipasas inducida por la persistencia de
nucleótidos cíclicos en los tejidos.
Las composiciones según la invención tienen
normalmente los siguientes intervalos de concentración en peso:
- -
- visnadina: al 0,05-2%;
- -
- amentoflavona: al 0,1-1%;
- -
- extracto de Centella asiatica, en forma libre o complejada con fosfolípidos: al 0,5%-2%.
\vskip1.000000\baselineskip
Estos compuestos pueden incorporarse en la
mayoría de las formulaciones farmacéuticas y cosméticas comunes,
tales como emulsiones aceite en agua y agua en aceite, portadas
adecuadamente por excipientes, tensioactivos y solubilizantes.
Además, los productos pueden formularse en forma
de crema, leche y gel para el tratamiento de zonas grandes de la
piel.
El siguiente ejemplo ilustra la invención en
detalle.
\vskip1.000000\baselineskip
Ejemplo
Claims (4)
1. Composición farmacéutica, cosmética,
dietética o nutracéutica que comprende:
- -
- visnadina;
- -
- amentoflavona;
- -
- extracto de Centella asiatica en forma libre o complejada con fosfolípidos.
\vskip1.000000\baselineskip
2. Composición según la reivindicación 1, que
tiene los siguientes intervalos de concentración en peso:
- -
- visnadina: al 0,05-2%;
- -
- amentoflavona: al 0,1-1%;
- -
- extracto de Centella asiatica en forma libre o complejada con fosfolípidos: al 0,5%-2%.
\vskip1.000000\baselineskip
3. Composiciones según las reivindicaciones
1-2, en forma de cremas, gel, lociones, leche.
4. Uso de una combinación de:
- -
- visnadina;
- -
- amentoflavona;
- -
- extracto de Centella asiatica en forma libre o complejada con fosfolípidos,
para la preparación de una composición para el
tratamiento de la paniculopatía.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001427A ITMI20031427A1 (it) | 2003-07-11 | 2003-07-11 | Combinazioni di agenti vasoattivi, loro uso in campo farmaceutico e cosmetico e formulazioni che li contengono |
| ITMI03A1427 | 2003-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2335995T3 true ES2335995T3 (es) | 2010-04-07 |
Family
ID=34044549
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09177048.7T Expired - Lifetime ES2621505T3 (es) | 2003-07-11 | 2004-07-06 | Combinaciones de agentes vasoactivos, su uso en el campo farmacéutico y cosmético, y formulaciones que los contienen |
| ES04740699T Expired - Lifetime ES2335995T3 (es) | 2003-07-11 | 2004-07-06 | Combinaciones de agentes vasoactivos, su uso en el campo farmaceutico y cosmetico, formulaciones que las contienen. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09177048.7T Expired - Lifetime ES2621505T3 (es) | 2003-07-11 | 2004-07-06 | Combinaciones de agentes vasoactivos, su uso en el campo farmacéutico y cosmético, y formulaciones que los contienen |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7976881B2 (es) |
| EP (2) | EP1658064B1 (es) |
| JP (1) | JP4964590B2 (es) |
| KR (2) | KR101166935B1 (es) |
| CN (1) | CN1819826A (es) |
| AT (1) | ATE455544T1 (es) |
| AU (1) | AU2004255442B2 (es) |
| BR (1) | BRPI0412365B8 (es) |
| CA (1) | CA2532828C (es) |
| DE (1) | DE602004025253D1 (es) |
| DK (2) | DK1658064T3 (es) |
| ES (2) | ES2621505T3 (es) |
| HU (1) | HUE032952T2 (es) |
| IT (1) | ITMI20031427A1 (es) |
| NO (1) | NO335285B1 (es) |
| PL (2) | PL1658064T3 (es) |
| PT (2) | PT2158909T (es) |
| RU (2) | RU2481852C2 (es) |
| SI (2) | SI2158909T1 (es) |
| WO (1) | WO2005004858A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20031789A1 (it) * | 2003-09-19 | 2005-03-20 | Indena Spa | Composizioni farmaceutiche e cosmetiche per il trattamento |
| BRPI0607967B1 (pt) * | 2005-03-12 | 2022-07-19 | Unilever Ip Holdings B.V | Uso de visnadina |
| ES2346900T3 (es) | 2005-03-12 | 2010-10-21 | Unilever N.V. | Composiciones para el cuidado del cabello y/o el cuero cabelludo que incorporan compuestos amino-oxo-indol-ilideno. |
| JP5179032B2 (ja) * | 2006-09-15 | 2013-04-10 | 株式会社ノエビア | 痩身用組成物 |
| KR20080025960A (ko) * | 2006-09-19 | 2008-03-24 | (주)아모레퍼시픽 | 이카리시드 ⅰⅰ의 제조 방법 및 이를 함유하는 미백용조성물 |
| EP2011496A1 (en) * | 2007-07-03 | 2009-01-07 | Indena S.P.A. | Combinations of vasoactive substances with estrogens and their use in the treatment of female sexual dysfunctions |
| FR2918885B1 (fr) | 2007-07-17 | 2009-08-28 | Oreal | Utilisation d'extrait de bacterie cultivee sur eau thermale pour diminuer les poches et/ou les cernes perioculaires |
| ITMI20110373A1 (it) * | 2011-03-10 | 2012-09-11 | Erbolario S R L L | "composizioni cosmetiche per il trattamento degli inestetismi cutanei della cellulite" |
| US20160206674A1 (en) | 2013-12-24 | 2016-07-21 | Biotropics Malaysia Bhd | Fruit extracts and extract formulations of canarium odontophyllum as actives and related invention embodiments |
| CN104387430B (zh) * | 2014-10-27 | 2017-03-15 | 广东东阳光药业有限公司 | 淫羊藿苷类化合物及其应用 |
| CN112107515A (zh) * | 2020-09-22 | 2020-12-22 | 鲁南制药集团股份有限公司 | 一种含有淫羊藿提取物的护肤品组合物及其用途 |
| RU2770422C1 (ru) * | 2021-02-18 | 2022-04-18 | Закрытое Акционерное Общество "Канонфарма Продакшн" | Фармацевтическая композиция в форме гидрогеля с венотонизирующим и ранозаживляющим действием |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1203515B (it) * | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| IT1233753B (it) * | 1989-09-21 | 1992-04-14 | Indena Spa | Composizioni farmaceutiche ad attivita' sulla microcircolazione cutanea. |
| IT1239281B (it) * | 1989-10-27 | 1993-10-19 | Indena Spa | Composizioni per la riduzione dei depositi di grasso superfluo a base di principi attivi di origine vegetale ad attivita' agonista dell'adenilato ciclasi o/e ad attivita' antifosfodiesterasica |
| IT1269634B (it) | 1994-05-06 | 1997-04-08 | Indena Spa | Medicamento topico ad attivita' cicatrizzante |
| IT1270602B (it) * | 1994-07-12 | 1997-05-07 | Indena Spa | Formulazioni a base di esculoside e loro uso in campo farmaceutico e cosmetico |
| IT1278997B1 (it) * | 1994-07-19 | 1997-12-02 | Indena Spa | Combinazioni di sostanze vasoattive con acidi grassi per combattere la caduta dei capelli |
| IT1270999B (it) * | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| US5529769A (en) * | 1994-12-20 | 1996-06-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic compositions containing betulinic acid |
| US5523090A (en) * | 1995-02-24 | 1996-06-04 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin treatment composition |
| FR2740681B1 (fr) | 1995-11-07 | 1998-01-23 | Fabre Pierre Dermo Cosmetique | Composition cosmetique a base d'un extrait de viburnum |
| US6267996B1 (en) * | 1996-10-17 | 2001-07-31 | Indena S.P.A | Pharmaceutical and cosmetic formulations with antimicrobial activity |
| WO1998046238A1 (en) * | 1997-04-15 | 1998-10-22 | Medichem Research, Inc. | Biflavinoids and derivatives thereof as antiviral agents, alone or in combination with at least one known antiviral agent |
| DE69804657T2 (de) * | 1997-11-19 | 2002-11-28 | Flavone Sunproducts A/S, Naestved | Eine oder mehrere flavonide enthaltende zusammensetzung, verfahren zu ihrer herstellung und ihre verwendung als uv-absorbierendes mittel |
| US20020013280A1 (en) * | 2000-06-16 | 2002-01-31 | Zhongcheng Xin | Pharmaceutical composition for preventing and treating sexual dysfunction and vasculargenic disease comprising icariin |
| KR100394329B1 (ko) * | 1999-06-17 | 2003-08-09 | 북경동방백오의약개발유한공사 | 성기능장애 및 혈관계질환의 치료용 약제학적 조성물 |
| JP2004517801A (ja) | 2000-04-18 | 2004-06-17 | セテリス・ホールディング・ベスローテン・フェンノートシャップ−アムステルダム（オランダ）−スックルサーレ・ディ・ルガーノ | 皮膚のしわの予防または治療に有用な天然抽出物に基づく組成物 |
| WO2002087700A1 (en) * | 2001-04-26 | 2002-11-07 | The Procter & Gamble Company | Method, kit and device for the treatment of cosmetic skin conditions |
| ITMI20011182A1 (it) * | 2001-06-05 | 2002-12-05 | Indena Spa | Composizioni farmaceutiche e/o cosmetiche per il trattamento di adiposita' localizzate e della cellulite |
-
2003
- 2003-07-11 IT IT001427A patent/ITMI20031427A1/it unknown
-
2004
- 2004-07-06 CA CA2532828A patent/CA2532828C/en not_active Expired - Lifetime
- 2004-07-06 PT PT91770487T patent/PT2158909T/pt unknown
- 2004-07-06 PL PL04740699T patent/PL1658064T3/pl unknown
- 2004-07-06 PL PL09177048T patent/PL2158909T3/pl unknown
- 2004-07-06 EP EP04740699A patent/EP1658064B1/en not_active Expired - Lifetime
- 2004-07-06 BR BRPI0412365A patent/BRPI0412365B8/pt not_active IP Right Cessation
- 2004-07-06 ES ES09177048.7T patent/ES2621505T3/es not_active Expired - Lifetime
- 2004-07-06 SI SI200432387A patent/SI2158909T1/sl unknown
- 2004-07-06 CN CNA2004800197457A patent/CN1819826A/zh active Pending
- 2004-07-06 KR KR1020067000543A patent/KR101166935B1/ko not_active Expired - Lifetime
- 2004-07-06 RU RU2009101337/15A patent/RU2481852C2/ru active
- 2004-07-06 RU RU2006100308/15A patent/RU2358726C2/ru active
- 2004-07-06 JP JP2006518124A patent/JP4964590B2/ja not_active Expired - Fee Related
- 2004-07-06 DK DK04740699.6T patent/DK1658064T3/da active
- 2004-07-06 AU AU2004255442A patent/AU2004255442B2/en not_active Expired
- 2004-07-06 AT AT04740699T patent/ATE455544T1/de active
- 2004-07-06 ES ES04740699T patent/ES2335995T3/es not_active Expired - Lifetime
- 2004-07-06 EP EP09177048.7A patent/EP2158909B1/en not_active Expired - Lifetime
- 2004-07-06 HU HUE09177048A patent/HUE032952T2/en unknown
- 2004-07-06 SI SI200431365T patent/SI1658064T1/sl unknown
- 2004-07-06 DK DK09177048.7T patent/DK2158909T3/en active
- 2004-07-06 DE DE602004025253T patent/DE602004025253D1/de not_active Expired - Lifetime
- 2004-07-06 US US10/563,965 patent/US7976881B2/en not_active Expired - Lifetime
- 2004-07-06 KR KR1020127004593A patent/KR101227788B1/ko not_active Expired - Fee Related
- 2004-07-06 WO PCT/EP2004/007375 patent/WO2005004858A1/en not_active Ceased
- 2004-07-06 PT PT04740699T patent/PT1658064E/pt unknown
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2006
- 2006-01-10 NO NO20060152A patent/NO335285B1/no unknown
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