ES2354824T3 - Pirazolo[1,5-a]pirimidinas útiles como inhibidores de proteínas cinasas. - Google Patents

Pirazolo[1,5-a]pirimidinas útiles como inhibidores de proteínas cinasas. Download PDF

Info

Publication number: ES2354824T3
Authority: ES; Spain
Prior art keywords: alkyl; aliphatic; aryl; heterocyclyl; optionally
Prior art date: 2004-11-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES05816516T

Other languages

English (en)

Spanish (es)

Inventor

Dean Stamos

Juan-Miguel Jimenez

Alex Aronov

Ronald Knegtel

Jon R. Come

Jean-Damien Charrier

Pan Li

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Vertex Pharmaceuticals Inc

Original Assignee

Vertex Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-04

Filing date

2005-11-04

Publication date

2011-03-18

2005-11-04 Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc

2011-03-18 Application granted granted Critical

2011-03-18 Publication of ES2354824T3 publication Critical patent/ES2354824T3/es

2025-11-04 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

0 CC=CC=C(C(C(N)=N*1=C(C)C2=CC=CC(C(N3COCC3)=O)N2)=C1N)N Chemical compound CC=CC=C(C(C(N)=N*1=C(C)C2=CC=CC(C(N3COCC3)=O)N2)=C1N)N 0.000 description 3
UTOGPRPIGILDRR-CVCGVWEVSA-O C/C(/C(O)=O)=C\C=C(\C(\C)=[NH+]\C(\N)=C(/C(N)=N)\c1ccc[nH]1)/N Chemical compound C/C(/C(O)=O)=C\C=C(\C(\C)=[NH+]\C(\N)=C(/C(N)=N)\c1ccc[nH]1)/N UTOGPRPIGILDRR-CVCGVWEVSA-O 0.000 description 1
IWJKKTCNYPQDJK-UHFFFAOYSA-N NC1=NC2=C(c3ccc(C(NCCNI)=O)[nH]3)NC2=C1c1ncccc1 Chemical compound NC1=NC2=C(c3ccc(C(NCCNI)=O)[nH]3)NC2=C1c1ncccc1 IWJKKTCNYPQDJK-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Neurology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)

ES05816516T 2004-11-04 2005-11-04 Pirazolo[1,5-a]pirimidinas útiles como inhibidores de proteínas cinasas. Expired - Lifetime ES2354824T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62544604P	2004-11-04	2004-11-04
US625446P		2004-11-04

Publications (1)

Publication Number	Publication Date
ES2354824T3 true ES2354824T3 (es)	2011-03-18

Family

ID=35809833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES05816516T Expired - Lifetime ES2354824T3 (es)	2004-11-04	2005-11-04	Pirazolo[1,5-a]pirimidinas útiles como inhibidores de proteínas cinasas.

Country Status (20)

Country	Link
US (1)	US7528138B2 (2)
EP (1)	EP1812440B1 (2)
JP (2)	JP5030229B2 (2)
KR (1)	KR20070090172A (2)
CN (1)	CN101094853B (2)
AT (1)	ATE482213T1 (2)
AU (1)	AU2005304784B2 (2)
CA (1)	CA2586375A1 (2)
DE (1)	DE602005023763D1 (2)
DK (1)	DK1812440T3 (2)
ES (1)	ES2354824T3 (2)
IL (1)	IL182893A0 (2)
MX (1)	MX337817B (2)
NO (1)	NO20072795L (2)
NZ (1)	NZ555236A (2)
PT (1)	PT1812440E (2)
RU (1)	RU2417996C2 (2)
SI (1)	SI1812440T1 (2)
WO (1)	WO2006052913A1 (2)
ZA (1)	ZA200704476B (2)

Families Citing this family (108)

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CN101878217B (zh) *	2007-09-28	2014-01-15	协和发酵麒麟株式会社	皮肤疾病的预防和/或治疗剂
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NZ586662A (en) *	2007-12-19	2012-08-31	Vertex Pharma	PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORS
AU2008343813B2 (en) *	2007-12-19	2012-04-12	Amgen Inc.	Inhibitors of PI3 kinase
JP5638961B2 (ja) *	2008-03-13	2014-12-10	ザジェネラルホスピタルコーポレイション	Ｂｍｐシグナル伝達経路のインヒビター
KR20110017445A (ko) *	2008-06-11	2011-02-21	아스트라제네카 아베	암 및 골수증식성 장애의 치료에 유용한 트리시클릭 2,4-디아미노-ｌ,3,5-트리아진 유도체
WO2010031816A1 (en) *	2008-09-19	2010-03-25	Nerviano Medical Sciences S.R.L.	3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES
PT2350075E (pt)	2008-09-22	2014-06-09	Array Biopharma Inc	Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase
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GB0821913D0 (en)	2008-12-02	2009-01-07	Price & Co	Antibacterial compounds
JP5775070B2 (ja) *	2009-05-22	2015-09-09	インサイト・コーポレイションＩｎｃｙｔｅＣｏｒｐｏｒａｔｉｏｎ	ヤヌスキナーゼ阻害剤としてのピラゾール−４−イル−ピロロ［２，３−ｄ］ピリミジンおよびピロール−３−イル−ピロロ［２，３−ｄ］ピリミジンのＮ−（ヘテロ）アリール−ピロリジン誘導体
SG176111A1 (en) *	2009-05-22	2011-12-29	Incyte Corp	3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
CN102448969A (zh) *	2009-05-28	2012-05-09	沃泰克斯药物股份有限公司	C-met蛋白激酶抑制剂
RS57869B1 (sr)	2009-06-17	2018-12-31	Vertex Pharma	Inhibitori replikacije virusa gripa
UA110324C2 (en)	2009-07-02	2015-12-25	Genentech Inc	Jak inhibitory compounds based on pyrazolo pyrimidine
AR077468A1 (es)	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
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PT2473049T (pt)	2009-09-04	2019-03-04	Sunesis Pharmaceuticals Inc	Inibidores de tirosina quinase de bruton
PT3354652T (pt)	2010-03-10	2020-07-20	Incyte Holdings Corp	Derivados de piperidin-4-ilazetidina como inibidores de jak1
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RS54824B1 (sr)	2010-05-21	2016-10-31	Incyte Holdings Corp	Topikalna formulacija za inhibiciju jak-a
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2005
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- 2005-11-04 CN CN2005800450252A patent/CN101094853B/zh not_active Expired - Fee Related
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Publication number	Publication date
AU2005304784B2 (en)	2011-03-24
HK1113569A1 (en)	2008-10-10
KR20070090172A (ko)	2007-09-05
CN101094853B (zh)	2011-07-13
MX337817B (es)	2011-11-04
IL182893A0 (en)	2007-08-19
DK1812440T3 (da)	2011-01-31
ZA200704476B (en)	2008-09-25
JP5030229B2 (ja)	2012-09-19
MX2007005439A (es)	2008-02-19
CA2586375A1 (en)	2006-05-18
AU2005304784A1 (en)	2006-05-18
RU2417996C2 (ru)	2011-05-10
DE602005023763D1 (de)	2010-11-04
EP1812440A1 (en)	2007-08-01
US20060135537A1 (en)	2006-06-22
ATE482213T1 (de)	2010-10-15
PT1812440E (pt)	2011-01-25
CN101094853A (zh)	2007-12-26
NZ555236A (en)	2010-10-29
SI1812440T1 (sl)	2011-04-29
JP2008519059A (ja)	2008-06-05
NO20072795L (no)	2007-06-01
JP2009067803A (ja)	2009-04-02
EP1812440B1 (en)	2010-09-22
RU2007120518A (ru)	2008-12-10
US7528138B2 (en)	2009-05-05
WO2006052913A1 (en)	2006-05-18

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