ES2356458B1 - Métodos y productos para genotipado in vitro de variaciones génicas humanas asociadas a reacciones adversas a fármacos. - Google Patents
Métodos y productos para genotipado in vitro de variaciones génicas humanas asociadas a reacciones adversas a fármacos. Download PDFInfo
- Publication number
- ES2356458B1 ES2356458B1 ES200901846A ES200901846A ES2356458B1 ES 2356458 B1 ES2356458 B1 ES 2356458B1 ES 200901846 A ES200901846 A ES 200901846A ES 200901846 A ES200901846 A ES 200901846A ES 2356458 B1 ES2356458 B1 ES 2356458B1
- Authority
- ES
- Spain
- Prior art keywords
- genotyping
- vitro
- products
- methods
- chips
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000002068 genetic effect Effects 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002411 adverse Effects 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000003205 genotyping method Methods 0.000 abstract 4
- 238000000018 DNA microarray Methods 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 abstract 1
- 206010064571 Gene mutation Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000013401 experimental design Methods 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000011458 pharmacological treatment Methods 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Métodos y productos para genotipado in vitro de variaciones génicas humanas asociadas a reacciones adversas a fármacos.#El método de genotipado se basa en la combinación de un diseño experimental de DNA-chips de genotipado y en el desarrollo de un sistema secuencial de procesamiento e interpretación de los datos experimentales generados por dichos DNA-chips de genotipado basado en el aumento de la señal de hibridación, lo que garantiza unos elevados niveles de especificidad, sensibilidad y reproducibilidad de los resultados, que permiten que dichos DNA-chips puedan ser utilizados como herramientas fiables de diagnóstico genético clínico; en particular, en la detección de variaciones génicas, por ejemplo, polimorfismos o mutaciones génicas asociadas con la resistencia a tratamientos farmacológicos.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200901846A ES2356458B1 (es) | 2009-09-11 | 2009-09-11 | Métodos y productos para genotipado in vitro de variaciones génicas humanas asociadas a reacciones adversas a fármacos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200901846A ES2356458B1 (es) | 2009-09-11 | 2009-09-11 | Métodos y productos para genotipado in vitro de variaciones génicas humanas asociadas a reacciones adversas a fármacos. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2356458A1 ES2356458A1 (es) | 2011-04-08 |
| ES2356458B1 true ES2356458B1 (es) | 2012-01-23 |
Family
ID=43778039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200901846A Expired - Fee Related ES2356458B1 (es) | 2009-09-11 | 2009-09-11 | Métodos y productos para genotipado in vitro de variaciones génicas humanas asociadas a reacciones adversas a fármacos. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2356458B1 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2356207C (en) * | 1999-10-21 | 2012-10-09 | Case Western Reserve University | Gene expression profiling of inflammatory bowel disease |
-
2009
- 2009-09-11 ES ES200901846A patent/ES2356458B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2356458A1 (es) | 2011-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 2356458 Country of ref document: ES Kind code of ref document: B1 Effective date: 20120123 |
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| FD2A | Announcement of lapse in spain |
Effective date: 20210929 |