ES2357971T3 - PROCEDURE AND DEVICE FOR THE NON-CONTACT AND SEQUENTIAL DISPERSION OF MACROCOMPONENTS, ESPECIALLY OF ACTIVE MICRONUTRIENTS. - Google Patents

Abstract

The invention relates to a method for the sequential dispersion of macrocomponents. According to said method, a container (130, 1300) comprising at least two chambers (100, 200) for respectively receiving a macrocomponent (8, 10) is used. The macrocomponents in the chambers in the initial state are sealed from each other by a separating element (9, 39, 59) and from the outside by another separating element (12, 59). Said method comprises the following steps: a) a first separating element (9, 39, 59) is opened by applying a mechanical force, b) the two macrocomponents (8, 10) which are respectively in contact with the first separating element (9, 39, 59) in the intial state are brought into contact or mixed, releasing a gas which leads to a pressure rise corresponding to the degree of mixture or dispersion and causing the second separating element to crack, and c) the mixture (189) of macrocomponents (8, 10) obtained in step b) is brought into contact or mixed with at least one third macrocomponent. The invention also relates to a device for carrying out the method.

Description

A procedure is exposed with the help of which components that have a tendency to agglomeration or degradation can be dispersed with extreme rapidity and with minimal agitation. The dispersibility of the different components 5 is achieved here with the help of a defined mixing or contact sequence, the degree of dispersion presented for many systems being considerably increased compared to procedures corresponding to the prior art. The procedure is characterized here above all because its manipulation and timing can be carried out very simply even by inexperienced users. The procedure is especially suitable for presenting unstable beverages of micronutrients that are hardly soluble a priori and, therefore, poorly bioavailable in a perfectly bioavailable form.

Devices with whose help the procedure can be performed in a very simple way are also revealed. In addition, optimally dispersed beverages can be produced without contact, that is, without risk of contamination and this together with a minimum of preservative or dispersing auxiliary agents to be used.

Drinks include only to a small extent bioavailable active substances that have a tendency to agglomerate in a free state. It is common for such active substances to be bioavailable only in freshly squeezed juices, since they probably occur only on a nanometric scale inside a cell, that is, they are protected against agglomeration by cell membranes. However, such active substances on a nanometric scale can be stabilized with the aid of accumulation procedures of various components.

For this reason, a technology is required regarding how corresponding components can be gathered in a beverage container, that is, particularly a bottle or a can of beverage, in a manner suitable for the user and how these components can be dispersed in a manner adequate. This technology, if implemented in a manner compatible with beverages, would have the essential advantage of integrating in a drink, at any time, active and particulate plant constituents. According to hygienic criteria, it is therefore essential that this advantage is not consumed by the disadvantage of the risk of contamination of the beverage during the mixing process. For this reason, it is essential to ensure a mixing process free of contamination.

It is also essential here that corresponding macrocomponents meet in a defined sequence and with a defined timing to achieve optimal dispersion and, therefore, optimal bioavailability. As a phenomenological example, the following can be mentioned:

A system consisting of the three macrocomponents - that is, those that can be separated macroscopically - 30 consisting of A, B and C. This system would have to disperse through the following sequence:

1. A + B  AB

2. AB + C  ABC

If the three components were combined at once in this case, the system could not then disperse, at least not in a suitable space of time. It is common for a component not to dissolve even over time periods of a few minutes to hours, or even to coagulate, provided that local pH fluctuations may occur as a result of renal mixing inhomogeneities.

For this reason, a device is also demanded with which two components can be deliberately brought into contact with each other and they can be mixed well with each other. As soon as the mixing has been done sufficiently well, the concentrated mixture must be mixed with the actual contents of a beverage container, each step having to be carried out in such a way that, in the meantime, they cannot reach in any case from outside to inside foreign substances, for example bacteria, viruses. It should also be taken into account in this regard that a sufficient amount of mechanical energy can be comfortably provided from the outside so that especially the individual components can be mixed well with one another. In fact, it is usually necessary to work with hardly soluble solid substances or high viscosity pasty fractions that a priori can only be mixed with difficulty. Four. Five

According to DE 699 13 682 T, two separate fractions that are separated by a partition are deposited in an inner vessel with slight overpressure, this inner vessel being opened after the opening of the outer vessel. The opening of the outer container is effected as a result of the decrease in pressure in the outer container, whereby the pressure difference across the membrane turns out to be so large that it opens.

Document DE 1939086 discloses a system that allows separate preservation and mixing of two or more fractions.

The fact that, on the one hand, sequential mixing is not possible, is disadvantageous; on the other hand, the process is difficult to apply, for example, for beverage cans, precisely when components that are a priori are difficult to dissolve or mix and an increased mechanical agitation of the components would be necessary to intermingle them with each other. This means that a can of drink, once opened, can no longer even be shaken to put in solution possible species that are hardly soluble or to disperse them well.

For this reason, the problem of the present invention lies in the creation of a method for non-contact and sequential dispersion of macrocomponents.

These problems are solved according to the invention with the characteristics of the independent claims. 5

The invention provides a method for sequential dispersion of macrocomponents. To carry out the procedure, a container is enabled, especially a container that can be arranged as an inner container in an outer main container, such as, for example, a bottle. This enabled container has at least two cameras that can each receive a macrocomponent. In the starting state, the chambers are isolated from each other by a respective separation element and are also closed outwards, that is, especially with respect to the outer main container, by means of another separation element. In the initial state of the filled inner container the macrocomponents contained in the chambers are presented separated from each other by at least one respective separation element. The inner container or at least one chamber is closed out by at least one additional separation element. Therefore, in the starting state all macrocomponents are packaged separately.

The procedure comprises the following steps: 15

a) opening a first separation element by applying a mechanical force,

b) contacted or mixed of the two macrocomponents that were in contact in the respective starting state with the first separation element, at the same time releasing a gas that leads to an increase in pressure that corresponds to the degree of mixing or dispersion and that makes that breaks a second element of separation,

c) contacted or mixed the mixture of the macrocomponents of step b) with at least a third macrocomponent. twenty

Due to the opening of a first separating element the inner container passes from its starting state to a not completely open state. In this state, at least two chambers are not completely open and, therefore, the macrocomponents deposited therein are in contact with each other, but the inner container is still sealed towards the main container through at least one closed separation element.

In an advantageous improvement the process comprises the step of 25

d) movement, especially shaking, of the mixture of step c) to increase the intermingling.

This movement can be carried out, for example, by shaking the main container.

The method according to the invention especially comprises the following steps:

a) opening a first separation element by applying a mechanical force,

i) crossing this force at least two substantially closed containers, 30

b) contacted or mixed of macrocomponents # 1 and # 2 that are in contact with the first separation element, while releasing a gas

 i) which leads to an increase in pressure corresponding to the degree of mixing or dispersion and causing a second separation element to burst from a defined burst pressure,

 ii) whereby the mixture of macrocomponents # 1 and # 2 is contacted or mixed with at least a third macrocomponent.

In this procedure it is essential that the correct timing of mixing of macrocomponents # 1 and macrocomponents # 2 with the third macrocomponent is ensured - in general an aqueous liquid. To this end, the increase in pressure, which is a consequence of gas production, which in turn corresponds to the degree of intermingling or dispersion of the corresponding macrocomponents # 1 and # 2, is the decisive characteristic magnitude. Therefore, if the dispersion of macrocomponents # 1 and # 2 has progressed sufficiently, then, so to speak, a corresponding pressure has been established in the area surrounding macrocomponents # 1 and # 2, which causes Then burst the second element of separation. A procedure that sets the timing of the mixing sequence is thus completed for the user. The time period from activation, that is, from the breakage of the first separation element, to the bursting of the second separation element, thus depends, first, on the intensity with which the system is agitated and on the effectiveness with the macrocomponents are then mixed.

Those components that are considered macroscopically as homogeneous are designated as macrocomponents. However, these are generally constituted each of them by a large number of species that in the context used here are designated as microcomponents, with complete independence of the actual dimension of their particles.

Another advantage of the process is that the dispersion process is carried out or can be carried out without contact, whereby

The user can optimally disperse the macrocomponents with each other at any time and in any environment, without them becoming contaminated, which is especially preferred in the food sector, especially in the beverage preparation sector, as well as in the sector of nutritional supplements and supplementary balanced diets.

The term "no contact" is used here in the context that macrocomponents are not touched during the dispersion process or are not exposed to an external atmosphere; for this reason, it is typically also a sterile process that is especially suitable for the dispersion of pharmaceutical products. Preferably, the main container is kept closed during the entire mixing process, so that no bacteria or germs of any kind can advance inwards. In addition or as an alternative to this, the main vessel is under high pressure, so that with the corresponding opening in question at least there is no forced exchange of atmosphere from outside to inside the vessel.

Typically, the result of the process performed according to the invention is an unstable solution or an unstable colloidal solution of different microcomponents. A feature is also that the corresponding solutions degrade or agglomerate over time, so that the biological quality of a corresponding beverage decreases significantly within hours or days. In general, the proportion of particles less than 100 nm is modified considerably in the 24-hour time frame, based on the proportion in a period of 10 minutes or 60 minutes after the initiation of the procedure. Typically, this proportion decreases more than 50% in this period of time, which can be determined by laser diffraction studies.

For this reason, the process according to the invention is suitable for dispersing macrocomponents containing microcomponents and incorporating active substances in particles, such as trace elements that are hardly soluble or vitamins that are hardly soluble or secondary plant constituents. The trace elements or trace elements that are hardly soluble are considered, for example, vanadium, silver, gold, platinum, but also those trace elements classified as essential, such as iron, copper, cobalt. Secondary plant constituents that are hardly soluble are considered, for example, carotinoids, flavonoids, hardly soluble vitamins, such as vitamins E and the like. The process can also adsorb enzymes in an unpasteurized form on a support matrix and can use the adsorbed and / or immobilized system as macrocomponents.

An advantageous variant of the process consists in also incorporating a fourth macrocomponent. The variant is used when a third component would otherwise comprise microcomponents that would degrade one another, such as, for example, an oxygen-enriched macrocomponent, which, for example, should not contain carbohydrates or oxidizable microcomponents. In this case, at least one inner container is introduced, for example, a concentrate of saporiferous substances which, as an alternative to this, in a system of three macrocomponents would have been introduced diluted in the main container, being introduced with the help of another Separation element the macrocomponent # 3 between the second and third separation elements.

The process according to the invention is especially suitable for enriching with oxygen drinks that can be decomposed with oxygen. However, since all the oxygen-decomposable species are contained in at least one inner vessel here, they are thus protected against oxidative or oxidative catalysts. Oxygen enrichment has physiological advantages for nutrition and especially stimulates digestion. The partial pressure of oxygen is here typically between 1.0 and 15 bars, preferably between 2 and 10 bars.

Preferably, a four macrocomponent process is also chosen when macrocomponent # 3 consists of a concentrate that, as a result of its very high proportion of ingredients with a conservative action - for example, 40 sugar or fruit acids, only has a preservative action in concentrated form.

An essential feature of the process according to the invention is the presentation of dispersions with a high proportion of nutritive active substances in perfectly bioavailable particles, since a high bioavailability of active substances in particles is correlated with a high active boundary surface which in turn is especially high in manometric scale microcomponents. In general, referring to the dry mass, at least 70% of the dissolved particles are less than 100 nm. Typically, at least 30% and preferably at least 50% of all particles are less than 100 nm. These percentage data refer to the number of particles.

Typically, the components are composed of respective basic or acidic microcomponents, preferably the basic and acidic microcomponents being separated. It is precisely the trace elements and trace elements that are hardly soluble that are protected in a basic suspension due to the high activity of the hydroxide ions against agglomeration or crystallization and, therefore, are stabilized in a perfectly bioavailable modification.

The gas that is released as a result of the contact of the macrocomponents and that leads to the increase in pressure that ultimately leads to the opening of a separation element is carbon dioxide in a preferred embodiment of the invention.

The present patent application comprises a device with which the process according to the invention can be performed. The device comprises a main container and at least one inner container. The inner container has at least two chambers to receive at least two macrocomponents that are deposited separately from each other in the inner container. The wall of the chambers, that is, their outer limitation, is formed at least partially by a respective separation element. The separation elements are sized so that a first separation element, which in the filled state of the inner container separates one from the other, in the starting state, the macrocomponents deposited in the chambers, open when an external force acts, with which establishes an open communication between the chambers, while a second element that in the not fully open state of the inner container closes at least one chamber of the inner container is still closed outwards and towards the main container.

The invention thus enables a step-by-step mixing of the macrocomponents in a preset sequence. The sequence is materialized by means of the dimensioning of the separation elements. The separating element that has to separate the macrocomponents that must be mixed first, has the minimum resistance against load and, therefore, is the first to open. Therefore, a previous stage is achieved in the path leading to the mixing of all the macrocomponents that must be achieved ultimately. In the simplest case of two deposited macrocomponents, this previous stage is the only intermediate stage before the opening of the additional separation element. If more than two macrocomponents are deposited, more chambers and more "first" separation elements corresponding to the desired number of intermediate stages are correspondingly provided. These intermediate stages characterize the not fully open state of the inner container.

In general, the separation element that closes the chamber with the macrocomponent to be added lastly with respect to the other chambers has the second lowest resistance against load. The lowest resistance is the separation element that closes the inner container or the last chamber outwards and towards the main container. Therefore, according to the invention, a sequential dispersion or mixing of the macrocomponents is first performed before they are sent abroad. The mixture can then be used directly or it can be mixed with an additional component deposited in the main container.

The chambers are formed, for example, as hollow bodies, especially based on plastic and / or glass, this hollow body having at least one opening that can be closed by a separating element.

In another embodiment the inner container is a double chamber bag in which the separation elements have been produced by means of a defined seal of a removable film.

In an advantageous development, the second separation element is sized so that it is opened only by the action of a high pressure that is established as a result of a pressure increase due to the reaction of the macrocomponents with one another after opening. of the first separation element.

The inner container may be configured, for example, in a substantially cylindrical shape along a main axis, the at least two chambers being arranged along this main axis in series with each other. This materializes a particularly slender construction that can be used simply, for example, in bottles or cans of drink. 30

In a preferred embodiment, the separation elements are made in the form of seals. A seal can be configured here in such a way that it bursts under a mechanical load greater than its resistance. However, it can also be configured so that in the closed state two films adhere tightly to each other, the films being separated from each other when the resistance against mechanical load is exceeded and thus the seal is opened. The two films, especially in a sealed tubular seal, can be the two film zones of the flexible tube opposite each other. This tubular-shaped seal can itself constitute an open joint between the chambers.

Alternatively or additionally, it is envisioned that at least one separation element comprises at least one preferred opening segment. This opening segment forms a nominal breaking site for the separation element, so that an especially reliable opening can be adjusted. 40

In order to immobilize the inner container in the main container, a retention device is provided in a preferred improvement. In particular, the inner container can present the retention device, so that said container can be offered full and only needs to be introduced still in a bottle or can, for example by the final consumer. In an advantageously simple embodiment, the retention device comprises an expansion plug.

In particular, the device is constituted in such a way that the first separation element that in the filled state of the container separates macrocomponents # 1 and # 2, is directly or indirectly contact with a flexible and / or mobile area of the inner surface. of the main vessel. In this way, at least the opening of the first separating element is correlated with the opening of the main container, thereby ensuring the manipulation of the sequential dispersion without any special attention or control of the user.

The device is especially distinguished by the following independent features: 50

It consists of a main container containing an aqueous liquid and at least one inner container, where the at least one inner container

a) contains at least two macrocomponents, a macrocomponent # 1 and a macrocomponent # 2, and

b) comprises at least two separation elements with respective preferred opening areas,

 i) wherein the first separating element separating macrocomponents # 1 and # 2 is in direct or indirect connection with a flexible and / or mobile area of the inner surface of the main container and

 ii) where macrocomponents # 1 and # 2 together represent an acid-base system that releases carbon dioxide by contact.

Typically, the device according to the invention is used as a beverage bottle, the inner container 5 being immobilized in the bottle through a retention element that is preferably fixed in the area of the bottle neck. The retention element, in combination with the pressure retransmission device, makes it possible that a force that is finally capable of opening this element can be exerted from outside on the first separation element.

Preferably, the distance between the flexible or mobile zone of the main vessel and the area in which the first separation element is located in the at least one inner vessel is bridged with the aid of a 10-pressure relay element that causes a contact indirect of both zones. The designation of "indirect contact" should be interpreted in the following so that, with respect to the flexibility or mobility of the corresponding contact area of the main container, the clearance between the inner surface of the main container and one of the ends of the pressure relay element or the clearance between the first separation element and the other end of the pressure relay element is small. In general, a corresponding clearance space is less than 50% and preferably less than 30% with respect to the necessary distance along which the pressure relay element is pushed in the direction of the separation element to open or break This element of separation.

The pressure relay element typically consists of a rod or a tube that, on the one hand, is solidly connected with a flexible zone of the at least one inner vessel and, on the other hand, is contacted with a zone of the inner surface of the main vessel that is flexible or mobile. Typically, this flexible or mobile zone of the main container constitutes a flexible plastic or metal wall or an area of the inner side of an asymmetric rotating closure of a bottle, typically a beverage bottle, which exerts on the pressure relay element, through a kind of screwing mechanism, a force that presses said relay element on the first separation element of the at least one inner container.

The process of opening the separation elements is typically irreversible. Preferably, the system has been composed or the separation element has been worked correspondingly so that the initially open segment of the separation element retains its opening position. Thus, rapid mixing of the macrocomponents is best favored.

The separating element preferably consists of a burst disk, generally made of plastic, which carries a groove along which the burst disk yields or opens and thus presents preferred opening segments. 30

In a special embodiment, the inner container is immobilized by means of at least two pressure relay elements that are contacted with the side wall of a flexible plastic bottle or a beverage can.

Typically, the pressure relay element is made of plastic and has a length between 1 and 20 cm, preferably between 3 and 10 cm. 35

It is especially advantageous if the dilution liquid is already deposited in the main container, since in this way the user can obtain in any circumstance an optimally dispersed solution, orally ingestible or ready to drink it, without contaminating the contents.

A special feature of the device according to the invention is a special arrangement of the various macrocomponents that sets the proper mixing sequence. It can thus be ensured that even systems 40 which, for example, would coagulate outside a specific pH value or a specific ionic intensity, could be optimally dispersed or would dissolve poorly or not dissolve at all.

Typically, the sequential mixing process with the aid of the device according to the invention is possible in a much more efficient way and, therefore, faster or in general within a reasonable period of time.

As the macrocomponent, an aqueous solution, in general mineral water or a drinking solution, is usually deposited in the main container, whose volume-specific dry mass is usually smaller by a factor 5, preferably by a factor 10, than that of the mixture constituted by macrocomponents # 1 and # 2,

Macrocomponents # 1 and # 2 represent acid-base systems in which, as the base component, carbonates and / or hydrogen carbonates are always contained. They release carbon dioxide on mutual contact or when mixed with each other, specifically in a pressure range between 0.1 and 30 bar, preferably between 0.5 and 5 bar. A corresponding pressure increase in the area of the inner vessel of approximately 1 bar can be used, with a sufficient depth of drawing, for the defined opening of the second separation element. The inner container generally has a volume of 2 to 200 ml, preferably between 5 and 50 ml, or a volume in the range of 0.5 to 100 ml, preferably between 2 and 50 ml. The main vessel typically has a volume between 20 ml and 3 l, preferably between 50 ml and 1.5 l and especially preferably between 100 ml and 1 l. The typical volume ratio between 55

main container and the inner container is between 100: 1 and 5: 1, preferably between 70: 1 and 10: 1.

In an especially preferred embodiment, the at least one inner container comprises three macrocomponents. Macrocomponent # 3 here typically represents a concentrate with sensory macrocomponents that typically act with a conservation effect on themselves as a result of the high concentration.

For oxygen-enriched systems that also prefer a system of three macrocomponents for the at least one inner vessel, they are then materialized in the aqueous solution, for physiological reasons of nutrition, as high as possible partial pressures of oxygen generally comprised between 1 , 0 and 15 bars, preferably between 2 and 10 bars.

In order for the third separation element to open in any case in which the second separation element is opened, it is designed such that its opening pressure is smaller than that of the second separation element. Typically, this third separation element is opened consecutively to the second separation element, that is to say, in a time interval up to the instant of opening of the second separation element of less than 0.2 seconds.

Typically, through a guide spiral that is disposed on the inner side of the bottle closure and which is defined, in the term used herein, as part of the main container, the pressure relay element is pressed downwardly, it is say, against the first element of separation. An immobilization disc or a guide rail located therein preferably directs, in the form of a lever, the movement of the pressure relay element towards the first separation element. The spiral element can be here highlighted from the outside towards the center or from the inside to the outside. In the first case, the pressure relay element is pressed from outside to inside against the first separation element and in the second case it is pressed from inside to outside. Preferably, the pressure relay element is transported in the direction of the first separation element during screwing. It is necessary for this that the slope of the guide spiral is greater than the height of the thread of the closure. In this way, the sealing capacity of the closure is generally higher and user manageability is better. However, the opposite case, that is, the case in which the pressure relay element moves towards the first separation element due to the tightening of the closure, it is preferable, among other situations, when the immobilization disc must settle to greater depth in the bottle neck. 25

Preferably, macrocomponents # 1 and # 2 consist of particulate substances, either in the form of a dry substance and / or in the form of an aqueous suspension. In order for them to dissolve easily and quickly with the aid of the method according to the invention, they must be less than 100 μm, preferably less than 10 μm. Typically, the particulate species of the suspension are, up to 80%, less than 1 μm.

Another essential feature of the procedure is that, as a result of the reaction of macrocomponent # 1 with macrocomponent # 2, the average diameter of the particles of the respective educts is drastically reduced very rapidly. Typically, this is a few seconds here. In a slow process, an agglomeration process is initiated at the same time, which, after hours, leads to the frequent recognition, even with the naked eye, of agglomerates that are subsequently deposited for days at the bottom of the liquid. In general, the process of agglomeration follows a recrystallization process in which the species involved, typically micronutrients, nutraceuticals or pharmaceuticals, lose their bioavailability to an important degree. For example, this applies to trace elements and trace ultraelements, such as iron, cobalt, silver, tungsten, gold, copper, as well as to many plant constituents, such as carotinoids.

In general, the inner container containing the macrocomponents # 1 and # 2 has the shape of a cylinder, so that the macrocomponents are separated by a correspondingly round separation element. As an alternative to this, the components may also be presented in two inner containers that are joined together with a flexible tube, a rigid tube or the like.

The main container is kept closed at all times during the mixing process. Whenever the transmission of force to the first separation element is effected through a rotary closure, two full sealing positions are typically present between the closure and the upper area of the bottle opening. In an especially advantageous embodiment of the device according to the invention, at least one of the sealing positions of the closure is an annular shaped bulge which is applied on the inner sealing cylinder. A corresponding cavity is then found on the inner side of the bottle closure. By turning from one sealing position to the next, the sealing capacity of the closure is provisionally reduced, but without the sealing action being completely suppressed.

Typically, for applications in the beverage sector, a PET bottle with a neck diameter of the bottle between 25 and 50 mm, preferably about 38 mm, is used. In this way, compact dimensions of the inner containers can be maintained.

The invention also provides an inner container for a device described above and / or for the implementation of a method described above, which has at least two cameras for receiving a respective macrocomponent, the cameras being isolated, in the state of heading, one with respect to another by means of a respective separation element and also being closed outwards by means of another separation element. The invention also provides for the use of the device described above as a beverage bottle, beverage can or drinkable vial for nutritional supplements and for a supplementary balanced diet. In addition, the invention provides for the use of the container

inside as an insert for a bottle of drink, a can of drink or a drinkable ampoule for nutritional supplements and for a supplementary balanced diet.

The invention is explained in more detail below with reference to the attached figures and using examples of embodiment. The same structural parts are provided with the same reference symbols in the figures. Show: 5

Figure 1, a schematic side sectional representation of the device according to the invention in a first embodiment, in section and in the starting state,

Figure 2, in section A a schematic representation of the closure of a first embodiment seen from below, in section B a schematic representation of the immobilization element, in section C a schematic representation of the pressure relay element with immobilization rod and in section D a schematic representation 10 of the second separation element seen in plan,

Figure 3, a schematic side sectional representation of the device according to the invention in a first embodiment, in section and in semi-open or semi-activated state,

Figure 4, a schematic side sectional representation of the device according to the invention in a first embodiment, in section and in an open state,

Figure 5, a schematic side sectional representation of the closure in a first embodiment, in section,

Figure 6, a schematic side sectional representation of the device according to the invention in a second embodiment, in section and in the starting state, and

Figure 7, a schematic side sectional representation of the device according to the invention in a third embodiment, in section, in the starting state (A), in the semi-open or activated state (B) shortly after activation / opening , in semi-open state or activated with intermingled macrocomponents (C) and in open state (D).

Examples of realization

Example 1

Figure 1 shows the device according to the invention in the "zero position", in which the device can be stored for a long time. The device has an inner container 130 with two chambers 100, 200 to receive the macrocomponents. 25 Macrocomponents # 1 (8) and # 2 (10) are separated from each other and with respect to macrocomponent # 3 - the contents of the bottle - in the inner container with the aid of closed separation elements 9 and 12. A an important integral part of the inner container is here the flexible closing lid, through which, on the one hand, the force is transmitted to the first separation unit (figure 3), but which, on the other hand, is sufficiently stable so that, under the increase in pressure that occurs during the mixing of macrocomponents # 1 and # 2, it yields to a lesser extent than the 30 second separation element.

The inner container, which is substantially limited by elements 6, 11, and 12, is immobilized within the immobilization rods. This immobilization is also a precondition for the pressure relay element 3 together with the impact pin 7, it can transmit a force to the first separation element. So that this force, which is originally introduced into the system through a turning movement of the closure 14, is transmitted to the first separation element in an important proportion, the cooperation of the guide spiral with the immobilization disc is required , whereby the upper end of the pressure relay element is pushed with a kind of lever movement in the direction of the first separation element.

Figure 2 shows in section A the view from below through the closure. The guide spiral 5, which is an integral part of the closure, is shaped in such a way that it pushes the pressure relay element 3 towards the center and downwards. 40 The force then exerted on the pressure relay element 3 is transformed into a movement directed through the locking rail 15 (see section B). In the case shown, the closure is tightened. In section B, through the perforation of the immobilization element 25, the outflow behavior of the liquid is homogenized. Section C shows that the immobilization rods 26 (the rear rod of the other images have been suppressed for the sake of clarity) do not substantially disturb the outflow behavior. Section D shows the second separation element 12 with an inlay 27, along which the opening process is completed, the inner segment 37 being pressed downward with respect to the image plane.

Figure 3 shows the semi-open or activated device, the macrocomponents # 1 and # 2 having already been mixed with one another to obtain a dispersion 180, in the second logic before the second separation element in the cell that is limited by the elements 6, 11 and 12. 50

Figure 4 shows the fully open inner container. The dispersion of macrocomponents # 1 and # 2 is poured here precisely into the liquid of the main vessel, the liquid of which has not been drawn for the sake of clarity.

Figure 5 shows details of the closure: Through the sealing ring 41 seated in the inner sealing cylinder 4, whose

ring cooperates with a corresponding groove on the inner side of the bottle neck, a second sealing position materializes in which the activation is usually carried out.

Example 2

Figure 6 shows a second embodiment of the device according to the invention. The device comprises an inner container with two chambers 100, 200 to receive two macrocomponents. Through the axially immobilized pressure relay elements 30, the first separation element 39 is pressed or leveraged by the compression of said pressure relay elements along the arrows. The corresponding plastic bottle immobilizes the pressure relay elements 30 through corresponding prominences and recesses in the intended contact areas 29.

Example 3 10

Figure 7 illustrates another embodiment of the invention that materializes a pneumatic opening mechanism. The inner container 1300 is configured in the example shown as a double chamber cartridge. It comprises two chambers 100, 200. The chamber 100 is closed with respect to the chamber 200 by a separation element 49 configured as a seal. The inner container 1300 is closed outwards in the starting state represented in the image A by another separation element 59 configured as a seal, that is to say it is closed especially with respect to the interior 15 of a main container - not shown. In the chamber 100 a first macrocomponent 8 is deposited. In the chamber 200 a second macrocomponent 10 is deposited. A gas space 60 is located above the macrocomponents.

In the starting state shown in the image A, a main container, for example a bottle with a built-in inner container 1300 that is full of macrocomponents, is in conditions suitable for storage. The main vessel 20 is at a pressure which is referred to herein as the external pressure, which corresponds to the pressure in the volume of gas 60 of the chambers 100, 200, the pressure of which is referred to herein as internal pressure. To place the contents of the main vessel under pressure, that is, so to speak, to prestress it, nitrogen and / or oxygen can advantageously be used. In principle, the use of other gases, such as carbon dioxide, is also within the scope of the invention, but this may be less advantageous in some application cases in which carbon dioxide would lead to bubbling. so strong of the drink that this bubbling would no longer be acceptable to the consumer.

If the main vessel is opened, the external pressure decreases, so that the volume of gas 60 expands due to the relatively high internal pressure. As a result of this expansion, the seal 49 is opened and the macrocomponents begin to mix (image B). The open seal 49 here forms a joint 300 between the chambers 100 and 200 of the inner container. Preferably, as later the main container is now closed again. 30

The macrocomponents are now in contact with each other. The main vessel can now be shaken to mix the macrocomponents more or more rapidly. Due to the intermingling of the macrocomponents 8, 10 CO2 is produced as a result of an acid-base reaction. The volume of the gas space 60 continues to enlarge (image C) until, finally, the second seal 59 (image D) is released. After the perforation of the second separation element 59, the mixture 180 of the macrocomponents 8, 10 is poured into or discharged into the surrounding liquid - not shown, which is deposited in the main vessel. With additional shaking, the distribution of the mixture 180 can be favored.

The double chamber cartridge 1300 is immobilized in the correct position with respect to the main container preferably by means of an expansion plug. In particular, the double chamber cartridge is positioned inside the main container. 40

It is obvious to the expert that the invention is not limited to the embodiments described above, but, on the contrary, can be varied in many ways. For example, the inner container may have more than two chambers and, consequently, more separation elements. In particular, the characteristics of the different embodiments can also be combined with each other.

Claims (10)

1.- Procedure of sequential dispersion of macrocomponents, for whose realization a container (130, 1300) is provided which has at least two chambers (100, 200) to receive two macrocomponents (8, 10), where, in the state of Starting, the macrocomponents (8, 10) contained in the chambers (100, 200) are isolated from each other by separate separation elements (9, 39, 49) and closed outwards by an additional separation element (12, 59) , whose procedure includes the following steps: a) opening a first separating element (9, 39, 49) applying a mechanical force, b) contacted or mixed of the two macrocomponents (8, 10) that were in contact with each of them, in the starting state, with the first separation element (9, 39, 49), releasing at the same time a gas that it leads to an increase in pressure that corresponds to the degree of mixing or dispersion and which causes a second separation element (12, 59) to burst, c) contacted or mixed the mixture (180) of the macrocomponents (8, 10) of step b) with at least one third a macrocomponent. 2. Method according to claim 1, comprising a step d) of movement, especially shaking, of the mixture of step c) to increase the intermingling. fifteen 3. Sequential dispersion method of macrocomponents according to claim 1 or 2, comprising the following steps: a) opening a first separation element by applying a mechanical force,  i) crossing this force at least two substantially closed containers, b) contacted or mixed of the two macrocomponents # 1 and # 2 that are in contact with the first separation element, at the same time releasing a gas  i) which leads to an increase in pressure that corresponds to the degree of mixing or dispersion and that at a defined threshold value causes a second separation element to burst,  ii) placing the mixture of macrocomponents # 1 and # 2 in contact with at least a third macrocomponent or mixing said mixture with it. 25 4. Method according to any of the preceding claims, characterized in that the third macrocomponent is an aqueous liquid contained in the main container. 5. Method according to any of the preceding claims, characterized in that at least 30% and preferably at least 50% of all dissolved colloidal particles are less than 100 nm. 6. Method according to any of the preceding claims, characterized in that a third separation element is opened consecutively to the second separation element. 7. Sequential dispersion production device according to claims 1 to 6, which has a main container and at least one inner container (130, 1300) comprising at least two chambers (100, 200) to receive at least two macrocomponents (8, 10) that are separated from each other in the inner container, the wall of the chambers (100, 200) being formed, at least partially, by a respective separation element (9, 35, 39, 49, 12, 59) and the separation elements being sized so that, under the action of an external force, a first separation element (9, 39, 49) is opened than in the filled state of the inner container, in the starting state, separates the macrocomponents (8, 10) deposited in the chambers (100, 200) from each other, thereby establishing an open communication (300) between the chambers, while a second separation element is still closed (12, 59) than in e The not fully open state of the inner vessel closes at least one chamber of the inner vessel 40 outwardly and towards the main vessel, characterized in that the second separation element is designed so that it separates only by the action of a high pressure which is set as a result of a pressure increase due to the reaction of the macrocomponents with each other after the opening of the first separation element. 8. Device according to claim 7, characterized in that at least one separation element comprises at least one preferred opening segment. 9. Device according to any of claims 7 or 8, characterized in that, to sequentially produce dispersions according to claims 1 to 6, at least one inner container is contained in a main container, wherein the latter c) contains at least two macrocomponents, a macrocomponent # 1 and a macrocomponent # 2, and 50 d) comprises at least two separation elements with respective preferred opening segments,  i) wherein the first separation element, which separates macrocomponents # 1 and # 2, is directly or indirectly contacted with a flexible and / or mobile area of the inner surface of the main container and  ii) where macrocomponents # 1 and # 2 together represent an acid-base system that releases carbon dioxide by contact. 5 10. Device according to any of the preceding claims, characterized in that the volume of the main container is between 20 ml and 3 l, preferably between 50 ml and 1.5 l and especially preferably between 100 ml and 1 l. List of reference symbols Figure 1 1 Retaining rod for inner container 2 Immobilization disk and spill homogenizer 3 Pressure relay element 5 4 Seal cylinder at the closure 5 Guide spiral 6 Flexible closure lid 7 Shock pin 8 Macrocomponent # 1 10 9 First separation element (closed) 10 Macrocomponent # 2 11 Interior vessel wall 12 Second separation element (closed) 13 Main container (bottle) 15 130 Inner container 14 Swivel lock Figure 2 Section A 140 Screw seal seal cylinder 20 5 Spiral with guide groove 34 Side closing wall Section b 15 Immobilization disc immobilization rail 25 Framing the immobilization disc 25 3 Pressure relay element Section C 3 Pressure relay element 26 Clamping bracing to immobilize the inner container Section D 30 17 Contact surface between inner container and separation element 27 Opening Stria 37 Internal segment that is pressed during opening Figure 5 5 Guide spiral of the swivel lock in profile 35 4 Internal sealing cylinder with sealed sealing shoulder 41 Sealing Highlight of Inner Sealing Cylinder 4 14 Side wall of the rotary lock 48 Thread of the closure 58 Bottle neck 40 thread Figure 6 30 Laterally expanded pressure relay elements 29 Contact areas with flexible wall of a plastic bottle 39 First separating element that comes off suddenly under lateral pressure Figure 7 59 Second separation element configured as a seal 10 Macrocomponent # 2 49 First separation element configured as seal 5 8 Macrocomponent # 1 60 Volume of gas 100, 200 Cameras 1300 Inner container configured as double chamber cartridge 180 Dispersion or mixing of macrocomponents # 1, # 2 10