ES2375973T3 - Aparato y método para oxigenación de sangre. - Google Patents

Aparato y método para oxigenación de sangre. Download PDF

Info

Publication number: ES2375973T3
Authority: ES; Spain
Prior art keywords: blood; assembly; fluid; end portion; oxygenated
Prior art date: 1999-09-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES06022545T

Other languages

English (en)

Spanish (es)

Inventor

William R. Patterson

Jeffrey L. Creech

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Therox Inc

Original Assignee

Therox Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-30

Filing date

2000-09-27

Publication date

2012-03-07

1999-09-30 Priority claimed from US09/410,179 external-priority patent/US6759008B1/en

1999-09-30 Priority claimed from US09/410,344 external-priority patent/US6602467B1/en

1999-09-30 Priority claimed from US09/409,952 external-priority patent/US6387324B1/en

1999-09-30 Priority claimed from US09/410,343 external-priority patent/US6576191B1/en

2000-09-27 Application filed by Therox Inc filed Critical Therox Inc

2012-03-07 Application granted granted Critical

2012-03-07 Publication of ES2375973T3 publication Critical patent/ES2375973T3/es

2020-09-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

210000004369 blood Anatomy 0.000 title claims abstract description 324
239000008280 blood Substances 0.000 title claims abstract description 324
238000006213 oxygenation reaction Methods 0.000 title claims abstract description 68
238000000034 method Methods 0.000 title description 42
230000036770 blood supply Effects 0.000 claims abstract description 21
230000001706 oxygenating effect Effects 0.000 claims abstract description 8
230000007704 transition Effects 0.000 claims abstract description 6
239000003550 marker Substances 0.000 claims description 2
230000002093 peripheral effect Effects 0.000 claims 4
239000012530 fluid Substances 0.000 description 189
239000001301 oxygen Substances 0.000 description 100
229910052760 oxygen Inorganic materials 0.000 description 100
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 98
239000007789 gas Substances 0.000 description 71
239000012528 membrane Substances 0.000 description 69
239000007788 liquid Substances 0.000 description 55
230000017531 blood circulation Effects 0.000 description 39
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 34
229910001882 dioxygen Inorganic materials 0.000 description 33
238000011282 treatment Methods 0.000 description 21
238000001802 infusion Methods 0.000 description 18
239000000835 fiber Substances 0.000 description 17
210000001519 tissue Anatomy 0.000 description 17
230000006870 function Effects 0.000 description 15
239000012510 hollow fiber Substances 0.000 description 13
238000002156 mixing Methods 0.000 description 13
238000012546 transfer Methods 0.000 description 13
239000003570 air Substances 0.000 description 12
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
102000001554 Hemoglobins Human genes 0.000 description 10
108010054147 Hemoglobins Proteins 0.000 description 10
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
208000028867 ischemia Diseases 0.000 description 10
238000011049 filling Methods 0.000 description 9
239000000463 material Substances 0.000 description 9
239000011780 sodium chloride Substances 0.000 description 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
230000000712 assembly Effects 0.000 description 8
238000000429 assembly Methods 0.000 description 8
230000015572 biosynthetic process Effects 0.000 description 8
238000010586 diagram Methods 0.000 description 8
238000012545 processing Methods 0.000 description 8
238000002399 angioplasty Methods 0.000 description 7
238000001514 detection method Methods 0.000 description 7
-1 polypropylene Polymers 0.000 description 7
230000000302 ischemic effect Effects 0.000 description 6
150000002926 oxygen Chemical class 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
238000005086 pumping Methods 0.000 description 6
206010000891 acute myocardial infarction Diseases 0.000 description 5
230000004888 barrier function Effects 0.000 description 5
229910002092 carbon dioxide Inorganic materials 0.000 description 5
230000004087 circulation Effects 0.000 description 5
210000004351 coronary vessel Anatomy 0.000 description 5
208000010125 myocardial infarction Diseases 0.000 description 5
208000031225 myocardial ischemia Diseases 0.000 description 5
230000002265 prevention Effects 0.000 description 5
230000037452 priming Effects 0.000 description 5
230000001105 regulatory effect Effects 0.000 description 5
239000000243 solution Substances 0.000 description 5
239000002904 solvent Substances 0.000 description 5
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
239000000560 biocompatible material Substances 0.000 description 4
230000036772 blood pressure Effects 0.000 description 4
239000001569 carbon dioxide Substances 0.000 description 4
238000004891 communication Methods 0.000 description 4
230000001276 controlling effect Effects 0.000 description 4
230000007423 decrease Effects 0.000 description 4
238000009792 diffusion process Methods 0.000 description 4
230000002526 effect on cardiovascular system Effects 0.000 description 4
230000000694 effects Effects 0.000 description 4
210000004165 myocardium Anatomy 0.000 description 4
229910052757 nitrogen Inorganic materials 0.000 description 4
210000000056 organ Anatomy 0.000 description 4
230000010412 perfusion Effects 0.000 description 4
238000002560 therapeutic procedure Methods 0.000 description 4
206010059484 Haemodilution Diseases 0.000 description 3
206010018910 Haemolysis Diseases 0.000 description 3
238000001816 cooling Methods 0.000 description 3
230000008878 coupling Effects 0.000 description 3
238000010168 coupling process Methods 0.000 description 3
238000005859 coupling reaction Methods 0.000 description 3
230000006378 damage Effects 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
238000010494 dissociation reaction Methods 0.000 description 3
230000005593 dissociations Effects 0.000 description 3
238000005534 hematocrit Methods 0.000 description 3
230000008588 hemolysis Effects 0.000 description 3
238000012986 modification Methods 0.000 description 3
230000004048 modification Effects 0.000 description 3
230000002107 myocardial effect Effects 0.000 description 3
230000000926 neurological effect Effects 0.000 description 3
230000008569 process Effects 0.000 description 3
238000010992 reflux Methods 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
230000009885 systemic effect Effects 0.000 description 3
230000002537 thrombolytic effect Effects 0.000 description 3
208000037816 tissue injury Diseases 0.000 description 3
238000011265 2D-echocardiography Methods 0.000 description 2
206010001526 Air embolism Diseases 0.000 description 2
206010061216 Infarction Diseases 0.000 description 2
GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
239000004698 Polyethylene Substances 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
208000006011 Stroke Diseases 0.000 description 2
206010052428 Wound Diseases 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
230000001070 adhesive effect Effects 0.000 description 2
238000013459 approach Methods 0.000 description 2
239000012298 atmosphere Substances 0.000 description 2
230000008901 benefit Effects 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
230000037396 body weight Effects 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
230000003750 conditioning effect Effects 0.000 description 2
238000013479 data entry Methods 0.000 description 2
238000011161 development Methods 0.000 description 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
210000001105 femoral artery Anatomy 0.000 description 2
210000005003 heart tissue Anatomy 0.000 description 2
238000002639 hyperbaric oxygen therapy Methods 0.000 description 2
230000002631 hypothermal effect Effects 0.000 description 2
230000007574 infarction Effects 0.000 description 2
208000014674 injury Diseases 0.000 description 2
230000003447 ipsilateral effect Effects 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
239000000203 mixture Substances 0.000 description 2
238000012544 monitoring process Methods 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
239000004417 polycarbonate Substances 0.000 description 2
229920000515 polycarbonate Polymers 0.000 description 2
229920000573 polyethylene Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
238000004886 process control Methods 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
230000005855 radiation Effects 0.000 description 2
230000004044 response Effects 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
230000001052 transient effect Effects 0.000 description 2
230000008733 trauma Effects 0.000 description 2
230000002792 vascular Effects 0.000 description 2
210000005166 vasculature Anatomy 0.000 description 2
230000002861 ventricular Effects 0.000 description 2
238000005406 washing Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
229930182837 (R)-adrenaline Natural products 0.000 description 1
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
239000002126 C01EB10 - Adenosine Substances 0.000 description 1
229940127291 Calcium channel antagonist Drugs 0.000 description 1
208000028399 Critical Illness Diseases 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
240000006890 Erythroxylum coca Species 0.000 description 1
229940123457 Free radical scavenger Drugs 0.000 description 1
229920001612 Hydroxyethyl starch Polymers 0.000 description 1
206010058490 Hyperoxia Diseases 0.000 description 1
206010021143 Hypoxia Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
208000019693 Lung disease Diseases 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
239000000006 Nitroglycerin Substances 0.000 description 1
206010053159 Organ failure Diseases 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
206010063837 Reperfusion injury Diseases 0.000 description 1
239000012891 Ringer solution Substances 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
108010023197 Streptokinase Proteins 0.000 description 1
108050006955 Tissue-type plasminogen activator Proteins 0.000 description 1
108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
239000012190 activator Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
229940099424 adenocard Drugs 0.000 description 1
229940060202 adenoscan Drugs 0.000 description 1
229960005305 adenosine Drugs 0.000 description 1
230000003288 anthiarrhythmic effect Effects 0.000 description 1
230000003556 anti-epileptic effect Effects 0.000 description 1
239000003416 antiarrhythmic agent Substances 0.000 description 1
230000010100 anticoagulation Effects 0.000 description 1
239000001961 anticonvulsive agent Substances 0.000 description 1
230000004872 arterial blood pressure Effects 0.000 description 1
YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
238000005452 bending Methods 0.000 description 1
239000002876 beta blocker Substances 0.000 description 1
229940097320 beta blocking agent Drugs 0.000 description 1
230000023555 blood coagulation Effects 0.000 description 1
230000036765 blood level Effects 0.000 description 1
238000009530 blood pressure measurement Methods 0.000 description 1
239000003633 blood substitute Substances 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000000480 calcium channel blocker Substances 0.000 description 1
BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2s)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
230000005779 cell damage Effects 0.000 description 1
208000037887 cell injury Diseases 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
238000005352 clarification Methods 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
235000008957 cocaer Nutrition 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000007887 coronary angioplasty Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
229960004166 diltiazem Drugs 0.000 description 1
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000002934 diuretic Substances 0.000 description 1
229940030606 diuretics Drugs 0.000 description 1
229960003638 dopamine Drugs 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
239000000806 elastomer Substances 0.000 description 1
229960005139 epinephrine Drugs 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
229960003745 esmolol Drugs 0.000 description 1
AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 description 1
VJDOPFARMOLELX-ZDUSSCGKSA-N ethyl 3-[[(3s)-1-(4-carbamimidoylphenyl)-2-oxopyrrolidin-3-yl]carbamoylamino]propanoate Chemical compound O=C1[C@@H](NC(=O)NCCC(=O)OCC)CCN1C1=CC=C(C(N)=N)C=C1 VJDOPFARMOLELX-ZDUSSCGKSA-N 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000010408 film Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000005350 fused silica glass Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
229960003711 glyceryl trinitrate Drugs 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000001307 helium Substances 0.000 description 1
229910052734 helium Inorganic materials 0.000 description 1
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
229940064366 hespan Drugs 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
230000000222 hyperoxic effect Effects 0.000 description 1
230000001299 hyperoxygenation Effects 0.000 description 1
208000018875 hypoxemia Diseases 0.000 description 1
238000002513 implantation Methods 0.000 description 1
229940095990 inderal Drugs 0.000 description 1
230000000053 inderal effect Effects 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
230000036512 infertility Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000004041 inotropic agent Substances 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000003902 lesion Effects 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
OZFSWVOEXHGDES-INIZCTEOSA-N lubeluzole Chemical compound C([C@@H](O)CN1CCC(CC1)N(C)C=1SC2=CC=CC=C2N=1)OC1=CC=C(F)C(F)=C1 OZFSWVOEXHGDES-INIZCTEOSA-N 0.000 description 1
229950009851 lubeluzole Drugs 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000007726 management method Methods 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
239000012229 microporous material Substances 0.000 description 1
238000012806 monitoring device Methods 0.000 description 1
230000010016 myocardial function Effects 0.000 description 1
230000000324 neuroprotective effect Effects 0.000 description 1
230000001067 neuroprotector Effects 0.000 description 1
229960002460 nitroprusside Drugs 0.000 description 1
239000001272 nitrous oxide Substances 0.000 description 1
230000007959 normoxia Effects 0.000 description 1
230000006911 nucleation Effects 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
238000011275 oncology therapy Methods 0.000 description 1
229950002383 orbofiban Drugs 0.000 description 1
230000004768 organ dysfunction Effects 0.000 description 1
238000012856 packing Methods 0.000 description 1
230000007170 pathology Effects 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
230000035699 permeability Effects 0.000 description 1
DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
229960002695 phenobarbital Drugs 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
230000006461 physiological response Effects 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920005749 polyurethane resin Polymers 0.000 description 1
238000004321 preservation Methods 0.000 description 1
REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
229960000244 procainamide Drugs 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
239000002516 radical scavenger Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000003507 refrigerant Substances 0.000 description 1
229940107685 reopro Drugs 0.000 description 1
210000005245 right atrium Anatomy 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
238000007789 sealing Methods 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000004945 silicone rubber Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
229960005202 streptokinase Drugs 0.000 description 1
239000000126 substance Substances 0.000 description 1
229920001169 thermoplastic Polymers 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
239000010409 thin film Substances 0.000 description 1
229960000103 thrombolytic agent Drugs 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1
229940072690 valium Drugs 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
238000013022 venting Methods 0.000 description 1
229960001722 verapamil Drugs 0.000 description 1
239000011800 void material Substances 0.000 description 1

Landscapes

External Artificial Organs (AREA)

ES06022545T 1999-09-30 2000-09-27 Aparato y método para oxigenación de sangre. Expired - Lifetime ES2375973T3 (es)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
US410134		1989-09-20
US410344		1995-03-24
US40923599A	1999-09-30	1999-09-30
US41013499A	1999-09-30	1999-09-30
US410179		1999-09-30
US09/410,179 US6759008B1 (en)	1999-09-30	1999-09-30	Apparatus and method for blood oxygenation
US09/410,344 US6602467B1 (en)	1998-07-24	1999-09-30	Apparatus and method for blood oxygenation
US09/409,952 US6387324B1 (en)	1999-09-30	1999-09-30	Apparatus and method for blood oxygenation
US409952		1999-09-30
US09/410,343 US6576191B1 (en)	1999-09-30	1999-09-30	Apparatus for blood oxygenation
US410343		1999-09-30
US409235		1999-09-30

Publications (1)

Publication Number	Publication Date
ES2375973T3 true ES2375973T3 (es)	2012-03-07

Family

ID=45217823

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES06022545T Expired - Lifetime ES2375973T3 (es)	1999-09-30	2000-09-27	Aparato y método para oxigenación de sangre.
ES06022543T Expired - Lifetime ES2375727T3 (es)	1999-09-30	2000-09-27	Aparato y método para oxigenación de sangre.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES06022543T Expired - Lifetime ES2375727T3 (es)	1999-09-30	2000-09-27	Aparato y método para oxigenación de sangre.

Country Status (2)

Country	Link
AT (2)	ATE533523T1 (de)
ES (2)	ES2375973T3 (de)

2000
- 2000-09-27 AT AT06022543T patent/ATE533523T1/de active
- 2000-09-27 ES ES06022545T patent/ES2375973T3/es not_active Expired - Lifetime
- 2000-09-27 AT AT06022545T patent/ATE537860T1/de active
- 2000-09-27 ES ES06022543T patent/ES2375727T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE533523T1 (de)	2011-12-15
ES2375727T3 (es)	2012-03-05
ATE537860T1 (de)	2012-01-15

Publication	Publication Date	Title
US6899847B2 (en)	2005-05-31	Apparatus for blood oxygenation
US6387324B1 (en)	2002-05-14	Apparatus and method for blood oxygenation
US6596235B2 (en)	2003-07-22	Method for blood oxygenation
US6759008B1 (en)	2004-07-06	Apparatus and method for blood oxygenation
US6602467B1 (en)	2003-08-05	Apparatus and method for blood oxygenation
JP5066156B2 (ja)	2012-11-07	血液酸素化装置および方法
ES2323820T3 (es)	2009-07-24	Sistema para la asistencia extracorporea generalizada.
US6890482B2 (en)	2005-05-10	Apparatus for blood oxygenation
ES2296396T3 (es)	2008-04-16	Aparato medico para la preparacion y administracion de fluidos enriquecidos en gas.
WO2022212346A1 (en)	2022-10-06	Systems and methods for combined vessel occlusion and gas enrichment therapy
ES2375727T3 (es)	2012-03-05	Aparato y método para oxigenación de sangre.