ES2404346T3 - Reactivos y procedimientos de radiomarcado - Google Patents

Reactivos y procedimientos de radiomarcado Download PDF

Info

Publication number: ES2404346T3
Authority: ES; Spain
Prior art keywords: formula; compound; peptide; biomolecule; ammonium
Prior art date: 2009-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES10710143T

Other languages

English (en)

Spanish (es)

Inventor

Dag Erland Olberg

Joseph Maduabuchi Arukwe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GE Healthcare Ltd

Original Assignee

GE Healthcare Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-30

Filing date

2010-03-22

Publication date

2013-05-27

2010-03-22 Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd

2013-05-27 Application granted granted Critical

2013-05-27 Publication of ES2404346T3 publication Critical patent/ES2404346T3/es

Status Active legal-status Critical Current

2030-03-22 Anticipated expiration legal-status Critical

Links

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GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 11
150000003839 salts Chemical class 0.000 claims description 7
238000003682 fluorination reaction Methods 0.000 claims description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
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DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Optics & Photonics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pyridine Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)

ES10710143T 2009-03-30 2010-03-22 Reactivos y procedimientos de radiomarcado Active ES2404346T3 (es)

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US16449409P	2009-03-30	2009-03-30
US164494P		2009-03-30
GBGB0905438.8A GB0905438D0 (en)	2009-03-30	2009-03-30	Radiolabelling reagents and methods
GB0905438		2009-03-30
PCT/US2010/028078 WO2010114723A1 (en)	2009-03-30	2010-03-22	Radiolabelling reagents and methods

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US (1)	US8530620B2 (pl)
EP (1)	EP2414333B1 (pl)
JP (1)	JP2012522052A (pl)
KR (1)	KR20110133038A (pl)
CN (2)	CN102356069B (pl)
AU (1)	AU2010232828A1 (pl)
BR (1)	BRPI1011531A2 (pl)
CA (1)	CA2757016A1 (pl)
ES (1)	ES2404346T3 (pl)
GB (1)	GB0905438D0 (pl)
MX (1)	MX2011010295A (pl)
PL (1)	PL2414333T3 (pl)
PT (1)	PT2414333E (pl)
RU (1)	RU2524284C2 (pl)
WO (1)	WO2010114723A1 (pl)

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PT2318366T (pt)	2008-08-01	2017-08-02	Univ Johns Hopkins	Agentes de ligação a psma e suas utilizações
CN107753962A (zh) *	2010-12-09	2018-03-06	通用电气健康护理有限公司	放射性示踪剂组合物
WO2013048811A1 (en)	2011-09-30	2013-04-04	Ge Healthcare Limited	Imaging and radiotherapy methods for tumour stem cells
TW201605852A (zh) *	2013-09-26	2016-02-16	美國禮來大藥廠	新穎化合物及其製備ｔａｕ造影劑及ｔａｕ造影調配物之用途
EP3183236B1 (en) *	2014-08-24	2022-04-20	Max-Planck-Gesellschaft zur Förderung der Wissenschaften	Method for the production of 18f-labeled active esters and their application exemplified by the preparation of a psma-specific pet-tracer
KR102233726B1 (ko)	2015-09-30	2021-03-31	도이체스 크렙스포르슝스첸트룸	전립선 특이적 막 항원（psma)의 18f-태그된 저해제 및 전립선암에 대한 조영제로서 이의 용도
GB201518918D0 (en)	2015-10-26	2015-12-09	Norsk Medisinsk Syklotronsenter As And Uni I Oslo	Method
WO2018022603A1 (en) *	2016-07-25	2018-02-01	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods of making 18f-labeled precursors and peptides, labeled c-met binding peptides, and methods of use thereof
US11628229B2 (en)	2017-03-13	2023-04-18	Arizona Board Of Regents On Behalf Of The University Of Arizona	Method of synthesizing 18F radiolabeled biomolecular agents
GB202019006D0 (en) *	2020-12-02	2021-01-13	Vestlandets Innovasjonsselskap As	GFR targeting compounds

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US5242680A (en) *	1991-08-23	1993-09-07	Merck & Co., Inc.	Thiol-reactive maleimido-based radiolabeling reagents
US5346686A (en) *	1992-10-05	1994-09-13	Mallinckrodt Medical, Inc.	Labelled interleukin-8 and medical uses thereof
DE69700902T2 (de) *	1996-01-23	2000-07-20	Rapigene, Inc.	Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
DK0932417T3 (da) *	1996-10-17	2003-04-14	Immunomedics Inc	Non-antigent toxinkonjugat og fusionsprotein af internaliserende receptorsystem
US6187284B1 (en) *	1997-09-03	2001-02-13	Immunomedics, Inc.	Fluorination of proteins and peptides for F-18 positron emission tomography
US6350360B1 (en)	2000-04-07	2002-02-26	Sandia Coroporation	Method of fabricating a 3-dimensional tool master
GB0115927D0 (en) *	2001-06-29	2001-08-22	Nycomed Amersham Plc	Solid-phase nucleophilic fluorination
BRPI0210886B8 (pt)	2001-07-10	2021-05-25	Amersham Health As	composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal
FR2841554B1 (fr) *	2002-07-01	2008-01-18	Commissariat Energie Atomique	Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules
GB0305704D0 (en)	2003-03-13	2003-04-16	Amersham Plc	Radiofluorination methods
GB0317815D0 (en)	2003-07-30	2003-09-03	Amersham Health As	Imaging agents
GB0329716D0 (en)	2003-12-23	2004-01-28	Amersham Plc	Radical trap
GB0420344D0 (en) *	2004-09-14	2004-10-13	Amersham Plc	Diagnostic compounds
KR20100022987A (ko) *	2007-06-20	2010-03-03	지이 헬쓰케어 리미티드	표지 방법
WO2009035959A2 (en) *	2007-09-10	2009-03-19	Ge Healthcare Limited	Radiofluorination methods
FR2926079B1 (fr) *	2008-01-03	2012-12-28	Commissariat Energie Atomique	Procede de preparation d'un derive de purine marque, ledit derive et ses utilisations

2009
- 2009-03-30 GB GBGB0905438.8A patent/GB0905438D0/en not_active Ceased
2010
- 2010-03-22 BR BRPI1011531A patent/BRPI1011531A2/pt not_active IP Right Cessation
- 2010-03-22 CN CN201080013540.3A patent/CN102356069B/zh not_active Expired - Fee Related
- 2010-03-22 KR KR1020117022881A patent/KR20110133038A/ko not_active Withdrawn
- 2010-03-22 PL PL10710143T patent/PL2414333T3/pl unknown
- 2010-03-22 JP JP2012503484A patent/JP2012522052A/ja not_active Ceased
- 2010-03-22 CN CN201410441411.4A patent/CN104292155A/zh active Pending
- 2010-03-22 MX MX2011010295A patent/MX2011010295A/es active IP Right Grant
- 2010-03-22 CA CA2757016A patent/CA2757016A1/en not_active Abandoned
- 2010-03-22 EP EP10710143A patent/EP2414333B1/en not_active Not-in-force
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- 2010-03-22 AU AU2010232828A patent/AU2010232828A1/en not_active Abandoned
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- 2010-03-22 US US13/256,511 patent/US8530620B2/en active Active
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Also Published As

Publication number	Publication date
PT2414333E (pt)	2013-05-07
GB0905438D0 (en)	2009-05-13
CN102356069A (zh)	2012-02-15
MX2011010295A (es)	2012-03-26
PL2414333T3 (pl)	2013-07-31
US8530620B2 (en)	2013-09-10
EP2414333B1 (en)	2013-02-13
US20120022227A1 (en)	2012-01-26
AU2010232828A1 (en)	2011-10-13
CN104292155A (zh)	2015-01-21
JP2012522052A (ja)	2012-09-20
RU2524284C2 (ru)	2014-07-27
KR20110133038A (ko)	2011-12-09
RU2011139219A (ru)	2013-05-10
EP2414333A1 (en)	2012-02-08
BRPI1011531A2 (pt)	2016-03-29
WO2010114723A1 (en)	2010-10-07
CA2757016A1 (en)	2010-10-07
CN102356069B (zh)	2014-09-24

Publication	Publication Date	Title
ES2404346T3 (es)	2013-05-27	Reactivos y procedimientos de radiomarcado
Becaud et al.	2009	Direct one-step18F-labeling of peptides via nucleophilic aromatic substitution
Miller et al.	2008	Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography
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