ES2420079B1 - Método de clasificación del carcinoma no microcítico de pulmón basado en la identificación de una respuesta inmune intratumoral. - Google Patents

Método de clasificación del carcinoma no microcítico de pulmón basado en la identificación de una respuesta inmune intratumoral. Download PDF

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ES2420079B1
ES2420079B1 ES201230250A ES201230250A ES2420079B1 ES 2420079 B1 ES2420079 B1 ES 2420079B1 ES 201230250 A ES201230250 A ES 201230250A ES 201230250 A ES201230250 A ES 201230250A ES 2420079 B1 ES2420079 B1 ES 2420079B1
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immune response
small cell
cell lung
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ES2420079R1 (es
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Julián SANZ ORTEGA
Milagros FERRER ALDEA
Susana HERNÁNDEZ PRIETO
Alejandro ROMERA LÓPEZ
Beatriz PÉREZ-VILLAMIL SALGADO
Florentino HERNANDO TRANCHO
Ana María GÓMEZ MARTÍNEZ
Jose Ramón JARABO SARCEDA
Antonio José TORRES GARCÍA
Jose Antonio LÓPEZ GARCÍA-ASENJO
Jose Luis GONZÁLEZ LARRIBA
Javier PUENTE VÁZQUEZ
Eduardo DÍAZ-RUBIO GARCÍA
José Luis SUBIZA GARRIDO-LESTACHE
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Fundacion para la Investigacion Biomedica del Hospital Clinico San Carlos
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Abstract

Método de clasificación del carcinoma no microcítico de pulmón basado en la identificación de una respuesta inmune intratumoral.#La presente invención se refiere a un método in vitro de clasificación del carcinoma no microcítico de pulmón basado en la expresión diferencial de 50 genes. Dichos genes identifican una respuesta inmune intratumoral. Mediante el método de la invención se diferencian pacientes con un perfil de expresión de genes asociados a una respuesta inmune que se asocia con buen pronóstico y pacientes sin ese perfil de expresión que tienen peor pronóstico. Esa clasificación puede usarse como marcador pronóstico, como clasificador de los tumores en función de la respuesta inmune antitumoral (“inmunoscore”) o como biomarcador predictor de terapias basadas en el sistema inmune (inmunoterapia). La presente invención también se refiere a un kit que comprende un conjunto de sondas que reconocen los 50 genes de la invención.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
3002
GZMB Granzima B
3493
IGHA1 Inmunoglobulina pesada constante alfa 1
3494
IGHA2 Inmunoglobulina pesada constante alfa 2
3500
IGHG1 Inmunoglobulina pesada constante gamma 1
3512
IGJ Polipéptido J de inmunoglobulina
3535
IGL@ Locus lambda de inmunoglobulina
3543
IGLL1 Polipéptido 1 "like" inmunoglobulina lambda
3662
IRF4 Factor 4 regulador del interferón
3782
KCNN3 Miembro 3 subfamilia N de canales de potasio activados por calcio
3887
KRT81 Keratina 81
4283
CXCL9 Ligando 9 del motivo CXC de quimioquinas
5368
PNOC Preponocipeptina
5450
POU2AF1 Factor 1 asociado a POU clase 2
8419
BFSP2 Faquinina
9834
KIAA0125 KIAA0125
10563
CXCL13 Ligando 13 del motivo CXC de quimioquinas
11040
PIM2 Oncogén Pim2
26952
SMR3A Proteína 3A regulada por glándula submaxilar
28904
IGKV1D-8 Cadena variable kappa 1D-8 de inmunoglobulina
51237
MZB1 Proteína especifica de las células B1 y B de la zona marginal
51303
FKBP11 Proteína 11 de unión a FK506
54900
LAX1 Adaptador 1 transmembrana de linfocitos
57699
CPNE5 Copina V
57823
SLAMF7 Miembro 7 de la familia SLAM
78986
DUSP26 Fosfatasa 26 especifica dual
79368
FCRL2 "like" receptor 2 Fc
80307
FER1L4 Pseudogen 4 "like" fer-1
83416
FCRL5 Receptor Fc "like” 5
84824
FCRLA Receptor Fc "like” A
90925
IGHV5-78 Pseudogen región pesada variable de cadena pesada de inmunoglobulina 5-78
91319
DERL3 Miembro 3 de la familia de dominio parecido a Der-1
92154
MTSS1L "like" supresor metástasis 1
126306
JSRP1 Proteína 1 de retículo sarcoplasmático
140947
C5orf20 Marco de lectura abierta 20 del cromosoma 5
150365
MEI1 Inhibidor de meiosis 1
221188
GPR114 Receptor 114 acoplado a proteína G
401847
LOC401847 Proteína hipotética LOC401847
642424
LOC642424 Región Walker "like" de la cadena kappa V-I de la inmunoglobulina
100132941
LOC100132941 Proteína hipotética LOC100132941
100133862
LOC100133862 Región V35 "like" de la cadena pesada V-I de la inmunoglobulina
100287723
LOC100287723 Región Walker "like" de la cadena kappa V-I de la inmunoglobulina
100290415
IGHV1-24 Inmunoglobulina pesada variable 1-24
100293440
LOC100293440 Similar a la cadena lambda de inmunoglobulina
A continuación se muestra una breve descripción de algunas de las funciones conocidas de los genes presentados en la tabla 1:
AMPD1: Cataliza la deaminación de la adenosina monofosfato (AMP) a inosina monofosfato (IMP) en el músculo esquelético y tiene un importante papel en el ciclo de las purinas. 6
imagen9
imagen10
imagen11
imagen12
imagen13
imagen14
imagen15
imagen16
imagen17
imagen18
imagen19
imagen20
imagen21
imagen22
imagen23
imagen24
imagen25
imagen26
imagen27
imagen28
imagen29
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imagen31
imagen32
dos grupos obtenidos con el ILE (log-rank p=0,001) (Fig. 8). El HR para el Grupo de mal pronóstico es de 3,4 frente al de buen pronóstico (IC 95%: 1,6-7,3; p=0,001).
1.2.5. Utilidad del predictor de 50 genes en CNMP separados por estadio.
5 Una de las principales críticas aparecidas en el estado del arte (Subramanian J. et al. J Natl Cancer Inst 2010;102:1–11) respecto a la utilidad de los predictores generados para el CNMP es que es necesario demostrar su utilidad para predecir el pronóstico de los pacientes de manera independiente del estadio en el que se clasificaron. Para ello, separamos los 162 pacientes de la matriz de validación en pacientes clasificados en estadio I (110 pacientes) y clasificados como estadio II (52 pacientes). Se utilizó el
10 predictor de 50 genes para obtener los grupos moleculares de alto y bajo riesgo (es decir, de mal y buen pronóstico, respectivamente) y se estudió su asociación con el ILE mediante las curvas de Kaplan-Meier. Tanto en estadios I por separado (Fig. 9 A) como en estadios II (Fig. 9 B) se observó una asociación estadísticamente significativa de los grupos con el ILE (p=0,013 y p=0,029 respectivamente) y los HR del grupo de mal pronóstico respecto del de buen pronóstico fueron en el estadio I de 3,2 (IC 95%:1,2-8,3;
15 p=0,018) y en el estadio II de 3,5 (IC 95%:1,1-12; p=0,041).
Tabla 3. Muestra los valores de referencia de los 50 genes obtenidos con las muestras de la matriz de desarrollo para cada uno de los grupos. Estos valores serán utilizados para clasificar las nuevas muestras en grupo de buen o mal pronóstico.
20
ID Entrez
Símbolo Buen Pronóstico (“Shrunken centroid”) Mal Pronóstico (“Shrunken centroid”)
3493
IGHA1 0,549 -0,29
100287723
LOC100287723 0,539 -0,284
642424
LOC642424 0,536 -0,282
100132941
LOC100132941 0,52 -0,274
401847
LOC401847 0,517 -0,273
3500
IGHG1 0,504 -0,266
90925
LOC90925 0,487 -0,257
3543
IGLL1 0,481 -0,254
973
CD79A 0,443 -0,234
100290415
LOC100290415 0,44 -0,232
100133862
LOC100133862 0,436 -0,23
608
TNFRSF17 0,433 -0,228
26952
SMR3A 0,428 -0,226
3535
IGL@ 0,428 -0,226
51237
MGC29506 0,428 -0,226
100293440
LOC100293440 0,427 -0,225
3887
KRT81 0,417 -0,22
28904
IGKV1D-8 0,407 -0,214
57823
SLAMF7 0,403 -0,212
91319
DERL3 0,386 -0,204
57699
CPNE5 0,381 -0,201
54900
LAX1 0,379 -0,2
150365
MEI1 0,378 -0,199
9834
KIAA0125 0,372 -0,196
5450
POU2AF1 0,364 -0,192
84824
FCRLA 0,346 -0,183
83416
FCRL5 0,344 -0,181
92154
MTSS1L 0,344 -0,181
3662
IRF4 0,333 -0,176
3782
KCNN3 0,333 -0,176
11040
PIM2 0,326 -0,172
939
CD27 0,322 -0,17
imagen33
imagen34
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
2
A2M 586 BCAT1 1004 CDH6
12
SERPINA3 590 BCHE 1028 CDKN1C
13
AADAC 595 CCND1 1029 CDKN2A
49
ACR 623 BDKRB1 1030 CDKN2B
55
ACPP 624 BDKRB2 1033 CDKN3
58
ACTA1 640 BLK 1036 CDO1
59
ACTA2 641 BLM 1047 CLGN
72
ACTG2 643 CXCR5 1066 CES1
104
ADARB1 650 BMP2 1073 CFL2
124
ADH1A 654 BMP6 1080 CFTR
126
ADH1C 658 BMPR1B 1111 CHEK1
136
ADORA2B 660 BMX 1117 CHI3L2
152
ADRA2C 687 KLF9 1118 CHIT1
154
ADRB2 699 BUB1 1138 CHRNA5
176
ACAN 718 C3 1160 CKMT2
216
ALDH1A1 721 C4B 1191 CLU
220
ALDH1A3 730 C7 1236 CCR7
231
AKR1B1 760 CA2 1264 CNN1
241
ALOX5AP 762 CA4 1268 CNR1
249
ALPL 767 CA8 1277 COL1A1
275
AMT 820 CAMP 1278 COL1A2
284
ANGPT1 828 CAPS 1281 COL3A1
290
ANPEP 857 CAV1 1289 COL5A1
301
ANXA1 858 CAV2 1290 COL5A2
306
ANXA3 862 RUNX1T1 1291 COL6A1
348
APOE 863 CBFA2T3 1292 COL6A2
356
FASLG 873 CBR1 1295 COL8A1
360
AQP3 874 CBR3 1296 COL8A2
362
AQP5 890 CCNA2 1299 COL9A3
367
AR 891 CCNB1 1300 COL10A1
374
AREG 898 CCNE1 1302 COL11A2
384
ARG2 909 CD1A 1305 COL13A1
395
ARHGAP6 911 CD1C 1306 COL15A1
430
ASCL2 925 CD8A 1307 COL16A1
443
ASPA 948 CD36 1311 COMP
444
ASPH 956 ENTPD3 1356 CP
445
ASS1 969 CD69 1359 CPA3
463
ZFHX3 970 CD70 1363 CPE
467
ATF3 971 CD72 1380 CR2
482
ATP1B2 978 CDA 1381 CRABP1
501
ALDH7A1 991 CDC20 1382 CRABP2
563
AZGP1 1000 CDH2 1400 CRMP1
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
1404
HAPLN1 1946 EFNA5 2346 FOLH1
1415
CRYBB2 1948 EFNB2 2352 FOLR3
1468
SLC25A10 1958 EGR1 2353 FOS
1490
CTGF 1960 EGR3 2354 FOSB
1501
CTNND2 1969 EPHA2 2358 FPR2
1511
CTSG 1999 ELF3 2444 FRK
1513
CTSK 2006 ELN 2525 FUT3
1524
CX3CR1 2009 EML1 2537 IFI6
1571
CYP2E1 2026 ENO2 2539 G6PD
1573
CYP2J2 2034 EPAS1 2568 GABRP
1594
CYP27B1 2041 EPHA1 2571 GAD1
1602
DACH1 2042 EPHA3 2579 GAGE7
1608
DGKG 2043 EPHA4 2591 GALNT3
1634
DCN 2059 EPS8 2619 GAS1
1668
DEFA3 2114 ETS2 2621 GAS6
1673
DEFB4A 2115 ETV1 2627 GATA6
1674
DES 2122 MECOM 2628 GATM
1690
COCH 2152 F3 2633 GBP1
1728
NQO1 2153 F5 2635 GBP3
1734
DIO2 2160 F11 2668 GDNF
1735
DIO3 2162 F13A1 2669 GEM
1740
DLG2 2172 FABP6 2681 GGTA1
1748
DLX4 2191 FAP 2719 GPC3
1755
DMBT1 2192 FBLN1 2731 GLDC
1756
DMD 2194 FASN 2735 GLI1
1763
DNA2 2202 EFEMP1 2736 GLI2
1776
DNASE1L3 2205 FCER1A 2781 GNAZ
1789
DNMT3B 2206 MS4A2 2786 GNG4
1805
DPT 2237 FEN1 2791 GNG11
1809
DPYSL3 2239 GPC4 2841 GPR18
1837
DTNA 2246 FGF1 2842 GPR19
1842
ECM2 2247 FGF2 2843 GPR20
1843
DUSP1 2254 FGF9 2850 GPR27
1848
DUSP6 2258 FGF13 2852 GPER
1852
DUSP9 2273 FHL1 2857 GPR34
1869
E2F1 2274 FHL2 2869 GRK5
1870
E2F2 2277 FIGF 2905 GRIN2C
1879
EBF1 2294 FOXF1 2920 CXCL2
1896
EDA 2295 FOXF2 2921 CXCL3
1906
EDN1 2327 FMO2 2922 GRP
1907
EDN2 2328 FMO3 2936 GSR
1945
EFNA4 2335 FN1 2939 GSTA2
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
2944
GSTM1 3400 ID4 3824 KLRD1
2952
GSTT1 3429 IFI27 3833 KIFC1
2953
GSTT2 3434 IFIT1 3834 KIF25
2999
GZMH 3437 IFIT3 3851 KRT4
3001
GZMA 3455 IFNAR2 3880 KRT19
3003
GZMK 3458 IFNG 3892 KRT86
3005
H1F0 3479 IGF1 3898 LAD1
3006
HIST1H1C 3481 IGF2 3902 LAG3
3007
HIST1H1D 3486 IGFBP3 3908 LAMA2
3008
HIST1H1E 3488 IGFBP5 3914 LAMB3
3013
HIST1H2AD 3489 IGFBP6 3925 STMN1
3024
HIST1H1A 3559 IL2RA 3934 LCN2
3042
HBM 3569 IL6 3945 LDHB
3043
HBB 3577 CXCR1 3953 LEPR
3045
HBD 3579 CXCR2 3957 LGALS2
3049
HBQ1 3598 IL13RA2 3998 LMAN1
3053
SERPIND1 3604 TNFRSF9 4015 LOX
3067
HDC 3620 IDO1 4017 LOXL2
3117
HLA-DQA1 3624 INHBA 4023 LPL
3131
HLF 3625 INHBB 4033 LRMP
3149
HMGB3 3627 CXCL10 4045 LSAMP
3161
HMMR 3640 INSL3 4057 LTF
3164
NR4A1 3653 IPW 4062 LY6H
3169
FOXA1 3663 IRF5 4068 SH2D1A
3199
HOXA2 3667 IRS1 4069 LYZ
3201
HOXA4 3679 ITGA7 4071 TM4SF1
3204
HOXA7 3690 ITGB3 4093 SMAD9
3212
HOXB2 3694 ITGB6 4105 MAGEA6
3216
HOXB6 3699 ITIH3 4117 MAK
3225
HOXC9 3706 ITPKA 4118 MAL
3235
HOXD9 3730 KAL1 4128 MAOA
3240
HP 3751 KCND2 4129 MAOB
3250
HPR 3768 KCNJ12 4131 MAP1B
3270
HRC 3772 KCNJ15 4133 MAP2
3292
HSD17B1 3775 KCNK1 4137 MAPT
3294
HSD17B2 3777 KCNK3 4151 MB
3303
HSPA1A 3778 KCNMA1 4166 CHST6
3316
HSPB2 3783 KCNN4 4199 ME1
3357
HTR2B 3800 KIF5C 4223 MEOX2
3371
TNC 3816 KLK1 4233 MET
3373
HYAL1 3821 KLRC1 4239 MFAP4
3397
ID1 3822 KLRC2 4241 MFI2
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
4248
MGAT3 4929 NR4A2 5563 PRKAA2
4256
MGP 4935 GPR143 5569 PKIA
4311
MME 4953 ODC1 5570 PKIB
4316
MMP7 5021 OXTR 5577 PRKAR2B
4318
MMP9 5023 P2RX1 5578 PRKCA
4325
MMP16 5029 P2RY2 5602 MAPK10
4332
MNDA 5046 PCSK6 5625 PRODH
4356
MPP3 5050 PAFAH1B3 5627 PROS1
4477
MSMB 5054 SERPINE1 5630 PRPH
4481
MSR1 5064 PALM 5655 KLK10
4490
MT1B 5087 PBX1 5727 PTCH1
4495
MT1G 5099 PCDH7 5730 PTGDS
4499
MT1M 5122 PCSK1 5740 PTGIS
4502
MT2A 5125 PCSK5 5743 PTGS2
4585
MUC4 5144 PDE4D 5753 PTK6
4599
MX1 5152 PDE9A 5783 PTPN13
4602
MYB 5154 PDGFA 5787 PTPRB
4605
MYBL2 5157 PDGFRL 5789 PTPRD
4606
MYBPC2 5167 ENPP1 5794 PTPRH
4629
MYH11 5172 SLC26A4 5801 PTPRR
4653
MYOC 5187 PER1 5806 PTX3
4674
NAP1L2 5196 PF4 5816 PVALB
4703
NEB 5225 PGC 5874 RAB27B
4739
NEDD9 5226 PGD 5909 RAP1GAP
4744
NEFH 5272 SERPINB9 5918 RARRES1
4751
NEK2 5324 PLAG1 5961 PRPH2
4774
NFIA 5327 PLAT 5990 RFX2
4792
NFKBIA 5328 PLAU 5996 RGS1
4810
NHS 5339 PLEC 5999 RGS4
4811
NID1 5347 PLK1 6019 RLN2
4824
NKX3-1 5348 FXYD1 6036 RNASE2
4837
NNMT 5350 PLN 6098 ROS1
4851
NOTCH1 5376 PMP22 6192 RPS4Y1
4856
NOV 5396 PRRX1 6236 RRAD
4857
NOVA1 5427 POLE2 6275 S100A4
4862
NPAS2 5460 POU5F1 6285 S100B
4881
NPR1 5468 PPARG 6286 S100P
4883
NPR3 5471 PPAT 6288 SAA1
4884
NPTX1 5502 PPP1R1A 6289 SAA2
4885
NPTX2 5507 PPP1R3C 6300 MAPK12
4902
NRTN 5521 PPP2R2B 6327 SCN2B
4907
NT5E 5549 PRELP 6335 SCN9A
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
6339
SCNN1D 6820 SULT2B1 7472 WNT2
6343
SCT 6941 TCF19 7475 WNT6
6354
CCL7 6999 TDO2 7481 WNT11
6355
CCL8 7010 TEK 7504 XK
6356
CCL11 7015 TERT 7538 ZFP36
6357
CCL13 7018 TF 7691 ZNF132
6358
CCL14 7022 TFAP2C 7694 ZNF135
6361
CCL17 7025 NR2F1 7704 ZBTB16
6362
CCL18 7031 TFF1 7762 ZNF215
6363
CCL19 7033 TFF3 7781 SLC30A3
6364
CCL20 7035 TFPI 7837 PXDN
6366
CCL21 7039 TGFA 7849 PAX8
6373
CXCL11 7042 TGFB2 7850 IL1R2
6374
CXCL5 7045 TGFBI 7941 PLA2G7
6376
CX3CL1 7048 TGFBR2 7976 FZD3
6387
CXCL12 7056 THBD 7991 TUSC3
6401
SELE 7058 THBS2 8000 PSCA
6403
SELP 7076 TIMP1 8013 NR4A3
6414
SEPP1 7078 TIMP3 8038 ADAM12
6423
SFRP2 7083 TK1 8076 MFAP5
6424
SFRP4 7093 TLL2 8111 GPR68
6440
SFTPC 7102 TSPAN7 8115 TCL1A
6442
SGCA 7122 CLDN5 8140 SLC7A5
6447
SCG5 7137 TNNI3 8190 MIA
6495
SIX1 7138 TNNT1 8208 CHAF1B
6505
SLC1A1 7139 TNNT2 8277 TKTL1
6518
SLC2A5 7153 TOP2A 8284 KDM5D
6540
SLC6A13 7177 TPSAB1 8302 KLRC4
6583
SLC22A4 7216 TRO 8313 AXIN2
6588
SLN 7262 PHLDA2 8322 FZD4
6590
SLPI 7296 TXNRD1 8325 FZD8
6615
SNAI1 7345 UCHL1 8326 FZD9
6623
SNCG 7356 SCGB1A1 8335 HIST1H2AB
6652
SORD 7365 UGT2B10 8339 HIST1H2BG
6662
SOX9 7367 UGT2B17 8357 HIST1H3H
6678
SPARC 7368 UGT8 8360 HIST1H4D
6689
SPIB 7373 COL14A1 8364 HIST1H4C
6691
SPINK2 7379 UPK2 8365 HIST1H4H
6695
SPOCK1 7391 USF1 8366 HIST1H4B
6696
SPP1 7422 VEGFA 8368 HIST1H4L
6769
STAC 7431 VIM 8395 PIP5K1B
6790
AURKA 7450 VWF 8404 SPARCL1
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
8406
SRPX 9077 DIRAS3 9833 MELK
8434
RECK 9084 VCY 9890 LPPR4
8436
SDPR 9086 EIF1AY 9899 SV2B
8437
RASAL1 9088 PKMYT1 9914 ATP2C2
8464
SUPT3H 9118 INA 9915 ARNT2
8483
CILP 9148 NEURL 9934 P2RY14
8490
RGS5 9156 EXO1 9940 DLEC1
8492
PRSS12 9172 MYOM2 9956 HS3ST2
8503
PIK3R3 9200 PTPLA 9957 HS3ST1
8516
ITGA8 9201 DCLK1 10024 TROAP
8528
DDO 9284 NPIP 10076 PTPRU
8537
BCAS1 9289 GPR56 10082 GPC6
8547
FCN3 9369 NRXN3 10085 EDIL3
8612
PPAP2C 9388 LIPG 10100 TSPAN2
8622
PDE8B 9401 RECQL4 10103 TSPAN1
8638
OASL 9420 CYP7B1 10112 KIF20A
8639
AOC3 9429 ABCG2 10135 NAMPT
8644
AKR1C3 9447 AIM2 10158 PDZK1IP1
8653
DDX3Y 9452 ITM2A 10164 CHST4
8660
IRS2 9455 HOMER2 10170 DHRS9
8685
MARCO 9481 SLC25A27 10186 LHFP
8693
GALNT4 9486 CHST10 10202 DHRS2
8727
CTNNAL1 9508 ADAMTS3 10203 CALCRL
8786
RGS11 9547 CXCL14 10231 RCAN2
8792
TNFRSF11A 9586 CREB5 10234 LRRC17
8835
SOCS2 9590 AKAP12 10253 SPRY2
8840
WISP1 9610 RIN1 10265 IRX5
8847
DLEU2 9612 NCOR2 10290 SPEG
8857
FCGBP 9625 AATK 10309 CCNO
8876
VNN1 9633 MTL5 10319 LAMC3
8908
GYG2 9636 ISG15 10332 CLEC4M
8914
TIMELESS 9639 ARHGEF10 10335 MRVI1
8938
BAIAP3 9700 ESPL1 10351 ABCA8
8942
KYNU 9718 ECE2 10361 NPM2
8968
HIST1H3F 9720 CCDC144A 10365 KLF2
8970
HIST1H2BJ 9721 GPRIN2 10371 SEMA3A
9033
PKD2L1 9732 DOCK4 10417 SPON2
9037
SEMA5A 9735 KNTC1 10418 SPON1
9038
TAAR5 9737 GPRASP1 10439 OLFM1
9060
PAPSS2 9770 RASSF2 10446 LRRN2
9068
ANGPTL1 9787 DLGAP5 10457 GPNMB
9071
CLDN10 9832 JAKMIP2 10462 CLEC10A
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
10512
SEMA3C 22983 MAST1 26108 PYGO1
10529
NEBL 23037 PDZD2 26150 RIBC2
10537
UBD 23066 CAND2 26153 KIF26A
10570
DPYSL4 23089 PEG10 26166 RGS22
10578
GNLY 23194 FBXL7 26172 LOC26172
10579
TACC2 23209 MLC1 26206 SPAG8
10580
SORBS1 23213 SULF1 26232 FBXO2
10606
PAICS 23236 PLCB1 26253 CLEC4E
10615
SPAG5 23242 COBL 26256 CABYR
10631
POSTN 23314 SATB2 26271 FBXO5
10643
IGF2BP3 23327 NEDD4L 26298 EHF
10656
KHDRBS3 23373 CRTC1 26353 HSPB8
10669
CGREF1 23414 ZFPM2 26470 SEZ6L2
10733
PLK4 23460 ABCA6 26577 PCOLCE2
10742
RAI2 23475 QPRT 26579 MYEOV
10744
PTTG2 23541 SEC14L2 26585 GREM1
10874
NMU 23562 CLDN14 26872 STEAP1
10875
FGL2 23587 C17orf81 26960 NBEA
10878
CFHR3 23657 SLC7A11 26974 ZNF285A
10891
PPARGC1A 23704 KCNE4 27074 LAMP3
10894
LYVE1 23743 BHMT2 27111 SDCBP2
10942
PRSS21 23767 FLRT3 27112 FAM155B
10964
IFI44L 23768 FLRT2 27122 DKK3
10974
C10orf116 24137 KIF4A 27123 DKK2
10984
KCNQ1OT1 24141 C20orf103 27129 HSPB7
11005
SPINK5 25791 NGEF 27145 FILIP1
11012
KLK11 25805 BAMBI 27147 DENND2A
11013
TMSB15A 25817 FAM19A5 27151 CPAMD8
11015
KDELR3 25833 POU2F3 27156 RTDR1
11065
UBE2C 25840 METTL7A 27165 GLS2
11082
ESM1 25878 MXRA5 27237 ARHGEF16
11096
ADAMTS5 25884 CHRDL2 27285 TEKT2
11130
ZWINT 25890 ABI3BP 27286 SRPX2
11169
WDHD1 25891 PAMR1 27299 ADAMDEC1
11197
WIF1 25894 PLEKHG4 27303 RBMS3
11226
GALNT6 25945 PVRL3 27306 HPGDS
11227
GALNT5 26002 MOXD1 27344 PCSK1N
11254
SLC6A14 26027 ACOT11 27345 KCNMB4
22801
ITGA11 26040 SETBP1 27443 CECR2
22885
ABLIM3 26049 FAM169A 28231 SLCO4A1
22915
MMRN1 26053 AUTS2 28999 KLF15
22949
PTGR1 26074 C20orf26 29070 CCDC113
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
29089
UBE2T 51678 MPP6 55086 CXorf57
29091
STXBP6 51705 EMCN 55107 ANO1
29126
CD274 51744 CD244 55118 CRTAC1
29128
UHRF1 51751 HIGD1B 55137 FIGN
29775
CARD10 51761 ATP8A2 55138 FAM90A1
29798
C2orf27A 51804 SIX4 55143 CDCA8
29802
VPREB3 53342 IL17D 55165 CEP55
29931
LOH3CR2A 53358 SHC3 55203 LGI2
29948
OSGIN1 53616 ADAM22 55228 PNMAL1
29993
PACSIN1 53832 IL20RA 55231 CCDC87
30001
ERO1L 54206 ERRFI1 55258 THNSL2
30846
EHD2 54360 CYTL1 55273 TMEM100
50486
G0S2 54361 WNT4 55286 C4orf19
50487
PLA2G3 54437 SEMA5B 55304 SPTLC3
50507
NOX4 54463 FAM134B 55344 PLCXD1
50509
COL5A3 54478 FAM64A 55351 STK32B
50617
ATP6V0A4 54551 MAGEL2 55353 LAPTM4B
50636
ANO7 54596 L1TD1 55359 STYK1
50863
NTM 54621 VSIG10 55366 LGR4
51083
GAL 54674 LRRN3 55388 MCM10
51087
YBX2 54682 MANSC1 55450 CAMK2N1
51090
PLLP 54739 XAF1 55510 DDX43
51129
ANGPTL4 54756 IL17RD 55521 TRIM36
51162
EGFL7 54829 ASPN 55545 MSX2P1
51196
PLCE1 54830 NUP62CL 55576 STAB2
51208
CLDN18 54847 SIDT1 55698 RADIL
51284
TLR7 54852 PAQR5 55714 ODZ3
51297
PLUNC 54855 FAM46C 55765 C1orf106
51299
NRN1 54869 EPS8L1 55786 ZNF415
51302
CYP39A1 54894 RNF43 55789 DEPDC1B
51308
REEP2 54906 C10orf18 55799 CACNA2D3
51311
TLR8 54922 RASIP1 55872 PBK
51316
PLAC8 54933 RHBDL2 55966 AJAP1
51348
KLRF1 54959 ODAM 56000 NXF3
51364
ZMYND10 54979 HRASLS2 56121 PCDHB15
51450
PRRX2 55034 MOCOS 56122 PCDHB14
51454
GULP1 55040 EPN3 56126 PCDHB10
51554
CCRL1 55061 SUSD4 56127 PCDHB9
51560
RAB6B 55064 C9orf68 56128 PCDHB8
51561
IL23A 55065 GPR172B 56129 PCDHB7
51659
GINS2 55083 KIF26B 56131 PCDHB4
51673
TPPP3 55084 SOBP 56143 PCDHA5
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
56147
PCDHA1 57758 SCUBE2 79071 ELOVL6
56164
STK31 57817 HAMP 79092 CARD14
56253
CRTAM 58189 WFDC1 79148 MMP28
56256
SERTAD4 58494 JAM2 79153 GDPD3
56477
CCL28 59269 HIVEP3 79173 C19orf57
56603
CYP26B1 59271 C21orf63 79191 IRX3
56649
TMPRSS4 59272 ACE2 79258 MMEL1
56673
C11orf16 59277 NTN4 79365 BHLHE41
56675
NRIP3 59285 CACNG6 79370 BCL2L14
56937
PMEPA1 59353 TMEM35 79413 ZBED2
56944
OLFML3 60437 CDH26 79589 RNF128
56967
C14orf132 63027 SLC22A23 79611 ACSS3
56977
STOX2 63876 PKNOX2 79614 C5orf23
56992
KIF15 63951 DMRTA1 79618 HMBOX1
57101
ANO2 64072 CDH23 79623 GALNT14
57110
HRASLS 64073 C19orf33 79633 FAT4
57188
ADAMTSL3 64093 SMOC1 79642 ARSJ
57194
ATP10A 64094 SMOC2 79645 EFCAB1
57210
SLC45A4 64108 RTP4 79682 MLF1IP
57214
KIAA1199 64131 XYLT1 79692 ZNF322A
57235
KIAA0485 64167 ERAP2 79723 SUV39H2
57335
ZNF286A 64220 STRA6 79739 TTLL7
57348
TTYH1 64283 RGNEF 79772 MCTP1
57393
TMEM27 64288 ZNF323 79774 GRTP1
57402
S100A14 64332 NFKBIZ 79801 SHCBP1
57452
GALNTL1 64344 HIF3A 79819 WDR78
57460
PPM1H 64377 CHST8 79825 CCDC48
57482
KIAA1211 64388 GREM2 79841 AGBL2
57484
RNF150 64399 HHIP 79844 ZDHHC11
57493
HEG1 64506 CPEB1 79852 EPHX3
57501
KIAA1257 64699 TMPRSS3 79875 THSD4
57514
ARHGAP31 64757 MOSC1 79901 CYBRD1
57535
KIAA1324 64849 SLC13A3 79919 C2orf54
57537
SORCS2 64866 CDCP1 79931 TNIP3
57608
KIAA1462 64919 BCL11B 79953 TMEM90B
57616
TSHZ3 65243 ZNF643 79957 PAQR6
57631
LRCH2 65997 RASL11B 79974 C7orf58
57633
LRRN1 66000 TMEM108 79977 GRHL2
57670
KIAA1549 78989 COLEC11 79987 SVEP1
57683
ZDBF2 78995 C17orf53 79992 C6orf59
57705
WDFY4 79006 METRN 79993 ELOVL7
57717
PCDHB16 79019 CENPM 80034 CSRNP3
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
80054
LOC80054 83988 NCALD 85004 RERG
80144
FRAS1 83992 CTTNBP2 85016 C11orf70
80150
ASRGL1 84000 TMPRSS13 85453 TSPYL5
80178
C16orf59 84057 MND1 85455 DISP2
80206
FHOD3 84059 GPR98 85462 FHDC1
80235
PIGZ 84069 PLEKHN1 89765 RSPH1
80237
ELL3 84073 MYCBPAP 89795 NAV3
80258
EFHC2 84152 PPP1R1B 89796 NAV1
80303
EFHD1 84171 LOXL4 89822 KCNK17
80310
PDGFD 84189 SLITRK6 89872 AQP10
80326
WNT10A 84206 MEX3B 89958 C9orf140
80705
TSGA10 84215 ZNF541 90050 FAM181A
80723
TMEM22 84258 SYT3 90362 FAM110B
80726
KIAA1683 84417 C2orf40 90865 IL33
80759
KHDC1 84419 C15orf48 91057 CCDC34
80760
ITIH5 84448 ABLIM2 91120 ZNF682
81029
WNT5B 84553 C6orf168 91133 L3MBTL4
81035
COLEC12 84623 KIRREL3 91543 RSAD2
81501
TM7SF4 84624 FNDC1 91614 DEPDC7
81557
MAGED4B 84627 ZNF469 91683 SYT12
81575
APOLD1 84632 AFAP1L2 91687 CENPL
81578
COL21A1 84649 DGAT2 91851 CHRDL1
81831
NETO2 84667 HES7 91977 MYOZ3
81931
ZNF93 84676 TRIM63 92291 CAPN13
83439
TCF7L1 84688 C9orf24 92304 SCGB3A1
83461
CDCA3 84696 ABHD1 92312 MEX3A
83481
EPPK1 84706 GPT2 92340 C17orf72
83540
NUF2 84707 BEX2 92747 C20orf114
83543
AIF1L 84708 LNX1 92949 ADAMTSL1
83604
TMEM47 84709 C4orf49 93082 NEURL3
83648
FAM167A 84803 AGPAT9 93099 DMKN
83657
DYNLRB2 84830 C6orf105 93273 LEMD1
83661
MS4A8B 84842 HPDL 93517 SDR42E1
83690
CRISPLD1 84848 MGC16121 93986 FOXP2
83849
SYT15 84870 RSPO3 94274 PPP1R14A
83853
ROPN1L 84900 RNFT2 96626 LIMS3
83869
TTTY14 84935 C13orf33 112476 PRRT2
83872
HMCN1 84952 CGNL1 113115 FAM54A
83879
CDCA7 84953 MICALCL 113130 CDCA5
83888
FGFBP2 84962 JUB 113146 AHNAK2
83903
GSG2 84966 IGSF21 113278 C20orf54
83959
SLC4A11 84969 TOX2 113730 KLHDC7B
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
114569
MAL2 126129 CPT1C 142683 ITLN2
114787
GPRIN1 126567 C2CD4C 143662 MUC15
114800
CCDC85A 127495 LRRC39 144193 AMDHD1
114818
KLHL29 127602 DNAH14 144347 FAM101A
114827
FHAD1 128153 SPATA17 144406 WDR66
114880
OSBPL6 128229 C1orf182 144501 KRT80
114899
C1QTNF3 128602 C20orf85 145258 GSC
114905
C1QTNF7 128611 ZNF831 145773 FAM81A
114907
FBXO32 128872 HMGB3L1 146212 KCTD19
115361
GBP4 129790 C7orf13 146330 FBXL16
115362
GBP5 130271 PLEKHH2 146434 ZNF597
115572
FAM46B 130367 SGPP2 146760 RTN4RL1
115908
CTHRC1 130733 TMEM178 146845 WDR16
116028
C16orf75 131177 FAM3D 147166 TRIM16L
116039
OSR2 131450 CD200R1 147372 CCBE1
116159
CYYR1 131578 LRRC15 147463 ANKRD29
116211
TM4SF19 131873 COL6A6 147525 C18orf18
116328
C8orf34 132671 SPATA18 147645 VSIG10L
116372
LYPD1 132864 CPEB2 147744 TMEM190
116442
RAB39B 133022 TRAM1L1 147906 DACT3
116832
RPL39L 133690 CAPSL 147920 IGFL2
116969
ART5 134147 CMBL 147968 CAPN12
117156
SCGB3A2 134265 AFAP1L1 148229 ATP8B3
117157
SH2D1B 134466 LOC134466 148252 DIRAS1
117166
WFIKKN1 135112 NCOA7 148418 SAMD13
117247
SLC16A10 135398 C6orf141 148641 SLC35F3
117248
GALNTL2 135932 TMEM139 149111 CNIH3
118491
TTC18 136306 SVOPL 149351 LOC149351
118663
BTBD16 137872 ADHFE1 149483 CCDC17
118932
ANKRD22 137902 PXDNL 150248 C22orf15
119391
GSTO2 137994 LETM2 150378 FLJ30901
119587
CPXM2 139065 SLITRK4 150696 PROM2
120071
GYLTL1B 139324 HDX 150763 GPAT2
120376
C11orf93 139886 SPIN4 151174 LOC151174
120892
LRRK2 140032 RPS4Y2 151176 FAM132B
122402
TDRD9 140578 CHODL 151242 PPP1R1C
122622
ADSSL1 140597 TCEAL2 151246 SGOL2
124093
CCDC78 140706 C20orf160 151473 SLC16A14
124220
ZG16B 140733 MACROD2 151507 MSL3L2
124602
KIF19 140766 ADAMTS14 151827 LRRC34
124739
USP43 140809 SRXN1 151887 CCDC80
124976
SPNS2 140862 ISM1 151888 BTLA
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
152078
C3orf55 200634 KRTCAP3 256076 COL29A1
153478
PLEKHG4B 200810 ALG1L 256435 ST6GALNAC3
153572
IRX2 200958 MUC20 256691 MAMDC2
153579
BTNL9 201161 CENPV 259173 ALS2CL
154313
C6orf165 201456 FBXO15 259266 ASPM
154796
AMOT 201799 TMEM154 259307 IL4I1
155368
WBSCR27 202333 CMYA5 260293 CYP4X1
157310
PEBP4 202915 TMEM184A 260436 C4orf7
157313
CDCA2 203111 C8orf47 266977 GPR110
157506
RDH10 219348 PLAC9 282679 AQP11
157570
ESCO2 219595 FOLH1B 283120 H19
157773
C8orf48 219736 STOX1 283208 P4HA3
157869
C8orf84 219790 RTKN2 283358 B4GALNT3
157927
C9orf62 220136 CCDC11 283481 LOC283481
158295
MGC24103 220164 DOK6 283518 KCNRG
158326
FREM1 220359 TIGD3 283663 LOC283663
158511
CSAG1 220594 LOC220594 284013 VMO1
159371
TMEM20 220963 SLC16A9 284047 CCDC144B
160364
CLEC12A 221002 RASGEF1A 284119 PTRF
160365
CLECL1 221150 SKA3 284307 ZIK1
160622
GRASP 221303 FAM162B 284339 TMEM145
161725
OTUD7A 221357 GSTA5 284367 SIGLECP3
162632
LOC162632 221424 C6orf154 284654 RSPO1
162963
ZNF610 221476 PI16 284716 RIMKLA
163255
ZNF540 221687 RNF182 284889 LOC284889
163782
KANK4 221806 VWDE 284904 SEC14L4
164832
LONRF2 221914 GPC2 284992 CCDC150
165055
CCDC138 221935 SDK1 285016 FAM150B
167359
MGC42105 221981 THSD7A 285141 LOC285141
167465
ZNF366 222171 PRR15 285489 DOK7
168002
DACT2 222235 FBXL13 285755 PPIL6
169792
GLIS3 245972 ATP6V0D2 286046 XKR6
170679
PSORS1C1 246100 CTAG1A 286527 TMSB15B
171024
SYNPO2 252995 FNDC5 286749 STON1-GTF2A1L
196740
C10orf72 253152 EPHX4 286827 TRIM59
198437
C20orf201 253264 LOC253264 338339 CLEC4D
199675
C19orf59 253650 ANKRD18A 338382 RAB7B
199713
NLRP7 253982 ASPHD1 339145 FAM92B
199786
FAM129C 254910 LCE5A 339184 CCDC144NL
200162
SPAG17 255480 LOC255480 339390 CLEC4G
200172
SLFNL1 255631 COL24A1 339524 LOC339524
200315
APOBEC3A 255743 NPNT 339768 ESPNL
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
339778
C2orf70 401233 LOC401233 728882 FAM182B
339804
C2orf74 401237 FLJ22536 729085 FAM198A
340286
FAM183B 401474 SAMD12 729680 LOC729680
340542
BEX5 402483 tcag7.907 729983 LOC729983
340719
NANOS1 439949 LOC439949 100113384 SNORD123
342035
GLDN 440068 CARD17 100128511 LOC100128511
342979
PALM3 440461 LOC440461 100130967 LOC100130967
344148
NCKAP5 440556 FLJ42875 100131170 LOC100131170
346689
KLRG2 440585 FAM183A 100131541 UNQ6228
347744
C6orf52 440712 C1orf186 100131564 LOC100131564
347902
AMIGO2 440792 LOC440792 100131733 LOC100131733
348751
LOC348751 440823 MIAT 100131997 FAM27E3
352961
HCG26 441027 TMEM150C 100132247 LOC100132247
353189
SLCO4C1 441168 FAM26F 100132885 LOC100132885
374569
ASPG 441208 LOC441208 100133161 LOC100133161
387066
SNHG5 441295 OR2A9P 100133941 CD24
387328
ZNF322B 441317 FAM90A7 100134018 hCG_1774568
387758
FIBIN 441376 C8orf85 100271835 LIMS3-LOC440895
387763
AG2 441631 TSPAN11 100288985 LOC100288985
387885
CCDC42B 441795 LOC441795 100289058 LOC100289058
387914
SHISA2 445328 ARHGEF5L 100293193 LOC100293193
388115
C15orf52 474354 LRRC18 — A_32_P149011
388125
C2CD4B 619279 ZNF704 — A_32_P208200
388135
C15orf59 642236 LOC642236 — A_24_P315862
388242
LOC388242 642477 FLJ39632 — A_23_P121234
388585
HES5 642521 LOC642521 — A_32_P148122
388630
LOC388630 644186 C22orf41 — A_32_P115277
388815
C21orf34 644246 LOC644246 — A_32_P33213
389136
VGLL3 645027 EVPLL — A_32_P124773
389432
SAMD5 645277 LOC645277 — A_32_P105465
389458
LOC389458 645722 LOC645722 — A_24_P5994
389493
LOC389493 650655 ABCA17P — A_23_P28307
389831
LOC389831 653140 C2orf84 — A_24_P890995
389834
LOC389834 653509 SFTPA1 — A_32_P210106
391267
C21orf81 654433 LOC654433 — A_24_P298228
399668
NCRNA00086 654790 PCP4L1 — A_24_P702749
399744
LOC399744 723790 HIST2H2AA4 — A_24_P307375
399948
C11orf92 727832 GOLGA6L6 — A_24_P930088
399959
LOC399959 727916 LOC727916 — A_24_P659980
400043
LOC400043 728215 FAM155A — A_32_P115749
400456
LOC400456 728242 XAGE2B — A_32_P181826
400566
C17orf97 728613 LOC728613 — A_32_P172578
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
—
A_32_P23810 — A_23_P211468 — A_24_P827096
—
A_32_P164917 — A_32_P50973 — A_32_P132194
—
A_24_P233560 — A_24_P936252 — A_32_P186865
—
A_23_P159435 — A_32_P406142 — A_24_P92174
—
A_32_P96752 — A_32_P15288 — A_23_P21907
—
A_24_P67494 — A_24_P204727 — A_32_P73991
—
A_32_P72351 — A_32_P146844 — A_24_P221903
—
A_24_P683861 — A_32_P157504 — A_32_P108033
—
A_24_P643776 — A_32_P227921 — A_32_P88587
—
A_32_P162862 — A_24_P263786 — A_24_P64442
—
A_24_P170136 — A_32_P17343 — A_32_P61298
—
A_23_P170719 — A_24_P110487 — A_32_P226941
—
A_24_P590547 — A_24_P490109 — A_32_P226356
—
A_24_P213134 — A_32_P125402 — A_24_P822869
—
A_32_P194563 — A_32_P35486 — A_32_P99533
—
A_24_P247074 — A_32_P198295 — A_24_P101742
—
A_24_P395415 — A_23_P43649 — A_32_P100947
—
A_32_P32463 — A_32_P227496 — A_23_P250516
—
A_32_P59277 — A_24_P494425 — A_32_P212258
—
A_24_P110618 — A_24_P604784 — A_32_P132748
—
A_32_P5205 — A_32_P126259 — A_24_P558135
—
A_32_P90812 — A_32_P32043 — A_23_P135123
—
A_32_P122715 — A_32_P229818 — A_24_P212024
—
A_32_P155512 — A_32_P118657 — A_24_P517918
—
A_24_P538459 — A_24_P15388 — A_23_P116195
—
A_24_P144346 — A_24_P204374 — A_32_P112100
—
A_24_P178444 — A_24_P92683 — A_24_P478940
—
A_32_P214395 — A_24_P589028 — A_24_P177844
—
A_23_P44053 — A_32_P117322 — A_24_P241996
—
A_32_P152255 — A_24_P929818 — A_32_P117186
—
A_23_P21260 — A_32_P151747 — A_32_P233799
—
A_32_P101623 — A_32_P109078 — A_24_P707102
—
A_32_P188921 — A_24_P484699 — A_23_P32793
—
A_32_P164971 — A_32_P43664 — A_24_P358474
—
A_24_P795230 — A_24_P608268 — A_32_P42224
—
A_24_P267814 — A_24_P24371 — A_24_P100684
—
A_32_P103678 — A_23_P111525 — A_32_P164477
—
A_24_P333306 — A_32_P214565 — A_32_P110485
—
A_32_P215556 — A_32_P1166 — A_24_P460763
—
A_23_P72252 — A_32_P153361 — A_32_P39944
—
A_24_P497843 — A_24_P315941 — A_24_P845631
—
A_24_P916853 — A_23_P158868 — A_32_P166733
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
—
A_32_P157465 — A_24_P927205 — A_32_P39440
—
A_32_P115122 — A_32_P196918 — A_23_P166508
—
A_24_P203418 — A_24_P315854 — A_32_P35303
—
A_23_P21249 — A_23_P435390 — A_32_P33802
—
A_24_P203886 — A_32_P182458 — A_32_P173922
—
A_32_P30874 — A_32_P155984 — A_23_P87421
—
A_32_P108516 — A_24_P478556 — A_32_P40673
—
A_32_P106615 — A_32_P21459 — A_32_P164916
—
A_24_P626951 — A_32_P161755 — A_24_P745352
—
A_24_P306814 — A_24_P8257 — A_32_P139163
—
A_24_P940469 — A_32_P189034 — A_23_P390206
—
A_24_P592060 — A_32_P122951 — A_32_P68055
—
A_24_P42453 — A_24_P565110 — A_24_P825969
—
A_24_P914479 — A_32_P226768 — A_24_P816844
—
A_24_P401124 — A_32_P157927 — A_32_P142602
—
A_24_P372189 — A_32_P114918 — A_23_P170713
—
A_32_P46456 — A_23_P140884 — A_24_P418744
—
A_24_P592591 — A_23_P9997 — A_32_P43959
—
A_24_P384119 — A_32_P330691 — A_24_P16214
—
A_24_P923271 — A_23_P98671 — A_32_P77102
—
A_32_P49552 — A_24_P813550 — A_24_P246825
—
A_32_P108748 — A_32_P47166 — A_23_P84791
—
A_24_P16337 — A_24_P213325 — A_32_P55414
—
A_24_P733308 — A_24_P871940 — A_32_P15081
—
A_24_P76868 — A_24_P677559 — A_24_P930327
—
A_24_P878419 — A_23_P217187 — A_32_P188993
—
A_24_P934162 — A_23_P56868 — A_23_P361654
—
A_24_P592871 — A_24_P932887 — A_32_P229493
—
A_23_P96191 — A_32_P177595 — A_24_P333357
—
A_32_P169550 — A_23_P170830 — A_23_P35546
—
A_24_P484904 — A_32_P68076 — A_32_P12372
—
A_24_P639701 — A_32_P212406 — A_24_P24053
—
A_32_P165990 — A_32_P877 — A_23_P112957
—
A_23_P20328 — A_32_P121537 — A_24_P341546
—
A_32_P214054 — A_23_P21393 — A_32_P43914
—
A_24_P932388 — A_32_P226073 — A_24_P621701
—
A_32_P106864 — A_32_P224586 — A_24_P75994
—
A_32_P45375 — A_24_P152345 — A_24_P665185
—
A_24_P376139 — A_24_P127462 — A_32_P44099
—
A_24_P361816 — A_32_P38313 — A_32_P30004
—
A_24_P919283 — A_24_P519504 — A_24_P916965
—
A_24_P844100 — A_24_P229447 — A_23_P8812
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
—
A_32_P202066 — A_24_P904845 — A_24_P514678
—
A_32_P221641 — A_32_P228886 — A_24_P750327
—
A_32_P9924 — A_23_P210158 — A_24_P358321
—
A_23_P408363 — A_23_P136753 — A_32_P72541
—
A_24_P576445 — A_32_P213678 — A_32_P213418
—
A_32_P97513 — A_32_P30075 — A_32_P214969
—
A_32_P74814 — A_24_P7750 — A_23_P159163
—
A_24_P195974 — A_24_P135841 — A_24_P504939
—
A_32_P722809 — A_24_P169713 — A_24_P862083
—
A_24_P318990 — A_24_P341126 — A_32_P199824
—
A_32_P52227 — A_32_P194704 — A_32_P115518
—
A_32_P42895 — A_24_P161764 — A_24_P16004
—
A_32_P224345 — A_32_P102581 — A_32_P82179
—
A_32_P226205 — A_23_P124313 — A_23_P21800
—
A_32_P36552 — A_32_P193240 — A_32_P79041
—
A_32_P133038 — A_32_P131998 — A_24_P298805
—
A_32_P157671 — A_32_P174214 — A_24_P925422
—
A_32_P76602 — A_32_P1291 — A_32_P227657
—
A_32_P46171 — A_23_P11980 — A_32_P53603
—
A_24_P33341 — A_32_P209582 — A_32_P117185
—
A_32_P104448 — A_32_P127019 — A_32_P29149
—
A_32_P144852 — A_32_P197720 — A_24_P357847
—
A_32_P48149 — A_24_P375691 — A_32_P201434
—
A_24_P195454 — A_24_P927639 — A_32_P134634
—
A_24_P384604 — A_32_P207885 — A_32_P230253
—
A_32_P224888 — A_32_P121234 — A_32_P171253
—
A_32_P130536 — A_24_P264143 — A_32_P185766
—
A_32_P15829 — A_24_P451992 — A_32_P71858
—
A_32_P2883 — A_32_P509964 — A_32_P132766
—
A_23_P3083 — A_23_P58137 — A_32_P8732
—
A_24_P703642 — A_24_P867201 — A_24_P671115
—
A_24_P417352 — A_32_P215143 — A_32_P75867
—
A_24_P109921 — A_32_P35575 — A_24_P139761
—
A_32_P3932 — A_32_P216888 — A_32_P72611
—
A_23_P32583 — A_24_P101226 — A_32_P226525
—
A_32_P49959 — A_32_P105940 — A_32_P61522
—
A_23_P149441 — A_32_P93352 — A_32_P179686
—
A_24_P465799 — A_32_P13823 — A_23_P350782
—
A_24_P472081 — A_32_P89480 — A_32_P429876
—
A_32_P184268 — A_24_P716405 — A_32_P167111
—
A_24_P173566 — A_24_P928306 — A_32_P133090
—
A_32_P12703 — A_32_P51988 — A_23_P357504
ID Entrez
Símbolo ID Entrez Símbolo ID Entrez Símbolo
—
A_32_P47285 — A_23_P136026 — A_32_P71476
—
A_32_P76137 — A_24_P15550 — A_24_P767725
—
A_24_P379629 — A_24_P185516 — A_24_P272146
—
A_24_P358606 — A_24_P281605 — A_24_P128361
—
A_32_P159192 — A_32_P65589 — A_32_P200144
—
A_32_P42329 — A_24_P659202 — A_32_P111072
—
A_24_P23327 — A_24_P649327 — A_24_P323298
—
A_32_P194423 — A_24_P110242 — A_32_P177843
—
A_32_P12065 — A_32_P85593 — A_23_P417363
—
A_24_P741023 — A_32_P94685 — A_24_P67063
—
A_23_P147224 — A_32_P232413
—
A_32_P232682 — A_24_P178834
—
A_32_P214860 — A_32_P65022
—
A_24_P367100 — A_32_P88163
—
A_23_P147578 — A_24_P475753
—
A_24_P488083 — A_32_P44210
—
A_24_P923854 — A_32_P215866
—
A_24_P33055 — A_32_P176036
—
A_23_P259763 — A_24_P918044
—
A_24_P900555 — A_23_P339954
—
A_24_P326084 — A_32_P13337
—
A_24_P68008 — A_32_P91186
—
A_23_P251002 — A_24_P255415
—
A_23_P113056 — A_24_P306905
—
A_24_P524452 — A_32_P74477
—
A_24_P288915 — A_32_P159289
—
A_32_P184039 — A_32_P168727
—
A_32_P35947 — A_32_P209104
—
A_24_P845223 — A_32_P134679
—
A_32_P78488 — A_23_P388146
—
A_32_P121978 — A_24_P204574
—
A_32_P212373 — A_32_P154445
—
A_32_P116488 — A_32_P206308
—
A_32_P144281 — A_24_P179107
—
A_24_P895836 — A_24_P398370
—
A_24_P418216 — A_32_P219581
—
A_32_P35668 — A_32_P175557
—
A_23_P73328 — A_32_P30434
—
A_32_P77742 — A_32_P327750
—
A_32_P191895 — A_32_P109835
—
A_32_P101653 — A_32_P185530
—
A_24_P315594 — A_32_P23731

Claims (1)

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ES201230250A 2011-12-30 2012-02-17 Método de clasificación del carcinoma no microcítico de pulmón basado en la identificación de una respuesta inmune intratumoral. Expired - Fee Related ES2420079B1 (es)

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PCT/ES2012/070919 WO2013098457A1 (es) 2011-12-30 2012-12-28 Método de clasificación del carcinoma no microcítico de pulmón basado en la identificación de una respuesta inmune intratumoral

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