ES2422558T3 - Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado - Google Patents

Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado

Info

Publication number
ES2422558T3
ES2422558T3 ES05816233T ES05816233T ES2422558T3 ES 2422558 T3 ES2422558 T3 ES 2422558T3 ES 05816233 T ES05816233 T ES 05816233T ES 05816233 T ES05816233 T ES 05816233T ES 2422558 T3 ES2422558 T3 ES 2422558T3
Authority
ES
Spain
Prior art keywords
hyperpolarized
pyruvate
imaging method
imaging
cardiac imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05816233T
Other languages
English (en)
Inventor
Mathilde Lerche
Rene Zandt
Klaes Golman
Mikkel Thaning
Jan-Henrik Ardenkjaer-Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Application granted granted Critical
Publication of ES2422558T3 publication Critical patent/ES2422558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Signal Processing (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Uso de 13C_piruvalo hiperpolarizado para la fabricadón de un medio de obtención de imágenes por RM parasu uso en un método para evaluar la viabilidad de tejido miocárdico, en el que dicho método comprende: (8) adquirir imágenes de 13C-RM directas de 13C-plruvalo y sus metabolitos que contienen 13C alsnioa,lactato y bicarbonato, a partir de un sujeto al que se le administra previamente diCho medio deobtención de imágenes; y (b) opcionalmente, correlacionar la senal de 13e de un melabo1ilo con la senal de Ile de cualquier otrometa bolito detectado para obtener un contraste basado en la diferencia en la inlensidad de sel'lal dedos, preferiblemente tres, lo mils preferiblemente cuatro 13C-metabolilos.
ES05816233T 2004-11-19 2005-11-18 Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado Expired - Lifetime ES2422558T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20045058 2004-11-19
PCT/NO2005/000434 WO2006054903A2 (en) 2004-11-19 2005-11-18 Method of cardiac imaging with the use of hyperpolarized 13 c-pyruvate

Publications (1)

Publication Number Publication Date
ES2422558T3 true ES2422558T3 (es) 2013-09-12

Family

ID=36182402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05816233T Expired - Lifetime ES2422558T3 (es) 2004-11-19 2005-11-18 Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado

Country Status (13)

Country Link
US (1) US8980224B2 (es)
EP (1) EP1824523B1 (es)
JP (1) JP5456256B2 (es)
KR (1) KR101249634B1 (es)
CN (1) CN101102799B (es)
AU (1) AU2005307194B2 (es)
BR (1) BRPI0518302A2 (es)
CA (1) CA2587795C (es)
ES (1) ES2422558T3 (es)
MX (1) MX2007006048A (es)
PL (1) PL1824523T3 (es)
RU (1) RU2391047C2 (es)
WO (1) WO2006054903A2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych
US7202665B1 (en) * 2006-04-19 2007-04-10 Wisconsin Alumni Research Foundation Magnetic resonance spectroscopy of species with multiple peaks
US20080171893A1 (en) * 2006-07-11 2008-07-17 Spectra Gases, Inc. Isotopically labeled alpha-keto acids and esters
ES2381380T3 (es) 2006-08-18 2012-05-25 Ge Healthcare As Formación de imagenes de 13C-RM o de espectroscopia de muerte celular
WO2008020765A2 (en) * 2006-08-18 2008-02-21 Ge Healthcare As Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
US20100040544A1 (en) * 2006-11-21 2010-02-18 Anne Waaler Method for managing patients with cancer
EP2117607A4 (en) 2007-01-11 2012-08-08 Huntington Medical Res Inst PICTURES AND METHOD FOR THEIR USE
US8483798B2 (en) * 2007-01-15 2013-07-09 General Electric Company System and method for metabolic MR imaging of a hyperpolarized agent
US8983570B2 (en) 2007-03-27 2015-03-17 Cardiovascular Biotherapeutics, Inc. Therapeutic angiogenesis for treatment of the spine
US11224635B2 (en) 2007-03-27 2022-01-18 Venturis Thereuptics, Inc. Therapeutic angiogenesis for treatment of the spine and other tissues
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
KR20100023802A (ko) * 2007-05-17 2010-03-04 제너럴 일렉트릭 캄파니 과분극화 １３ｃ－피루베이트를 포함하는 영상화 매질을 사용하여 종양을 등급화하는 ｍｒ 방법
GB0713074D0 (en) 2007-07-05 2007-08-15 Univ London A method of hyperpolarising a magnetic resonance agent
JP2010534498A (ja) * 2007-07-26 2010-11-11 ジーイー・ヘルスケア・ユーケイ・リミテッド 方法及び該方法で使用するためのイメージング媒体
CA2698622A1 (en) * 2007-09-07 2009-03-12 Ge Healthcare Limited Method of determination of pdh activity and imaging media for use in said method
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
WO2009133169A1 (en) 2008-05-02 2009-11-05 General Electric Company Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
AU2010230330B2 (en) * 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
SG179067A1 (en) 2009-09-10 2012-04-27 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
EP2343568A1 (en) * 2009-12-30 2011-07-13 Koninklijke Philips Electronics N.V. Dynamic nuclear polarization apparatus with sample transport system
US8929626B2 (en) * 2010-02-22 2015-01-06 Koninklijke Philips N.V. RF antenna arrangement and method for multi nuclei MR image reconstruction involving parallel MRI
WO2012145733A1 (en) 2011-04-22 2012-10-26 Vanderbilt University Para-hydrogen polarizer
EP2872520B1 (en) * 2012-07-13 2016-09-14 Bracco Imaging S.p.A Triarylmethyl radicals
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
KR101516634B1 (ko) * 2014-07-09 2015-05-06 연세대학교 산학협력단 13c-자기공명분광영상을 이용한 암 환자의 치료 예후를 예측하는 방법
RU2622983C1 (ru) * 2016-07-25 2017-06-21 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ интраоперационной визуализации ишемически-реперфузионного повреждения миокарда
EP3756024B1 (en) * 2018-02-19 2026-04-29 BRUKER FRANCE (Société par Actions Simplifiée) Nuclear spin hyperpolarization in a porous matrix
US11350888B2 (en) * 2019-09-03 2022-06-07 Siemens Healthcare Gmbh Risk prediction for sudden cardiac death from image derived cardiac motion and structure features
WO2025137625A1 (en) * 2023-12-22 2025-06-26 The Board Of Regents Of The University Of Texas System Hyperpolarized 13c pyruvate mri and pet in single exam using pet-mr for ischemic heart disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
EP0951650B1 (en) * 1997-01-08 2003-12-10 Amersham Health AS Method of magnetic resonance imaging
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6958244B2 (en) * 2002-04-12 2005-10-25 Bruker Biospin Corp. Low-conductivity buffers for magnetic resonance measurements

Also Published As

Publication number Publication date
CA2587795C (en) 2015-01-20
RU2391047C2 (ru) 2010-06-10
JP5456256B2 (ja) 2014-03-26
US8980224B2 (en) 2015-03-17
BRPI0518302A2 (pt) 2008-11-11
AU2005307194A1 (en) 2006-05-26
WO2006054903A3 (en) 2007-03-15
CN101102799A (zh) 2008-01-09
PL1824523T3 (pl) 2013-12-31
RU2007118383A (ru) 2008-12-27
CN101102799B (zh) 2011-05-04
EP1824523A2 (en) 2007-08-29
EP1824523B1 (en) 2013-05-01
WO2006054903A2 (en) 2006-05-26
JP2008520335A (ja) 2008-06-19
MX2007006048A (es) 2007-07-25
CA2587795A1 (en) 2006-05-26
US20090162287A1 (en) 2009-06-25
AU2005307194B2 (en) 2011-02-10
KR20070089171A (ko) 2007-08-30
KR101249634B1 (ko) 2013-04-01

Similar Documents

Publication Publication Date Title
ES2422558T3 (es) Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado
ATE387144T1 (de) Datenerfassung , analyse und abbildung von ultraschall diagnostische herzbildern
EP1715407A3 (en) Position determination utilizing a cordless device
DE60120360D1 (de) Dehnungsratenanalyse in diagnostischen ultraschallbildern
EP2064991A3 (en) Flashlight view of an anatomical structure
ATE530921T1 (de) Echtzeit-traktographie
EP2428164A3 (en) Body motion detection device, as well as radiographic imaging apparatus
DE602006012050D1 (de) Verfahren und Computerprogramm zur räumlichen Vereinigung von Bildern
EP2019284A3 (en) Deactivatable measurement apparatus
ATE534330T1 (de) Synchronisierung von ultraschallbilddaten mit elektrischer abbildung
EP2077526A3 (en) Three-dimensional image reconstruction using doppler ultrasound
BRPI0705911A (pt) registro de imagens de um órgão usando caracterìsticas anatÈmicas fora do órgão
WO2011156810A3 (en) Second generation hand-held optical imager
WO2012143885A9 (en) Mpr slice selection for visualization of catheter in three-dimensional ultrasound
WO2012021862A3 (en) Detection of anatomical landmarks
EP1648166A3 (en) Image pickup unit
ATE272366T1 (de) Vorrichtung zur bildung eines zahnersatzes
WO2008067072A3 (en) Systems and methods for visualizing a cannula trajectory
EP2328339A3 (en) Electronic endoscope system, processing apparatus for electronic endoscope, and image processing method
EP1779769A3 (en) Method of detecting proper connection of an endoscope to a washing system
WO2006121984A3 (en) Erythrocyte movement imaging and analysis
BR112018003378A2 (pt) dispositivo para ser usado junto ao corpo, e sistema para o monitoramento do tempo de trânsito de pulso e/ou do tempo da chegada de pulso
EP2166375A3 (en) System and method of extracting plane features
EP1836956A3 (en) Activity-induced energy expenditure estimating instrument
EP2442277A3 (en) Diagnosis assisting apparatus, diagnosis assisting program, and diagnosis assisting method