ES2422729T3 - Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen - Google Patents

Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen

Info

Publication number
ES2422729T3
ES2422729T3 ES09153379T ES09153379T ES2422729T3 ES 2422729 T3 ES2422729 T3 ES 2422729T3 ES 09153379 T ES09153379 T ES 09153379T ES 09153379 T ES09153379 T ES 09153379T ES 2422729 T3 ES2422729 T3 ES 2422729T3
Authority
ES
Spain
Prior art keywords
formulations
procedure
preparation
medicines containing
tiotropium salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09153379T
Other languages
English (en)
Inventor
Rolf Banholzer
Peter Sieger
Waldemar Pfrengle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2422729(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2422729T3 publication Critical patent/ES2422729T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cloruro de tiotropio cristalino, el cual se caracteriza porque en el diagrama de rayos X en polvo presenta, entre otros, los valores característicos d >= 6,15 Å; 5,58 Å; 4,45 Å y 3,93 Å.
ES09153379T 2003-11-03 2004-10-29 Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen Expired - Lifetime ES2422729T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03

Publications (1)

Publication Number Publication Date
ES2422729T3 true ES2422729T3 (es) 2013-09-13

Family

ID=34530660

Family Applications (2)

Application Number Title Priority Date Filing Date
ES04791028T Expired - Lifetime ES2342468T3 (es) 2003-11-03 2004-10-29 Procedimiento para la preparacion de sales de tiotropio.
ES09153379T Expired - Lifetime ES2422729T3 (es) 2003-11-03 2004-10-29 Sales de tiotropio, procedimiento para su preparación y formulaciones de medicamentos que las contienen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES04791028T Expired - Lifetime ES2342468T3 (es) 2003-11-03 2004-10-29 Procedimiento para la preparacion de sales de tiotropio.

Country Status (34)

Country Link
US (1) US8686148B2 (es)
EP (3) EP2067779B9 (es)
JP (1) JP5165244B2 (es)
KR (1) KR20060117334A (es)
CN (3) CN100549010C (es)
AR (1) AR046317A1 (es)
AT (1) ATE460414T1 (es)
AU (1) AU2004285683C1 (es)
BR (1) BRPI0416136A (es)
CA (1) CA2544348A1 (es)
CO (1) CO5690553A2 (es)
CY (2) CY1110048T1 (es)
DE (1) DE502004010885D1 (es)
DK (2) DK2067779T3 (es)
EA (1) EA012326B1 (es)
ES (2) ES2342468T3 (es)
HR (1) HRP20100149T1 (es)
IL (1) IL175023A (es)
ME (1) ME00361B (es)
MX (1) MXPA06004697A (es)
MY (1) MY143364A (es)
NO (1) NO335814B1 (es)
NZ (1) NZ547276A (es)
PE (1) PE20050446A1 (es)
PL (2) PL2067779T3 (es)
PT (2) PT2067779E (es)
RS (2) RS20060292A (es)
SG (1) SG137859A1 (es)
SI (2) SI2067779T1 (es)
TW (2) TWI435876B (es)
UA (1) UA82413C2 (es)
UY (1) UY28590A1 (es)
WO (1) WO2005042526A1 (es)
ZA (1) ZA200602342B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2083007T3 (da) * 2003-11-03 2013-07-29 Boehringer Ingelheim Int Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
JP5165244B2 (ja) 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
US8163913B2 (en) 2005-12-19 2012-04-24 Sicor Inc. Forms of tiotropium bromide and processes for preparation thereof
DK1971332T3 (da) * 2006-01-04 2011-04-18 Boehringer Ingelheim Int Anvendelse af tiotropium-salte til behandling af moderat vedvarende astma
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2597329A (en) * 1947-08-06 1952-05-20 Merck & Co Inc Process for anion exchange of thiamin salts
US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
JPS6165885A (ja) 1984-09-07 1986-04-04 Tanabe Seiyaku Co Ltd 新規合成中間体及びその製法
AU591152B2 (en) 1985-07-30 1989-11-30 Glaxo Group Limited Devices for administering medicaments to patients
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
JP3302647B2 (ja) 1992-04-24 2002-07-15 小野薬品工業株式会社 フェニルアルカン酸エステルの塩酸塩、およびその製造方法
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) * 1999-12-27 2007-12-19 和光純薬工業株式会社 スルホニウム塩化合物
WO2002030928A1 (de) * 2000-10-12 2002-04-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
TR200402367T4 (tr) * 2000-10-12 2004-12-21 Boehringer Ingelheim Pharma Gmbh& Co.Kg Yeni tiotropyum içeren inhalasyon tozları
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
CZ300794B6 (cs) * 2000-10-31 2009-08-12 Boehringer Ingelheim Pharma Gmbh And Co. Kg Farmaceutický prostredek a jeho použití jako inhalacní roztok
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193393A1 (en) * 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10061877A1 (de) 2000-12-12 2002-06-13 Basf Ag Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
US20020193394A1 (en) * 2001-03-13 2002-12-19 Bernd Disse Compounds for treating inflammatory diseases
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
GB0203193D0 (en) 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
AU2003201745A1 (en) 2002-02-11 2003-09-04 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
KR101007151B1 (ko) 2002-04-04 2011-01-13 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 흡입용 분말 제형
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
DE10216036A1 (de) 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
US6908055B2 (en) * 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
JP5165244B2 (ja) 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DK2083007T3 (da) * 2003-11-03 2013-07-29 Boehringer Ingelheim Int Tiotropiumsalte, fremgangsmåder til deres fremstilling og lægemiddelformuleringer indeholdende disse
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
CY1114157T1 (el) 2016-08-31
HK1153409A1 (en) 2012-03-30
TWI363758B (en) 2012-05-11
SI2067779T1 (sl) 2013-08-30
JP5165244B2 (ja) 2013-03-21
CN101407514B (zh) 2013-05-29
TW201231465A (en) 2012-08-01
CN102070630A (zh) 2011-05-25
MY143364A (en) 2011-04-29
DE502004010885D1 (de) 2010-04-22
EA200600886A1 (ru) 2006-10-27
PE20050446A1 (es) 2005-08-02
CA2544348A1 (en) 2005-05-12
PL1682541T3 (pl) 2010-08-31
EP2336126A1 (de) 2011-06-22
UY28590A1 (es) 2005-06-30
AU2004285683B2 (en) 2011-04-21
PL2067779T3 (pl) 2013-09-30
NO20061440L (no) 2006-07-12
HK1129111A1 (en) 2009-11-20
CO5690553A2 (es) 2006-10-31
MXPA06004697A (es) 2006-07-05
BRPI0416136A (pt) 2007-01-02
WO2005042526A1 (de) 2005-05-12
RS20060292A (sr) 2008-08-07
AR046317A1 (es) 2005-11-30
EP2067779B9 (de) 2013-10-16
RS51758B (sr) 2011-12-31
DK2067779T3 (da) 2013-07-29
CN101407514A (zh) 2009-04-15
KR20060117334A (ko) 2006-11-16
AU2004285683A1 (en) 2005-05-12
CN1882582A (zh) 2006-12-20
CY1110048T1 (el) 2015-01-14
ATE460414T1 (de) 2010-03-15
AU2004285683C1 (en) 2011-09-08
CN102070630B (zh) 2013-04-17
JP2007509893A (ja) 2007-04-19
EP2067779B1 (de) 2013-04-24
IL175023A0 (en) 2006-08-20
EP1682541A1 (de) 2006-07-26
MEP51308A (en) 2011-05-10
NZ547276A (en) 2009-08-28
DK1682541T3 (da) 2010-06-28
EP1682541B1 (de) 2010-03-10
IL175023A (en) 2011-02-28
PT2067779E (pt) 2013-07-25
HRP20100149T1 (hr) 2010-04-30
ZA200602342B (en) 2007-06-27
EA012326B1 (ru) 2009-08-28
PT1682541E (pt) 2010-04-14
ES2342468T3 (es) 2010-07-07
ME00361B (me) 2011-10-10
SI1682541T1 (sl) 2010-06-30
US8686148B2 (en) 2014-04-01
EP2067779A1 (de) 2009-06-10
CN100549010C (zh) 2009-10-14
UA82413C2 (uk) 2008-04-10
TW200526653A (en) 2005-08-16
HK1099748A1 (zh) 2007-08-24
SG137859A1 (en) 2007-12-28
NO335814B1 (no) 2015-02-23
US20050131007A1 (en) 2005-06-16
TWI435876B (zh) 2014-05-01

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