ES2427352T3 - Use of fragrance compositions to restrict the formation of indole from dirt based on fecal substances and urine - Google Patents

Abstract

The use of a fragrance composition comprising 2.5% to 100% by weight of fragrance compounds selected from: aldehydes, alcohols, ketones and mixtures thereof in any household or personal hygiene product that comes into contact with dirt based in fecal matter and urine, as an agent to restrict the formation of indole from dirt based on fecal material and urine, each compound being able to restrict the formation of indole to less than 0.01 ppm (weight / weight) as it comes determined by the following test: A) 0.02 g of fragrance and 0.02 g of Tergitol 15-s-12 (CAS 68131-40-8) were added to 7 g of purple human urine in a sealed 20 ml Headspace vial with a double-sided PTFE plug and mixed well for 10 minutes using a magnetic stirrer. As a blank to test the adequacy of a batch of pure human urine, 7 g of human urine with 0.02 g of demineralized water and 0.02 g of Tergitol 15-s-12 (CAS 68131-40-8) were used. If a control was required to test the efficacy of the product base, for example, the control contained 7 g of human urine to which 0.02 g of fragrance was added, minus the active agents and 0.02 g of Tergitol 15-s-12 (CAS 68131-40-8); B) The vials were placed in an automatic sampling tray at room temperature; C) Samples were taken from the head spaces of the vials at different times for 5 minutes at 35 ° C by means of an SPME fiber after 10 minutes at 35 ° C; D) The SPME fiber is subjected to desorption for 1 minute at 265 ° C from an automatic sampling device and is injected without division into a gas chromatography column of 30 mx 0.25 x 0.25 in the following oven conditions: 50 ° C for 2 min - up to 250 ° C at 10 ° C / min - 250 ° C for 5 minutes; E) Under the above conditions of gas chromatography, indole has a retention time of 19.1425 minutes, and can be recognized by its characteristic ions m / z 117, m / z 89 and m / z 90; F) In the range of values determined in the present work, the indole peak area (117) is linearly related to the current concentration of the vial, and was used without additional correction to establish the indole concentration in "Active" and "White" and if any "Control" fragrances were present. G) The material is considered to be active if the concentration of indole in the test sample is below 0.01 ppm (weight / weight) after 24 hours of incubation at room temperature and the indole in the urine blank sample is lower that 0.01 ppm (weight / weight) at the beginning of the experiment and between 0.25ppm (weight / weight) and 1.25 ppm (weight / weight) of indole after 24 hours of storage at room temperature; H) The change in the concentration of active substance is determined by comparing the measurements at the beginning of the experiment and after 24 hours using the appropriate characteristic ions.

Description

Use of fragrance compositions to restrict the formation of indole from dirt based on fecal substances and urine.

Field of the Invention

The present invention relates to fragrances and fragrance ingredients of a variety of products to prevent the development of bad odors from the action of microorganisms on excreted matter such as feces and urine. The present invention prevents the creation of indole-based odor compounds and related compounds.

Background of the invention

Perfumes are used in many applications to mask the bad smell. An important category of bad odors are, for example, those from substances perspired or excreted by humans in particular sweating, urine, feces or menstrual fluids, and odors caused by the urine or feces of animals, especially domestic pets.

Normally, bad odors are caused by particularly odorous substances such as sulfur compounds, for example hydrogen sulfide, and low molecular weight thiols and thioethers, nitrogen-containing compounds such as ammonia and amines that include heterocyclic compounds such as pyrazines and indoles, compounds They contain oxygen such as fatty acids and steroids. Frequently, these bad odors are created by the action of microorganisms in the excreted material or during the digestion of food or beverages. As natural products, bad smells are complex mixtures in themselves, not only of several compounds in each of the categories but also include members of all categories to different degrees depending on the source of the smell. Therefore, avoiding, counteracting, reducing or eliminating bad smell is not easy.

Several methods have been developed to counteract or reduce bad smell in addition to masking bad smell with intense fragrances. Activated carbon and zeolites have been used as absorbents for bad odors, but these are not suitable for incorporation into many products. Antimicrobial agents such as zinc and Triclosan compounds (2´, 4´, 4´-trichloro-2-hydroxy-diphenyl ether) are used to kill microorganisms involved in the production of bad odors, but many are not specific and can lead to imbalances in the natural microflora.

U.S. patents 4,304,679; 4,322,308; 4,278,658 and 4,134,838 describe all of them fragrances that exhibit a deodorant action when applied to human skin or when included in a washing product. They are thought to work by any or all of the different mechanisms; reduction of the vapor pressure of the odor compounds, inhibition of the enzymes that generate the bad odors and combination with the bad smell to modify the perceived odor note.

U.S. Pat. 4,719,105 describes the use of cyclomethane and esters as low odor materials that can be used to mask odors without presenting themselves unwanted intense fragrances.

U.S. patent application 2004/0147416 describes the use of cyclodextrins to trap odor molecules. Bad odors tend to become more intense over time as the population of microorganisms grows and the production of bad odors increases. The present report is based on a main disadvantage of the use of perfumes to mask the bad smell. Although a perfume can mask a bad smell right after application, over time the intensity of the fragrance decreases, while the intensity of the bad smell will, in all likelihood, increase from the colonies of growing microorganisms. The same argument can also be applied to agents that counteract bad odor, which work by reacting with bad smelling molecules, insofar as they are overcome by bad odors. Its effect is to delay or reduce the intensity of the bad smell and, as such, this may be sufficient for some commercial applications.

A different approach is to inhibit specific biological mechanisms. Compounds that act more specifically include saturated C3-C10 dioic acids that inhibit a sweat decay esterase as described in patent application DE 4,343,265.

U.S. Pat. 6,183,731 describes the use of agents that are 5a-reductase inhibitors, such as octadecendioic acid as a preservative agent for body odor.

U.S. Pat. 5,395,555 shows an aqueous cleaning composition for carpets, rags and textile materials, in particular useful for reducing the bad smell of urine stains containing metal inhibitors that are thought to capture the heavy metals essential for the development of microorganisms.

However, as mentioned above, bad odors are complex and such approaches may not counteract all the components of the bad smell, so that they are more likely to modify the nature of the smell, which may again be an advantage but only It is a partial solution to the problem.

Sometimes, aldehydes are cited as agents to counteract the bad smell. U.S. Pat. 4,906,454 describes pyroctone acid and a perfume with a high concentration of aldehydes and / or ketones for use in deodorants to avoid bad body odors. U.S. Pat. 6,177,070 describes a deodorant product containing at least two different aldehydes present in the form of addition compounds such as acetals and hemi-acetals and an unsaturated compound. This is quite different from the aldehydes of the present invention that are not present as addition compounds but that comprise part of the fragrance added directly to the product.

U.S. patent application 2005/0124512 describes the use of safe aldehydes for fabrics (that is, they do not cause discoloration) as components of air-renewing spray products or fabrics that react with airborne odor components. There is nothing in this patent to show that aldehydes could inhibit odor formation, especially that they could do so in a non-reactive manner, which would mean that the fragrance would not be harmed.

U.S. Pat. 5,676,163 describes two classes of aldehydes that act additively or synergistically to reduce the bad smell from tobacco smoke. Again, the patent only shows that the aldehydes react with some bad odor molecules and there is no evidence of the prevention of biologically generated odors.

U.S. patent applications 2005/1087123 and 2005/0187124 describe compositions to be incorporated in a solid and liquid carpet cleaner and deodorant products to remove bad odors from carpets. In US patent application: 2005/0187123, aldehydes are optional components of the mixture and nothing is shown other than having a smell reaction and a masking effect. However, in the US patent application co-presented 2005/187124 aldehydes are described as enzyme inhibitors while aldehydes and ketones are described as odor reactants. No evidence is provided on which enzymes are inhibited or which odor compounds are reduced or avoided and only benzaldehyde would be considered as a fragrance aldehyde among the group of aldehydes mentioned and the efficacy of benzaldehyde in the examples is not demonstrated.

U.S. patent application 2002/0010447 describes two categories of aldehydes for reducing odor in fibrous absorbents for body fluids. The categories of aldehydes that are claimed to function synergistically are aliphatic aldehydes and aldehydes having a carbon with sp2 hybridization in the alpha position with respect to the aldehyde carbon. Again, there is nothing in the text to suggest that aldehydes have any inhibitory effect beyond the chemical reaction or the reduction of vapor pressure.

U.S. patent application 2003/0044309 describes mixtures of two types of aldehydes to counteract the bad smell in carpet cleaners, but all examples described the narrow mixing of the test formulation with the source of bad smell, allowing the chemical reaction. Nowhere does the document suggest that bad smells based on indole could be avoided.

Among all references and examples of the prior art, aldehydes, with the specific exception of formaldehyde, are predominantly considered to work by chemical reaction with a pre-existing odorant rather than specifically avoiding indole-based bad odors. Formaldehyde is well known that, as an antimicrobial agent, it is frequently incorporated into formulations directly or in the form of any different derivatives that slowly release formaldehyde.

EP-A-0 780 132 and US-A-3 675 625 describe the use of fragrance compositions comprising citral aldehyde and cinnamic aldehyde to prevent odors from urine and fecal materials.

Thus, although it is evident from the prior art that there are many methods that seek to avoid bad smell, none is completely satisfactory. The present invention describes a simple and inexpensive way of preventing the development of some of the components of fecal odors by means of the specific selection of fragrance ingredients incorporated in a wide range of household products and for personal hygiene.

Summary of the invention

The present invention relates to the use of a fragrance composition, as defined in claim 1.

In this specification, "products for domestic or personal hygiene" designate all products normally used for home and body care, in particular:

a) edge block products, tank blocks or liquid edge block products, b) household cleaners in the form of gel, paste or liquid for difficult surfaces, c) delicate furniture cleaners or renovators, in particular liquid sprayers, d) air fresheners, e) animal beds, f) liquid and fibrous personal hygiene absorbent devices such as compresses, diapers for Babies or incontinence products.

A particularly preferred form of the invention relates to the use of fragrance compositions comprising fragrance compounds selected from: aldehydes, alcohols and ketones as defined above, but without decreasing their own concentration by more than 60% by weight under incubation conditions defined in claim 1.

Another preferred form of the invention relates to the use of fragrance compounds selected from: aldehydes, aldehyde, 1-unsaturated and allyl alcohols that meet the indole inhibition assay as defined above for use in any household hygiene product or personnel in order to avoid the development of indole-based bad odors from fecal dirt or urine.

Detailed description of the invention

The present invention relates to the use of fragrance compositions comprising fragrance compounds, containing from 2.5% to 100%, more preferably containing from 10% to 100%, even more preferably from 20% at 100% and especially preferably from 40% to 100% by weight of fragrance compounds that are selected from aldehydes, alcohols or ketones and mixtures thereof.

The effective compounds of the invention are fragrance materials that are aldehydes, alcohols or ketones that pass the indole inhibition test, that is, that are capable of restricting indole formation to less than 0.01 ppm (weight / weight) of indole compounds after 24 hours of incubation at room temperature in an air tight container under the conditions defined in claim 1.

Appropriate pure human urine

Urine is a variable material and it has been proven that not all batches of urine are suitable for carrying out the indole inhibition test. In addition, it is essential that the pure human urine blank sample be tested at the same time as the samples containing the candidate fragrance compounds, and only when the blank urine samples meet certain criteria can the test result be accepted. of fragrance compound as valid. In order to ensure that pure human urine is appropriate, the urine should have less than 0.01 ppm (weight / weight) of indole at the beginning of the experiment and after 24 hours of storage at room temperature in an air tight container should contain between 0.25 ppm (weight / weight) and 1.25 ppm (weight / weight) of indole, determined according to the test method described below. Only if the urine blank meets both criteria, the results can be considered valid of any fragrance compound tested. If the urine blank does not meet both criteria, then the results of any fragrance compound tested should be discarded and a new batch of urine should be tested.

Without intending to be bound by any theory, it seems that the compounds of the invention interfere with the biological process of tryptophan metabolism rather than as a reagent. The fact that many effective compounds remain slightly modified while remaining highly effective is an important advantage of the present invention. If the compounds react with bad odors, then the fragrance note should change, which presumably decreases the quality of the smell carefully created by the perfume manufacturer.

In a preferred aspect of the invention, the change in the concentrations of aldehyde, alcohol or ketone is less than 60%, preferably less than 30%, so that the original fragrance note is maintained.

For these aldehydes, alcohols and ketones that decrease over time, it is possible that they may react with ammonia or other amine species but it is not desirable nor is it a major aspect of the invention. However, due to the complexity of the different product formulations, the fragrance of these formulations and the bad odors, any or all of them may affect the availability of active agents for the reaction, as well as the inherent reactivity of the compounds individual, the inventors do not intend to speculate more on this point.

Perfume composition

In the context of the present specification a "fragrance composition", which is also called "perfume composition" is an essential part of the invention. The term "perfume composition" means any mixture, that is, more than one chemical species, of odoriferous materials including materials that act as agents to counteract the bad smell. A wide variety of chemical substances are known for use in perfumery, including materials possessing the required functional groups of the aldehydes of the invention, alcohols, including allyl alcohols and ketones but also including alkenes, esters, ethers, nitriles, amines, oximes, acetals, ketals, thiols, acetals, etc. Without intending to be limited, preferably the perfume compounds have molecular weights of less than 325 atomic mass units, preferably less than 300 atomic mass units and more preferably less than 275 atomic mass units, to ensure sufficient volatility that is noticeable. In addition, perfume compounds have molecular weights greater than 100 atomic mass units, preferably greater than 120 atomic mass units, since smaller masses may be too volatile to inhibit the generation of bad odors for any period of time. In addition, the ingredients of the fragrance compositions will not contain strongly ionizing functional groups such as sulphonates, sulfates or quaternary ammonium ions that avoid volatilization.

Animal and vegetable exudates and oils of natural origin comprising complex mixtures of various chemical components are also known for use as perfumes, and such materials may be used herein. The perfume compositions of the present invention may be relatively simple in composition with a minimum of two perfume or fragrance ingredients or may comprise highly complex mixtures of natural and synthetic chemical components, chosen to provide any desired odor. Perfume ingredients are described more fully in S. Arctander, Perfume Flavors and Chemicals, Vols. I and II, Montclair, N.J., and in Merck Index, 8th edition, Merck & Co., Inc. Rahway, N.J., both incorporated herein by reference.

Not all fragrance compounds that have the aldehyde, alcohol or ketone groups are effective in preventing bad odors from indole. Therefore, the indole inhibition assay is described as a way to determine which compounds are effective.

The selection of appropriate fragrance compounds useful in the present invention can be carried out by the person skilled in the art, by detecting the effect of indole inhibition provided by those compounds, measuring the formation of indole after 24 hours of incubation at room temperature in an air tight container of appropriate pure human urine containing 0.28% by weight of each fragrance compound and comparing the formation of indole with a control stored under the same conditions. The indole formation can be determined by means of any analysis techniques well known to the person skilled in the art, for example, by detecting the indole ions characteristic under standard GC-MS conditions.

Aldehydes, alcohols, ketones or mixtures thereof that are useful for the purposes of the invention are those that restrict the formation to less than 0.01 ppm (weight / weight) of indole under the above conditions.

The ambient temperature is defined as being between 18 ° C and 22 ° C.

Indole Inhibition Assay

Advantageously, the appropriate fragrance compounds can be selected by use of the following preferred indole inhibition assay comprising the following steps.

A) 0.02 g of fragrance and 0.02 g of Tergitol 15-s-12 were added to 7 g of pure human urine in a 20 ml Headspace vial sealed with a two-sided PTFE stopper and mixed well for 10 minutes using a magnetic stirrer. As a blank to test the adequacy of a batch of pure human urine, 7 g of human urine with 0.02 g of demineralized water and 0.02 g of Tergitol 15s12 were used. If a control was required to test the efficacy of the product base, for example, the control contained 7 g of human urine to which 0.02 g of fragrance was added, less active agents and 0.02 g of Tergitol 15-s-12. B) the vials were placed in an automatic sampling tray at room temperature. C) Samples were taken from the header spaces of the vials at different times for 5 minutes at 35 ° C by means of an SPME fiber (Supelco PDMS fibers) after 10 minutes at 35 ° C (incubation time). D) The SPME fiber is subjected to desorption for 1 minute at 265 ° C from an automatic Cipa Combipal sampling device and injected without division into an Agilent GC-MS 5973N with an HP-INNOWAS column (30 mx 0.25 x 0.25). (Baking conditions: 50 ° C for 2 min - up to 250 ° C at 10 ° C / min

-

 250 ° C for 5 minutes). E) Under the previous GM-MS conditions, indole has a retention time of 19.14 minutes, and can be recognized by its characteristic ions (m / z 117, m / z 89 and m / z 90). F) In the range of values determined in the present work, the indole peak area (117) is linearly related to the current concentration of the vial, and was used without additional correction to set the indole concentration to "Active" and " White "and if any" Control "fragrances were present. G) The material is considered to be active if the concentration of indole in the test sample is below 0.01 ppm (weight / weight) after 24 hours of incubation at room temperature and the indole in the blank samples is between 0.25 ppm (weight / weight) and 1.25 ppm (weight / weight) of indole after 24 hours storage at room temperature. H) The change in the concentration of the active substance is determined by comparing the measurements at the beginning of the experiment and after 24 hours using the appropriate characteristic ions.

Figure 1 compares the indole peaks for a blank, control sample and active fragrance composition of Example 2 in a liquid edge block.

The calibration line has been derived to quantify the indole by constructing a series of standardized solutions that contain indole amounts accurately measured in pure human urine and Tergitol 15-s-12, which were measured according to the described method. This calibration is essentially linear at 0.01 ppm indole and below that indole level cannot be quantified. Tergitol 15-s-12 is a trade name of the Dow Chemical company for a commercial grade of secondary alcohol ethoxylate surfactant. It is also available in Sigma Aldrich. Tergitol 15-s-12 and identical products from other suppliers have a Chemical Abstract CAS number 68131-40-8. Tergitol 15-s-12 acts as a solubilizing agent for fragrance ingredients that may not be directly soluble in urine at that concentration.

The efficacy of fragrances on products can be detected by using the above protocol starting with the addition of an aliquot of fragrance product containing 0.02 g of fragrance compound to 7 g of appropriate pure human urine in a vial 20ml header space sealed with a double-sided PTFE stopper and mixing well for 10 minutes using a magnetic stirrer. As a blank, in order to assess the adequacy of urine, 0.02 g of demineralized water and 0.02 g of Tergitol 15-s-12 were added to 7 g of an identical sample of human urine and for any control, in order to assess whether other parts of the formulation could inhibit urine formation, the same product weight containing 0.02 g of fragrance was added, minus any known active ingredients to another 7 g of human urine taken from the same lot that was used for the sample and the blank.

There is an advantage in choosing aldehydes, alcohols and ketones that do not change the concentration during the course of the indole inhibition test, since the fragrance note will not be adversely affected by the depletion of effective fragrance compounds. This can be determined by measuring the concentration of fragrance in the sample containing the test mixture at the beginning and at the end of the indole inhibition test as described in step I of the test. If the difference between the measurements is less than 60%, preferably less than 30%, then it is considered that the material has not changed enough to alter the fragrance note and that it is particularly preferred.

The present invention also relates to the use of a fragrance compound selected from acetophenone, aldehyde C-11, aldehyde C-10, benzaldehyde, benzophenone, cinnamic aldehyde, citronelal, citral, heliobuquet, trans-2hexenal, tran-2-hexenol, perdehyde perilla, perilla alcohol and veltol Plus or mixtures thereof, as indole inhibitors.

The invention also relates to the use of a fragrance compound selected from: acetophenone, C11 aldehyde, C-10 aldehyde, benzaldehyde, benzophenone, cinnamic aldehyde, citronelal, citral, heliobuquet, trans 2-hexenal, trans 2- hexenol, aldehyde perilla, perilla alcohol and vetlol Plus or their mixtures, for the preparation of a fragrance composition intended to prevent the development of bad odors derived from indole from fecal or urine dirt.

Optional ingredients

Frequently, it is desirable to combine methods to counteract or prevent the development of bad odors. Thus, the following are optional ingredients that can be used advantageously in some of the products to further reduce the bad smell. Due to the diverse range of products between which the invention can be supplied, not all optional ingredients would be appropriate for all potential product applications, but experts in the formulation of these products will recognize which ingredients are appropriate and which are not.

Inhibitors

Examples of inhibitors that have enzyme inhibitory and antimicrobial effects on their own or that may enhance the efficacy of conventional biocides include aminocarboxylates such as ethylene diamine tetraacetic acid (EDTA), diethylene triaminopentaacetic acid, amino phosphonates, such as hydroxyethane dimethylephosphonic acid, ethylene diamino tetra (methylene phosphonic) acid, diethylene triamino penta (methyl phosphonic) acid and its salts used either individually or as a mixture. Especially preferred are biodegradable inhibitors, exemplified by, but not limited to, S, S-ethylene diamino disuccinic acid, and its salts or glutamic acid, tetra sodium salts of N, N-diacetic acid (Dissolvine GL-38 of Akzo Nobel) and their combinations. Due to the diversity of the product forms and the possibility that some products can be diluted with water that may have a significant calcium and magnesium content, "hard water", the inhibitor can be included in any wide range of concentrations in the 0.01-0.5% formulations.

Antimicrobial agents

Broad spectrum antimicrobial agents that can be used advantageously together with the present invention are: cationic agents such as quaternium 15, benzalkonium chloride, cetrimonium chloride, myristalconium chloride, cetylpyridinium chloride, lauryl pyridinium chloride and the like. Non-limiting examples of acids and their associated anions that have antimicrobial properties include sorbic acid, benzoic acid and dehydroacetic acid. Other antimicrobials include benzyl alcohol, phenethyl alcohol, DMDM hydantoin, imidazolinurea, 2-bromo-2-nitropropan-1,3-diol and 4,4-dimethyloxazolidine. Phenolic antimicrobials that could be used include cycloxylenol, salicylic acid and isothiazoline derivatives marketed under the trade names of Kathon (Lonza) and Proxel and Proxemal (Astra Zeneca).

Smell Absorbers

Smelly absorbers include zinc ricinoleate marketed as Degosa's Tego Deo and cyclodextrins as described in US Pat. 5,942,217; 5,955,093 and 6,033,679. Other absorbers that can be used in pet bed trays and could absorb bad odors include clays and zeolites.

Products for the application of the invention

Solid blocks for toilet edge

An embodiment of the present invention relates to a toilet block that includes those that, during use, are intended to be located at the edge of the toilet bowl or urinal so that, during a wash cycle, the water in the toilet tank flow over the block dissolving part of it. Generally, such blocks are known in the art as "edge blocks" and are referred to as such or simply as "blocks" herein. The invention also relates to the so-called cistern blocks that are placed in the cistern and slowly dissolve in the water containing it. It will be appreciated that the solubility characteristics of these two products are quite different, since one is constantly underwater while the other has intermittent and short-term contact with water. However, both contain a surfactant, a filler, a fragrance that may contain ingredients of the present invention and, optionally, bleaching agents, germicides and lime antifouling agents. Typical formulations are shown in international patent applications WO 97/7721, WO 82/03532, European patent application 0 462 643, United Kingdom patent application 2 178 442 and US Pat. 4,874,536.

Liquid blocks for edge

Another embodiment of the fragrances of the present invention relates to toilet cleaners known as liquid edge blocks. Liquid edge blocks are devices that supply liquid compositions directly into the toilet bowl under the edge of said cup. Normally, said edge blocks are attached in various ways, such as hooks and the like, to the edge of the toilet bowl. Each time a toilet equipped with edge blocks is washed, a quantity of composition is supplied to the inside of the toilet bowl. Examples of liquid edge blocks are provided in international application WO 02/40792 which shows a liquid edge block device having a suspension means and at least two compartments for active substances. International application WO 02/04951 shows a liquid edge block, a toilet cleaning system comprising a dispenser for supplying a liquid composition from the edge of a toilet bowl, where the composition has a viscosity greater than 2500 mPa · s. Other similar systems are described in European patent application 0 775 741 and in international application WO 01/94520.

Liquid cleaning formulation for difficult surfaces

Other embodiments of the invention relate to cleaning formulations for difficult surfaces also known as multi-use cleaners or cleaners for all uses. They are a wide category of products that include isotonic liquids, thickened liquids with or without abrasive or in the form of a mousse. They can be used directly from the bottle or after dilution with water. Different delivery methods are provided according to the user's convenience, some are sprayed on the surfaces from spray bottles with actuator, alternatively they can be poured directly onto the surfaces and removed for example when the toilet is washed. They may contain additional ingredients such as acids for removing lime scale, biocides for hygiene, or bleach. Therefore, there is a wide range of formulations in this category. Table 1 below shows the main ingredients of the formulation and the quantities (it is taken from Surfactant Science Series Vol 67 chapter of Liquid Detergents of Specialty Liquid Household Surface Cleaners p 479 table 4). In all cases, except when oxidizing bleaches (for example, sodium hypochlorite or hydrogen peroxide) are incorporated into the formulation, the fragrances incorporated in the present invention can be used as fragrance in the product.

Table 1. Range of Formulations for Domestic Cleaners

Ingredient

Example Amount in% by weight

Anionic surfactant

Alkylbenzene sulphonate, supplied by Shell as Dobs 055, alkane sulphonate eg Hostaspur SAS60 0-35

Nonionic Surfactant

Ethoxylated alcohol for example Neodol 9-11 6 EO, mixed ethoxy / propoxy alcohol such as the pluronic serif of BASF, amine oxide, alkanolamides and betaines 1-35

Hydrotropes

Xylene sulphonate or cumen sodium sulfonate 0-10

Adjuvant / Inhibitor

Citrates, EDTA salts, phosphonate salts, lactic acid and polyacrylates 0-10

Solvent

Higher alcohols, glycol ethers, benzyl alcohol or hydrocarbons for example limonene 0.5-50

Disinfectant

Hypochlorite bleach, pine oil, lower alcohols, quaternary ammonium salts 0-15

Perfume, color, polymers thickener, inhibitor, preservatives

 0.1-3

Water

up to 100

Pet bed

10 The increase in the animal population of pets has led to an increasing use of animal bedding materials. There are numerous products of commercially available and shown animal beds by means of the prior art.

Normally, they are based on non-expensive materials such as abundant natural minerals, for example,

15 sand, granulated clays and zeolites, or residual recycled cellulosic materials such as wood briquettes, wood sawdust, chopped paper, recycled or chopped microgranules, ground wood bark, alfalfa or other plant material such as corn husk ground. In order to improve the performance of animal beds, additional materials are added to improve absorption, to fix particles, to facilitate removal and odor treatment agents. U.S. Pat. 4,437,429 shows the use of

20 zeolites to control odors in clay-based beds. U.S. Pat. 3,789,717 combines bentonite clay with alfalfa which provides chlorophyll as a deodorant. Fragrances of the present invention may be incorporated either into the pet's bed during manufacture or may be added later during use.

Carpet cleaners

25 Carpet cleaners come in several forms: treatments of stains in the form of dust, liquids, foams and spraying. Many of these products have to be used together with a cleaning machine specifically if large areas have to be treated. However, a desirable attribute of carpet cleaning is to leave a pleasant smell so that, generally, the products contain fragrances and

The fragrances of the present invention are on the one hand desirable and on the other hand, suitable for application in carpet cleaning products.

Air fresheners, deodorant sprays for delicate furniture and textile materials

35 Products are known to reduce or mask bad odors from the air or delicate textile and furniture materials, such as SC Johnson's Glade and Proctor and Gamble's Febreze. These products are designed for spraying in the air or on surfaces. They can be supplied either from aerosols with a volatile propellant gas or using an actuator spray that does not require propellant gas. U.S. patent application 2005/0124512 shows a product that contains cyclodextrin where aldehydes that are not incorporated are incorporated

40 produce discoloration of fabrics, to react with air amines. The patent does not show in any way that aldehydes can inhibit the formation of bad odors without reacting with themselves. U.S. patent application 2003/0044309 shows an emulsion composition that contains a selection of fragrance aldehydes that counteract existing bad odors when they come into direct contact with the fabrics, which again shows the reactive chemistry instead of preventing the development of bad odors based in indole Fragrances incorporating indole inhibitor materials can also be used advantageously in these products.

Air fresheners

General air fresheners or air fresheners that counteract odors or insect repellent devices include devices that have no energy source and work by diffusion or by electric heating of a wick in contact with a liquid reservoir , so that the fragrance rate can be controlled. Such devices may have power supply, the so-called plug air fresheners described in US Pat. 6,917,754 or battery powered so that they are portable or for use in a motor vehicle. Optionally, the device can use an atomizer sprayer to disperse the fragrance or to contain an electric drive fan. The fragrance compositions of the present invention can be dispersed by means of these air fresheners and deposited on the surfaces to prevent the development of bad odors.

Fibrous articles intended for the absorption of body fluids

Considerable successes have been achieved in the design of products intended to absorb and retain residual materials of animal and human origin. The construction of articles such as disposable diapers and underpants for the control of sphincters, pads and tampons and incontinence products, for example, has been sophisticated with the addition of elastic materials, barrier layers, super-absorbent polymers and the like to retain more residue and prevent leaks. Reference can be made to US Pat. 4,846,823; 5,932,495 or 4,335,722 for technology descriptions. Odor control remains a challenge that is exacerbated by the technical improvements mentioned above, which have led to greater amounts of residue retained in products designed to require less frequent replacement.

Frequently, attempts to avoid such odors from their formation or in order to absorb them have involved antimicrobial treatments. The use of additives such as activated carbon, zeolites, metals such as copper, metal oxides, hydrated alumina, minerals such as holmita, laconite, kaolin and molecular sieve modifications has been suggested, as well as the use of acid / base interactions to neutralize the different components of odor formation. U.S. Pat. 6,031,147 shows the use of surfactants to prevent odor in disposable absorbent products. U.S. patent application 2002/0010447 also shows several of the above and also the use of a mixture of two types of aldehydes but does not show that aldehydes prevent the development of bad odors associated with indole compounds, nor that aldehydes remain unmodified by of the interaction. Despite these efforts, there is still a need to better control odors.

Example 1: Identification of active fragrance compounds

A sample of pure human urine is divided equally and a fragrance containing one or more of the effective materials is added as described in the Indol Inhibition Assay. Control samples were prepared in which the inactive compounds were replaced and a blank containing no fragrance was also prepared to determine urine adequacy. The samples were stored and after 24 hours the indole content and the active fragrance content were measured by means of gas chromatography detection with mass spectrometry (GC-MS). These formulations containing active ingredients prevented the formation of indole although both the samples that did not contain fragrance and the control samples that contained alcohol had much greater amounts of indole present. Also for the active compounds the GCMS measurement indicated the extent to which the compound itself was consumed as part of the process. In Table 2, the decrease in fragrance components has been classified into 3 categories and the letter Y indicates the appropriate category for the compounds that have been measured. The absence of the letter Y in any category indicates that the decrease was not measured for that compound.

Table 2: Examples of effective materials

Active compounds / Nos CAS

Decrease in Fragrance Compounds after 24 hours (%)

0-30%

0-60% > 60%

Acetophenone 98-86-2

Benzaldehyde 100-52-7

Y

Benzophenone 119-61-9

Cinnamic Aldehyde 104-55-2

Y

Cintronelal 5949-05-3

Hex 2 Trans 6728-26-3

Y

Trans 2 hexenol 928-95-0

Aldehyde C11 112-44-7

Y

Citral 5392-40-5

Y

Aldehyde C-10 112-31-2

Knob Aldehyde 2111-75-3

Y

Knob Alcohol 536-59-4

Veltol Plus 4940-11-8

Y

Heliobuquet 1205-17-0

Y = Yes

The following compounds were found to be ineffective in reducing indole levels in urine after 24 hours.

Inactive compounds / Nos. CAS:

Benzyl alcohol 100-51-6

10 Ethyl phenyl alcohol 60-12-8 Cinnamic alcohol 104-54-1 Citronellol 106-22-9 C10 alcohol 112-30-1 Cinnamic hexyl aldehyde 101-86-0

15 Cinnamic amyl alcohol 101-85-9 Kovanol 31906-04-4 Anise alcohol 105-13-5 Dimethyl octenone 2550-11-0 Dimethyl octanol 106-21-8

20 to Damascona 24720-09-0 Phenylacetaldehyde 122-78-1 Lilial 80-54-6 Laurinal 107-75-5 Geraniol 106-24-1

25 Nerol 106-25-2 B lonona 14901-07-6 Cyclamen aldehyde 103-95-7 Mirac aldehyde 37677-14-8 Vanillin 121-33-5

30 Ethyl vanillin 121-32-4 Cantoxal 5462-06-6 Cuminic acid 122-03-2 Phenoxanol 55066-48-3 Triplal 68039-49-6

Example 2: Performance of a liquid block for edge

The active composition of Table 3 (example 2) was mixed with a liquid block-edge formulation having the composition of example 6, of which 0.25 g to 7.0 g of a sample of pure human urine was added. appropriate to give 0.02 g of active fragrance as described in part B of the indole inhibition assay. After 24 hours the indole content was measured and the result was shown as the file URIN40.D in the figure

1. A comparative example control A was mixed with the same liquid block-edge formulation and provided the results of the URIN41.D file of Figure 1, while the blank sample containing 0.2 g of the liquid formulation of Urine block provided the file URIN39.D in Figure 1. It

10 it can be seen that the fragrance composition of the invention reduced the concentration of indole below 0.01 ppm (weight / weight). Note that the dosage of Example 2 and Example A of the liquid edge block represents approximately 30% of the normal total fragrance dose.

Table 3. Efficacy of the Liquid Edge Block - Formulation of Active Components

Example 2

Comparative Example A

Compound

%  Compound %

Benzaldehyde

 33.3 Benzyl alcohol 33.3

Cinnamic aldehyde

33.3 Cinnamic alcohol 33.3

Phenylacetaldehyde

33.3 Phenylethyl alcohol 33.3

15 Example 3

Table 4 below demonstrates a fragrance composition according to the present invention containing 5% of active ingredient suitable for use in household products, together with a comparative example B of control fragrance containing inactive alcohols with respect to the active aldehydes.

20 Table 4. Example of Effective and Ineffective Fragrances

Example 3

Comparative Example B

Compound

%  Compound %

Benzaldehyde

 5 Benzyl alcohol 5

Geraniol 98%

twenty  Geraniol 98% twenty

Egypt nat geranium oil

2  Egypt nat geranium oil 2

Verdox

5  Verdox 5

Manzanato

 5 Manzanato 5

Musk t-93

5  Musk t-93 5

Phenal Acetaldehyde

10 Phenyl ethyl alcohol 10

Phenyl ethyl alcohol

42  Phenyl ethyl alcohol 42

Phenylethylphenylacetate

5  Phenylethylphenylacetate 5

Rose oxide

one  Rose oxide one

Example 4

Table 5 demonstrates a fragrance composition according to the present invention containing 23% active ingredients for use in household products, together with a comparative example C of control fragrance containing the corresponding inactive alcohols with respect to active aldehydes.

Table 5. Effective and Inefficient Fragrances

Example 3

Comparative Example C

Compound

%  Compound %

Aldehyde C-10 FCC

2 Decaneol  2

C8 Aldehyde

one Octanol  one

Allyl caproate

5  Allyl caproate 5

Benzaldehyde

 10 Benzyl alcohol 10

Citral

10 Citronellol  10

Citronellol

 10 Citronellol 10

Citronellyl Nitrile

5  Citronellyl Nitrile 5

Dihydromyrcenol

fifteen  Dihydromyrcenol fifteen

Lemon oil

5  Lemon oil 5

Terpineol alpha

35  Terpineol alpha 35

Triplal

2 2,4-dimethyl cyclohex-3-enyl methanol 2

Example 5: household cleaner

Table 6 shows an example of a domestic liquid cleaner that can be used to deliver the fragrances of the invention.

Table 6: Domestic Cleaner

Ingredient

Purity % in weigh

Secondary alkane sulphonate Hostapur SAS 60

60 13.0

Alcohol ethoxylate for example Neodol 91-6 EO

100 2.0

Lactic acid

100 0.5

n butyl propylene glycol ether

0.5

Perfume of the composition as in example 3

100 0.35

Other minor components of dye and preservative

c.s.

Water

100  up to 100

Hostapur SAS 60 supplied by Clariant Neodol 91-6 supplied by Shell Chemicals

Example 6: liquid block for edge

Table 7 shows an example of the liquid edge block that can be used to deliver the fragrances of the invention.

Table 7. Household cleaner

Ingredient

% in weigh

Emulgina HF70

16.7

1,2 propylene glycol

4.0

Perfume of the composition as in example 3

8.0

Kathon CG

0.005

Natrosol 250 MR

11.7

Dyes and other minor components

c.s.

Water

 up to 100

Emulgina HF70 supplied by Cognis Kathon CG supplied by Seppic Natrosol 250 MR supplied by Hercules

Example 7

Table 8 shows an example of an acidic toilet bowl cleaner that can be used to supply

fragrances of the invention.

Table 8. Toilet bowl cleaner

Ingredient

Purity % in weigh

Hostapur SAS60 secondary alkane sulphonate

60 7.5

Alcohol ethoxylate for example Neodol 91-6 EO

100 3.0

C12 / 18 amine oxide

30 5.0

Citric acid

100 10

Perfume of the composition as in example 3

100 0.4

Other minor components of dyes and preservatives

c.s.

Water

 100 up to 100

Example 8: concentrated toilet bowl cleaner Table 9 shows an example of a concentrated toilet bowl cleaner that can be used to deliver the fragrances of the invention. 15 Table 9. toilet bowl cleaner

Ingredient

Purity % in weigh

Hostapur SAS60 secondary alkane sulphonate

60 12.0

Alcohol ethoxylate for example Neodol 91-7 EO

100 9.0

Citric acid

100 fifteen

Phosphoric acid

15.0

Hordaphos CCMS

15.0

Perfume of the composition as in example 3

100 0.8

Other minor components of dyes and preservatives

 c.s.

Water

 100 up to 100

Hordaphos CCMS supplied by Clariant

Example 9: acid abrasive cleaner

Table 10 shows an example of an acidic abrasive liquid household cleaner that can be used to deliver the fragrances of the invention.

Table 10. Acid abrasive cleaner

Ingredient

Purity % in weigh

Hostapur SAS60 secondary alkane sulphonate

60 5.3

Alcohol ethoxylate for example Neodol 91-6 EO

100 6.4

Ingredient

Purity % in weigh

Lactic acid

100 3.3

Water

 100 66.2

Perfume of the composition as in example 3

100 0.4

Other minor components of dyes and preservatives

 c.s.

Quartz Powder *

100 18.8

Water

 100 up to 100

* for example Alsigra 25 from Alpha Calcit Fullstoff Gmbh

Claims (5)

1. The use of a fragrance composition comprising from 2.5% to 100% by weight of fragrance compounds selected from: aldehydes, alcohols, ketones and mixtures thereof in any household or personal hygiene product that enters into contact with dirt based on fecal matter and urine, as an agent to restrict the formation of indole from dirt based on fecal material and urine, each fragrance compound being able to restrict the formation of indole to less than 0.01 ppm (weight / weight) as determined by the following test: A) 0.02 g of fragrance and 0.02 g of Tergitol 15-s-12 (CAS 68131-40-8) were added to 7 g of pure human urine in a 20 ml Headspace vial sealed with a two-stopper PTFE faces and mixed well for 10 minutes using a magnetic stirrer. As a blank to test the adequacy of a batch of pure human urine, 7 g of human urine with 0.02 g of demineralized water and 0.02 g of Tergitol 15-s-12 (CAS 68131-40-8 were used ). If a control was required to test the efficacy of the product base, for example, the control contained 7 g of human urine to which 0.02 g of fragrance was added, less active agents and 0.02 g of Tergitol 15-s-12 (CAS 68131-40-8); B) The vials were placed in an automatic sampling tray at room temperature; C) Samples were taken from the head spaces of the vials at different times for 5 minutes at 35 ° C by means of an SPME fiber after 10 minutes at 35 ° C; D) The SPME fiber is subjected to desorption for 1 minute at 265 ° C from an automatic sampling device and is injected in a non-split mode in a gas chromatography column of 30 mx 0.25 x 0.25 in the following oven conditions: 50 ° C for 2 min - up to 250 ° C at 10 ° C / min -250 ° C for 5 minutes; E) Under the above conditions of gas chromatography, indole has a retention time of 19.14 minutes, and can be recognized by its characteristic ions m / z 117, m / z 89 and m / z 90; F) In the range of values determined in the present work, the indole peak area (117) is linearly related to the current concentration of the vial, and was used without additional correction to set the indole concentration to "Active" and " White "and if any" Control "fragrances were present. G) The material is considered to be active if the concentration of indole in the test sample is below 0.01 ppm (weight / weight) after 24 hours of incubation at room temperature and the indole in the urine blank sample it is less than 0.01 ppm (weight / weight) at the beginning of the experiment and between 0.25 ppm (weight / weight) and 1.25 ppm (weight / weight) of indole after 24 hours storage at room temperature; H) The change in the concentration of active substance is determined by comparing the measurements at the beginning of the experiment and after 24 hours using the appropriate characteristic ions.

2.

 The use according to claim 1, wherein the fragrance compounds are selected from aldehydes.

3.

 The use according to claim 1 or 2, wherein the concentration of aldehydes, alcohols, ketones and mixtures thereof, does not decrease by more than 60% by weight under the incubation conditions defined in claim 1.

Four.

 The use according to claim 1 or 2, wherein the fragrance compounds are selected from acetophenone, C-11 aldehyde, C-10 aldehyde, benzaldehyde, benzophenone, cinnamic aldehyde, citronelal, citral, heliobuquet (CAS 1205-17-0 ), trans 2-hexenal, trans 2-hexenol, knob aldehyde, perilla alcohol, Veltol Plus (CAS No. 4940-11-8) or mixtures thereof.

5.

The use according to claim 4, wherein the fragrance composition contains from 10% to 100% by weight of any of the fragrance compounds selected from acetophenone, C-11 aldehyde, C-10 aldehyde, benzaldehyde, benzophenone, cinnamic aldehyde, citronelal, citral, heliobuquet (CAS 1205-17-0), trans 2-hexenal, trans 2-hexenol, knob aldehyde, perilla alcohol, Veltol Plus (CAS No. 4940-11-8) or mixtures thereof.