ES2440938T3 - Formas anhidrato de un derivado de piridina - Google Patents

Formas anhidrato de un derivado de piridina Download PDF

Info

Publication number: ES2440938T3
Authority: ES; Spain
Prior art keywords: compound; formula; crystalline anhydrate; disorders; disorder
Prior art date: 2009-08-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES10747619.4T

Other languages

English (en)

Spanish (es)

Inventor

Andrew Simon Craig

Salima Zarah Ismail

Ronnie Maxwell Lawrence

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nerre Therapeutics Ltd

GlaxoSmithKline LLC

Original Assignee

Nerre Therapeutics Ltd

GlaxoSmithKline LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-08-27

Filing date

2010-08-25

Publication date

2014-01-31

2010-08-25 Application filed by Nerre Therapeutics Ltd, GlaxoSmithKline LLC filed Critical Nerre Therapeutics Ltd

2014-01-31 Application granted granted Critical

2014-01-31 Publication of ES2440938T3 publication Critical patent/ES2440938T3/es

Status Active legal-status Critical Current

2030-08-25 Anticipated expiration legal-status Critical

Links

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WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ES10747619.4T 2009-08-27 2010-08-25 Formas anhidrato de un derivado de piridina Active ES2440938T3 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US23743509P	2009-08-27	2009-08-27
US237435P		2009-08-27
PCT/EP2010/062420 WO2011023733A1 (en)	2009-08-27	2010-08-25	Anhydrate forms of a pyridine derivative

Publications (1)

Publication Number	Publication Date
ES2440938T3 true ES2440938T3 (es)	2014-01-31

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ID=42790943

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ES10747619.4T Active ES2440938T3 (es)	2009-08-27	2010-08-25	Formas anhidrato de un derivado de piridina

Country Status (17)

Country	Link
US (1)	US8796269B2 (2)
EP (1)	EP2470545B1 (2)
JP (3)	JP2013503134A (2)
KR (1)	KR20120056258A (2)
CN (1)	CN102639536B (2)
AU (1)	AU2010288502B2 (2)
CA (1)	CA2772168C (2)
DK (1)	DK2470545T3 (2)
EA (1)	EA021411B1 (2)
ES (1)	ES2440938T3 (2)
IL (1)	IL217922A (2)
IN (1)	IN2012DN01292A (2)
MX (1)	MX2012002369A (2)
PL (1)	PL2470545T3 (2)
SG (1)	SG178231A1 (2)
WO (1)	WO2011023733A1 (2)
ZA (1)	ZA201200812B (2)

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CN102639536B (zh) *	2009-08-27	2015-03-18	尼尔医疗有限公司	吡啶衍生物的无水晶型
WO2015200594A2 (en)	2014-06-25	2015-12-30	Emory University	Methods of managing conditioned fear with neurokinin receptor antagonists
EP3574907B1 (en) *	2015-05-18	2023-08-23	KaNDy Therapeutics Limited	A dual nk-1/nk-3 receptor antagonist for the treatment of sex-hormone-dependent diseases
CA3044773A1 (en) *	2016-12-15	2018-06-21	Glaxosmithkline Intellectual Property Development Limited	Nrf2 activators
JP7433252B2 (ja) *	2018-03-14	2024-02-19	キャンディ・セラピューティクス・リミテッド	Ｎｋ－１／ｎｋ－３受容体二重アンタゴニストを含む新規な医薬製剤
WO2021030335A1 (en) *	2019-08-12	2021-02-18	Millendo Therapeutics, Inc.	A stereoisomerically pure nk-3 receptor antagonist and crystalline forms thereof
KR102950227B1 (ko)	2019-11-15	2026-04-08	칸디 테라퓨틱스 리미티드	Nt-814의 핵심 중간체인 6-클로로-4-(4-플루오로-2-메틸페닐)피리딘-3-아민의 새로운 화학적 제조 방법
EP4431512A1 (en)	2023-03-16	2024-09-18	Bayer Consumer Care AG	Novel dual nk-1/nk-3 receptor antagonists
WO2025242584A1 (en)	2024-05-24	2025-11-27	Bayer Consumer Care Ag	A stable soft gelatin capsule formulation for elinzanetant
WO2025242585A1 (en)	2024-05-24	2025-11-27	Bayer Consumer Care Ag	Crystalline forms of salts of elinzanetant and compositions containing salts of elinzanetant
WO2025242583A1 (en)	2024-05-24	2025-11-27	Bayer Consumer Care Ag	Novel formulation comprising elinzanetant in a solid dispersion
WO2025261856A1 (en) *	2024-06-18	2025-12-26	Bayer Consumer Care Ag	Improved process for producing an elinzanetant precursor
US12533358B1 (en)	2025-05-14	2026-01-27	Bayer Consumer Care Ag	Methods of treatment with elinzanetant

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EP1394150B1 (en) *	1999-02-24	2011-01-19	F. Hoffmann-La Roche AG	4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists
GB0203022D0 (en) *	2002-02-08	2002-03-27	Glaxo Group Ltd	Chemical compounds
ATE366576T1 (de) *	2003-01-31	2007-08-15	Hoffmann La Roche	Neue kristallmodifikation von 2-(3,5-bis- trifluormethyl-phenyl)-n-6-(1,1-dioxo-1lamda-6-
SI1643998T1 (sl) *	2003-07-03	2007-12-31	Hoffmann La Roche	Dvojni nk1/nk3 antagonisti za zdravljenje shizofrenije
EP1928886B1 (en) *	2005-09-09	2011-04-13	GlaxoSmithKline LLC	Pyridine derivatives and their use in the treatment of psychotic disorders
WO2009087667A2 (en) *	2007-12-11	2009-07-16	Cipla Ltd.	A new method for preparation of zopiclone and its polymorphs
GB0814340D0 (en) *	2008-08-05	2008-09-10	Smithkline Beecham Corp	Anhydrous crystol form fo a pyridine derivative
CN102639536B (zh) *	2009-08-27	2015-03-18	尼尔医疗有限公司	吡啶衍生物的无水晶型
JP6342662B2 (ja) *	2014-01-29	2018-06-13	京セラ株式会社	ドリルおよびそれを用いた切削加工物の製造方法

2010
- 2010-08-25 CN CN201080037918.3A patent/CN102639536B/zh active Active
- 2010-08-25 US US13/389,525 patent/US8796269B2/en active Active
- 2010-08-25 WO PCT/EP2010/062420 patent/WO2011023733A1/en not_active Ceased
- 2010-08-25 DK DK10747619.4T patent/DK2470545T3/da active
- 2010-08-25 SG SG2012007464A patent/SG178231A1/en unknown
- 2010-08-25 AU AU2010288502A patent/AU2010288502B2/en active Active
- 2010-08-25 PL PL10747619T patent/PL2470545T3/pl unknown
- 2010-08-25 KR KR1020127004865A patent/KR20120056258A/ko not_active Ceased
- 2010-08-25 EA EA201270302A patent/EA021411B1/ru not_active IP Right Cessation
- 2010-08-25 CA CA2772168A patent/CA2772168C/en active Active
- 2010-08-25 JP JP2012526048A patent/JP2013503134A/ja active Pending
- 2010-08-25 EP EP10747619.4A patent/EP2470545B1/en active Active
- 2010-08-25 IN IN1292DEN2012 patent/IN2012DN01292A/en unknown
- 2010-08-25 ES ES10747619.4T patent/ES2440938T3/es active Active
- 2010-08-25 MX MX2012002369A patent/MX2012002369A/es active IP Right Grant
2012
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- 2012-02-02 IL IL217922A patent/IL217922A/en active IP Right Grant
2015
- 2015-07-13 JP JP2015139845A patent/JP6404186B2/ja active Active
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Also Published As

Publication number	Publication date
EA201270302A1 (ru)	2012-07-30
EP2470545A1 (en)	2012-07-04
EP2470545B1 (en)	2013-10-09
PL2470545T3 (pl)	2014-03-31
MX2012002369A (es)	2012-03-29
US8796269B2 (en)	2014-08-05
AU2010288502A1 (en)	2012-02-23
IL217922A0 (en)	2012-03-29
US20120157450A1 (en)	2012-06-21
JP6404186B2 (ja)	2018-10-10
JP2013503134A (ja)	2013-01-31
JP2017193564A (ja)	2017-10-26
IL217922A (en)	2016-06-30
CN102639536A (zh)	2012-08-15
JP2016000739A (ja)	2016-01-07
CN102639536B (zh)	2015-03-18
AU2010288502B2 (en)	2013-12-12
ZA201200812B (en)	2013-03-27
KR20120056258A (ko)	2012-06-01
IN2012DN01292A (2)	2015-06-05
WO2011023733A1 (en)	2011-03-03
CA2772168A1 (en)	2011-03-03
EA021411B1 (ru)	2015-06-30
SG178231A1 (en)	2012-03-29
DK2470545T3 (da)	2014-01-13
BR112012003435A2 (pt)	2016-02-23
CA2772168C (en)	2019-01-08

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