ES2454773T3 - Fragmentos solubles de la proteína PB2 del virus influenza con capacidad para unirse a un casquete de ARN - Google Patents
Fragmentos solubles de la proteína PB2 del virus influenza con capacidad para unirse a un casquete de ARN Download PDFInfo
- Publication number
- ES2454773T3 ES2454773T3 ES08838119.9T ES08838119T ES2454773T3 ES 2454773 T3 ES2454773 T3 ES 2454773T3 ES 08838119 T ES08838119 T ES 08838119T ES 2454773 T3 ES2454773 T3 ES 2454773T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- polypeptide
- seq
- terminal end
- aligned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
- B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
- B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2501/00—Containers having bodies formed in one piece
- B65D2501/0009—Bottles or similar containers with necks or like restricted apertures designed for pouring contents
- B65D2501/0018—Ribs
- B65D2501/0036—Hollow circonferential ribs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Ceramic Engineering (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers Having Bodies Formed In One Piece (AREA)
Abstract
Fragmento polipeptídico soluble de una subunidad PB2 de ARN-polimerasa dependiente de ARN del virus de la gripe, en que dicho fragmento polipeptídico soluble es seleccionado del grupo consistente en: (i) un fragmento polipeptídico cuyo extremo N-terminal está localizado en la posición de aminoácido 220 del polipéptido de PB2 conforme a la SEQ ID N.º 1 o en un residuo de aminoácido que ocupa una posición análoga en un polipéptido de PB2 alineado con ella o una posición de aminoácido superior; y cuyo extremo C-terminal está localizado en la posición de aminoácido 510 del polipéptido de PB2 conforme a la SEQ ID N.º 1 o en un residuo de aminoácido que ocupa una posición análoga en un polipéptido de PB2 alineado con ella o en una posición de aminoácido inferior; o (ii) un fragmento polipeptídico cuyo extremo N-terminal está localizado en la posición de aminoácido 222 del polipéptido de PB2 conforme a la SEQ ID N.º 2 o en un residuo de aminoácido que ocupa una posición análoga en un polipéptido de PB2 alineado con ella o una posición de aminoácido superior; y cuyo extremo C-terminal está localizado en la posición de aminoácido 511 del polipéptido de PB2 conforme a la SEQ ID N.º 2 o en un residuo de aminoácido que ocupa una posición análoga en un polipéptido de PB2 alineado con ella o en una posición de aminoácido inferior; o (iii) un fragmento polipeptídico cuyo extremo N-terminal está localizado en la posición de aminoácido 227 del polipéptido de PB2 conforme a la SEQ ID N.º 3 o en un residuo de aminoácido que ocupa una posición análoga en un polipéptido de PB2 alineado con ella o una posición de aminoácido superior; y cuyo extremo C-terminal está localizado en la posición de aminoácido 528 del polipéptido de PB2 conforme a la SEQ ID N.º 3 o en un residuo de aminoácido que ocupa una posición análoga en un polipéptido de PB2 alineado con ella o en una posición de aminoácido inferior; o (iv) un variante de fragmento polipeptídico, la cual mantiene una identidad de secuencia de como mínimo el 80% con el fragmento polipeptídico conforme a (i), (ii) o (iii) y en la cual el fragmento polipeptídico conforme a (i), (ii) o (iii) o la variante de fragmento polipeptídico conforme a (iv) conserva la capacidad para asociarse con un casquete de ARN o un análogo de éste; en que el análogo del casquete de ARN se selecciona del grupo consistente en m7G, m7GMP, m7GTP, m7GpppN, m7GpppNm.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70792P | 1998-01-08 | ||
| US99839807P | 2007-10-09 | 2007-10-09 | |
| US998398P | 2007-10-09 | ||
| US7079208P | 2008-03-25 | 2008-03-25 | |
| US12345608P | 2008-04-08 | 2008-04-08 | |
| US123456P | 2008-04-08 | ||
| PCT/EP2008/008543 WO2009046983A1 (en) | 2007-10-09 | 2008-10-09 | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2454773T3 true ES2454773T3 (es) | 2014-04-11 |
Family
ID=40364724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08838119.9T Active ES2454773T3 (es) | 2007-10-09 | 2008-10-09 | Fragmentos solubles de la proteína PB2 del virus influenza con capacidad para unirse a un casquete de ARN |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9045248B2 (es) |
| EP (2) | EP2574619A3 (es) |
| JP (3) | JP5725861B2 (es) |
| KR (1) | KR101672554B1 (es) |
| CN (1) | CN101970465B (es) |
| AU (1) | AU2008309939B2 (es) |
| CA (1) | CA2701362A1 (es) |
| ES (1) | ES2454773T3 (es) |
| IL (3) | IL204891A (es) |
| SG (1) | SG185289A1 (es) |
| WO (1) | WO2009046983A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101672554B1 (ko) | 2007-10-09 | 2016-11-03 | 유럽피안 몰레큘러 바이올로지 래보러토리 | Ｒｎａ 캡에 결합 가능한 인플루엔자 바이러스 ｐｂ２ 단백질의 가용성 단편 |
| GEP20207129B (en) | 2009-06-17 | 2020-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
| EP2547696B1 (en) * | 2010-03-16 | 2018-05-23 | European Molecular Biology Laboratory (Embl) | Fragments of the pa subunit of rna dependent rna polymerase from pandemic influenza virus a 2009 h1n1, and their use |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| CA2879443A1 (en) * | 2012-07-19 | 2014-01-23 | Zoetis Llc | Bovine influenza virus compositions |
| HUE038820T2 (hu) | 2013-11-13 | 2018-11-28 | Vertex Pharma | Eljárás influenzavírusok replikációjának inhibitorai elõállítására |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| CN105002149B (zh) * | 2014-04-22 | 2018-04-06 | 中国科学院生物物理研究所 | 流感病毒rna聚合酶纯化或结晶的方法 |
| CN105018441A (zh) * | 2014-04-22 | 2015-11-04 | 中国科学院生物物理研究所 | 流感病毒rna聚合酶结晶的方法 |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| CN107286044B (zh) | 2016-04-13 | 2021-07-13 | 香港神农有限公司 | 一种能够抑制流感病毒pb2蛋白与rna帽结合的化合物 |
| CL2018003871A1 (es) | 2018-12-28 | 2021-01-15 | Univ Pontificia Catolica Chile | Anticuerpos monoclonales específicos para el antígeno pb2 del virus de la influenza humana (flu), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por flu |
| WO2020239822A1 (en) | 2019-05-27 | 2020-12-03 | The European Molecular Biology Laboratory | Nucleic acid construct binding to influenza polymerase pb1 rna synthesis active site |
| CN113122596B (zh) * | 2020-08-20 | 2023-01-24 | 深圳市瑞吉生物科技有限公司 | 一种Cap2结构5′帽子类似物及其制备方法和应用 |
| CN114741315B (zh) * | 2022-04-28 | 2023-06-13 | 深圳市紫光同创电子有限公司 | 用例更新方法、装置、电子设备及存储介质 |
| CN116024301B (zh) * | 2023-01-16 | 2025-10-28 | 北京协同创新研究院 | 一种rna依赖性rna聚合酶截短体的筛选方法、截短体及应用 |
| WO2025055169A1 (en) * | 2023-09-12 | 2025-03-20 | The Chinese University Of Hong Kong | A fluorescent probe to measure rna binding and elongation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837852A (en) * | 1993-10-14 | 1998-11-17 | Bristol-Myers Squibb Company | Capped nucleic acid oligomers that inhibit cap-dependent transcription of the influenza virus endonuclease |
| KR101672554B1 (ko) * | 2007-10-09 | 2016-11-03 | 유럽피안 몰레큘러 바이올로지 래보러토리 | Ｒｎａ 캡에 결합 가능한 인플루엔자 바이러스 ｐｂ２ 단백질의 가용성 단편 |
| JP6614523B2 (ja) * | 2014-03-28 | 2019-12-04 | 地方独立行政法人神奈川県立産業技術総合研究所 | インフルエンザウイルスのｒｎａ依存性ｒｎａポリメラーゼのｐｂ２サブユニットに対するモノクローナル抗体 |
-
2008
- 2008-10-09 KR KR1020107008765A patent/KR101672554B1/ko not_active Expired - Fee Related
- 2008-10-09 SG SG2012075354A patent/SG185289A1/en unknown
- 2008-10-09 CN CN200880119968.9A patent/CN101970465B/zh not_active Expired - Fee Related
- 2008-10-09 US US12/681,974 patent/US9045248B2/en not_active Expired - Fee Related
- 2008-10-09 JP JP2010528317A patent/JP5725861B2/ja not_active Expired - Fee Related
- 2008-10-09 ES ES08838119.9T patent/ES2454773T3/es active Active
- 2008-10-09 EP EP12175945.0A patent/EP2574619A3/en not_active Withdrawn
- 2008-10-09 AU AU2008309939A patent/AU2008309939B2/en not_active Ceased
- 2008-10-09 EP EP08838119.9A patent/EP2197901B1/en not_active Not-in-force
- 2008-10-09 WO PCT/EP2008/008543 patent/WO2009046983A1/en not_active Ceased
- 2008-10-09 CA CA2701362A patent/CA2701362A1/en not_active Abandoned
-
2010
- 2010-04-06 IL IL204891A patent/IL204891A/en not_active IP Right Cessation
-
2012
- 2012-11-12 IL IL222997A patent/IL222997A0/en unknown
-
2014
- 2014-10-08 JP JP2014207447A patent/JP5937169B2/ja not_active Expired - Fee Related
-
2015
- 2015-03-23 IL IL237903A patent/IL237903A/en not_active IP Right Cessation
-
2016
- 2016-05-10 JP JP2016094331A patent/JP6309563B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2197901A1 (en) | 2010-06-23 |
| CA2701362A1 (en) | 2009-04-16 |
| CN101970465A (zh) | 2011-02-09 |
| EP2197901B1 (en) | 2013-12-11 |
| JP2015062417A (ja) | 2015-04-09 |
| IL222997A0 (en) | 2012-12-31 |
| EP2574619A2 (en) | 2013-04-03 |
| IL204891A0 (en) | 2010-11-30 |
| AU2008309939B2 (en) | 2013-11-14 |
| JP6309563B2 (ja) | 2018-04-11 |
| KR101672554B1 (ko) | 2016-11-03 |
| SG185289A1 (en) | 2012-11-29 |
| JP2016176955A (ja) | 2016-10-06 |
| JP2011501942A (ja) | 2011-01-20 |
| US9045248B2 (en) | 2015-06-02 |
| IL237903A (en) | 2017-10-31 |
| JP5937169B2 (ja) | 2016-06-22 |
| KR20100074212A (ko) | 2010-07-01 |
| US20110008348A1 (en) | 2011-01-13 |
| CN101970465B (zh) | 2016-03-16 |
| AU2008309939A1 (en) | 2009-04-16 |
| WO2009046983A1 (en) | 2009-04-16 |
| EP2574619A3 (en) | 2013-07-31 |
| JP5725861B2 (ja) | 2015-05-27 |
| IL204891A (en) | 2015-04-30 |
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