ES245655A1 - Procedimiento para la sintesis de steroides 18-oxigenados - Google Patents

Info

Publication number

ES245655A1

ES245655A1 ES0245655A ES245655A ES245655A1 ES 245655 A1 ES245655 A1 ES 245655A1 ES 0245655 A ES0245655 A ES 0245655A ES 245655 A ES245655 A ES 245655A ES 245655 A1 ES245655 A1 ES 245655A1

Authority

ES

Spain

Prior art keywords

acetoxy

oxo

ketals

hydroxy

double bond

Prior art date

1957-12-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 title abstract 3
• 230000015572 biosynthetic process Effects 0.000 title abstract 2
• 238000003786 synthesis reaction Methods 0.000 title abstract 2
• 150000003431 steroids Chemical class 0.000 title 1
• 239000002253 acid Substances 0.000 abstract 3
• UYNXNPZDSGEDON-XFMWHNAVSA-N (5r,8s,9s,10s,13r,14s)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,17-tetradecahydrocyclopenta[a]phenanthren-16-one Chemical class C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC(=O)C[C@@]2(C)CC1 UYNXNPZDSGEDON-XFMWHNAVSA-N 0.000 abstract 1
• VSGLMCNTRRDZSW-ZYKVSKEMSA-N (8S,9S,10S,11S,13S,14S)-11-hydroxy-10-methyl-16-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde Chemical class O[C@@H]1[C@@H]2[C@]3(CCCCC3CC[C@H]2[C@@H]2CC(C[C@@]2(C=O)C1)=O)C VSGLMCNTRRDZSW-ZYKVSKEMSA-N 0.000 abstract 1
• PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 abstract 1
• PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 abstract 1
• BAHXRNXWCADRAO-HSYAIAAASA-N [(8S,9S,10S,11S,13S,14S)-13-formyl-10-methyl-16-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,17-tetradecahydrocyclopenta[a]phenanthren-11-yl] acetate Chemical class C(C)(=O)O[C@@H]1[C@@H]2[C@]3(CCCCC3CC[C@H]2[C@@H]2CC(C[C@@]2(C=O)C1)=O)C BAHXRNXWCADRAO-HSYAIAAASA-N 0.000 abstract 1
• 229960002478 aldosterone Drugs 0.000 abstract 1
• 150000001875 compounds Chemical class 0.000 abstract 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
• 230000033444 hydroxylation Effects 0.000 abstract 1
• 238000005805 hydroxylation reaction Methods 0.000 abstract 1
• 238000007248 oxidative elimination reaction Methods 0.000 abstract 1
• 238000006385 ozonation reaction Methods 0.000 abstract 1
• WURFKUQACINBSI-UHFFFAOYSA-M ozonide Chemical compound [O]O[O-] WURFKUQACINBSI-UHFFFAOYSA-M 0.000 abstract 1
• KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 abstract 1
• 238000002360 preparation method Methods 0.000 abstract 1
• 238000006894 reductive elimination reaction Methods 0.000 abstract 1