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Novartis AG
BASF Schweiz AG
Original Assignee
Ciba Geigy AG
Ciba AG
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Publication date
Application filed by Ciba Geigy AG, Ciba AGfiledCriticalCiba Geigy AG
Publication of ES245657A1publicationCriticalpatent/ES245657A1/en
Process for the synthesis of 18-oxygenated steroids, particularly 20-oxo-pregnane-21 saturated or unsaturated acids in position 16,17 and their derivatives, characterized in that in a compound of the formula ** (See formula) ** where R means a ketalized oxo group, R 'an alkoxy group or a substituted amino group and X the remainder ** (See formula) ** where Y stands for a protected hydroxyl group, the double bond is catalytically hydrolyzed 14, 15, simultaneously or subsequently the 16-oxo groups are reduced to the hydroxyl group, these are removed under the effects of alkaline agents under simultaneous dissociation of the 20-acyl group and formation of a Δ 16-20-ketone, if appropriate, a 21-acid derivative is saponified to the free 21-acid and a free 21-acid group, if desired, the keto-ketalized group is esterified or released in the position 3. (Machine-translation by Google Translate, not legally binding)
ES0245657A1957-12-051958-11-29Procedure for the synthesis of 18-oxygenated steroids (Machine-translation by Google Translate, not legally binding)
ExpiredES245657A1
(en)
Procedure for the obtaining of progestativally active energy esters of the carboxylicode acid the pregnadine-17 alfaol-3,20-diona (Machine-translation by Google Translate, not legally binding)
Procedure for obtaining esters of strictly progressive activity of the carboxylic acid of 1-alopregnene-17 a-o1-3,20-diona (Machine-translation by Google Translate, not legally binding)