ES2466221T8 - Monohidrato de mesilato de N-[5-aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida - Google Patents

Monohidrato de mesilato de N-[5-aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida Download PDF

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Publication number
ES2466221T8
ES2466221T8 ES13157396.6T ES13157396T ES2466221T8 ES 2466221 T8 ES2466221 T8 ES 2466221T8 ES 13157396 T ES13157396 T ES 13157396T ES 2466221 T8 ES2466221 T8 ES 2466221T8
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Spain
Prior art keywords
methyl
aminosulfonyl
thiazol
pyridinyl
phenyl
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ES13157396.6T
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ES2466221T3 (es
Inventor
Wilfried Dr. Schwab
Alexander Birkmann
Kurt Vögtli
Dieter Haag
Andreas Lender
Alfons Grunenberg
Birgit Keil
Joachim Rehse
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Aicuris GmbH and Co KG
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Aicuris GmbH and Co KG
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Publication of ES2466221T3 publication Critical patent/ES2466221T3/es
Publication of ES2466221T8 publication Critical patent/ES2466221T8/es
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ES13157396.6T 2011-09-26 2012-09-26 Monohidrato de mesilato de N-[5-aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida Active ES2466221T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/EP2011/007823 2011-09-26
EP11007823A EP2573086A1 (en) 2011-09-26 2011-09-26 N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP11007823 2011-09-26

Publications (2)

Publication Number Publication Date
ES2466221T3 ES2466221T3 (es) 2014-06-09
ES2466221T8 true ES2466221T8 (es) 2016-09-13

Family

ID=46889067

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12762300.7T Active ES2462492T3 (es) 2011-09-26 2012-09-26 Monohidrato de mesilato de N-[5-aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida
ES13157396.6T Active ES2466221T3 (es) 2011-09-26 2012-09-26 Monohidrato de mesilato de N-[5-aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES12762300.7T Active ES2462492T3 (es) 2011-09-26 2012-09-26 Monohidrato de mesilato de N-[5-aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida

Country Status (29)

Country Link
US (1) US9340535B2 (es)
EP (3) EP2573086A1 (es)
JP (2) JP6161614B2 (es)
KR (4) KR20190104249A (es)
CN (2) CN103842359B (es)
AR (3) AR088043A1 (es)
AU (2) AU2012314536B2 (es)
BR (1) BR112014003245B1 (es)
CA (1) CA2791142C (es)
CL (1) CL2014000149A1 (es)
DK (2) DK2598501T3 (es)
ES (2) ES2462492T3 (es)
HK (1) HK1220978A1 (es)
HR (1) HRP20140351T1 (es)
IL (2) IL230152A (es)
IN (1) IN2014DN01993A (es)
JO (2) JO3037B1 (es)
MX (2) MX338736B (es)
MY (2) MY185063A (es)
PE (1) PE20141148A1 (es)
PH (2) PH12014500567A1 (es)
PL (2) PL2602258T3 (es)
PT (1) PT2598501E (es)
RU (2) RU2669388C1 (es)
SG (1) SG10201407430TA (es)
TW (2) TWI532739B (es)
UA (2) UA115317C2 (es)
WO (1) WO2013045479A1 (es)
ZA (2) ZA201401773B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
JP6918823B2 (ja) * 2016-04-06 2021-08-11 イノベーティブ モレキュールズ ゲーエムベーハーInnovative Molecules Gmbh 抗ウイルス剤として有用なアミノチアゾール誘導体
AR110250A1 (es) * 2016-11-28 2019-03-13 Aicuris Anti Infective Cures Gmbh Formulación tópica que comprende n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida
AR110251A1 (es) 2016-11-28 2019-03-13 Aicuris Anti Infective Cures Gmbh Una sal maleato de la base libre de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, formulaciones farmacéuticas, métodos de fabricación y usos de la misma
LT3544976T (lt) * 2016-11-28 2021-08-10 Aicuris Gmbh & Co. Kg N-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamido laisvos bazės hemihidratas, jo gamybos būdai ir panaudojimai
KR102335327B1 (ko) 2017-04-28 2021-12-03 현대자동차 주식회사 수냉식 이지알 쿨러
PT3644958T (pt) 2017-06-28 2021-11-08 Aicuris Gmbh & Co Kg Dispositivos aplicáveis intravaginalmente que compreendem compostos antivirais
WO2019068817A1 (en) 2017-10-05 2019-04-11 Innovative Molecules Gmbh SUBSTITUTED THIAZOLEAN ENANTIOMERS AS ANTIVIRAL COMPOUNDS
JP7150368B2 (ja) * 2018-07-06 2022-10-11 フェーノ・セラピューティクス・カンパニー・リミテッド チアゾール系化合物の結晶形およびその応用
AU2019345067A1 (en) * 2018-09-19 2021-04-08 Modernatx, Inc. High-purity peg lipids and uses thereof
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑
CA3168721A1 (en) * 2020-03-26 2021-09-30 Jessica Redmer Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide hemihydrate
WO2024047507A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
JP2025527942A (ja) 2022-08-29 2025-08-25 アセンブリー・バイオサイエンシーズ・インコーポレイテッド 新規な結晶形態
IL319024A (en) 2022-08-29 2025-04-01 Assembly Biosciences Inc Pharmaceutical preparations for the herpes virus

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DOP2000000109A (es) * 1999-12-23 2002-08-30 Gerald Kleymann Derivados de tiazolilamida
DE10129716A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Kombinationspräparate zur Herpes-Behandlung
DE10129714A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Topische Anwendung von Thiazolylamiden
DE10129717A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Kombinationspräparate zur Herpes-Behandlung
DE10131128A1 (de) * 2001-06-28 2003-01-16 Bayer Ag Sekundäre Sulfonamide
GB0423653D0 (en) * 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
DE102005014248A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
JP2007314516A (ja) * 2006-04-25 2007-12-06 Daiichi Sankyo Co Ltd 2以上の置換基を有するベンゼン化合物を含有する医薬
BRPI0712332A2 (pt) * 2006-06-09 2012-12-18 Icos Corp composto e derivados farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, método de antagonização de um receptor dp-2, e, uso de um composto
AR070127A1 (es) * 2008-01-11 2010-03-17 Novartis Ag Pirrolo - pirimidinas y pirrolo -piridinas
UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range

Also Published As

Publication number Publication date
NZ621615A (en) 2016-04-29
JP2017114859A (ja) 2017-06-29
IN2014DN01993A (es) 2015-05-15
IL230152A (en) 2015-04-30
JO3037B1 (ar) 2016-09-05
CA2791142C (en) 2017-08-01
BR112014003245A2 (pt) 2017-03-01
PH12014500567A1 (en) 2014-04-14
HK1220978A1 (zh) 2017-05-19
KR20180088530A (ko) 2018-08-03
AR116394A2 (es) 2021-05-05
CN105541829A (zh) 2016-05-04
RU2669388C1 (ru) 2018-10-11
KR20190104249A (ko) 2019-09-06
ZA201408734B (en) 2016-08-31
RU2620604C2 (ru) 2017-05-29
WO2013045479A1 (en) 2013-04-04
BR112014003245B1 (pt) 2021-11-09
HRP20140351T1 (hr) 2014-07-04
DK2602258T3 (da) 2014-04-22
IL234405A (en) 2015-04-30
PH12015502801B1 (en) 2016-10-03
KR20140066704A (ko) 2014-06-02
SG10201407430TA (en) 2014-12-30
EP2598501A1 (en) 2013-06-05
KR20170055565A (ko) 2017-05-19
US9340535B2 (en) 2016-05-17
EP2602258B1 (en) 2014-03-19
CA2791142A1 (en) 2013-03-26
AU2015260762A1 (en) 2016-02-04
MY190878A (en) 2022-05-13
ES2466221T3 (es) 2014-06-09
JP6161614B2 (ja) 2017-07-12
PL2602258T3 (pl) 2014-08-29
AU2015260762B2 (en) 2016-06-09
EP2573086A1 (en) 2013-03-27
PH12015502801A1 (en) 2016-10-03
CN103842359A (zh) 2014-06-04
MX2014003389A (es) 2014-07-09
NZ718867A (en) 2016-05-27
AR120291A2 (es) 2022-02-09
AU2012314536A1 (en) 2014-02-06
MX338736B (es) 2016-04-29
EP2598501B1 (en) 2014-03-12
TW201317234A (zh) 2013-05-01
MY185063A (en) 2021-04-30
PE20141148A1 (es) 2014-09-15
DK2598501T3 (da) 2014-04-22
TW201625603A (zh) 2016-07-16
ZA201401773B (en) 2015-12-23
UA119574C2 (uk) 2019-07-10
ES2462492T3 (es) 2014-05-23
PT2598501E (pt) 2014-06-25
EP2602258B8 (en) 2016-09-28
TWI532739B (zh) 2016-05-11
CN103842359B (zh) 2016-05-25
EP2602258A1 (en) 2013-06-12
CL2014000149A1 (es) 2014-09-05
AR088043A1 (es) 2014-05-07
KR101768295B1 (ko) 2017-08-14
TWI567070B (zh) 2017-01-21
MX371088B (es) 2020-01-16
US20140221433A1 (en) 2014-08-07
JO3734B1 (ar) 2021-01-31
PL2598501T3 (pl) 2014-08-29
JP6353022B2 (ja) 2018-07-04
JP2014528948A (ja) 2014-10-30
RU2014107430A (ru) 2015-11-10
AU2012314536B2 (en) 2016-01-14
UA115317C2 (uk) 2017-10-25

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