ES247882A1 - Procedimiento para la obtencion de compuestos carbociclicos - Google Patents

Procedimiento para la obtencion de compuestos carbociclicos

Info

Publication number: ES247882A1
Authority: ES; Spain
Prior art keywords: lower alkyl; acid; benzyl; tertiary amino; reacting
Prior art date: 1958-03-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES0247882A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

BASF Schweiz AG

Original Assignee

Ciba Geigy AG

Ciba AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1958-03-20

Filing date

1959-03-13

Publication date

1959-12-16

1959-03-13 Application filed by Ciba Geigy AG, Ciba AG filed Critical Ciba Geigy AG

1959-12-16 Publication of ES247882A1 publication Critical patent/ES247882A1/es

Status Expired legal-status Critical Current

Links

125000003454 indenyl group Chemical class C1(C=CC2=CC=CC=C12)* 0.000 title 1
239000002253 acid Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
-1 alkyl Grignard reagent Chemical class 0.000 abstract 3
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
150000001204 N-oxides Chemical class 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
239000002585 base Substances 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
229920000137 polyphosphoric acid Polymers 0.000 abstract 2
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
239000003826 tablet Substances 0.000 abstract 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
HFLYLOMENQCOGF-UHFFFAOYSA-N 3-benzyl-5-(dimethylamino)-1-phenylpentan-2-one Chemical compound C(C1=CC=CC=C1)C(C(CC1=CC=CC=C1)=O)CCN(C)C HFLYLOMENQCOGF-UHFFFAOYSA-N 0.000 abstract 1
XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 abstract 1
IYXGSMUGOJNHAZ-UHFFFAOYSA-N Ethyl malonate Chemical compound CCOC(=O)CC(=O)OCC IYXGSMUGOJNHAZ-UHFFFAOYSA-N 0.000 abstract 1
239000007818 Grignard reagent Substances 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000012445 acidic reagent Substances 0.000 abstract 1
150000001339 alkali metal compounds Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229940125715 antihistaminic agent Drugs 0.000 abstract 1
239000000739 antihistaminic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
CREXVNNSNOKDHW-UHFFFAOYSA-N azaniumylideneazanide Chemical group N[N] CREXVNNSNOKDHW-UHFFFAOYSA-N 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
239000006071 cream Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000911 decarboxylating effect Effects 0.000 abstract 1
125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
239000008298 dragée Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
239000000839 emulsion Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002430 hydrocarbons Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1
SCEZYJKGDJPHQO-UHFFFAOYSA-M magnesium;methanidylbenzene;chloride Chemical compound [Mg+2].[Cl-].[CH2-]C1=CC=CC=C1 SCEZYJKGDJPHQO-UHFFFAOYSA-M 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000002674 ointment Substances 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1
125000001302 tertiary amino group Chemical group 0.000 abstract 1
238000011200 topical administration Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES0247882A 1958-03-20 1959-03-13 Procedimiento para la obtencion de compuestos carbociclicos Expired ES247882A1 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US72264158A	1958-03-20	1958-03-20
US74432858A	1958-06-25	1958-06-25
US78531459A	1959-01-07	1959-01-07

Publications (1)

Publication Number	Publication Date
ES247882A1 true ES247882A1 (es)	1959-12-16

Family

ID=27419038

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES0247882A Expired ES247882A1 (es)	1958-03-20	1959-03-13	Procedimiento para la obtencion de compuestos carbociclicos

Country Status (3)

Country	Link
CH (3)	CH391722A (es)
ES (1)	ES247882A1 (es)
GB (1)	GB912684A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10033459A1 (de) *	2000-07-10	2002-01-24	Gruenenthal Gmbh	Cyclische substituierte Aminomethylverbindungen und diese Verbindungen enthaltende Arzeimittel

1959
- 1959-03-11 CH CH1416163A patent/CH391722A/de unknown
- 1959-03-11 CH CH1416263A patent/CH391723A/de unknown
- 1959-03-11 CH CH7065659A patent/CH394229A/de unknown
- 1959-03-13 ES ES0247882A patent/ES247882A1/es not_active Expired
- 1959-03-20 GB GB9814/59A patent/GB912684A/en not_active Expired

Also Published As

Publication number	Publication date
CH391723A (de)	1965-05-15
CH394229A (de)	1965-06-30
CH391722A (de)	1965-05-15
GB912684A (en)	1962-12-12

Publication	Publication Date	Title
GB1221324A (en)	1971-02-03	New processes for the production of benzazepine derivatives
ES334942A1 (es)	1968-03-01	Un procedimiento de preparacion de derivados nitrogenados.
ES8103743A1 (es)	1981-03-16	Un metodo para la preparacion de derivados de ftalimidina
GB904208A (en)	1962-08-22	New phenthiazine derivatives and processes for their preparation
FR1159125A (fr)	1958-06-23	Procédé pour préparer des dérivés de la phényl-thiazine présentant comme substituant basique un noyau hétérocyclique contenant un atome d'azote
ES453690A1 (es)	1977-12-01	Procedimiento para la preparacion de compuestos heterocicli-cos.
GB962293A (en)	1964-07-01	New sydnonimines and process for their manufacture
ES247882A1 (es)	1959-12-16	Procedimiento para la obtencion de compuestos carbociclicos
GB915804A (en)	1963-01-16	Process for the production of basically substituted carboxylic acid amides
ES448629A1 (es)	1977-07-01	Procedimiento para la preparacion de nuevos derivados de 1,4-bis-(carboxil-alcohil-benzoxazolil)-naftaleno.
GB858792A (en)	1961-01-18	New pyridazine derivatives and processes for their manufacture
GB1096983A (en)	1967-12-29	5-nitrothiazolyl-dioxo-diazacycloalkanes and process for their manufacture
GB1120186A (en)	1968-07-17	Cyclohexene amino acid derivatives and process for their preparation
ES359070A1 (es)	1970-05-16	Procedimiento para la preparacion de derivados de la fena- tridina.
GB1010231A (en)	1965-11-17	Substituted 3-phenyl-5-imino-4,5 dihydro-1,2,4-oxadiazoles, process for their manufacture and therapeutic compositions containing same
ES266752A1 (es)	1961-09-16	Un procedimiento para la preparaciën de un derivado de sulfanilamidoquinazolina
JPS6438063A (en)	1989-02-08	Flugimide compound and production thereof
GB1011039A (en)	1965-11-24	Improvements in or relating to propynylamides
OA06528A (fr)	1981-07-31	2-aminoalkyl-5-pyridinols, procédé pour leur préparation, compositions pharmaceutiques contenant ces composés et leurs utilisations thérapeutiques.
GB967890A (en)	1964-08-26	Improvements in antibiotics
GB969790A (en)	1964-09-16	New aminoalkyl aryloxyalkanoic esters of use as local anaesthetics and a process for their preparation
ES267254A1 (es)	1961-11-01	Procedimiento para la preparaciën de nuevos derivados de azetidina
GB861938A (en)	1961-03-01	Tetrahydrofuran carbamates
GB992565A (en)	1965-05-19	Acid amides and a process for the manufacture thereof
GB936685A (en)	1963-09-11	Heterocyclic compounds