ES248944A1 - Procedimiento para la preparacion de nuevos compuestos esteroides - Google Patents
Procedimiento para la preparacion de nuevos compuestos esteroidesInfo
- Publication number
- ES248944A1 ES248944A1 ES0248944A ES248944A ES248944A1 ES 248944 A1 ES248944 A1 ES 248944A1 ES 0248944 A ES0248944 A ES 0248944A ES 248944 A ES248944 A ES 248944A ES 248944 A1 ES248944 A1 ES 248944A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- allopregnane
- diol
- treatment
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 5
- -1 STEROID COMPOUNDS Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 238000006735 epoxidation reaction Methods 0.000 abstract 2
- HXUKLEOOKNOIJM-UHFFFAOYSA-N 2-cyclopentylpropanoic acid Chemical class OC(=O)C(C)C1CCCC1 HXUKLEOOKNOIJM-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB12998/58A GB882387A (en) | 1958-04-24 | 1958-04-24 | 6ª--methyl-17ª--hydroxyprogesterone and esters thereof and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES248944A1 true ES248944A1 (es) | 1959-12-01 |
Family
ID=10014962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0248944A Expired ES248944A1 (es) | 1958-04-24 | 1959-04-23 | Procedimiento para la preparacion de nuevos compuestos esteroides |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE578036A (da) |
| CH (1) | CH372047A (da) |
| DK (1) | DK105018C (da) |
| ES (1) | ES248944A1 (da) |
| FR (1) | FR249M (da) |
| GB (1) | GB882387A (da) |
-
1958
- 1958-04-24 GB GB12998/58A patent/GB882387A/en not_active Expired
-
1959
- 1959-04-20 CH CH7225859A patent/CH372047A/de unknown
- 1959-04-22 DK DK142259AA patent/DK105018C/da active
- 1959-04-23 ES ES0248944A patent/ES248944A1/es not_active Expired
- 1959-04-23 BE BE578036A patent/BE578036A/fr unknown
-
1960
- 1960-08-18 FR FR836093A patent/FR249M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH372047A (de) | 1963-09-30 |
| BE578036A (fr) | 1959-10-23 |
| FR249M (fr) | 1961-03-06 |
| GB882387A (en) | 1961-11-15 |
| DK105018C (da) | 1966-08-08 |
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