ES2491340A1 - Nueva composición de conjugados de chitosan o derivados con tiolactonas - Google Patents

Nueva composición de conjugados de chitosan o derivados con tiolactonas Download PDF

Info

Publication number
ES2491340A1
ES2491340A1 ES201300228A ES201300228A ES2491340A1 ES 2491340 A1 ES2491340 A1 ES 2491340A1 ES 201300228 A ES201300228 A ES 201300228A ES 201300228 A ES201300228 A ES 201300228A ES 2491340 A1 ES2491340 A1 ES 2491340A1
Authority
ES
Spain
Prior art keywords
conjugates
thiolactones
derivatives
properties
chitosan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201300228A
Other languages
English (en)
Other versions
ES2491340B1 (es
Inventor
María Violante DE PAZ BÁÑEZ
María Rosa JIMÉNEZ-CASTELLANOS BALLESTEROS
María Jesús LUCERO MUÑOZ
Marta CASAS DELGADO
Cristina FERRIS VILLANUEVA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
Original Assignee
Universidad de Sevilla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Sevilla filed Critical Universidad de Sevilla
Priority to ES201300228A priority Critical patent/ES2491340B1/es
Publication of ES2491340A1 publication Critical patent/ES2491340A1/es
Application granted granted Critical
Publication of ES2491340B1 publication Critical patent/ES2491340B1/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a conjugados del chitosan (o sus derivados) con tiolactonas (síntesis y estructuras químicas), en las composiciones cosméticas, biomédicas-farmacéuticas que contienen dichos conjugados, y a sus aplicaciones, que presentan las siguientes propiedades: no tóxicos, biodegradables, con excelentes propiedades de mucoadhesión, cohesión e inhibición enzimática, con propiedades mejoradas de permeabilidad, captación celular y gran estabilidad como agentes de recubrimiento de cánulas y otros dispositivos médicos y como sistemas transportadores de fármacos, esto es, con largos tiempos de permanencia de los principios activos englobados, lo que garantiza un excelente control en la liberación de los fármacos incluidos en la formulación y además, capaces de gelificar en presencia de oxígeno.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10
imagen11
imagen12
imagen13
imagen14
imagen15
imagen16
imagen17
imagen18
imagen19
imagen20
imagen21
imagen22
imagen23
imagen24
imagen25
imagen26
imagen27
imagen28
imagen29
imagen30
imagen31
imagen32
imagen33
imagen34

Claims (1)

  1. imagen1
    imagen2
ES201300228A 2013-03-05 2013-03-05 Nueva composición de conjugados de chitosan o derivados con tiolactonas Active ES2491340B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201300228A ES2491340B1 (es) 2013-03-05 2013-03-05 Nueva composición de conjugados de chitosan o derivados con tiolactonas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201300228A ES2491340B1 (es) 2013-03-05 2013-03-05 Nueva composición de conjugados de chitosan o derivados con tiolactonas

Publications (2)

Publication Number Publication Date
ES2491340A1 true ES2491340A1 (es) 2014-09-05
ES2491340B1 ES2491340B1 (es) 2015-03-31

Family

ID=51452824

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201300228A Active ES2491340B1 (es) 2013-03-05 2013-03-05 Nueva composición de conjugados de chitosan o derivados con tiolactonas

Country Status (1)

Country Link
ES (1) ES2491340B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110217084A (zh) * 2019-06-28 2019-09-10 佛山科学技术学院 一种汽车防护围栏

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3104325C (en) 2016-10-19 2023-01-24 Alcon Inc. Hydrophilic copolymer with pendant thiol groups

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040236095A1 (en) * 2001-08-31 2004-11-25 Martin Prinz Chitosan-thio-amidine conjugates and their cosmetic as well as pharmeceutic use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040236095A1 (en) * 2001-08-31 2004-11-25 Martin Prinz Chitosan-thio-amidine conjugates and their cosmetic as well as pharmeceutic use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
K Juntapram et al, Carbohydrate Polymers marzo 2012, vol 87, nº 4, págs 2399-2408. "Synthesis and characterization of chitosan-homocysteine thiolactone as a mucoadhesive polymer", todo el documento *
T Schmitz et al, International Journal of Pharmaceutics 2008, vol 347, nº 1, págs 79-85. "Synthesis and characterization of a chitosan-N-acetyl cysteine conjugate" *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110217084A (zh) * 2019-06-28 2019-09-10 佛山科学技术学院 一种汽车防护围栏
CN110217084B (zh) * 2019-06-28 2024-03-26 佛山科学技术学院 一种汽车防护围栏

Also Published As

Publication number Publication date
ES2491340B1 (es) 2015-03-31

Similar Documents

Publication Publication Date Title
TR201904455T4 (tr) Nükleer taşıma modülatörleri olarak 1,2,4-triazoller ve bunların kullanımları.
UY35268A (es) Modulador del receptor de andrógeno 4-[7-(6-ciano-5-trifluorometilpiridin-3-il)-8-oxo-6-tioxo-5,7-diazaespiro[3.4]oct-5-il]-2-fluoro-N-metilbenzamida y sus usos
EA201591003A1 (ru) Производные бороновой кислоты и их терапевтическое применение
SV2017005461A (es) Benzamidas sustituidas con 1,3-tiazol-2-ilo
ECSP12011915A (es) Derivados de purina o deazapurina útiles para el tratamiento de inter alia infecciones virales.
MX2015012456A (es) Compuestos heterociclicos y usos de los mismos.
BR112015022263A2 (pt) N-acil-n’-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica
EA201591004A1 (ru) Производные бороновой кислоты и их терапевтическое применение
CL2015003357A1 (es) Derivados de nucleósidos 4'-fluoro-2'-metil sustituidos
CL2012002189A1 (es) Compuestos derivados de pirrolidina-2-carboxamidas sustituidas; inhibidores de la interaccion mdm2-p53; composicion farmaceutica; y su uso para el tratamiento del cancer, en particular de tumores solidos.
BR112015005878A2 (pt) nanopartículas terapêuticas compreendendo agente terapêutico e métodos de preparar e usar as mesmas
UY35827A (es) Derivados de triazolopirazina como inhibidores de la proteína brd4
ECSP20023535A (es) Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
EA201591632A1 (ru) Цитотоксические и антимитотические соединения и способы их применения
EA201890436A1 (ru) Жидкая полимерная система доставки для длительного введения лекарственных средств
CL2008001123A1 (es) Compuestos derivados de acido lipoico; formulacion farmaceutica que lo comprende; y uso en el tratamiento del cancer.
EA201390612A1 (ru) Биоразлагаемая композиция для доставки лекарственного средства
DOP2015000170A (es) Compuestos químicos
BR112017000246A2 (pt) composto, sal farmaceuticamente aceitável de um composto, composição farmacêutica, e, uso de um composto ou de um sal
CL2015003444A1 (es) Compuestos de 3,4 dihidroisoquinolin-2(1h)-ilo
EA201591196A1 (ru) Композиции и способы для трансдермальной доставки гормонов и других лекарственных средств
CU24352B1 (es) DERIVADOS DE ISOINDOLINA O ISOQUINOLINA ÚTILES COMO INHIBIDORES ANTIAPOPTÓTICOS DE Bcl-2 EN EL TRATAMIENTO DE CÁNCERES Y ENFERMEDADES AUTOINMUNES Y DEL SISTEMA INMUNITARIO, Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN
PY2039849A (es) Derivados de 3,6-diamino-piridazin-3-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos
CL2017001539A1 (es) Compuestos indenil, composiciones farmacéuticas y sus usos médicos de los mismos
MX382596B (es) Composiciones que contienen arsénico y su uso en métodos de tratamiento.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 2491340

Country of ref document: ES

Kind code of ref document: B1

Effective date: 20150331