ES2505253T3 - Método y aparato para aplicar fluidos a una muestra biológica - Google Patents
Método y aparato para aplicar fluidos a una muestra biológica Download PDFInfo
- Publication number
- ES2505253T3 ES2505253T3 ES05775429.3T ES05775429T ES2505253T3 ES 2505253 T3 ES2505253 T3 ES 2505253T3 ES 05775429 T ES05775429 T ES 05775429T ES 2505253 T3 ES2505253 T3 ES 2505253T3
- Authority
- ES
- Spain
- Prior art keywords
- biological sample
- applying fluids
- moistened
- curved
- fluids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/112499—Automated chemical analysis with sample on test slide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Un método automatizado que pone en contacto una muestra biológica situada en un portaobjetos para microscopio con una solución que contiene una biomolécula conjugada, que consiste en desplazar una superficie curvada humedecida con la solución cerca de dicha muestra biológica de manera que la distancia que separa dicha superficie curvada humedecida y dicha muestra biológica sea suficiente para formar una capa de menisco líquida que se desplaza entre las dos.
Description
Claims (1)
-
imagen1 imagen2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59084304P | 2004-07-23 | 2004-07-23 | |
| US590843P | 2004-07-23 | ||
| PCT/US2005/026014 WO2006012498A1 (en) | 2004-07-23 | 2005-07-21 | Method and apparatus for applying fluids to a biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2505253T3 true ES2505253T3 (es) | 2014-10-09 |
Family
ID=35241206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05775429.3T Expired - Lifetime ES2505253T3 (es) | 2004-07-23 | 2005-07-21 | Método y aparato para aplicar fluidos a una muestra biológica |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7820381B2 (es) |
| EP (1) | EP1771730B1 (es) |
| JP (1) | JP4806410B2 (es) |
| AU (1) | AU2005267018B2 (es) |
| CA (1) | CA2573787C (es) |
| DK (1) | DK1771730T3 (es) |
| ES (1) | ES2505253T3 (es) |
| WO (1) | WO2006012498A1 (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| WO2006012498A1 (en) | 2004-07-23 | 2006-02-02 | Ventana Medical Systems, Inc. | Method and apparatus for applying fluids to a biological sample |
| US8034610B2 (en) * | 2005-04-21 | 2011-10-11 | Celerus Diagnostics, Inc. | Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry |
| US8883509B2 (en) * | 2007-07-10 | 2014-11-11 | Ventana Medical Systems, Inc. | Apparatus and method for biological sample processing |
| WO2009085842A1 (en) * | 2007-12-21 | 2009-07-09 | Ventana Medical Systems, Inc. | Relative-translational liquid application and removal |
| US9602777B2 (en) | 2008-04-25 | 2017-03-21 | Roche Diagnostics Hematology, Inc. | Systems and methods for analyzing body fluids |
| JP2012515931A (ja) | 2008-04-25 | 2012-07-12 | ウィンケルマン、ジェイムズ | 全血球数及び白血球百分率を決定するシステム及び方法 |
| WO2010025425A1 (en) | 2008-08-29 | 2010-03-04 | Angros Lee H | Multiplexed microscope slide staining apparatus |
| WO2010074915A2 (en) * | 2008-12-23 | 2010-07-01 | Ventana Medical Systems, Inc. | Evaporation mitigation for slide staining apparatus |
| WO2010078214A1 (en) * | 2008-12-31 | 2010-07-08 | Ventana Medical Systems, Inc. | Automated dewatering apparatus |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| JP5611363B2 (ja) * | 2009-11-13 | 2014-10-22 | ベンタナ メディカル システムズ, インコーポレイテッド | 調整可能な体積を収容する薄膜処理装置 |
| US9498791B2 (en) | 2009-11-13 | 2016-11-22 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US10509216B2 (en) | 2012-12-26 | 2019-12-17 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for aligning slides |
| WO2011139978A1 (en) * | 2010-05-04 | 2011-11-10 | Ventana Medical Systems, Inc. | Moving meniscus rinsing and mixing in cell staining |
| WO2012048154A1 (en) | 2010-10-06 | 2012-04-12 | Biocare Medical, Llc | Methods and systems for efficient processing of biological samples |
| JP5801410B2 (ja) * | 2010-11-10 | 2015-10-28 | コンスティテューション・メディカル・インコーポレイテッドConstitution Medical, Inc. | 検査用に生物試料を準備するための自動化されたシステムおよび方法 |
| US9945763B1 (en) | 2011-02-18 | 2018-04-17 | Biocare Medical, Llc | Methods and systems for immunohistochemistry heat retrieval of biological samples |
| CN107255584B (zh) | 2011-02-28 | 2021-04-13 | 安捷伦科技有限公司 | 用于预处理包埋的生物样本的不混溶两相系统 |
| EP2819775A1 (en) | 2012-03-01 | 2015-01-07 | Victorious Medical Systems ApS | Method and system for distributing and agitating an amount of liquid over a microscope slide |
| JP5981664B2 (ja) * | 2012-12-26 | 2016-08-31 | ベンタナ メディカル システムズ, インコーポレイテッド | 対向部および対向部を有する自動検体処理システム |
| JP6117936B2 (ja) * | 2012-12-26 | 2017-04-19 | ベンタナ メディカル システムズ, インコーポレイテッド | 標本処理システムおよび蒸発を抑える方法 |
| USD728120S1 (en) | 2013-03-15 | 2015-04-28 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
| ES2939124T3 (es) | 2013-04-05 | 2023-04-19 | Roche Diagnostics Hematology Inc | Sistemas y procedimientos automatizados para preparar muestras biológicas para su examen |
| US9121798B2 (en) | 2013-08-26 | 2015-09-01 | Rarecyte, Inc. | Apparatus for spreading a fluid across a substrate and method of using the same |
| CN111089980B (zh) | 2013-12-13 | 2023-08-15 | 文塔纳医疗系统公司 | 生物样本的自动化组织学处理及相关的技术 |
| US10634590B2 (en) | 2014-03-11 | 2020-04-28 | Emd Millipore Corporation | IHC, tissue slide fluid exchange disposable and system |
| US10209166B2 (en) | 2014-11-18 | 2019-02-19 | Alfonso Heras | System and method for processing biological specimens |
| WO2018118786A1 (en) | 2016-12-19 | 2018-06-28 | Ventana Medical Systems, Inc. | Methods and systems for quantitative immunohistochemistry |
| ES2869903T3 (es) | 2016-12-19 | 2021-10-26 | Ventana Med Syst Inc | Sistema pasivo accionado por gravedad para el tratamiento de un efluente en un sistema de diagnóstico |
| JP7025430B2 (ja) | 2016-12-21 | 2022-02-24 | ヴェンタナ メディカル システムズ, インク. | 試薬送達のための方法、システム、及び固体組成物 |
| WO2018119295A1 (en) | 2016-12-22 | 2018-06-28 | Ventana Medical Systems, Inc. | Fully automated nucleic acid extraction method for tissue samples |
| CN108387428A (zh) * | 2018-02-26 | 2018-08-10 | 深圳安诺康生物医疗有限公司 | 一种病理切片的染色方法 |
| CN113785184B (zh) | 2019-05-14 | 2025-02-28 | 文塔纳医疗系统公司 | 包括生物学样品处理腔室的系统 |
| WO2021224293A1 (en) | 2020-05-07 | 2021-11-11 | Ventana Medical Systems, Inc. | Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples |
| WO2022008641A1 (en) | 2020-07-08 | 2022-01-13 | Roche Sequencing Solutions, Inc. | Split-pool synthesis apparatus and methods of performing split-pool synthesis |
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| US4203797A (en) | 1977-05-09 | 1980-05-20 | Cytologiska Centrallaboratoriet Ab | Method of and apparatus for applying cover-slips to slides carrying specimens for microscopic examination |
| US4146414A (en) | 1977-05-09 | 1979-03-27 | Cytologiska Centrallaboratoriet Ab | Method for applying cover-slips to slides carrying specimens for microscopic examination |
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| US4392450A (en) | 1981-02-12 | 1983-07-12 | Prevo Donald L | Device for spreading monolayered films |
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| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5425918A (en) * | 1990-07-18 | 1995-06-20 | Australian Biomedical Corporation | Apparatus for automatic tissue staining for immunohistochemistry |
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| US5696887A (en) | 1991-08-05 | 1997-12-09 | Biotek Solutions, Incorporated | Automated tissue assay using standardized chemicals and packages |
| US5256241A (en) | 1992-08-28 | 1993-10-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method for controlling protein crystallization |
| CA2105828C (en) | 1992-09-29 | 2000-02-01 | Charles Leo Carrico, Jr. | Apparatus for depositing and staining cytological material on a microscope slide |
| US5308460A (en) * | 1992-10-30 | 1994-05-03 | Glyko, Incorporated | Rapid synthesis and analysis of carbohydrates |
| AUPN038995A0 (en) | 1995-01-05 | 1995-01-27 | Australian Biomedical Corporation Limited | Method and apparatus for human or animal cell sample treatment |
| JP3005480B2 (ja) * | 1996-02-15 | 2000-01-31 | アロカ株式会社 | 生物組織の処理装置 |
| AUPN923596A0 (en) * | 1996-04-12 | 1996-05-09 | Australian Biomedical Corporation Limited | Method and apparatus for treatment of human or animal cell samples |
| US6192945B1 (en) | 1997-08-11 | 2001-02-27 | Ventana Medical Systems, Inc. | Fluid dispenser |
| US6093574A (en) | 1997-08-11 | 2000-07-25 | Ventana Medical Systems | Method and apparatus for rinsing a microscope slide |
| US6405609B1 (en) | 1998-02-27 | 2002-06-18 | Ventana Medical Systems, Inc. | System and method of aspirating and dispensing reagent |
| JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
| WO1999063342A1 (en) * | 1998-06-02 | 1999-12-09 | Ventana Medical Systems, Inc. | Method for staining biological specimens by combining unstable reagents on a microscope slide |
| US6544798B1 (en) | 1999-02-26 | 2003-04-08 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
| US7361821B2 (en) * | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
| WO2004038037A2 (en) * | 2002-09-20 | 2004-05-06 | Intel Corporation | Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (spm) reading |
| JP2004357698A (ja) | 2003-05-09 | 2004-12-24 | Aloka Co Ltd | 処理装置 |
| JP2004333349A (ja) | 2003-05-09 | 2004-11-25 | Aloka Co Ltd | 処理装置 |
| JP4173046B2 (ja) | 2003-05-09 | 2008-10-29 | アロカ株式会社 | 処理装置 |
| JP4312499B2 (ja) | 2003-05-09 | 2009-08-12 | アロカ株式会社 | 処理装置 |
| CA2526126C (en) * | 2003-05-19 | 2012-05-15 | Ventana Medical Systems, Inc. | Electrophoretic in situ tissue staining |
| US20070199519A1 (en) * | 2003-08-25 | 2007-08-30 | Innovative Cleaning Equipment, Inc. | Teat foam ring |
| WO2005064309A1 (en) | 2003-12-23 | 2005-07-14 | Ventana Medical Systems, Inc. | Method and apparatus for efficient thin film fluid |
| WO2006012498A1 (en) | 2004-07-23 | 2006-02-02 | Ventana Medical Systems, Inc. | Method and apparatus for applying fluids to a biological sample |
| US8034610B2 (en) | 2005-04-21 | 2011-10-11 | Celerus Diagnostics, Inc. | Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry |
-
2005
- 2005-07-21 WO PCT/US2005/026014 patent/WO2006012498A1/en not_active Ceased
- 2005-07-21 DK DK05775429.3T patent/DK1771730T3/da active
- 2005-07-21 AU AU2005267018A patent/AU2005267018B2/en not_active Expired
- 2005-07-21 EP EP05775429.3A patent/EP1771730B1/en not_active Expired - Lifetime
- 2005-07-21 JP JP2007522795A patent/JP4806410B2/ja not_active Expired - Lifetime
- 2005-07-21 US US11/187,183 patent/US7820381B2/en active Active
- 2005-07-21 ES ES05775429.3T patent/ES2505253T3/es not_active Expired - Lifetime
- 2005-07-21 CA CA2573787A patent/CA2573787C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008507701A (ja) | 2008-03-13 |
| JP4806410B2 (ja) | 2011-11-02 |
| DK1771730T3 (da) | 2014-09-08 |
| EP1771730B1 (en) | 2014-08-20 |
| US20060019302A1 (en) | 2006-01-26 |
| CA2573787A1 (en) | 2006-02-02 |
| WO2006012498A1 (en) | 2006-02-02 |
| US7820381B2 (en) | 2010-10-26 |
| AU2005267018A1 (en) | 2006-02-02 |
| EP1771730A1 (en) | 2007-04-11 |
| AU2005267018B2 (en) | 2008-10-23 |
| CA2573787C (en) | 2010-11-30 |
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