ES2528272T3 - Métodos de reparación de cartílago - Google Patents

Métodos de reparación de cartílago Download PDF

Info

Publication number
ES2528272T3
ES2528272T3 ES06839104.4T ES06839104T ES2528272T3 ES 2528272 T3 ES2528272 T3 ES 2528272T3 ES 06839104 T ES06839104 T ES 06839104T ES 2528272 T3 ES2528272 T3 ES 2528272T3
Authority
ES
Spain
Prior art keywords
poly
cartilage repair
repair methods
acid
polyester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06839104.4T
Other languages
English (en)
Inventor
Mitchell S. Seyedin
Matthew Matava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isto Technologies Inc
Original Assignee
Isto Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isto Technologies Inc filed Critical Isto Technologies Inc
Application granted granted Critical
Publication of ES2528272T3 publication Critical patent/ES2528272T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Composite Materials (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

Una membrana en combinación con células madre mesenquimales autólogas, dicha membrana comprende un poliéster seleccionado del grupo que consiste en poli(ácido láctico) (PLA), poli(ácido glicólico) (PGA) y un copolímero que comprende poli(ácido láctico) y poli(ácido glicólico) (PLGA), el poliéster se enreda con ácido hialurónico, para el uso en un método para reparar un defecto de cartílago hialino en una articulación de mamífero.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8

Claims (1)

  1. imagen1
ES06839104.4T 2005-12-07 2006-12-07 Métodos de reparación de cartílago Active ES2528272T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74802705P 2005-12-07 2005-12-07
US748027P 2005-12-07
PCT/US2006/046576 WO2007067637A2 (en) 2005-12-07 2006-12-07 Cartilage repair methods

Publications (1)

Publication Number Publication Date
ES2528272T3 true ES2528272T3 (es) 2015-02-06

Family

ID=38123465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06839104.4T Active ES2528272T3 (es) 2005-12-07 2006-12-07 Métodos de reparación de cartílago

Country Status (6)

Country Link
US (1) US8444968B2 (es)
EP (1) EP1973554B1 (es)
JP (1) JP2009518132A (es)
CA (1) CA2631520A1 (es)
ES (1) ES2528272T3 (es)
WO (1) WO2007067637A2 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0896825B1 (en) * 1997-08-14 2002-07-17 Sulzer Innotec Ag Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7824711B2 (en) 2003-12-11 2010-11-02 Isto Technologies, Inc. Particulate cartilage system
US8192759B2 (en) * 2004-07-12 2012-06-05 Isto Technologies, Inc. Matrix made of polyester polymers entangled with hyaluronic polymers useful for supporting tissue repair
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
JP5292533B2 (ja) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
EP1764117A1 (en) * 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
ES2528272T3 (es) 2005-12-07 2015-02-06 Isto Technologies Inc. Métodos de reparación de cartílago
US20080138414A1 (en) * 2006-12-08 2008-06-12 Smith & Nephew, Inc. Methods of Regenerating Cartilage
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US8464125B2 (en) * 2009-12-10 2013-06-11 Intel Corporation Instruction-set architecture for programmable cyclic redundancy check (CRC) computations
US9119605B2 (en) 2010-05-06 2015-09-01 Zimmer, Inc. Synthetic polymer adhesives and methods for making, using and delivering the same
AU2012275335B2 (en) 2011-06-29 2017-04-20 Biorestorative Therapies, Inc. Brown fat cell compositions and methods
AU2012323963B2 (en) * 2011-10-13 2017-10-12 Solventum Intellectual Properties Company Stimulation of cartilage repair using reduced pressure treatment
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
AU2014253920B2 (en) 2013-04-19 2019-07-04 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
AU2015245194B2 (en) * 2014-04-08 2018-07-26 Antonio Sambusseti Resorbable device for the reconstruction of cartilage
EP3197496B1 (en) 2014-09-23 2021-05-26 Cytex Therapeutics, Inc. Articular cartilage repair
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10524774B2 (en) 2015-04-02 2020-01-07 Arthrex, Inc. Method of repairing cartilage defects
US10524775B2 (en) 2015-07-02 2020-01-07 Arthrex, Inc. Methods of repairing cartilage defects
KR102355223B1 (ko) 2016-05-16 2022-01-25 아스렉스, 인코퍼레이티드 무릎 관절낭 파열 및 복구
US10022231B2 (en) 2016-07-22 2018-07-17 Cytex Therapeutics, Inc. Articular cartilage repair
JP7480454B2 (ja) * 2018-06-05 2024-05-10 メディポスト・カンパニー・リミテッド 有効成分として間葉系幹細胞を含む炎症性疾患の予防又は治療のための医薬組成物

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438102A (en) 1982-08-10 1984-03-20 Ciro's Touch, Ltd. Method of promoting tissue growth
US4692371A (en) 1985-07-30 1987-09-08 Kimberly-Clark Corporation High temperature method of making elastomeric materials and materials obtained thereby
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5290552A (en) 1988-05-02 1994-03-01 Matrix Pharmaceutical, Inc./Project Hear Surgical adhesive material
WO1993000050A1 (en) 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
ITPD940054A1 (it) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US5855608A (en) * 1994-05-13 1999-01-05 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US20030086975A1 (en) 2001-11-08 2003-05-08 Timothy Ringeisen Method for making a porous Polymeric material
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5700289A (en) 1995-10-20 1997-12-23 North Shore University Hospital Research Corporation Tissue-engineered bone repair using cultured periosteal cells
IT1282207B1 (it) 1995-11-20 1998-03-16 Fidia Advanced Biopolymers Srl Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5916585A (en) 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
ES2205467T3 (es) 1997-03-31 2004-05-01 The Regents Of The University Of Michigan Matrices biodegradables de poros abiertos.
DE69809892T2 (de) 1997-04-04 2003-08-28 Fidia Advanced Biopolymers S.R.L., Brindisi N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
WO1999001143A1 (en) 1997-07-03 1999-01-14 Orquest, Inc. Cross-linked polysaccharide drug carrier
CA2212300A1 (en) 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
US6395253B2 (en) * 1998-04-23 2002-05-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production
WO2000021470A1 (en) * 1998-10-12 2000-04-20 Therics, Inc. Composites for tissue regeneration and methods of manufacture thereof
US6328765B1 (en) 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
US6663870B2 (en) 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
AU5701200A (en) 1999-07-02 2001-01-22 Petrus Besselink Reinforced expandable cage
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
AU1618201A (en) 1999-11-19 2001-05-30 Children's Medical Center Corporation Methods for inducing chondrogenesis and producing de novo cartilage in vitro
CA2402191C (en) 2000-03-24 2012-03-13 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
WO2001087575A2 (en) 2000-05-12 2001-11-22 The Regents Of The University Of Michigan Reverse fabrication of porous materials
JP2004504835A (ja) * 2000-07-29 2004-02-19 スミス　アンド　ネフュー　ピーエルシー 組織インプラント
US6748954B2 (en) 2000-10-27 2004-06-15 The Regents Of The University Of Michigan Drug release from polymer matrices through mechanical stimulation
AU2002247044B2 (en) * 2001-01-30 2006-11-16 Orthogene, Inc. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
DE10111767B4 (de) 2001-03-12 2005-03-24 Schwarz Pharma Ag Verfahren zur Herstellung von Polyestern aus Hydroxycarbonsäuren und Polyolen durch Polykondensation
JP4500898B2 (ja) 2001-03-23 2010-07-14 高木産業株式会社 生物学的組織および組織構築物を製造するための組成物および方法
US7128760B2 (en) 2001-03-27 2006-10-31 Warsaw Orthopedic, Inc. Radially expanding interbody spinal fusion implants, instrumentation, and methods of insertion
US6626950B2 (en) * 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US7252837B2 (en) 2002-06-28 2007-08-07 Ethicon, Inc. Hemostatic wound dressing and method of making same
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20040126405A1 (en) 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells
FI20045223A7 (fi) 2004-06-15 2005-12-16 Bioretec Oy Monitoiminen biohajoava komposiitti ja kirurginen implantti, joka käsittää mainitun komposiitin
US20050148512A1 (en) 2003-11-10 2005-07-07 Angiotech International Ag Medical implants and fibrosis-inducing agents
US7316822B2 (en) * 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
US8192759B2 (en) * 2004-07-12 2012-06-05 Isto Technologies, Inc. Matrix made of polyester polymers entangled with hyaluronic polymers useful for supporting tissue repair
ATE524121T1 (de) 2004-11-24 2011-09-15 Abdou Samy Vorrichtungen zur platzierung eines orthopädischen intervertebralen implantats
ES2528272T3 (es) 2005-12-07 2015-02-06 Isto Technologies Inc. Métodos de reparación de cartílago

Also Published As

Publication number Publication date
EP1973554A4 (en) 2009-11-25
JP2009518132A (ja) 2009-05-07
US8444968B2 (en) 2013-05-21
WO2007067637A3 (en) 2008-12-24
WO2007067637A2 (en) 2007-06-14
US20070128155A1 (en) 2007-06-07
EP1973554A2 (en) 2008-10-01
EP1973554B1 (en) 2015-01-14
CA2631520A1 (en) 2007-06-14

Similar Documents

Publication Publication Date Title
ES2528272T3 (es) Métodos de reparación de cartílago
Lam et al. Photopolymerizable gelatin and hyaluronic acid for stereolithographic 3D bioprinting of tissue‐engineered cartilage
Nguyen et al. Engineering articular cartilage with spatially-varying matrix composition and mechanical properties from a single stem cell population using a multi-layered hydrogel
Wu et al. Preparation and assessment of glutaraldehyde‐crosslinked collagen–chitosan hydrogels for adipose tissue engineering
Masoumi et al. Electrospun PGS: PCL microfibers align human valvular interstitial cells and provide tunable scaffold anisotropy
Lee et al. Scaffold technologies for controlling cell behavior in tissue engineering
Xu et al. Electrospun polycaprolactone 3D nanofibrous scaffold with interconnected and hierarchically structured pores for bone tissue engineering
ES2660204T3 (es) Método de reparación tisular
Roman et al. Developing a tissue engineered repair material for treatment of stress urinary incontinence and pelvic organ prolapse—which cell source?
Azeem et al. The influence of anisotropic nano-to micro-topography on in vitro and in vivo osteogenesis
ES2541486T3 (es) Injertos quirúrgicos para reparar defectos condrales
Singh et al. Engineering three-dimensional macroporous hydroxyethyl methacrylate-alginate-gelatin cryogel for growth and proliferation of lung epithelial cells
Bai et al. Bioprinted living tissue constructs with layer-specific, growth factor-loaded microspheres for improved enthesis healing of a rotator cuff
Liu et al. Prolonged in vitro precultivation alleviates post-implantation inflammation and promotes stable subcutaneous cartilage formation in a goat model
Kim et al. In vitro osteogenic differentiation of human amniotic fluid-derived stem cells on a poly (lactide-co-glycolide)(PLGA)–bladder submucosa matrix (BSM) composite scaffold for bone tissue engineering
Kuppan et al. Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)-based nanofibrous scaffolds to support functional esophageal epithelial cells towards engineering the esophagus
Sivandzade et al. Design and fabrication of injectable microcarriers composed of acellular cartilage matrix and chitosan
Ahn et al. Development of arginine-glycine-aspartate-immobilized 3D printed poly (propylene fumarate) scaffolds for cartilage tissue engineering
Ye et al. Scaffold precoating with human autologous extracellular matrix for improved cell attachment in cardiovascular tissue engineering
Knight et al. Fabrication of a multi-layer three-dimensional scaffold with controlled porous micro-architecture for application in small intestine tissue engineering
WO2013002953A1 (en) Membrane-scaffold composites for tissue engineering applications
Bai et al. Coaxial electrohydrodynamic printing of core–shell microfibrous scaffolds with layer-specific growth factors release for enthesis regeneration
Yen et al. Fabrication of precision scaffolds using liquid-frozen deposition manufacturing for cartilage tissue engineering
Weidenhamer et al. Influence of culture conditions and extracellular matrix alignment on human mesenchymal stem cells invasion into decellularized engineered tissues
Deng et al. Cartilage regeneration using a novel gelatin–chondroitin–hyaluronan hybrid scaffold containing bFGF-impregnated microspheres