ES2530574T3 - Biomarcadores asociados a la nefropatía - Google Patents

Biomarcadores asociados a la nefropatía Download PDF

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Publication number
ES2530574T3
ES2530574T3 ES10735453T ES10735453T ES2530574T3 ES 2530574 T3 ES2530574 T3 ES 2530574T3 ES 10735453 T ES10735453 T ES 10735453T ES 10735453 T ES10735453 T ES 10735453T ES 2530574 T3 ES2530574 T3 ES 2530574T3
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ES
Spain
Prior art keywords
nephropathy
combination
biomarkers
biomarker
level
Prior art date
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Active
Application number
ES10735453T
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English (en)
Inventor
Tzu-Ling Tseng
Ching-Fang Lu
Wei-Ya Lin
Tsai-Wei Hsu
Mary Ya-Ping Yeh
Yi-Ting Chen
Chwei-Shiun Yang
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Industrial Technology Research Institute ITRI
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Industrial Technology Research Institute ITRI
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Filing date
Publication date
Application filed by Industrial Technology Research Institute ITRI filed Critical Industrial Technology Research Institute ITRI
Application granted granted Critical
Publication of ES2530574T3 publication Critical patent/ES2530574T3/es
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4728—Details alpha-Glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Un método de diagnóstico de la nefropatía en un sujeto, que comprende: obtener una muestra de orina de un sujeto que se sospecha que tiene nefropatía, determinar en la muestra de orina un nivel de un biomarcador o de una combinación de biomarcadores seleccionado del grupo que consiste en: (i) receptor-2 similar a Ig asociado a leucocitos o uno de sus fragmentos, y (ii) una combinación del receptor-2 similar a Ig asociado a leucocitos o uno de sus fragmentos y de la alfa- 1-glicoproteína ácida o uno de sus fragmentos, en donde el fragmento de receptor-2 similar a Ig asociado a leucocitos es DFLELLVKGTVPGTEASGFDAP (SEQ ID NO:1) y el fragmento de alfa-1-glicoproteína ácida es GQEHFAHLLILRDTKTYMLAFDVNDEKNWGLS (SEQ ID NO:2); y evaluar si el sujeto tiene nefropatía basándose en el nivel del biomarcador o de la combinación de biomarcadores, en donde un aumento en el nivel del biomarcador o de la combinación de biomarcadores, en comparación con un punto de referencia que representa el nivel del mismo biomarcador o de la combinación de biomarcadores en un sujeto sin nefropatía, indica que el sujeto tiene nefropatía, en donde el punto de referencia es el punto medio entre el nivel medio del biomarcador o de la combinación de biomarcadores en un grupo de pacientes con nefropatía y el de un grupo de sujetos sin nefropatía.
ES10735453T 2009-01-28 2010-01-27 Biomarcadores asociados a la nefropatía Active ES2530574T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14778509P 2009-01-28 2009-01-28
PCT/CA2010/000096 WO2010085878A1 (en) 2009-01-28 2010-01-27 Biomarkers associated with nephropathy

Publications (1)

Publication Number Publication Date
ES2530574T3 true ES2530574T3 (es) 2015-03-03

Family

ID=42395075

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10735453T Active ES2530574T3 (es) 2009-01-28 2010-01-27 Biomarcadores asociados a la nefropatía

Country Status (12)

Country Link
US (5) US20100209948A1 (es)
EP (1) EP2391653B8 (es)
JP (1) JP5524241B2 (es)
CN (1) CN102300875B (es)
BR (1) BRPI1007483B1 (es)
CA (1) CA2748852C (es)
DK (1) DK2391653T3 (es)
ES (1) ES2530574T3 (es)
MX (1) MX2011007810A (es)
PT (1) PT2391653E (es)
TW (1) TWI397687B (es)
WO (1) WO2010085878A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8465980B2 (en) * 2009-01-28 2013-06-18 Industrial Technology Research Institute Urine and serum biomarkers associated with diabetic nephropathy
KR101732706B1 (ko) * 2015-06-05 2017-05-04 압타바이오 주식회사 신증 진단용 마커로서의 sh3yl1의 용도
EP3469372B1 (en) * 2016-06-10 2023-03-08 Warszawski Uniwersytet Medyczny Methods for diagnosis and monitoring using urine proteins as markers in iga nephropathy
CN119165152A (zh) * 2019-01-17 2024-12-20 国立大学法人冈山大学 IgA肾病发病可能性的判断方法及试剂盒

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4640909A (en) * 1985-05-07 1987-02-03 J. T. Baker Chemical Company Bonded phase of silica and carboalkoxyalkyl silanes for solid phase extraction
ES2258793T5 (es) * 1996-05-24 2010-01-25 Biogen Idec Ma Inc. Moduladores de la regeneracion tisular.
US6140076A (en) * 1996-12-06 2000-10-31 Schering Corporation Ig superfamily `dlair` receptors expressed in monocytes
ATE456656T1 (de) * 1996-12-06 2010-02-15 Schering Corp Isolierte gene aus säuger monozyten und betreffende reagentien
CA2356174A1 (en) * 1998-12-21 2000-06-29 Monash University Kidney disease detection and treatment
US20040029175A1 (en) * 1998-12-21 2004-02-12 Comper Wayne D. Method for kidney disease detection
AUPP784398A0 (en) * 1998-12-21 1999-01-21 Monash University Kidney disease detection and treatment
US6682917B1 (en) * 1999-06-28 2004-01-27 Takeda Chemical Industries, Ltd Protein having a ribonucleotide Reductase activity and a DNA thereof
ATE405670T1 (de) * 2002-05-13 2008-09-15 Arexis Ab Autoimmunerkrankungen und nadph-oxidase-defekte
GB0215509D0 (en) * 2002-07-04 2002-08-14 Novartis Ag Marker genes
DE602004022150D1 (de) * 2003-03-27 2009-09-03 Childrens Hosp Medical Center Verfahren und kit zum nachweis des frühstadiums einer nierentubuluszellenverletzung
DE602005023216D1 (de) * 2004-12-15 2010-10-07 Beth Israel Hospital Nukleinsäuren und polypeptide zur diagnose und behandlung von schwangerschaftskomplikationen
US20060257481A1 (en) * 2005-04-21 2006-11-16 Decode Genetics Ehf. Sustained release formulation and dosing schedule of leukotriene synthesis inhibitor for human therapy
US20090304686A1 (en) * 2006-03-08 2009-12-10 Universotair Medisch Centrum Utrecht Interfering in activation of an immune cell by influencing interaction of lair and collagen
US7662578B2 (en) * 2006-04-21 2010-02-16 Children's Hospital Medical Center Method and kit for the early detection of impaired renal status
AU2007284651B2 (en) * 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
JP5363984B2 (ja) * 2006-10-13 2013-12-11 メタボロン インコーポレイテッド 代謝年齢に関するバイオマーカー及びその使用方法
US20080187944A1 (en) * 2007-01-31 2008-08-07 Appa Rao Allam Butyrylcholinesterase as a marker of low-grade systemic inflammation
WO2008113363A1 (en) * 2007-03-21 2008-09-25 Bioporto Diagnostics A/S Diagnostic test for renal injury
EP2153234A2 (en) * 2007-05-11 2010-02-17 The Institutes for Pharmaceutical Discovery, LLC Methods for early diagnosis of kidney disease
US8465980B2 (en) * 2009-01-28 2013-06-18 Industrial Technology Research Institute Urine and serum biomarkers associated with diabetic nephropathy

Also Published As

Publication number Publication date
US20110086372A1 (en) 2011-04-14
CN102300875A (zh) 2011-12-28
BRPI1007483A2 (pt) 2016-02-16
WO2010085878A1 (en) 2010-08-05
EP2391653B8 (en) 2015-09-30
MX2011007810A (es) 2011-09-30
PT2391653E (pt) 2015-02-13
US9442120B2 (en) 2016-09-13
CA2748852A1 (en) 2010-08-05
DK2391653T3 (en) 2015-02-09
US20110081667A1 (en) 2011-04-07
CA2748852C (en) 2019-05-28
EP2391653A4 (en) 2012-06-27
EP2391653B1 (en) 2014-12-31
JP2012516430A (ja) 2012-07-19
TW201033615A (en) 2010-09-16
US20110081668A1 (en) 2011-04-07
US8470547B2 (en) 2013-06-25
JP5524241B2 (ja) 2014-06-18
CN102300875B (zh) 2014-07-16
TWI397687B (zh) 2013-06-01
US20100209948A1 (en) 2010-08-19
EP2391653A1 (en) 2011-12-07
US20130266976A1 (en) 2013-10-10
BRPI1007483B1 (pt) 2021-11-30

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ES2530574T3 (es) Biomarcadores asociados a la nefropatía