ES2530872T3 - Organos y células modificados para xenotrasplante - Google Patents

Organos y células modificados para xenotrasplante Download PDF

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Publication number
ES2530872T3
ES2530872T3 ES02766869T ES02766869T ES2530872T3 ES 2530872 T3 ES2530872 T3 ES 2530872T3 ES 02766869 T ES02766869 T ES 02766869T ES 02766869 T ES02766869 T ES 02766869T ES 2530872 T3 ES2530872 T3 ES 2530872T3
Authority
ES
Spain
Prior art keywords
xenotransplantation
organs
cells modified
cells
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02766869T
Other languages
English (en)
Inventor
Alex Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RBC Biotechnology Inc
Original Assignee
RBC Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RBC Biotechnology Inc filed Critical RBC Biotechnology Inc
Application granted granted Critical
Publication of ES2530872T3 publication Critical patent/ES2530872T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un método para obtener un órgano, tejido o células porcinos modificados que son resistentes a rechazo mediado por anticuerpo preformado tras el trasplante a un ser humano, que comprende derivar las células, el tejido o el órgano de un cerdo que se ha modificado por ingeniería genética para evitar la expresión de CMP-ácido Nacetilneuramínico hidroxilasa y para evitar la expresión de α-1,3-galactosiltransferasa.
ES02766869T 2001-04-30 2002-04-29 Organos y células modificados para xenotrasplante Expired - Lifetime ES2530872T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28768401P 2001-04-30 2001-04-30
US30060401P 2001-06-22 2001-06-22
US33387601P 2001-11-28 2001-11-28
PCT/US2002/013564 WO2002088351A1 (en) 2001-04-30 2002-04-29 Modified organs and cells for xenotransplantation

Publications (1)

Publication Number Publication Date
ES2530872T3 true ES2530872T3 (es) 2015-03-06

Family

ID=27403740

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02766869T Expired - Lifetime ES2530872T3 (es) 2001-04-30 2002-04-29 Organos y células modificados para xenotrasplante

Country Status (7)

Country Link
US (3) US7166278B2 (es)
EP (1) EP1383889B1 (es)
JP (1) JP2004533242A (es)
AU (1) AU2002308533B2 (es)
CA (1) CA2445945A1 (es)
ES (1) ES2530872T3 (es)
WO (1) WO2002088351A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2528500A1 (en) * 2003-06-06 2004-12-16 University Of Pittsburgh Porcine cmp-n-acetylneuraminic acid hydroxylase gene
WO2005009134A1 (en) 2003-07-21 2005-02-03 Lifecell Corporation ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE
CN104721883A (zh) 2004-03-17 2015-06-24 雷维维科公司 来源于缺乏任何功能性α1,3半乳糖基转移酶表达的动物的组织产品
JP2006129736A (ja) * 2004-11-02 2006-05-25 Nippon Dobutsu Kogaku Kenkyusho:Kk 異種移植用豚細胞、その選抜方法及び異種移植用豚
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
US20070010897A1 (en) * 2005-01-06 2007-01-11 Stone Kevin R Immunochemically modified and sterilized xenografts and allografts
WO2006133356A2 (en) 2005-06-08 2006-12-14 The Regents Of The University Of California Elimination of n-glycolylneuraminic acid from mammalian products for human use
FI20055398A0 (fi) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
FI20075030A0 (fi) 2007-01-18 2007-01-18 Suomen Punainen Risti Veripalv Menetelmä solujen modifioimiseksi
KR101149475B1 (ko) 2007-11-30 2012-05-25 한국생명공학연구원 이종 장기 이식용 미니 복제돼지 생산을 위한 유전자 조작된 세포주 및 그의 생산방법
EP2166085A1 (en) 2008-07-16 2010-03-24 Suomen Punainen Risti Veripalvelu Divalent modified cells
US20110195921A1 (en) * 2008-09-09 2011-08-11 Ajit Varki Elimination of a contaminating non-human sialic acid by metabolic competition
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
KR101276801B1 (ko) * 2011-01-21 2013-06-19 한화엘앤씨 주식회사 ｓＴＮＦＲ1-Ｆｃ 유전자를 발현하는 형질전환 돼지 및 이의 용도
WO2013151649A1 (en) 2012-04-04 2013-10-10 Sialix Inc Glycan-interacting compounds
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
EP3065790B1 (en) 2013-11-04 2020-10-28 LifeCell Corporation Methods of removing alpha-galactose
KR102659529B1 (ko) 2014-10-22 2024-04-23 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 이종이식에 적합한 삼중 트랜스제닉 돼지
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
IL313511A (en) 2014-11-12 2024-08-01 Seagen Inc Compounds acting on glycans and methods of using them
AU2015360502A1 (en) 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
EP3373969A4 (en) 2015-11-12 2019-08-14 Siamab Therapeutics, Inc. GLYCANINTERAGING COMPOUNDS AND METHOD OF USE
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
KR102653141B1 (ko) 2017-03-03 2024-04-01 씨젠 인크. 글리칸-상호작용 화합물 및 사용 방법
WO2018195402A1 (en) 2017-04-20 2018-10-25 Egenesis, Inc. Methods for generating genetically modified animals

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03255028A (ja) * 1990-03-01 1991-11-13 Imeeji Meekaa:Kk 免疫抑制剤
WO1992017189A1 (en) * 1991-03-29 1992-10-15 The Regents Of The University Of California Gangliosides with immunosuppressive activity
US6228631B1 (en) * 1992-10-22 2001-05-08 New York Blood Center, Inc. Recombinant α-N-acetylgalactosaminidase enzyme and cDNA encoding said enzyme
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
US6331658B1 (en) * 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
JPH09508277A (ja) 1994-01-27 1997-08-26 ブレサゲン リミテッド ヒト異種移植における超急性拒絶の管理のための物質及び方法
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
US6245890B1 (en) * 1999-03-26 2001-06-12 New York Blood Center, Inc. Porcine protein and uses thereof

Also Published As

Publication number Publication date
CA2445945A1 (en) 2002-11-07
EP1383889B1 (en) 2014-11-19
JP2004533242A (ja) 2004-11-04
EP1383889A1 (en) 2004-01-28
US8034330B2 (en) 2011-10-11
AU2002308533B2 (en) 2007-07-19
US20070089178A1 (en) 2007-04-19
US20110301341A1 (en) 2011-12-08
EP1383889A4 (en) 2005-01-26
WO2002088351A1 (en) 2002-11-07
US7166278B2 (en) 2007-01-23
US20030165480A1 (en) 2003-09-04

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