ES2531115T3 - Combinaciones de clados de RrgB neumocócicos - Google Patents
Combinaciones de clados de RrgB neumocócicos Download PDFInfo
- Publication number
- ES2531115T3 ES2531115T3 ES10723798T ES10723798T ES2531115T3 ES 2531115 T3 ES2531115 T3 ES 2531115T3 ES 10723798 T ES10723798 T ES 10723798T ES 10723798 T ES10723798 T ES 10723798T ES 2531115 T3 ES2531115 T3 ES 2531115T3
- Authority
- ES
- Spain
- Prior art keywords
- seq
- acid sequence
- amino acid
- pneumococcal
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Una composición inmunogénica que comprende al menos dos de: (a) un primer polipéptido que comprende una primera secuencia de aminoácidos, en el que la primera secuencia de aminoácidos comprende una secuencia de aminoácidos (i) que tiene al menos el 90 % de identidad de secuencias con SEC ID Nº: 1 y/o (ii) que consiste en un fragmento de al menos 7 aminoácidos contiguos de SEC ID Nº: 1, y que comprende un epítope de SEC ID Nº: 1; (b) un segundo polipéptido, que comprende una segunda secuencia de aminoácidos, en el que la segunda secuencia de aminoácidos comprende una secuencia de aminoácidos (i) que tiene al menos el 90 % de identidad de secuencias con SEC ID Nº: 2 y/o (ii) que consiste en un fragmento de al menos 7 aminoácidos contiguos de SEC ID Nº: 2, y que comprende un epítope de SEC ID Nº: 2; y/o (c) un tercer polipéptido, que comprende una tercera secuencia de aminoácidos, en el que la tercera secuencia de aminoácidos comprende una secuencia de aminoácidos (i) que tiene al menos el 90 % de identidad de secuencias con SEC ID Nº: 3 y/o (ii) que consiste en un fragmento de al menos 7 aminoácidos contiguos de SEC ID Nº: 3, y que comprende un epítope de SEC ID Nº: 3.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21762909P | 2009-06-01 | 2009-06-01 | |
| US25442609P | 2009-10-23 | 2009-10-23 | |
| US31420310P | 2010-03-16 | 2010-03-16 | |
| US31892610P | 2010-03-30 | 2010-03-30 | |
| PCT/IB2010/052445 WO2010140119A1 (en) | 2009-06-01 | 2010-06-01 | COMBINATIONS OF PNEUMOCOCCAL RrgB CLADES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2531115T3 true ES2531115T3 (es) | 2015-03-10 |
Family
ID=42557471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10723798T Active ES2531115T3 (es) | 2009-06-01 | 2010-06-01 | Combinaciones de clados de RrgB neumocócicos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8609106B2 (es) |
| EP (1) | EP2437777B1 (es) |
| JP (2) | JP6008741B2 (es) |
| KR (1) | KR20120035168A (es) |
| CN (1) | CN102481354A (es) |
| AU (1) | AU2010255356A1 (es) |
| BR (1) | BRPI1011857A2 (es) |
| CA (1) | CA2764022A1 (es) |
| CO (1) | CO6470864A2 (es) |
| ES (1) | ES2531115T3 (es) |
| IL (1) | IL216696A0 (es) |
| MX (1) | MX2011012854A (es) |
| RU (1) | RU2011154363A (es) |
| SG (1) | SG176285A1 (es) |
| WO (1) | WO2010140119A1 (es) |
| ZA (1) | ZA201109046B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| WO2011030218A1 (en) * | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| MX343914B (es) | 2010-09-01 | 2016-11-18 | Glaxosmithkline Biologicals Sa | Adsorcion de inmunopotenciadores en sales metalicas insolubles. |
| WO2012072769A1 (en) * | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| EP2652511B8 (en) | 2010-12-14 | 2017-06-28 | GlaxoSmithKline Biologicals SA | Flow cytometry analysis of materials adsorbed to metal salts |
| US20140112950A1 (en) | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| SG194733A1 (en) | 2011-05-17 | 2013-12-30 | Glaxosmithkline Biolog Sa | Vaccine against streptococcus pneumoniae |
| DK2822947T3 (en) | 2012-03-07 | 2016-09-19 | Glaxosmithkline Biologicals Sa | ARGINAL SALTS OF A TLR-7 AGONIST |
| CN104519910B (zh) | 2012-03-07 | 2017-05-03 | 诺华股份有限公司 | 肺炎链球菌抗原的含佐剂制剂 |
| JP6345603B2 (ja) | 2012-03-08 | 2018-06-20 | ノバルティス アーゲー | 追加免疫ワクチンのアジュバント化された処方物 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| US20010016200A1 (en) * | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| JP2007532656A (ja) * | 2004-04-12 | 2007-11-15 | アメリカ合衆国 | アデノウイルスベクターを用いて免疫応答を誘導するための方法 |
| US20060165716A1 (en) * | 2004-07-29 | 2006-07-27 | Telford John L | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
| US20090298196A1 (en) * | 2005-01-28 | 2009-12-03 | Uwabe Ken-Ichiro | Quantitative measurement method for recombinant protein |
| MX2008010604A (es) * | 2006-02-17 | 2009-03-05 | Novartis Ag | Purificacion y uso de pilosidades de streptococcus pneumoniae y proteinas pilosas. |
| EP2063911A2 (en) * | 2006-07-26 | 2009-06-03 | Novartis Ag | Immunogenic compositions for gram positive bacteria |
| PL2121011T3 (pl) * | 2006-12-06 | 2014-10-31 | Novartis Ag | Szczepionki zawierające antygeny czterech szczepów wirusa grypy |
| GB0714963D0 (en) * | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| EA019836B1 (ru) * | 2007-11-02 | 2014-06-30 | Те Джонс Хопкинс Юниверсити | Композиции многотипных пептидов hpv и способы лечения или предотвращения папилломавирусной инфекции у человека |
-
2010
- 2010-06-01 US US12/791,186 patent/US8609106B2/en not_active Expired - Fee Related
- 2010-06-01 EP EP10723798.4A patent/EP2437777B1/en not_active Not-in-force
- 2010-06-01 BR BRPI1011857A patent/BRPI1011857A2/pt not_active IP Right Cessation
- 2010-06-01 WO PCT/IB2010/052445 patent/WO2010140119A1/en not_active Ceased
- 2010-06-01 US US13/375,759 patent/US20120076814A1/en not_active Abandoned
- 2010-06-01 JP JP2012513718A patent/JP6008741B2/ja not_active Expired - Fee Related
- 2010-06-01 AU AU2010255356A patent/AU2010255356A1/en not_active Abandoned
- 2010-06-01 ES ES10723798T patent/ES2531115T3/es active Active
- 2010-06-01 CN CN2010800310544A patent/CN102481354A/zh active Pending
- 2010-06-01 MX MX2011012854A patent/MX2011012854A/es active IP Right Grant
- 2010-06-01 RU RU2011154363/10A patent/RU2011154363A/ru not_active Application Discontinuation
- 2010-06-01 KR KR1020117031617A patent/KR20120035168A/ko not_active Withdrawn
- 2010-06-01 SG SG2011088275A patent/SG176285A1/en unknown
- 2010-06-01 CA CA2764022A patent/CA2764022A1/en not_active Abandoned
-
2011
- 2011-11-30 IL IL216696A patent/IL216696A0/en unknown
- 2011-12-05 CO CO11167166A patent/CO6470864A2/es not_active Application Discontinuation
- 2011-12-08 ZA ZA2011/09046A patent/ZA201109046B/en unknown
-
2015
- 2015-09-04 JP JP2015174523A patent/JP2015227376A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010140119A1 (en) | 2010-12-09 |
| ZA201109046B (en) | 2013-05-29 |
| BRPI1011857A2 (pt) | 2016-03-29 |
| CN102481354A (zh) | 2012-05-30 |
| CO6470864A2 (es) | 2012-06-29 |
| IL216696A0 (en) | 2012-02-29 |
| US20120076814A1 (en) | 2012-03-29 |
| RU2011154363A (ru) | 2013-07-20 |
| EP2437777A1 (en) | 2012-04-11 |
| MX2011012854A (es) | 2011-12-16 |
| SG176285A1 (en) | 2012-01-30 |
| US20110020385A1 (en) | 2011-01-27 |
| CA2764022A1 (en) | 2010-12-09 |
| AU2010255356A1 (en) | 2011-12-22 |
| JP2015227376A (ja) | 2015-12-17 |
| KR20120035168A (ko) | 2012-04-13 |
| JP2012528848A (ja) | 2012-11-15 |
| US8609106B2 (en) | 2013-12-17 |
| JP6008741B2 (ja) | 2016-10-19 |
| EP2437777B1 (en) | 2014-09-17 |
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