ES2533256T3 - Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor - Google Patents
Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor Download PDFInfo
- Publication number
- ES2533256T3 ES2533256T3 ES04802396.4T ES04802396T ES2533256T3 ES 2533256 T3 ES2533256 T3 ES 2533256T3 ES 04802396 T ES04802396 T ES 04802396T ES 2533256 T3 ES2533256 T3 ES 2533256T3
- Authority
- ES
- Spain
- Prior art keywords
- pain
- case
- bone
- treatment
- tooth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000002193 Pain Diseases 0.000 title abstract 8
- 239000003814 drug Substances 0.000 title abstract 5
- 229940079593 drug Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- DSDNAKHZNJAGHN-MXTYGGKSSA-N resiniferatoxin Chemical compound C1=C(O)C(OC)=CC(CC(=O)OCC=2C[C@]3(O)C(=O)C(C)=C[C@H]3[C@@]34[C@H](C)C[C@@]5(O[C@@](O4)(CC=4C=CC=CC=4)O[C@@H]5[C@@H]3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-MXTYGGKSSA-N 0.000 title abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 4
- 238000002347 injection Methods 0.000 abstract 4
- 239000007924 injection Substances 0.000 abstract 4
- 208000006820 Arthralgia Diseases 0.000 abstract 3
- 206010006002 Bone pain Diseases 0.000 abstract 3
- 206010003246 arthritis Diseases 0.000 abstract 3
- 208000000112 Myalgia Diseases 0.000 abstract 2
- 206010028851 Necrosis Diseases 0.000 abstract 2
- 206010034464 Periarthritis Diseases 0.000 abstract 2
- 201000010603 frozen shoulder Diseases 0.000 abstract 2
- 230000017074 necrotic cell death Effects 0.000 abstract 2
- 208000004371 toothache Diseases 0.000 abstract 2
- 206010002153 Anal fissure Diseases 0.000 abstract 1
- 208000016583 Anus disease Diseases 0.000 abstract 1
- 206010058029 Arthrofibrosis Diseases 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010007710 Cartilage injury Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 208000009531 Fissure in Ano Diseases 0.000 abstract 1
- 206010061159 Foot deformity Diseases 0.000 abstract 1
- 208000001963 Hallux Valgus Diseases 0.000 abstract 1
- 208000004575 Infectious Arthritis Diseases 0.000 abstract 1
- 206010061246 Intervertebral disc degeneration Diseases 0.000 abstract 1
- 206010023230 Joint stiffness Diseases 0.000 abstract 1
- 208000002472 Morton Neuroma Diseases 0.000 abstract 1
- 208000005890 Neuroma Diseases 0.000 abstract 1
- 201000009859 Osteochondrosis Diseases 0.000 abstract 1
- 208000004983 Phantom Limb Diseases 0.000 abstract 1
- 206010056238 Phantom pain Diseases 0.000 abstract 1
- 206010035623 Pleuritic pain Diseases 0.000 abstract 1
- 206010068771 Soft tissue neoplasm Diseases 0.000 abstract 1
- 208000000491 Tendinopathy Diseases 0.000 abstract 1
- 206010043255 Tendonitis Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 208000002849 chondrocalcinosis Diseases 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 210000002391 femur head Anatomy 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000014617 hemorrhoid Diseases 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 210000003041 ligament Anatomy 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 230000005499 meniscus Effects 0.000 abstract 1
- 210000001087 myotubule Anatomy 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 208000007538 neurilemmoma Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 210000003281 pleural cavity Anatomy 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 206010039667 schwannoma Diseases 0.000 abstract 1
- 201000001223 septic arthritis Diseases 0.000 abstract 1
- 230000001148 spastic effect Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 201000004595 synovitis Diseases 0.000 abstract 1
- 201000004415 tendinitis Diseases 0.000 abstract 1
- 206010044652 trigeminal neuralgia Diseases 0.000 abstract 1
- 210000000689 upper leg Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Uso de la Resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor en caso de Artrosis Artritis, especialmente artritis reumatoide y artritis infecciosa Condrocalcinosis Deterioro de ligamentos Lesiones de menisco Deterioros de cartílago Sinovitis Artrofibrosis Morbus Sudeck Necrosis de secciones de una articulación Dolor articular neuropático Tratamiento del dolor de huesos después de una cirugía de hueso por la aplicación al hueso, por ejemplo después de una osteotomía pélvica Corrección Hallux-Valgus Tratamiento del dolor óseo por inyección en el hueso, en particular para necrosis de la cabeza de fémur en la cabeza de fémur en las vértebras en caso de osteocondrosis Tratamiento local del dolor en caso de rigidez articular, en particular en caso de artrofibrosis o hombro congelado; Tratamiento local de dolores musculares, mediante una inyección intramuscular, en particular en caso de desgarre de la fibra muscular, agujetas o enfermedades espásticas Inyección en el menisco dolorido en caso de degeneración o rotura de menisco Tratamiento de los dolores de espalda mediante inyección en el disco intervertebral en caso de degeneración del disco o rotura del disco Inyección alrededor de un nervio dolorido, en caso de: Neuralgia del trigémino Neurinoma Neuroma de Morton Dolor fantasma Neuroma de la cicatriz; Tratamiento del dolor de dientes intra/peridental, en caso de: Caries Todas las formas de dolor de dientes Antes/en/después de la extracción del diente Antes/en/después del implante del diente Aplicación en caso de periodontitis Uso en un cuello de un diente expuesto. Inyección en la cavidad pleural en caso de dolor pleurítico Instilación en los intestinos en el caso de dolor intestinal, en particular colitis ulcerosa, enfermedad de Crohn, y fisura anal, hemorroides; Dolor de la articulación después de una osteotomía; Dolor en caso de hombro congelado; Dolor en caso de tendinitis; Dolor en caso de mialgia; Dolor en caso de tumores en partes blandas; Dolor de huesos o bien Dolor de la articulación del hueso, que se caracteriza por, que A) El medicamento contiene además una sal de calcio; B) La concentración de iones de calcio es mayor de 2 mmoles; C) El medicamento se disuelve en una solución tampón de pH mayor de 7,6 y preferiblemente mayor de 8,5 y D) El medicamento no contiene ningún anestésico local.
Description
Claims (1)
-
imagen1 imagen2 imagen3 imagen4 imagen5
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CH2004/000756 WO2006069451A1 (de) | 2004-12-28 | 2004-12-28 | Verwendung von resiniferatoxin (rtx) für die herstellung eines mittels zur behandlung von gelenkschmerzen und verfahren zur applikation dieses mittels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2533256T3 true ES2533256T3 (es) | 2015-04-08 |
Family
ID=34959549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04802396.4T Expired - Lifetime ES2533256T3 (es) | 2004-12-28 | 2004-12-28 | Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20080139641A1 (es) |
| EP (1) | EP1838301B1 (es) |
| JP (1) | JP5775246B2 (es) |
| CA (1) | CA2594202C (es) |
| DK (1) | DK1838301T3 (es) |
| ES (1) | ES2533256T3 (es) |
| PL (1) | PL1838301T3 (es) |
| WO (1) | WO2006069451A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2089023A2 (en) | 2006-11-02 | 2009-08-19 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
| US8697155B2 (en) * | 2008-07-22 | 2014-04-15 | Mayo Foundation For Medical Education And Research | Treatment of obesity and related disorders |
| US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
| US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| WO2012168450A1 (en) | 2011-06-10 | 2012-12-13 | Queen Mary & Westfield College | Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions |
| JP2015523401A (ja) * | 2012-08-03 | 2015-08-13 | メステックス・アー・ゲー | レシニフェラトキシン溶液 |
| JP6144775B2 (ja) | 2012-12-12 | 2017-06-07 | クイーン マリー アンド ウエストフィールド カレッジ， ユニバーシティー オブ ロンドン | 腎臓病の治療に使用されるアーテミシニンおよびその誘導体 |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
| ES3066533T3 (en) | 2016-11-02 | 2026-05-13 | Centrexion Therapeutics Corp | Stable aqueous capsaicin injectable formulations and medical uses thereof |
| US11400136B2 (en) * | 2017-06-19 | 2022-08-02 | President And Fellows Of Harvard College | Methods and compositions for treating a microbial infection |
| US20200206166A1 (en) | 2017-07-20 | 2020-07-02 | Centrexion Therapeutics Corporation | Methods and compositions for treatment of pain using capsaicin |
| MX2020002692A (es) * | 2017-09-11 | 2020-10-14 | Sorrento Therapeutics Inc | Formulacion de resiniferatoxina. |
| CA3123222A1 (en) | 2018-12-21 | 2020-06-25 | Sorrento Therapeutics, Inc. | Perineural administration of resiniferatoxin for treatment of maladaptive pain |
| US11254659B1 (en) | 2019-01-18 | 2022-02-22 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| US11447444B1 (en) | 2019-01-18 | 2022-09-20 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| SG11202107815UA (en) * | 2019-01-22 | 2021-08-30 | Sorrento Therapeutics Inc | Method for treating osteoarthritis pain by administering resiniferatoxin |
| CN110123833A (zh) * | 2019-05-31 | 2019-08-16 | 龚啸元 | 一种关节镜手术用灌流液及其制备方法 |
| CA3172784A1 (en) * | 2020-04-15 | 2021-10-21 | Grunenthal Gmbh | Resiniferatoxin compositions |
| WO2025153517A1 (en) | 2024-01-15 | 2025-07-24 | Grünenthal GmbH | Treating knee joint pain by injecting resiniferatoxin at ultra low doses |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3104085A (en) | 1960-07-18 | 1963-09-17 | Ind Paper Log Inc | Compressed fibrous articles |
| US4939149A (en) * | 1988-10-24 | 1990-07-03 | The United States Of America As Represented By The Department Of Health And Human Services | Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization |
| US4997853A (en) * | 1988-12-02 | 1991-03-05 | Galenpharma, Inc. | Method and compositions utilizing capsaicin as an external analgesic |
| WO1990014083A1 (en) * | 1989-05-15 | 1990-11-29 | Afferon Corporation | Composition and method for neural desensitization |
| DE69841907D1 (de) | 1997-03-13 | 2010-11-04 | James N Campbell | Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum |
| GB9711962D0 (en) | 1997-06-10 | 1997-08-06 | Reckitt & Colmann Prod Ltd | Therapeutically active compositions |
| WO2002033411A1 (en) * | 2000-10-16 | 2002-04-25 | Ortho-Mcneil Pharmaceutical, Inc. | Improved ligand binding assays for vanilloid receptors |
| JP2004521112A (ja) * | 2001-01-24 | 2004-07-15 | メステックス アクチエンゲゼルシャフト | 関節痛治療薬を製造することへの神経毒性物質の使用 |
| CA2442049C (en) | 2001-03-22 | 2010-06-01 | Michael J. Iadarola | Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist |
| US20030104085A1 (en) * | 2001-12-05 | 2003-06-05 | Yeomans David C. | Methods and compositions for treating back pain |
| CN102205127A (zh) | 2002-12-18 | 2011-10-05 | 阿尔乔医疗公司 | 类辣椒素的给药 |
| ATE489086T1 (de) * | 2004-12-22 | 2010-12-15 | Mestex Ag | Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels |
-
2004
- 2004-12-28 WO PCT/CH2004/000756 patent/WO2006069451A1/de not_active Ceased
- 2004-12-28 ES ES04802396.4T patent/ES2533256T3/es not_active Expired - Lifetime
- 2004-12-28 PL PL04802396T patent/PL1838301T3/pl unknown
- 2004-12-28 DK DK04802396.4T patent/DK1838301T3/en active
- 2004-12-28 JP JP2007548653A patent/JP5775246B2/ja not_active Expired - Lifetime
- 2004-12-28 US US11/722,779 patent/US20080139641A1/en not_active Abandoned
- 2004-12-28 CA CA 2594202 patent/CA2594202C/en not_active Expired - Lifetime
- 2004-12-28 EP EP04802396.4A patent/EP1838301B1/de not_active Expired - Lifetime
-
2010
- 2010-04-07 US US12/755,994 patent/US9044452B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2594202C (en) | 2013-12-03 |
| WO2006069451A1 (de) | 2006-07-06 |
| JP5775246B2 (ja) | 2015-09-09 |
| JP2008525504A (ja) | 2008-07-17 |
| EP1838301B1 (de) | 2015-01-28 |
| CA2594202A1 (en) | 2006-07-06 |
| PL1838301T3 (pl) | 2015-08-31 |
| US9044452B2 (en) | 2015-06-02 |
| EP1838301A1 (de) | 2007-10-03 |
| US20100196281A1 (en) | 2010-08-05 |
| DK1838301T3 (en) | 2015-04-27 |
| US20080139641A1 (en) | 2008-06-12 |
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