ES2540159A1 - Método para el modelado del nivel de glucemia mediante programación genética - Google Patents
Método para el modelado del nivel de glucemia mediante programación genética Download PDFInfo
- Publication number
- ES2540159A1 ES2540159A1 ES201331726A ES201331726A ES2540159A1 ES 2540159 A1 ES2540159 A1 ES 2540159A1 ES 201331726 A ES201331726 A ES 201331726A ES 201331726 A ES201331726 A ES 201331726A ES 2540159 A1 ES2540159 A1 ES 2540159A1
- Authority
- ES
- Spain
- Prior art keywords
- patient
- modeling
- genetic programming
- glucose level
- applying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 5
- 239000008103 glucose Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 230000002068 genetic effect Effects 0.000 title abstract 3
- 239000008280 blood Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 238000013507 mapping Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
- G16Z99/00—Subject matter not provided for in other main groups of this subclass
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Primary Health Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Método para el modelado del nivel de glucemia mediante programación genética. La invención consiste en un método que, aplicando algoritmos evolutivos sobre soluciones aleatorias y datos tomados de un paciente con glucemia, permite establecer un modelado del nivel de glucemia para obtener un modelado del nivel de glucosa en instantes futuros a los momentos de obtención de los datos del paciente. Los datos del paciente son al menos los niveles de glucosa, ingesta e insulina rápida y lenta para un intervalo de tiempo. El algoritmo evolutivo consiste básicamente en aplicar programación genética en su variante de gramáticas evolutivas o evolución gramatical. Es decir, aplicar gramáticas personalizadas en formato BNF, procesos de mapeo personalizados y evaluaciones de error concretas a las soluciones aleatorias o a modelos generados con anterioridad para obtener una expresión que describa y prediga los niveles de glucosa de un paciente. De entre todos los pacientes, el método de la presente invención está especialmente indicado para sujetos con Diabetes Mellitus.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201331726A ES2540159B1 (es) | 2013-11-27 | 2013-11-27 | Método para el modelado del nivel de glucemia mediante programación genética |
| PCT/ES2014/000190 WO2015079079A1 (es) | 2013-11-27 | 2014-11-05 | Método para el modelado del nivel de glucemia mediante programación genética |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201331726A ES2540159B1 (es) | 2013-11-27 | 2013-11-27 | Método para el modelado del nivel de glucemia mediante programación genética |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2540159A1 true ES2540159A1 (es) | 2015-07-08 |
| ES2540159B1 ES2540159B1 (es) | 2016-03-09 |
Family
ID=53198407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201331726A Active ES2540159B1 (es) | 2013-11-27 | 2013-11-27 | Método para el modelado del nivel de glucemia mediante programación genética |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2540159B1 (es) |
| WO (1) | WO2015079079A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12205686B2 (en) * | 2020-02-27 | 2025-01-21 | The Cleveland Clinic Foundation | Identifying patients for intensive hyperglycemia management |
| ES2900099A1 (es) | 2022-01-12 | 2022-03-15 | Univ Madrid Complutense | Método y sistema para predicción de valores de glucosa y generación de alertas de hipoglucemia e hiperglucemia |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005113036A1 (en) * | 2004-05-13 | 2005-12-01 | The Regents Of The University Of California | Method and apparatus for glucose control and insulin dosing for diabetics |
| US20080154513A1 (en) * | 2006-12-21 | 2008-06-26 | University Of Virginia Patent Foundation | Systems, Methods and Computer Program Codes for Recognition of Patterns of Hyperglycemia and Hypoglycemia, Increased Glucose Variability, and Ineffective Self-Monitoring in Diabetes |
| WO2010019919A1 (en) * | 2008-08-14 | 2010-02-18 | University Of Toledo | Multifunctional neural network system and uses thereof for glycemic forecasting |
| US20110077930A1 (en) * | 2008-02-12 | 2011-03-31 | Alferness Clifton A | Computer-implemented method for providing a personalized tool for estimating 1,5-anhydroglucitol |
-
2013
- 2013-11-27 ES ES201331726A patent/ES2540159B1/es active Active
-
2014
- 2014-11-05 WO PCT/ES2014/000190 patent/WO2015079079A1/es not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005113036A1 (en) * | 2004-05-13 | 2005-12-01 | The Regents Of The University Of California | Method and apparatus for glucose control and insulin dosing for diabetics |
| US20080154513A1 (en) * | 2006-12-21 | 2008-06-26 | University Of Virginia Patent Foundation | Systems, Methods and Computer Program Codes for Recognition of Patterns of Hyperglycemia and Hypoglycemia, Increased Glucose Variability, and Ineffective Self-Monitoring in Diabetes |
| US20110077930A1 (en) * | 2008-02-12 | 2011-03-31 | Alferness Clifton A | Computer-implemented method for providing a personalized tool for estimating 1,5-anhydroglucitol |
| WO2010019919A1 (en) * | 2008-08-14 | 2010-02-18 | University Of Toledo | Multifunctional neural network system and uses thereof for glycemic forecasting |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015079079A1 (es) | 2015-06-04 |
| ES2540159B1 (es) | 2016-03-09 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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