ES2542999T3 - Optimización del aclaramiento para moléculas unidas a proteínas usando terapia de filtración en cascada - Google Patents

Optimización del aclaramiento para moléculas unidas a proteínas usando terapia de filtración en cascada Download PDF

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Publication number
ES2542999T3
ES2542999T3 ES08841705.0T ES08841705T ES2542999T3 ES 2542999 T3 ES2542999 T3 ES 2542999T3 ES 08841705 T ES08841705 T ES 08841705T ES 2542999 T3 ES2542999 T3 ES 2542999T3
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Prior art keywords
optimization
clearance
protein bound
cascade filtration
bound molecules
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ES08841705.0T
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ES2542999T5 (es
Inventor
Jean-Michel Lannoy
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Nikkiso Co Ltd
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Nikkiso Co Ltd
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3431—Substitution fluid path upstream of the filter
    • A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1692—Detection of blood traces in dialysate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3663—Flow rate transducers; Flow integrators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
    • A61M2205/705—Testing of filters for leaks

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

Un sistema de filtración sanguínea extracorpóreo (100) para eliminar moléculas no deseadas de un flujo de sangre procedente de un paciente, que comprende: un primer hemofiltro (13) para elevar la hemoconcentración de la sangre en un flujo sanguíneo filtrado; un primer fluido de sustitución (17) para suplementar el flujo sanguíneo filtrado; un segundo hemofiltro (19) para filtrar moléculas no deseadas del flujo sanguíneo suplementado; y un segundo fluido de sustitución (23) para suplementar el flujo de salida procedente del segundo hemofiltro para retorno al paciente.

Description

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Claims (1)

  1. imagen1
ES08841705T 2007-10-24 2008-10-15 Optimización del aclaramiento para moléculas unidas a proteínas usando terapia de filtración en cascada Active ES2542999T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98239607P 2007-10-24 2007-10-24
US982396P 2007-10-24
PCT/US2008/080023 WO2009055287A1 (en) 2007-10-24 2008-10-15 Optimizing clearance for protein bound molecules using cascade filtration therapy

Publications (2)

Publication Number Publication Date
ES2542999T3 true ES2542999T3 (es) 2015-08-13
ES2542999T5 ES2542999T5 (es) 2024-02-23

Family

ID=40427427

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08841705T Active ES2542999T5 (es) 2007-10-24 2008-10-15 Optimización del aclaramiento para moléculas unidas a proteínas usando terapia de filtración en cascada

Country Status (4)

Country Link
US (2) US8535521B2 (es)
EP (1) EP2227268B2 (es)
ES (1) ES2542999T5 (es)
WO (1) WO2009055287A1 (es)

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AU2010338448B2 (en) 2009-12-17 2014-01-23 Gambro Lundia Ab System and method for monitoring the presence of blood
RU2421246C1 (ru) * 2010-01-12 2011-06-20 Алексей Альбертович Соколов Способ проведения каскадной плазмофильтрации и устройство для его осуществления
DE102010007914A1 (de) * 2010-02-12 2012-12-27 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zur Überwachung eines Gefäßzugangs für eine extrakorporale Blutbehandlung
PL2436406T3 (pl) * 2010-09-30 2014-09-30 Gambro Lundia Ab Urządzenie do pozaustrojowego oczyszczania krwi
DE102011112221B4 (de) * 2011-09-02 2017-05-24 Fresenius Medical Care Deutschland Gmbh Blutbehandlungsvorrichtung
CN103830791B (zh) * 2012-11-27 2017-02-22 深圳先进技术研究院 自动化腹膜透析机
WO2016014987A2 (en) 2014-07-24 2016-01-28 Thomas Jefferson University Long-term implantable monitoring system & methods of use
DE102016007828A1 (de) * 2016-06-29 2018-01-04 Fresenius Medical Care Deutschland Gmbh Steuereinheit zur Bluterkennung in einer Dialysierflüssigkeitsabführleitung einer Blutbehandlungsvorrichtung und Blutbehandlungsvorrichtung
JP7144979B2 (ja) 2018-06-20 2022-09-30 日機装株式会社 血液浄化装置及び血液浄化装置による患者の栄養状態の推定方法
JP7098433B2 (ja) 2018-06-20 2022-07-11 日機装株式会社 血液浄化装置及び血液浄化装置による血漿流量取得方法
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Also Published As

Publication number Publication date
EP2227268B2 (en) 2023-08-23
US8535521B2 (en) 2013-09-17
US20130313194A1 (en) 2013-11-28
WO2009055287A1 (en) 2009-04-30
ES2542999T5 (es) 2024-02-23
EP2227268B1 (en) 2015-05-27
EP2227268A1 (en) 2010-09-15
US8795218B2 (en) 2014-08-05
US20090152200A1 (en) 2009-06-18

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