ES2543419T3 - Proceso de injerto de polímeros bioactivos en materiales protésicos - Google Patents
Proceso de injerto de polímeros bioactivos en materiales protésicos Download PDFInfo
- Publication number
- ES2543419T3 ES2543419T3 ES07815059.6T ES07815059T ES2543419T3 ES 2543419 T3 ES2543419 T3 ES 2543419T3 ES 07815059 T ES07815059 T ES 07815059T ES 2543419 T3 ES2543419 T3 ES 2543419T3
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- Prior art keywords
- titanium
- prosthetic material
- titanium alloy
- grafting process
- alloy prosthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000463 material Substances 0.000 title abstract description 7
- 238000000034 method Methods 0.000 title abstract description 3
- 230000000975 bioactive effect Effects 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 title abstract 3
- 239000000178 monomer Substances 0.000 abstract description 10
- 229910001069 Ti alloy Inorganic materials 0.000 abstract 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 5
- 229910052719 titanium Inorganic materials 0.000 abstract 5
- 239000010936 titanium Substances 0.000 abstract 5
- 238000010526 radical polymerization reaction Methods 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- WROUWQQRXUBECT-UHFFFAOYSA-N 2-ethylacrylic acid Chemical compound CCC(=C)C(O)=O WROUWQQRXUBECT-UHFFFAOYSA-N 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 229920000578 graft copolymer Polymers 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- MNCGMVDMOKPCSQ-UHFFFAOYSA-M sodium;2-phenylethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 MNCGMVDMOKPCSQ-UHFFFAOYSA-M 0.000 description 2
- KSMWLICLECSXMI-UHFFFAOYSA-N sodium;benzene Chemical compound [Na+].C1=CC=[C-]C=C1 KSMWLICLECSXMI-UHFFFAOYSA-N 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- -1 alkali metal salts Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F292/00—Macromolecular compounds obtained by polymerising monomers on to inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0016—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy polymeric material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/84—Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/10—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to inorganic materials
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials Engineering (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Ceramic Engineering (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Graft Or Block Polymers (AREA)
Abstract
Proceso de injerto de polímeros bioactivos sobre un material protésico de titanio o de aleación de titanio que comprende las siguientes etapas: - la generación de especies activas donadoras de radicales libres en la superficie del material protésico de titanio o de aleación de titanio por oxidación de dicho material protésico de titanio o de aleación de titanio; - la generación de radicales libres en la superficie del material protésico de titanio o de aleación de titanio por reacción térmica a una temperatura comprendida entre 40 y 100ºC; y - la colocación de dicho material protésico de titanio o de aleación de titanio sobre el que se generan los radicales libres en presencia de al menos un monómero portador de una función que permite una polimerización radicalaria, permitiendo la polimerización radicalaria de dicho monómero la formación de un polímero bioactivo, realizándose dicha polimerización radicalaria en ausencia de oxígeno.
Description
E07815059
23-07-2015
en las que M representa un ión metálico, preferiblemente un metal alcalino.
El metal alcalino se elige preferiblemente de sodio y potasio, ventajosamente sodio.
Entre los radicales alquilo de C1 a C6, lineales o ramificados, se pueden citar, en particular, los radicales metilo, etilo, 5 n-propilo, isopropilo, n-butilo o t-butilo, pentilo, y hexilo.
Entre los monómeros de fórmula (I), se pueden citar, en particular, ácido acrílico (AA), ácido metacrílico (MA), ácido etacrílico (EA), sus sales correspondientes (en particular sales de metal alcalino, preferiblemente de sodio) y sus mezclas. Se prefiere el ácido metacrílico.
Entre los monómeros de fórmula (II), se pueden citar, en particular, acrilamida de N-(sulfonato de fenil sodio) 10 (NaAS), metacrilamida de N-(sulfonato de fenil sodio) (NaMS), estireno sulfonato de sodio (NaSS) y sus mezclas. Se prefiere el estireno sulfonato de sodio.
Como ilustración, cuando A del monómero de fórmula (II) presenta la fórmula (III), el copolímero injertado sobre el material protésico puede estar representado más específicamente por la siguiente fórmula general (V):
15 en la que R, R', y M son tal como se han definido anteriormente, y n representa un número real comprendido entre 10 y 1000.
La prima significa que la cantidad, la razón y el encadenamiento de las unidades monoméricas presentes en los copolímeros varían. Esta variación está relacionada directamente con los parámetros del proceso de polimerización, tales como por ejemplo la cantidad de cada monómero que se utiliza.
20 Los pesos moleculares de los polímeros injertados de acuerdo con el proceso de la presenta la invención pueden variar en gran medida y se eligen o se controlan por el experto en la materia en función de su aplicación o uso posterior. Para dar un orden de magnitud, el peso molecular promedio en peso puede variar de 1 000 a 100 000 daltons.
Para esto, las cantidades de los monómeros de fórmulas (I) y (II) pueden variar en gran medida y dependen en
25 particular de las propiedades deseadas para los copolímeros. Preferiblemente, la razón molar de (I) sobre (II) varía de 90/10 a 10/90, ventajosamente de 80/20 a 20/80. Los copolímeros de acuerdo con la invención presentan en particular las siguientes fracciones molares de (I) sobre (II): 90/10, 80/20, 70/30, 60/40, 50/50, 40/60, 30/70, 20/80 y 10/90 (estas fracciones corresponden en realidad a las fracciones de los monómeros introducidos, variando las fracciones de los monómeros incorporados en los copolímeros obtenidos por análisis RMN un máximo de ± 2
30 respecto a aquellas mencionadas anteriormente).
7
Claims (1)
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imagen1 imagen2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0605073 | 2006-06-07 | ||
| FR0605073A FR2902102B1 (fr) | 2006-06-07 | 2006-06-07 | Procede de greffage de polymeres bioactifs sur des materiaux prothetiques |
| PCT/FR2007/051389 WO2007141460A2 (fr) | 2006-06-07 | 2007-06-07 | Procédé de greffage de polymères bioactifs sur des matériaux prothétiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2543419T3 true ES2543419T3 (es) | 2015-08-19 |
Family
ID=37818077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07815059.6T Active ES2543419T3 (es) | 2006-06-07 | 2007-06-07 | Proceso de injerto de polímeros bioactivos en materiales protésicos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9139678B2 (es) |
| EP (1) | EP2032663B1 (es) |
| JP (2) | JP6062139B2 (es) |
| ES (1) | ES2543419T3 (es) |
| FR (1) | FR2902102B1 (es) |
| PL (1) | PL2032663T3 (es) |
| WO (1) | WO2007141460A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2902102B1 (fr) * | 2006-06-07 | 2011-11-18 | Univ Paris 13 | Procede de greffage de polymeres bioactifs sur des materiaux prothetiques |
| TW201315451A (zh) * | 2011-10-06 | 2013-04-16 | Metal Ind Res & Dev Ct | 金屬植入物表面處理方法及其金屬植入物 |
| JP5954798B2 (ja) * | 2011-11-16 | 2016-07-20 | 東ソー有機化学株式会社 | 高純度パラスチレンスルホン酸（塩）、それを用いたポリスチレンスルホン酸（塩）、およびポリスチレンスルホン酸（塩）を用いた、分散剤、導電性ポリマードーパント、ナノカーボン材料水性分散体、導電性ポリマー水性分散体、ならびにポリスチレンスルホン酸（塩）の製造方法 |
| US8545951B2 (en) | 2012-02-29 | 2013-10-01 | Kimberly-Clark Worldwide, Inc. | Endotracheal tubes and other polymer substrates including an anti-fouling treatment |
| FR3039772B1 (fr) * | 2015-08-07 | 2017-09-08 | Univ Paris Xiii Paris-Nord Villetaneuse | Procede de greffage de polymeres bioactifs sur des materiaux metalliques |
| FR3042715B1 (fr) * | 2015-10-22 | 2017-12-08 | Les Laboratoires Osteal Medical | Procede pour greffer un polymere bioactif sur des implants |
| FR3042698A1 (fr) | 2015-10-22 | 2017-04-28 | Les Laboratoires Osteal Medical | Dispositifs de support pour supporter des implants ou des protheses |
| FR3042728B1 (fr) * | 2015-10-22 | 2017-12-08 | Les Laboratoires Osteal Medical | Enceinte etanche de polymerisation |
| EP3246002A1 (en) * | 2016-05-20 | 2017-11-22 | DENTSPLY DETREY GmbH | Dental composition |
| FR3092988B1 (fr) * | 2019-02-22 | 2021-12-03 | Les Laboratoires Osteal Medical | Membrane |
| FR3118699A1 (fr) | 2021-01-13 | 2022-07-15 | Activ' Biomat | Implant et son procédé de fabrication |
| FR3131328B1 (fr) * | 2021-12-23 | 2024-12-13 | Activ Biomat | Solution de greffage |
| JP7365444B2 (ja) * | 2022-03-09 | 2023-10-19 | 東ソー・ファインケム株式会社 | 高純度４－（２－ブロモエチル）ベンゼンスルホン酸及びそれから誘導される高純度スチレンスルホン酸類とそのポリマー、並びにそれらの製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4421569A (en) * | 1982-05-07 | 1983-12-20 | Sharon Tube Corp. | Corrosion protection of steel pipes |
| US5804263A (en) * | 1990-10-24 | 1998-09-08 | University Of Florida Research Foundation, Inc. | Combined plasma and gamma radiation polymerization method for modifying surfaces |
| US5607475A (en) * | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
| JPH1072681A (ja) * | 1996-08-29 | 1998-03-17 | Ishikawajima Harima Heavy Ind Co Ltd | 骨伝導性を有するチタンまたはチタン合金の表面処理方法 |
| DE59800682D1 (de) * | 1997-04-14 | 2001-06-13 | Degussa | Verfahren zur Modifizierung der Oberfläche von Polymersubstraten durch Pfropfpolymerisation |
| EP0893164A2 (de) * | 1997-06-28 | 1999-01-27 | Hüls Aktiengesellschaft | Bioaktive Beschichtung von Oberflächen unter Mitverwendung von Vernetzern |
| EP1425315A2 (en) * | 2001-06-04 | 2004-06-09 | University of Liege | Process for depositing strong adherend polymer coating onto an electrically conductive surface |
| FR2843756B1 (fr) | 2002-08-26 | 2005-04-22 | Commissariat Energie Atomique | Procede de soudage d'une surface polymere avec une surface conductrice ou semi-conductrice et ses applications |
| JP2004183017A (ja) * | 2002-11-29 | 2004-07-02 | Ota Kk | 金属チタン系基材の表面処理方法及び金属チタン系医用材料 |
| FR2850026B1 (fr) * | 2003-01-17 | 2007-08-31 | L A R S Laboratoire D Applic E | Ligament prothetique biomimetique et procede d'obtention |
| JP4505578B2 (ja) * | 2004-05-20 | 2010-07-21 | 株式会社神戸製鋼所 | インプラント材料およびその製造方法 |
| FR2871162B1 (fr) * | 2004-06-02 | 2007-06-29 | Univ Paris 7 Denis Diderot | Materiau de surface modifiee, son procede de preparation et ses utilisations |
| FR2902102B1 (fr) * | 2006-06-07 | 2011-11-18 | Univ Paris 13 | Procede de greffage de polymeres bioactifs sur des materiaux prothetiques |
-
2006
- 2006-06-07 FR FR0605073A patent/FR2902102B1/fr not_active Expired - Fee Related
-
2007
- 2007-06-07 PL PL07815059T patent/PL2032663T3/pl unknown
- 2007-06-07 WO PCT/FR2007/051389 patent/WO2007141460A2/fr not_active Ceased
- 2007-06-07 US US12/227,935 patent/US9139678B2/en active Active
- 2007-06-07 EP EP20070815059 patent/EP2032663B1/fr active Active
- 2007-06-07 JP JP2009513738A patent/JP6062139B2/ja not_active Expired - Fee Related
- 2007-06-07 ES ES07815059.6T patent/ES2543419T3/es active Active
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2016
- 2016-09-29 JP JP2016191696A patent/JP2017035506A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP6062139B2 (ja) | 2017-01-18 |
| EP2032663A2 (fr) | 2009-03-11 |
| JP2017035506A (ja) | 2017-02-16 |
| JP2009539453A (ja) | 2009-11-19 |
| US20090318622A1 (en) | 2009-12-24 |
| EP2032663B1 (fr) | 2015-05-06 |
| PL2032663T3 (pl) | 2015-10-30 |
| FR2902102B1 (fr) | 2011-11-18 |
| US9139678B2 (en) | 2015-09-22 |
| WO2007141460A3 (fr) | 2008-01-24 |
| WO2007141460A2 (fr) | 2007-12-13 |
| FR2902102A1 (fr) | 2007-12-14 |
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