ES2544954T3 - Péptidos multiméricos ramificados para diagnóstico y terapia de tumores - Google Patents

Péptidos multiméricos ramificados para diagnóstico y terapia de tumores Download PDF

Info

Publication number
ES2544954T3
ES2544954T3 ES07722808.8T ES07722808T ES2544954T3 ES 2544954 T3 ES2544954 T3 ES 2544954T3 ES 07722808 T ES07722808 T ES 07722808T ES 2544954 T3 ES2544954 T3 ES 2544954T3
Authority
ES
Spain
Prior art keywords
formula
therapy
tumor diagnosis
multimeric peptides
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07722808.8T
Other languages
English (en)
Inventor
Luisa Bracci
Chiara Falciani
Alessandro Pini
Monica Fabbrini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Siena
Original Assignee
Universita degli Studi di Siena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Siena filed Critical Universita degli Studi di Siena
Application granted granted Critical
Publication of ES2544954T3 publication Critical patent/ES2544954T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/083—Neurotensin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un péptido multimérico que tiene las fórmulas generales A o B:**Fórmula** o**Fórmula** en las que n >= 1 a 5, X >=**Fórmula** en la que m >= 1 a 27, o**Fórmula** en la que p >= 1 a 5,**Fórmula** en la que m >= 1-27 y q >= 1 a 5, o,**Fórmula** en la que q >= 1 a 5, o**Fórmula** en la que q >= 1 a 5 W >=**Fórmula** o**Fórmula** o**Fórmula** o**Fórmula** o**Fórmula** y Z >= NH2 u OH, en las que cada péptido tiene una secuencia derivada de Neurotensina (NT), para su uso como agente antitumoral.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8

Claims (1)

  1. imagen1
    imagen2
    imagen3
ES07722808.8T 2006-02-14 2007-02-13 Péptidos multiméricos ramificados para diagnóstico y terapia de tumores Active ES2544954T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77369306P 2006-02-14 2006-02-14
US773693P 2006-02-14
PCT/EP2007/001224 WO2007093373A2 (en) 2006-02-14 2007-02-13 Branched multimeric peptides for tumor diagnosis and therapy

Publications (1)

Publication Number Publication Date
ES2544954T3 true ES2544954T3 (es) 2015-09-07

Family

ID=38371865

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07722808.8T Active ES2544954T3 (es) 2006-02-14 2007-02-13 Péptidos multiméricos ramificados para diagnóstico y terapia de tumores

Country Status (3)

Country Link
EP (1) EP1991561B1 (es)
ES (1) ES2544954T3 (es)
WO (1) WO2007093373A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012507573A (ja) * 2008-11-06 2012-03-29 ルイーザ ブラッチ、 ニューロテンシン誘導分岐ペプチドおよびその使用
ES2538002T3 (es) 2009-01-07 2015-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos para el tratamiento, la evaluación pronóstica y la detección de cáncer de mama
WO2012014046A2 (en) * 2010-07-27 2012-02-02 Diego Tesauro Supramolecular aggregates as drug carriers on cell expressing receptors for branched neurotensin
US20150307554A1 (en) * 2011-02-10 2015-10-29 Rosa Angelica CASTILLO RODRIGUEZ Nts-polyplex nanoparticles system for gene therapy of cancer
CN103308689B (zh) * 2012-03-08 2017-04-12 思芬构技术有限公司 用于预测雌性对象中患上癌症的风险或诊断癌症的方法
ITRM20130565A1 (it) * 2013-10-14 2015-04-15 Univ Siena Composti anti tnf-alpha e loro usi
US20200078468A1 (en) * 2016-04-13 2020-03-12 Tarveda Therapeutics, Inc. Neurotensin receptor binding conjugates and formulations thereof
WO2018061004A1 (en) 2016-09-29 2018-04-05 Aebi Ltd. Therapeutic multi-targeting constructs and uses thereof
EP3927361A4 (en) * 2019-02-21 2022-11-30 Ramot at Tel-Aviv University Ltd. TREATMENT OF DISEASES WITH MULTIMERIC PEPTIDES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39048E1 (en) * 1995-06-07 2006-03-28 Pepscan Systems B.V. Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
CN1159338C (zh) * 1995-06-07 2004-07-28 佩普斯甘系统公司 Lhrh串联重复肽及其疫苗和免疫原性组合物
US20040202673A1 (en) * 2003-04-08 2004-10-14 Jen-Pin Huang Constructs of branched synthetic peptide immunogens with artificial T helper cell epitopes coupled to B cell epitopes

Also Published As

Publication number Publication date
WO2007093373A2 (en) 2007-08-23
EP1991561B1 (en) 2015-06-17
WO2007093373A3 (en) 2008-03-06
EP1991561A2 (en) 2008-11-19

Similar Documents

Publication Publication Date Title
ES2544954T3 (es) Péptidos multiméricos ramificados para diagnóstico y terapia de tumores
ES2512141T3 (es) Análogo peptídico de oxintomodulina
ES2483725T3 (es) Composición básica cosmética y su uso
ES2652643T3 (es) Péptidos terapéuticos y su uso contra la corea de Huntington
CL2010000188A1 (es) Metodo para el tratamiento de una infeccion en un sujeto que comprende la administracion de 9-[(2,2-dimetil-propilamino)-metil]-minociclina o de una sal de la misma; composicion farmaceutica que comprende dicho compuesto; y su uso.
JP2009511485A5 (es)
ES2531009T3 (es) Análogos sustituidos de dicetopiperazina para su uso como agentes para la administración de fármacos
JP2008543729A5 (es)
ATE404225T1 (de) Radiofluorierte peptide
JP2009507826A5 (es)
AR067980A1 (es) Peptidos de cdh3 y agentes que los comprenden
JP2008533230A5 (es)
JP2009520703A5 (es)
JP2007231207A5 (es)
ES2609817T3 (es) Leucotoxina E/D como nuevo agente antiinflamatorio y microbicida
JP2009503140A5 (es)
JP2008543830A5 (es)
CO6400226A2 (es) Micrólido anti-inflamatorio
JP2007321035A5 (es)
JP2007246653A5 (es)
JP2007190226A5 (es)
JP2009512653A5 (es)
JP2007254440A5 (es)
RU2012137206A (ru) Лигнангидроксилаза
JP2009520857A5 (es)