ES2549329T3 - Administración tópica de arginina para el tratamiento del dolor - Google Patents

Administración tópica de arginina para el tratamiento del dolor Download PDF

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Publication number
ES2549329T3
ES2549329T3 ES09014985.7T ES09014985T ES2549329T3 ES 2549329 T3 ES2549329 T3 ES 2549329T3 ES 09014985 T ES09014985 T ES 09014985T ES 2549329 T3 ES2549329 T3 ES 2549329T3
Authority
ES
Spain
Prior art keywords
arginine
topical administration
pain treatment
relief
beneficial effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09014985.7T
Other languages
English (en)
Inventor
Eric Fossel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Strategic Science and Technologies LLC
Original Assignee
Strategic Science and Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/932,595 external-priority patent/US5922332A/en
Priority claimed from US08/932,227 external-priority patent/US7914814B2/en
Priority claimed from US08/936,189 external-priority patent/US6207713B1/en
Priority claimed from US08/936,188 external-priority patent/US5895658A/en
Application filed by Strategic Science and Technologies LLC filed Critical Strategic Science and Technologies LLC
Application granted granted Critical
Publication of ES2549329T3 publication Critical patent/ES2549329T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Una composición para uso como un medicamento para la aplicación tópica a la piel para tratar el dolor, comprendiendo la composición: una sustancia liberadora de óxido nítrico, seleccionada de un miembro del grupo que consiste en L-arginina, sales de L-arginina y derivados de L-arginina seleccionados del grupo que consiste en ésteres etílico, metílico, propílico, isopropílico, butílico, isobutílico o t-butílico de L-arginina y sus sales; y una sal iónica, en donde la sal iónica tiene una fuerza iónica de al menos dos veces la fuerza iónica fisiológica de la sangre.

Description

imagen1
imagen2
imagen3

Claims (1)

  1. imagen1
ES09014985.7T 1997-09-17 1998-09-17 Administración tópica de arginina para el tratamiento del dolor Expired - Lifetime ES2549329T3 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08/932,595 US5922332A (en) 1997-09-17 1997-09-17 Topical delivery of arginine to overcome pain
US936188 1997-09-17
US08/932,227 US7914814B2 (en) 1997-09-17 1997-09-17 Topical delivery of arginine of cause beneficial effects
US936189 1997-09-17
US08/936,189 US6207713B1 (en) 1997-09-17 1997-09-17 Topical and oral delivery of arginine to cause beneficial effects
US08/936,188 US5895658A (en) 1997-09-17 1997-09-17 Topical delivery of L-arginine to cause tissue warming
US932595 1997-09-17
US932227 1997-09-17

Publications (1)

Publication Number Publication Date
ES2549329T3 true ES2549329T3 (es) 2015-10-27

Family

ID=27506014

Family Applications (2)

Application Number Title Priority Date Filing Date
ES98946099T Expired - Lifetime ES2340450T3 (es) 1997-09-17 1998-09-17 Un suministro de arginina para el calentamiento de tejidos frios/enfriados.
ES09014985.7T Expired - Lifetime ES2549329T3 (es) 1997-09-17 1998-09-17 Administración tópica de arginina para el tratamiento del dolor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES98946099T Expired - Lifetime ES2340450T3 (es) 1997-09-17 1998-09-17 Un suministro de arginina para el calentamiento de tejidos frios/enfriados.

Country Status (8)

Country Link
EP (2) EP1041880B1 (es)
JP (3) JP4352114B2 (es)
AT (1) ATE456302T1 (es)
AU (1) AU737199B2 (es)
CA (1) CA2303394C (es)
DE (1) DE69841481D1 (es)
ES (2) ES2340450T3 (es)
WO (1) WO1999013717A1 (es)

Families Citing this family (44)

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US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US7629384B2 (en) 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
US6284797B1 (en) * 1999-04-12 2001-09-04 Donald A. Rhodes Topical treatment of pain and to promote healing
JP2000327560A (ja) * 1999-05-18 2000-11-28 Noevir Co Ltd 入浴剤組成物
FR2794974B1 (fr) * 1999-06-16 2001-08-17 Exsymol Sa Composition cosmetique pour l'amincissement a base de l-arginine, d'un analogue de l-arginine ou d'un de leurs derives, applicable par voie topique
US6322493B1 (en) * 1999-07-01 2001-11-27 40 J's Llc Expanded clitoral sensitizing compounds with methods and apparatus for the delivery of these compounds
JP4681132B2 (ja) * 2001-01-29 2011-05-11 味の素株式会社 一酸化窒素合成酵素産生促進剤および化粧料若しくは医薬組成物
DE10113446A1 (de) * 2001-03-19 2002-09-26 Schwarzkopf Gmbh Hans Haarbehandlungsmittel mit Betainen
US20050226821A1 (en) * 2002-02-22 2005-10-13 Jacob Waugh Cosmetic formulations containing l-arginine oligomers
US7326717B2 (en) 2003-05-06 2008-02-05 L'oreal Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof
EP1732577B1 (en) * 2004-02-23 2013-04-10 Strategic Science & Technologies, LLC Topical delivery of l-arginine to improve body and skin appearance
JP2005281272A (ja) * 2004-03-31 2005-10-13 Suntory Ltd 末梢血流改善剤
JP4837896B2 (ja) * 2004-03-31 2011-12-14 焼津水産化学工業株式会社 精力増強剤
JP4836044B2 (ja) * 2004-04-02 2011-12-14 味の素株式会社 経口アミノ酸ニキビ治療剤
EP2417979A1 (en) 2004-04-19 2012-02-15 Strategic Science & Technologies, LLC Beneficial effects of increasing local blood flow
WO2005102307A2 (en) * 2004-04-19 2005-11-03 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
AU2012201048B2 (en) * 2004-04-19 2013-06-06 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
JP2006169406A (ja) * 2004-12-16 2006-06-29 Fuji Latex Kk コンドーム用水性潤滑剤および当該潤滑剤を塗布したコンドーム
JP2008179540A (ja) * 2005-01-07 2008-08-07 Noevir Co Ltd 細胞分化、発生、増殖を制御する物質および該物質を含む細胞分化・発生・増殖調節剤
EP1863431A1 (en) * 2005-03-18 2007-12-12 L'Oréal Hair and/or eyelash care composition containing aminexil in combination with an agent for promoting the no production and uses thereof
FR2883167B1 (fr) * 2005-03-18 2009-07-10 Oreal Composition de soin capillaire et/ou des cils contenant de l'aminexil en association avec un vasodilatateur, destinee a stimuler la croissance des cheveux et/ou des cils et/ou freiner leur chute, ses utilisations
JP5046174B2 (ja) * 2005-03-31 2012-10-10 味の素株式会社 アルギニン含有血流増加用組成物
US8445536B2 (en) 2005-03-31 2013-05-21 Ajinomoto Co., Inc. Arginine-containing compositions and methods for increasing blood flow using same
WO2007079394A2 (en) 2005-12-30 2007-07-12 Revance Therapeutics, Inc. Arginine heteromers for topical administration
WO2008089435A1 (en) * 2007-01-18 2008-07-24 Wyeth Methods of identifying pain modulators
CA2700335C (en) * 2007-09-21 2015-12-01 Pharmabrand S.A. Composition comprising mucilaginous polysaccharides derived from aloe barbadensis combined with liposomes, method for obtaining same and use thereof as a sun protector, an anti-acne agent, an epidermal regenerator and a moisturiser
FR2929118B1 (fr) 2008-03-28 2010-05-07 Oreal Utilisation de l'association de madecassoside et/ou de terminoloside et d'une arginine pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute
WO2010151241A1 (en) * 2009-06-24 2010-12-29 Strategic Science & Technologies, Llc Topical composition containing naproxen
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
US12138268B2 (en) 2009-06-24 2024-11-12 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
AU2015203547B2 (en) * 2009-06-24 2017-05-18 Strategic Science & Technologies, Llc Topical composition containing ibuprofen
KR101643797B1 (ko) 2009-06-24 2016-07-28 스트러티직 사이언스 앤드 테크놀로지스, 엘엘씨 이부프로펜을 함유하는 국소 조성물
JP2014501283A (ja) 2010-12-29 2014-01-20 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー アレルギーおよび他の適応症の処置のためのシステムおよび方法
EP4491225A3 (en) 2010-12-29 2025-03-26 Strategic Science & Technologies, LLC Treatment of erectile dysfunction and other indications
EP2968130A1 (en) 2013-03-15 2016-01-20 Strategic Science & Technologies, LLC Transdermal delivery of sildenafil and other phosphodiesterase type 5 inhibitors
JP2016513686A (ja) 2013-03-15 2016-05-16 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー フルチカゾンの経皮製剤
US10894024B2 (en) * 2014-12-08 2021-01-19 Synaptamine, Inc. Anti-RDS compounds and method of manufacture and administration thereof to induce dopamine homeostatis
WO2016112201A1 (en) 2015-01-07 2016-07-14 Strategic Science & Technologies, Llc Techniques and systems for transdermal delivery involving treatment of psoriasis, skin cancer, and other indications
MY194410A (en) * 2015-08-06 2022-11-30 Coats Agri Aloe Llc Compositions and Methods to Increase Plant Yield
GB201620701D0 (en) * 2016-12-06 2017-01-18 Glaxosmithkline Consumer Healthcare (Uk) Ip Ltd Novel composition
EP3609503A4 (en) * 2017-04-12 2020-12-16 Performance Labs Pte. Ltd. PRODUCTION OF ASPIRIN-TRIGGERED RESOLVINS WITHOUT THE USE OF ASPIRIN IN AN OMEGA-3-BASED DIETARY SUPPLEMENT
CN110870914A (zh) * 2018-08-31 2020-03-10 成都夸常奥普医疗科技有限公司 氨基酸类营养素的应用以及包含它的药物组合物
JP7642955B2 (ja) * 2021-02-04 2025-03-11 株式会社ファンケル 嗅覚受容体発現促進用組成物

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Also Published As

Publication number Publication date
EP2158907B1 (en) 2015-08-05
ATE456302T1 (de) 2010-02-15
JP2015038119A (ja) 2015-02-26
CA2303394A1 (en) 1999-03-25
WO1999013717A1 (en) 1999-03-25
AU737199B2 (en) 2001-08-09
EP1041880A1 (en) 2000-10-11
JP2002515401A (ja) 2002-05-28
DE69841481D1 (de) 2010-03-18
ES2340450T3 (es) 2010-06-02
CA2303394C (en) 2011-12-20
EP1041880A4 (en) 2006-04-12
JP2009143968A (ja) 2009-07-02
EP2158907A2 (en) 2010-03-03
EP2158907A3 (en) 2010-05-26
WO1999013717B1 (en) 1999-04-22
AU9318698A (en) 1999-04-05
EP1041880B1 (en) 2010-01-27
JP4352114B2 (ja) 2009-10-28

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