ES255209A1 - Process for the preparation of atyxic penicillins and salts of the same (Machine-translation by Google Translate, not legally binding) - Google Patents
Process for the preparation of atyxic penicillins and salts of the same (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES255209A1 ES255209A1 ES0255209A ES255209A ES255209A1 ES 255209 A1 ES255209 A1 ES 255209A1 ES 0255209 A ES0255209 A ES 0255209A ES 255209 A ES255209 A ES 255209A ES 255209 A1 ES255209 A1 ES 255209A1
- Authority
- ES
- Spain
- Prior art keywords
- penicillins
- translation
- preparation
- machine
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 4
- 150000002960 penicillins Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 2
- 150000008064 anhydrides Chemical class 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- -1 tri-substituted acetic acid Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Process for the preparation of penicillins and non-toxic salts thereof, characterized in that new penicillins of the general formula: under R1 and R2 or the group OR4 or SR4, where R4 is an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group, are obtained by the reaction of 6-aminopenicillanic acid or a fermentation liquor containing 6-aminopenicillanic acid obtained by the development of a penicillin-producing mold in a nutrient medium, with or without subsequent partial purification, with an acid chloride, bromide or anhydride or mixed anhydride derived from a tri-substituted acetic acid of the general formula: (see formula) (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2435/59A GB878233A (en) | 1959-01-22 | 1959-01-22 | Improvements in or relating to penicillins |
| GB3554659 | 1959-10-20 | ||
| GB3620459 | 1959-10-26 | ||
| GB3830459 | 1959-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES255209A1 true ES255209A1 (en) | 1960-05-16 |
Family
ID=27447227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0255209A Expired ES255209A1 (en) | 1959-01-20 | 1960-01-22 | Process for the preparation of atyxic penicillins and salts of the same (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE586738R (en) |
| CH (1) | CH393329A (en) |
| ES (1) | ES255209A1 (en) |
-
1960
- 1960-01-20 BE BE586738A patent/BE586738R/en active
- 1960-01-22 ES ES0255209A patent/ES255209A1/en not_active Expired
- 1960-01-22 CH CH67260A patent/CH393329A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH393329A (en) | 1965-06-15 |
| BE586738R (en) | 1960-07-20 |
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