ES2552754T1 - Formulaciones de daptomicina y usos de la misma - Google Patents
Formulaciones de daptomicina y usos de la misma Download PDFInfo
- Publication number
- ES2552754T1 ES2552754T1 ES13837694.2T ES13837694T ES2552754T1 ES 2552754 T1 ES2552754 T1 ES 2552754T1 ES 13837694 T ES13837694 T ES 13837694T ES 2552754 T1 ES2552754 T1 ES 2552754T1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutically acceptable
- daptomycin formulations
- acceptable salts
- daptomycin
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010013198 Daptomycin Proteins 0.000 title abstract 2
- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 title abstract 2
- 229960005484 daptomycin Drugs 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 150000002303 glucose derivatives Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una formulación de daptomicina liofilizada que comprende un aditivo seleccionado del grupo que consiste en antioxidantes farmacéuticamente aceptables, ácidos orgánicos farmacéuticamente aceptables y sales de los mismos farmacéuticamente aceptables, derivados de glucosa farmacéuticamente aceptables y sales de los mismos farmacéuticamente aceptables, y combinaciones de los mismos.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699570P | 2012-09-11 | 2012-09-11 | |
| US201261699570P | 2012-09-11 | ||
| US201361839699P | 2013-06-26 | 2013-06-26 | |
| US201361839699P | 2013-06-26 | ||
| PCT/IB2013/002191 WO2014041425A1 (en) | 2012-09-11 | 2013-09-11 | Daptomycin formulations and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2552754T1 true ES2552754T1 (es) | 2015-12-02 |
Family
ID=50277707
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13837694.2T Pending ES2552754T1 (es) | 2012-09-11 | 2013-09-11 | Formulaciones de daptomicina y usos de la misma |
| ES22169277T Active ES3018415T3 (es) | 2012-09-11 | 2013-09-11 | Formulaciones de daptomicina y usos de las mismas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES22169277T Active ES3018415T3 (es) | 2012-09-11 | 2013-09-11 | Formulaciones de daptomicina y usos de las mismas |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9655946B2 (es) |
| EP (2) | EP2895187A4 (es) |
| AU (2) | AU2013316779A1 (es) |
| BR (1) | BR112015005400B1 (es) |
| CA (1) | CA2884484C (es) |
| CL (1) | CL2015000608A1 (es) |
| CY (1) | CY2200004T2 (es) |
| DE (1) | DE13837694T1 (es) |
| DK (1) | DK2895187T1 (es) |
| ES (2) | ES2552754T1 (es) |
| HK (1) | HK1207006A1 (es) |
| HU (2) | HUE071031T2 (es) |
| IL (1) | IL237652B (es) |
| MX (1) | MX366122B (es) |
| NZ (3) | NZ706286A (es) |
| PL (1) | PL4066849T3 (es) |
| SA (1) | SA515360129B1 (es) |
| SG (1) | SG11201506113WA (es) |
| TN (1) | TN2015000090A1 (es) |
| WO (1) | WO2014041425A1 (es) |
| ZA (1) | ZA201502310B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| EP2895187A4 (en) * | 2012-09-11 | 2015-12-02 | Hospira Australia Pty Ltd | DAPTOMYCIN FORMULATIONS AND USES THEREOF |
| US10933019B2 (en) | 2016-10-21 | 2021-03-02 | Xellia Pharmaceuticals Aps | Liquid formulations of daptomycin |
| JP7229999B2 (ja) | 2017-08-31 | 2023-02-28 | クセリア ファーマシューティカルズ エーピーエス | ダプトマイシン製剤 |
| CN110339342A (zh) * | 2018-04-03 | 2019-10-18 | 江苏恒瑞医药股份有限公司 | 一种达托霉素的盐或含盐的组合物及其制备方法 |
| US11058745B1 (en) | 2018-10-04 | 2021-07-13 | Good Health, Llc | Stable liquid pharmaceutical compositions of daptomycin |
| US12527776B2 (en) | 2019-02-04 | 2026-01-20 | Genzyme Corporation | Treatment of ciliopathies using inhibitors of glucosylceramide synthase (GCS) |
| JP7582205B2 (ja) * | 2019-12-26 | 2024-11-13 | ニプロ株式会社 | ダプトマイシンを含有する安定した凍結乾燥製剤 |
| EP4100009A1 (en) | 2020-02-03 | 2022-12-14 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
| CN115243675A (zh) | 2020-03-12 | 2022-10-25 | 巴克斯特国际公司 | 含有山梨糖醇和甘露糖醇的组合的达托霉素制剂 |
| KR20230043024A (ko) | 2020-07-24 | 2023-03-30 | 젠자임 코포레이션 | 벤글루스타트를 포함하는 제약 조성물 |
| CN115590825B (zh) * | 2022-10-20 | 2024-02-02 | 安士制药（中山）有限公司 | 一种注射用达托霉素及其制备方法 |
| CN120478324B (zh) * | 2025-04-28 | 2025-12-26 | 暨南大学 | 泛酸或其药学上可接受的盐在制备增强病原菌对达托霉素的敏感性的药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5560906A (en) * | 1995-03-27 | 1996-10-01 | Oral Technology Laboratories, Inc. | Non-alcoholic antimicrobial mouthwash for removal of dental plaque |
| DK1115417T3 (da) * | 1998-09-25 | 2006-07-31 | Cubist Pharm Inc | Anvendelse af daptomycin |
| US6696412B1 (en) | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| WO2002059145A1 (en) * | 2000-12-18 | 2002-08-01 | Cubist Pharmaceuticals, Inc. | Methods for preparing purified lipopeptides |
| US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| CN1616083A (zh) | 2004-09-01 | 2005-05-18 | 魏雪纹 | 注射用达托霉素冻干制剂及制备方法 |
| CA2610716A1 (en) * | 2005-05-31 | 2006-12-07 | Cubist Pharmaceuticals, Inc. | Daptomycin for the treatment of biofilm and catheter salvage |
| WO2011062676A1 (en) | 2009-11-23 | 2011-05-26 | Eagle Pharmaceuticals, Inc. | Formulations of daptomycin |
| PT2504353T (pt) | 2009-11-23 | 2018-10-18 | Cubist Pharmaceuticals Llc | Composições de lipopéptido e métodos relacionados |
| JP2015526463A (ja) * | 2012-08-23 | 2015-09-10 | アギラ・スペシャルティーズ・プライベート・リミテッド | 改善されたダプトマイシン注射用製剤 |
| EP2895187A4 (en) * | 2012-09-11 | 2015-12-02 | Hospira Australia Pty Ltd | DAPTOMYCIN FORMULATIONS AND USES THEREOF |
-
2013
- 2013-09-11 EP EP13837694.2A patent/EP2895187A4/en not_active Withdrawn
- 2013-09-11 PL PL22169277.5T patent/PL4066849T3/pl unknown
- 2013-09-11 WO PCT/IB2013/002191 patent/WO2014041425A1/en not_active Ceased
- 2013-09-11 DK DK13837694.2T patent/DK2895187T1/da unknown
- 2013-09-11 SG SG11201506113WA patent/SG11201506113WA/en unknown
- 2013-09-11 NZ NZ706286A patent/NZ706286A/en unknown
- 2013-09-11 CA CA2884484A patent/CA2884484C/en active Active
- 2013-09-11 NZ NZ74134213A patent/NZ741342A/en unknown
- 2013-09-11 DE DE13837694.2T patent/DE13837694T1/de active Pending
- 2013-09-11 ES ES13837694.2T patent/ES2552754T1/es active Pending
- 2013-09-11 HK HK15107795.5A patent/HK1207006A1/xx unknown
- 2013-09-11 NZ NZ742241A patent/NZ742241A/en unknown
- 2013-09-11 AU AU2013316779A patent/AU2013316779A1/en not_active Abandoned
- 2013-09-11 MX MX2015003164A patent/MX366122B/es active IP Right Grant
- 2013-09-11 HU HUE22169277A patent/HUE071031T2/hu unknown
- 2013-09-11 US US14/427,618 patent/US9655946B2/en active Active
- 2013-09-11 BR BR112015005400-5A patent/BR112015005400B1/pt active IP Right Grant
- 2013-09-11 EP EP22169277.5A patent/EP4066849B1/en active Active
- 2013-09-11 ES ES22169277T patent/ES3018415T3/es active Active
-
2015
- 2015-03-10 IL IL237652A patent/IL237652B/en active IP Right Grant
- 2015-03-10 TN TNP2015000090A patent/TN2015000090A1/fr unknown
- 2015-03-11 CL CL2015000608A patent/CL2015000608A1/es unknown
- 2015-03-11 SA SA515360129A patent/SA515360129B1/ar unknown
- 2015-04-07 ZA ZA2015/02310A patent/ZA201502310B/en unknown
- 2015-11-11 HU HUE13837694A patent/HUE13837694T1/hu unknown
- 2015-11-20 CY CY20152200004T patent/CY2200004T2/el unknown
-
2017
- 2017-04-20 US US15/492,111 patent/US20170216396A1/en not_active Abandoned
-
2018
- 2018-02-23 US US15/903,764 patent/US10357535B2/en active Active
- 2018-08-17 AU AU2018217322A patent/AU2018217322B2/en active Active
-
2020
- 2020-04-15 US US16/849,387 patent/US20200237858A1/en not_active Abandoned
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