ES2553085T3 - Procedimiento para la preparación de 2,2-difluoroetanol - Google Patents

Procedimiento para la preparación de 2,2-difluoroetanol Download PDF

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Publication number
ES2553085T3
ES2553085T3 ES12735152.6T ES12735152T ES2553085T3 ES 2553085 T3 ES2553085 T3 ES 2553085T3 ES 12735152 T ES12735152 T ES 12735152T ES 2553085 T3 ES2553085 T3 ES 2553085T3
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Spain
Prior art keywords
difluoroethyl
difluoroethanol
preparation
difluoroethane
chloro
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ES12735152.6T
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English (en)
Inventor
Thomas Norbert MÜLLER
Norbert Lui
Stefan MOCZARSKI
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C07C67/11—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond being mineral ester groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/128—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by alcoholysis
    • C07C29/1285—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by alcoholysis of esters of organic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/38—Halogenated alcohols containing only fluorine as halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedimiento para la preparación de 2,2-difluoroetanol que comprende las siguientes etapas: etapa (i): reacción de 1-cloro-2,2-difluoroetano con una sal de metal alcalino del ácido fórmico o del ácido acético en un disolvente adecuado hasta dar el correspondiente formiato de 2,2-difluoroetilo o acetato de 2,2- difluoroetilo, caracterizado porque el 1-cloro-2,2-difluoroetano se añade lentamente a una mezcla calentada a la temperatura de reacción deseada de disolvente y sal de metal alcalino del ácido fórmico o del ácido acético; etapa (ii): transesterificación del formiato de 2,2-difluoroetilo o acetato de 2,2-difluoroetilo de la etapa (i) en presencia de un alcohol y dado el caso de una base.

Description

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Claims (1)

  1. imagen1
ES12735152.6T 2011-07-19 2012-07-16 Procedimiento para la preparación de 2,2-difluoroetanol Active ES2553085T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11174510 2011-07-19
EP11174510 2011-07-19
US201161509800P 2011-07-20 2011-07-20
US201161509800P 2011-07-20
PCT/EP2012/063898 WO2013010985A1 (de) 2011-07-19 2012-07-16 Verfahren zur herstellung 2,2-difluorethanol

Publications (1)

Publication Number Publication Date
ES2553085T3 true ES2553085T3 (es) 2015-12-04

Family

ID=47557684

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12735152.6T Active ES2553085T3 (es) 2011-07-19 2012-07-16 Procedimiento para la preparación de 2,2-difluoroetanol

Country Status (9)

Country Link
US (1) US8975448B2 (es)
EP (1) EP2734493B1 (es)
JP (1) JP2014523912A (es)
KR (1) KR20140048983A (es)
CN (1) CN103687831B (es)
DK (1) DK2734493T3 (es)
ES (1) ES2553085T3 (es)
IL (1) IL230477A0 (es)
WO (1) WO2013010985A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2844796C (en) 2011-09-02 2020-12-29 E. I. Du Pont De Nemours And Company Lithium ion battery with nonaqueous electrolyte comprising fluorinated acyclic carboxylic acid ester and/or fluorinated acyclic carbonate
JP6178316B2 (ja) 2011-09-02 2017-08-09 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ フッ素化電解質組成物
US10044066B2 (en) 2012-06-01 2018-08-07 Solvary SA Fluorinated electrolyte compositions
CN104704657A (zh) 2012-06-01 2015-06-10 纳幕尔杜邦公司 锂离子电池
EP2855417A1 (en) * 2012-06-01 2015-04-08 E. I. Du Pont de Nemours and Company Fluorine-containing esters and methods of preparation thereof
PL2982002T3 (pl) 2013-04-04 2020-01-31 Solvay Sa Niewodne kompozycje elektrolitów
CN103709009B (zh) * 2014-01-07 2015-08-05 江苏蓝色星球环保科技股份有限公司 一种氟化物的液相反应制备方法
CN104030886B (zh) * 2014-06-04 2016-01-13 湖北海之杰化工有限公司 以2,2-二氟-1-卤代乙烷为原料制备2,2-二氟乙醇的方法
CN104098444A (zh) * 2014-07-22 2014-10-15 南通得宝氟化学有限公司 2,2-二氟乙醇的制备方法
CN106083528B (zh) * 2016-06-03 2018-06-08 山东飞源新材料有限公司 一种2,2-二氟乙醇的制备方法
FR3056590B1 (fr) * 2016-09-27 2020-05-08 Arkema France Composition comprenant du 1-chloro-2,2-difluoroethane
FR3056586B1 (fr) * 2016-09-27 2020-05-08 Arkema France Composition comprenant du 1-chloro-2,2-difluoroethane
FR3056585B1 (fr) * 2016-09-27 2020-05-08 Arkema France Composition comprenant du 1-chloro-2,2-difluoroethane
US20190300473A1 (en) * 2016-09-27 2019-10-03 Arkema France Composition comprising 1-chloro-2,2-difluoroethane
FR3056588B1 (fr) * 2016-09-27 2018-10-12 Arkema France Composition comprenant du 1-chloro-2,2-difluoroethane
CN107353179A (zh) * 2017-06-17 2017-11-17 南通宝凯化工有限公司 一种二氟乙醇的制备工艺
CN107986944B (zh) * 2017-12-19 2021-06-15 西安近代化学研究所 一种以2,2-二氟-1-氯乙烷为原料合成二氟乙醇的方法
CN108178723A (zh) * 2017-12-19 2018-06-19 西安近代化学研究所 2,2-二氟乙醇的合成方法
CN108069820A (zh) * 2017-12-19 2018-05-25 西安近代化学研究所 一种三氟乙醇合成工艺
CN108069822A (zh) * 2017-12-19 2018-05-25 西安近代化学研究所 一种合成二氟乙醇的方法
CN111039751B (zh) * 2019-12-23 2023-04-07 山东东岳化工有限公司 一种以r142为原料合成2,2-二氟乙醇的方法
CN112645796B (zh) * 2020-12-17 2022-11-25 常熟三爱富中昊化工新材料有限公司 一种制备2,2-二氟乙醇的方法
CN112374983A (zh) * 2020-12-30 2021-02-19 山东华安新材料有限公司 一种2-丙烯酸2,2-二氟乙基酯的合成方法
CN116023267A (zh) * 2022-12-14 2023-04-28 南通宝凯药业有限公司 一种乙酸二氟乙酯的制备工艺
CN115784837B (zh) * 2023-01-19 2023-04-25 山东潍坊润丰化工股份有限公司 3-氯双环[3.2.1]-3-辛烯-2-醇的制备方法
CN116969837A (zh) * 2023-06-27 2023-10-31 胜华新能源科技(东营)有限公司 一种电子级乙酸2,2-二氟乙酯的制备方法
CN119390530B (zh) * 2024-12-30 2025-05-13 山东东岳绿冷科技有限公司 硼烷参与的2,2-二氟乙醇制备反应
CN120842056A (zh) * 2025-09-22 2025-10-28 山东华安新材料有限公司 一种1,1-二氟乙基甲醚的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134043A (ja) * 1982-02-04 1983-08-10 Onoda Cement Co Ltd ２，２，２−トリフルオロエタノ−ルの製造法
JPS5913742A (ja) * 1982-07-09 1984-01-24 ハルカ−ボン・プロダクツ・コ−ポレイシヨン トリフルオロエタノ−ルの製造方法
US4590310A (en) * 1984-08-02 1986-05-20 The Boc Group, Inc. Process for the preparation of 2,2,2-trifluoroethanol
JPS62273925A (ja) 1986-05-23 1987-11-28 Asahi Chem Ind Co Ltd ２，２−ジフルオロエタノ−ルの製造方法
FR2721312B1 (fr) * 1994-06-17 1996-09-06 Atochem Elf Sa Procédé de fabrication d'halogénoalcanols.
JP4507327B2 (ja) * 1999-02-15 2010-07-21 東ソー株式会社 改良されたベンジルアルコールの製造方法
CN1286788C (zh) * 2001-09-14 2006-11-29 东曹氟技术株式会社 2,2,2－三氟乙醇的制造方法
FR2894958B1 (fr) 2005-12-19 2008-04-18 Rhodia Recherches & Tech Procede de preparation de difluoroethanol
EP1820789A1 (en) 2006-02-13 2007-08-22 SOLVAY (Société Anonyme) Process for the manufacture of fluorinated alcohols
WO2009040367A1 (en) * 2007-09-28 2009-04-02 Solvay (Société Anonyme) Process for the preparation of fluorine containing organic compound

Also Published As

Publication number Publication date
JP2014523912A (ja) 2014-09-18
EP2734493A1 (de) 2014-05-28
CN103687831A (zh) 2014-03-26
IL230477A0 (en) 2014-03-31
DK2734493T3 (en) 2015-11-30
EP2734493B1 (de) 2015-08-19
CN103687831B (zh) 2015-11-25
US8975448B2 (en) 2015-03-10
WO2013010985A1 (de) 2013-01-24
US20140243561A1 (en) 2014-08-28
KR20140048983A (ko) 2014-04-24

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