ES2554527T3 - Proceso para rellenar partículas poliméricas con un fármaco - Google Patents

Proceso para rellenar partículas poliméricas con un fármaco Download PDF

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Publication number
ES2554527T3
ES2554527T3 ES07704121.8T ES07704121T ES2554527T3 ES 2554527 T3 ES2554527 T3 ES 2554527T3 ES 07704121 T ES07704121 T ES 07704121T ES 2554527 T3 ES2554527 T3 ES 2554527T3
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ES
Spain
Prior art keywords
drug
polymer
polymer particles
solution
beads
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07704121.8T
Other languages
English (en)
Inventor
Andrew Lennard Lewis
Hind Hassan Sidahmed Goreish
Yiqing Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocompatibles UK Ltd
Original Assignee
Biocompatibles UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles UK Ltd filed Critical Biocompatibles UK Ltd
Application granted granted Critical
Publication of ES2554527T3 publication Critical patent/ES2554527T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Un proceso en el que se ponen en contacto perlas hinchables de polímero insoluble en aceite e insoluble en agua con una disolución de un fármaco cristalizable en un disolvente orgánico que es capaz de penetrar en las perlas, de modo que el fármaco se absorbe en el interior de las perlas, caracterizado por que la disolución además contiene un modificador de cristal que inhibe la cristalización del fármaco, en el que el modificador de cristal es miscible con el disolvente y está seleccionado entre aceites, glicoles y éteres de glicol, y por que el polímero tiene carga aniónica, en el que los grupos aniónicos están seleccionados entre sulfonato, fosfonato y carboxilato y el polímero es poli(alcohol vinílico) reticulado.

Description

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Claims (1)

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    imagen2
ES07704121.8T 2006-01-24 2007-01-24 Proceso para rellenar partículas poliméricas con un fármaco Active ES2554527T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06250387 2006-01-24
EP06250387 2006-01-24
PCT/EP2007/050690 WO2007085615A1 (en) 2006-01-24 2007-01-24 Process for loading polymer particles with drug

Publications (1)

Publication Number Publication Date
ES2554527T3 true ES2554527T3 (es) 2015-12-21

Family

ID=36600126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07704121.8T Active ES2554527T3 (es) 2006-01-24 2007-01-24 Proceso para rellenar partículas poliméricas con un fármaco

Country Status (5)

Country Link
US (1) US20080305176A1 (es)
EP (1) EP1978938B1 (es)
JP (1) JP5075130B2 (es)
ES (1) ES2554527T3 (es)
WO (1) WO2007085615A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1267839B1 (en) 2000-03-24 2007-10-03 Biosphere Medical, Inc. Microspheres for active embolization
KR20140090270A (ko) 2005-05-09 2014-07-16 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법
JP2010270111A (ja) * 2009-04-21 2010-12-02 Taisho Pharmaceutical Co Ltd アルギニン含有錠剤
FR3002232B1 (fr) 2013-02-15 2015-03-27 Ab7 Innovation Support polymere de distribution de substance naturellement cristalline et procede d'obtention
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
US20200397766A1 (en) * 2018-02-23 2020-12-24 Van Rijn Beheer B.V. Porous embolization microspheres comprising drugs
WO2020003147A2 (en) 2018-06-29 2020-01-02 Biocompatibles Uk Limited Radiopaque polymers
GB201810788D0 (en) 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Biodegradable polymer
CN110327300B (zh) * 2019-07-23 2020-08-07 赵修文 一种负载药物的聚乙烯醇微球
US20230201122A1 (en) 2021-12-23 2023-06-29 Boston Scientific Medical Device Limited Chemoembolic compositions and methods of treatment using them

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3120187B2 (ja) * 1990-08-08 2000-12-25 武田薬品工業株式会社 血管新生阻害物質を含む血管内塞栓剤
JPH06329542A (ja) * 1993-05-21 1994-11-29 Kibun Food Chemifa Co Ltd 不溶性アルギン酸塩粒子を含む局所血管止血用組成物および動脈化学塞栓用組成物
DE69922681T2 (de) * 1998-10-16 2005-05-25 Mercian Corp. Kristallisation von doxorubicin-hydrochlorid
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6575888B2 (en) * 2000-01-25 2003-06-10 Biosurface Engineering Technologies, Inc. Bioabsorbable brachytherapy device
DE60130544T2 (de) * 2000-03-13 2008-06-26 Biocure, Inc. Embolische zusammensetzungen
EP1267839B1 (en) * 2000-03-24 2007-10-03 Biosphere Medical, Inc. Microspheres for active embolization
US20020128179A1 (en) * 2000-12-01 2002-09-12 Tacon William C. Shaped microparticles for pulmonary drug delivery
ES2364816T3 (es) * 2001-04-02 2011-09-14 Genentech, Inc. Terapia de combinación.
US8012454B2 (en) * 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
ES2308149T3 (es) * 2003-02-12 2008-12-01 Biocompatibles Uk Limited Composicion para la quimioemboloterapia de tumores solidos.
US20040161466A1 (en) * 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
US20060057198A1 (en) * 2003-02-21 2006-03-16 Biocompatibles Uk Limited Drug delivery from embolic agents
EP1796653A2 (en) * 2004-07-26 2007-06-20 Actelion Pharmaceuticals Ltd. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation

Also Published As

Publication number Publication date
JP2009524621A (ja) 2009-07-02
EP1978938A1 (en) 2008-10-15
WO2007085615A1 (en) 2007-08-02
EP1978938B1 (en) 2015-09-09
US20080305176A1 (en) 2008-12-11
JP5075130B2 (ja) 2012-11-14

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