ES2559007T3 - Alfa1 antitripsina humana recombinante - Google Patents

Alfa1 antitripsina humana recombinante Download PDF

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Publication number
ES2559007T3
ES2559007T3 ES10716318.0T ES10716318T ES2559007T3 ES 2559007 T3 ES2559007 T3 ES 2559007T3 ES 10716318 T ES10716318 T ES 10716318T ES 2559007 T3 ES2559007 T3 ES 2559007T3
Authority
ES
Spain
Prior art keywords
recombinant human
alpha1
human antitrypsin
glucans
antitrypsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10716318.0T
Other languages
English (en)
Inventor
Elisabeth C. M. Brinkman
Cornelis Erik Hack
Ingrid Van Den Nieuwenhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Vaccines and Prevention BV
Original Assignee
Crucell Holand BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holand BV filed Critical Crucell Holand BV
Application granted granted Critical
Publication of ES2559007T3 publication Critical patent/ES2559007T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

α1-antitripsina humana recombinante (AAThr) que comprende glucanos unidos en N, caracterizado por que: (a) al menos el 10% de dichos glucanos unidos en N son glucanos tetra-antenarios; y (b) el grado de protección con ácido siálico en dichos glucanos unidos en N (Z/A) es de al menos el 50%, en la que al menos el 50% de la sialilación en dichos glucanos unidos en N es α-2,3-sialilación.

Description

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Claims (1)

  1. imagen1
ES10716318.0T 2009-04-23 2010-04-20 Alfa1 antitripsina humana recombinante Active ES2559007T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21449209P 2009-04-23 2009-04-23
EP09158640 2009-04-23
EP09158640 2009-04-23
US214492P 2009-04-23
PCT/EP2010/055177 WO2010127939A1 (en) 2009-04-23 2010-04-20 Recombinant human alpha1-antitrypsin

Publications (1)

Publication Number Publication Date
ES2559007T3 true ES2559007T3 (es) 2016-02-10

Family

ID=40929544

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10716318.0T Active ES2559007T3 (es) 2009-04-23 2010-04-20 Alfa1 antitripsina humana recombinante

Country Status (14)

Country Link
US (1) US8357661B2 (es)
EP (1) EP2421895B1 (es)
JP (1) JP5711215B2 (es)
KR (1) KR101640962B1 (es)
CN (1) CN102439037B (es)
AU (1) AU2010244592B2 (es)
CA (1) CA2756591C (es)
DK (1) DK2421895T3 (es)
EA (1) EA025021B1 (es)
ES (1) ES2559007T3 (es)
IL (1) IL215537A (es)
PL (1) PL2421895T3 (es)
WO (1) WO2010127939A1 (es)
ZA (1) ZA201107416B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2421895T3 (pl) 2009-04-23 2016-04-29 Crucell Holland Bv Rekombinowana ludzka alfa1-antytrypsyna
EP2793936A4 (en) * 2011-12-19 2015-05-27 Lfb Usa Inc RECOMBINANT HUMAN ALPHA-1-ANTITRYPINE FOR THE TREATMENT OF INFLAMMATORY DISEASES
US9353165B2 (en) 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
CN102994514B (zh) * 2012-11-07 2015-06-10 武汉禾元生物科技股份有限公司 一种从水稻种子生产和分离纯化重组人抗胰蛋白酶(OsrAAT)的方法
US10034921B2 (en) 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
EP3600345A4 (en) 2017-03-29 2021-01-06 Cornell University OXIDATION-RESISTANT AAT GENE THERAPY
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
WO2019105770A1 (en) 2017-11-28 2019-06-06 Danmarks Tekniske Universitet Glycosylation of proteins
CA3127750A1 (en) * 2019-01-24 2020-07-30 Excellgene Sa Methods of producing and using recombinant alpha 1-antitrypsin (aat) and compositions thereof
AU2023355912A1 (en) * 2022-10-06 2025-04-24 Kamada Ltd. Highly fucosylated recombinant human alpha 1 antitrypsin (aat) protein having immunomodulatory activity and compositions comprising the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160406A0 (en) 1995-06-15 2004-07-25 Crucell Holland Bv A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products
US20050164386A1 (en) 1999-04-15 2005-07-28 Uytdehaag Alphonsus G. Overexpression of enzymes involved in post-translational protein modifications in human cells
HK1048138B (zh) 1999-04-15 2009-06-12 荷兰克鲁塞尔公司 用编码腺病毒e1蛋白的序列在人体细胞中生产重组蛋白
US7297680B2 (en) * 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
PT1465987E (pt) * 2001-12-07 2008-04-15 Crucell Holland Bv Produção de vírus, isolados virais e vacinas
WO2004099396A1 (en) 2003-05-09 2004-11-18 Crucell Holland B.V. Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom
CN101090973B (zh) * 2004-12-30 2012-03-28 克鲁塞尔荷兰公司 从表达腺病毒e1a蛋白的细胞中获得唾液酸化增加的重组蛋白质的方法及由此获得的蛋白质
WO2007102432A1 (ja) * 2006-03-02 2007-09-13 Kyowa Hakko Kogyo Co., Ltd. 糖蛋白質組成物の製造方法
WO2008069244A1 (ja) * 2006-12-05 2008-06-12 Kyowa Hakko Kogyo Co., Ltd. 糖蛋白質組成物の製造方法
EP2171052B1 (en) * 2007-07-12 2014-08-27 Sangamo BioSciences, Inc. Methods and compositions for inactivating alpha 1,6 fucosyltransferase (fut 8) gene expression
PL2421895T3 (pl) 2009-04-23 2016-04-29 Crucell Holland Bv Rekombinowana ludzka alfa1-antytrypsyna

Also Published As

Publication number Publication date
KR101640962B1 (ko) 2016-07-19
PL2421895T3 (pl) 2016-04-29
EA025021B1 (ru) 2016-11-30
DK2421895T3 (en) 2016-01-25
EP2421895B1 (en) 2015-11-11
AU2010244592B2 (en) 2016-05-19
EA201171275A1 (ru) 2012-03-30
ZA201107416B (en) 2017-11-29
JP5711215B2 (ja) 2015-04-30
AU2010244592A1 (en) 2011-10-27
CA2756591C (en) 2018-11-06
CN102439037A (zh) 2012-05-02
EP2421895A1 (en) 2012-02-29
JP2012524747A (ja) 2012-10-18
IL215537A (en) 2016-06-30
WO2010127939A1 (en) 2010-11-11
US8357661B2 (en) 2013-01-22
CN102439037B (zh) 2015-01-07
KR20120096871A (ko) 2012-08-31
CA2756591A1 (en) 2010-11-11
US20120214747A1 (en) 2012-08-23
IL215537A0 (en) 2011-12-29

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