ES2566934T3 - Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina - Google Patents
Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina Download PDFInfo
- Publication number
- ES2566934T3 ES2566934T3 ES11718122.2T ES11718122T ES2566934T3 ES 2566934 T3 ES2566934 T3 ES 2566934T3 ES 11718122 T ES11718122 T ES 11718122T ES 2566934 T3 ES2566934 T3 ES 2566934T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- under
- retina
- compositions
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts or implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un antagonista del receptor de mineralocorticoides (RM) o un inhibidor de la expresión génica del receptor de mineralocorticoides, para su uso en el tratamiento de la acumulación de líquido en y/o bajo la retina asociada con coriorretinitis serosa central.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10305493 | 2010-05-10 | ||
| EP10305493 | 2010-05-10 | ||
| US35907510P | 2010-06-28 | 2010-06-28 | |
| US359075P | 2010-06-28 | ||
| US35957510P | 2010-06-29 | 2010-06-29 | |
| US359575P | 2010-06-29 | ||
| PCT/EP2011/057497 WO2011141456A1 (en) | 2010-05-10 | 2011-05-10 | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2566934T3 true ES2566934T3 (es) | 2016-04-18 |
Family
ID=42289485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11718122.2T Active ES2566934T3 (es) | 2010-05-10 | 2011-05-10 | Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina |
| ES15183988.3T Active ES2641144T3 (es) | 2010-05-10 | 2011-05-10 | Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15183988.3T Active ES2641144T3 (es) | 2010-05-10 | 2011-05-10 | Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8957052B2 (es) |
| EP (3) | EP2977084B1 (es) |
| JP (3) | JP6148175B2 (es) |
| CA (1) | CA2796307A1 (es) |
| ES (2) | ES2566934T3 (es) |
| IL (1) | IL222482A0 (es) |
| WO (1) | WO2011141456A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2977084B1 (en) | 2010-05-10 | 2017-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
| WO2014202744A1 (en) | 2013-06-21 | 2014-12-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning |
| US10350223B2 (en) | 2015-03-03 | 2019-07-16 | Richard W. Yee | Compositions and methods for treating ocular diseases |
| JP6835836B2 (ja) * | 2015-10-13 | 2021-02-24 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 脈絡膜血管新生の処置のための方法及び医薬組成物 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3013012A (en) | 1960-12-22 | 1961-12-12 | Searle & Co | Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones |
| US3257390A (en) | 1963-06-12 | 1966-06-21 | Merck & Co Inc | Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents |
| DE2652761C2 (de) | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4559332A (en) | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| DE3506100A1 (de) | 1985-02-18 | 1986-08-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| EA009176B1 (ru) | 1995-12-11 | 2007-12-28 | Дж.Д.Серл Энд Ко. | Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов и промежуточных продуктов, используемых для их получения, и общий способ эпоксидирования по олефиновым двойным связям |
| WO1998025948A2 (en) | 1996-12-11 | 1998-06-18 | G.D. Searle & Co. | Processes for preparation of 9,11-epoxy steroids and intermediates useful therein |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| US6566131B1 (en) | 2000-10-04 | 2003-05-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of Smad6 expression |
| US6410323B1 (en) | 1999-08-31 | 2002-06-25 | Isis Pharmaceuticals, Inc. | Antisense modulation of human Rho family gene expression |
| US6107091A (en) | 1998-12-03 | 2000-08-22 | Isis Pharmaceuticals Inc. | Antisense inhibition of G-alpha-16 expression |
| US5981732A (en) | 1998-12-04 | 1999-11-09 | Isis Pharmaceuticals Inc. | Antisense modulation of G-alpha-13 expression |
| US6046321A (en) | 1999-04-09 | 2000-04-04 | Isis Pharmaceuticals Inc. | Antisense modulation of G-alpha-i1 expression |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| HUP0201457A3 (en) | 1999-12-08 | 2003-07-28 | Pharmacia Corp Chicago | Eplerenone crystalline form, pharmaceutical compositions containing them and their preparations |
| WO2001042272A2 (en) | 1999-12-08 | 2001-06-14 | Pharmacia Corporation | Eplerenone crystalline form exhibiting enhanced dissolution rate |
| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| US6365354B1 (en) | 2000-07-31 | 2002-04-02 | Isis Pharmaceuticals, Inc. | Antisense modulation of lysophospholipase I expression |
| US6566135B1 (en) | 2000-10-04 | 2003-05-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of caspase 6 expression |
| WO2003049745A1 (en) * | 2001-12-12 | 2003-06-19 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
| AU2003230581A1 (en) | 2002-03-15 | 2003-09-29 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
| TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| WO2004028477A2 (en) * | 2002-09-29 | 2004-04-08 | Surmodics, Inc. | Methods for treatment and/or prevention of retinal disease |
| US20050013845A1 (en) * | 2002-11-12 | 2005-01-20 | Warren Stephen L. | Adhesive bioerodible ocular drug delivery system |
| BRPI0406883A (pt) | 2003-01-22 | 2006-01-03 | Lilly Co Eli | Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto |
| WO2004069181A2 (en) * | 2003-02-03 | 2004-08-19 | Pharmacia Corporation | Composition for the treatment of intraocular pressure |
| MXPA05008396A (es) * | 2003-02-20 | 2006-03-30 | Alcon Inc | Formulaciones de glucocorticoides para tratar angiogenesis ocular patologica. |
| CA2516782A1 (en) * | 2003-02-20 | 2004-09-02 | Alcon, Inc. | Use of steroids to treat ocular disorders |
| CN1918151A (zh) | 2003-12-19 | 2007-02-21 | 伊莱利利公司 | 三环甾类激素核受体调节剂 |
| RU2363497C2 (ru) * | 2003-12-24 | 2009-08-10 | Новартис Аг | Фармацевтические композиции |
| WO2005079781A1 (en) * | 2004-02-25 | 2005-09-01 | La Trobe University | Therapeutic and/or prophylactic method |
| JP2007230869A (ja) | 2004-04-05 | 2007-09-13 | Takeda Chem Ind Ltd | アルドステロン受容体拮抗剤 |
| SI1755616T1 (sl) * | 2004-04-08 | 2014-04-30 | Eye Co Pty Ltd. | Zdravljenje eksudativne retinopatije z mineralkortikoidi |
| US8119154B2 (en) * | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
| WO2006010142A2 (en) | 2004-07-14 | 2006-01-26 | Ligand Pharmaceuticals, Inc. | Mineralocorticoid receptor modulator compounds, processes for their preparation, and their use |
| SG155188A1 (en) | 2004-07-30 | 2009-09-30 | Exelixis Inc | Pyrrole derivatives as pharmaceutical agents |
| WO2006076202A1 (en) | 2005-01-10 | 2006-07-20 | Exelixis, Inc. | Heterocyclic carboxamide compounds as steroid nuclear receptors ligands |
| WO2006077821A1 (ja) | 2005-01-19 | 2006-07-27 | Dainippon Sumitomo Pharma Co., Ltd. | アルドステロン受容体調節剤としての芳香族スルホン化合物 |
| US20090082321A1 (en) * | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Steroid containing drug delivery systems |
| JP4273235B2 (ja) * | 2006-06-01 | 2009-06-03 | 国立大学法人 新潟大学 | アクアポリン4阻害薬 |
| SI2089367T1 (sl) | 2006-10-31 | 2012-02-29 | Pfizer Prod Inc | Spojine pirazolina kot antagonisti mineralokortikoidnih receptorjev |
| TWI431010B (zh) | 2007-12-19 | 2014-03-21 | Lilly Co Eli | 礦皮質素受體拮抗劑及使用方法 |
| EP2977084B1 (en) | 2010-05-10 | 2017-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
-
2011
- 2011-05-10 EP EP15183988.3A patent/EP2977084B1/en active Active
- 2011-05-10 CA CA2796307A patent/CA2796307A1/en not_active Abandoned
- 2011-05-10 US US13/696,345 patent/US8957052B2/en active Active
- 2011-05-10 EP EP17168625.6A patent/EP3238781B1/en active Active
- 2011-05-10 JP JP2013509541A patent/JP6148175B2/ja active Active
- 2011-05-10 ES ES11718122.2T patent/ES2566934T3/es active Active
- 2011-05-10 WO PCT/EP2011/057497 patent/WO2011141456A1/en not_active Ceased
- 2011-05-10 ES ES15183988.3T patent/ES2641144T3/es active Active
- 2011-05-10 EP EP11718122.2A patent/EP2568986B1/en active Active
-
2012
- 2012-10-16 IL IL222482A patent/IL222482A0/en unknown
-
2015
- 2015-01-02 US US14/588,785 patent/US9610294B2/en active Active
-
2016
- 2016-02-25 JP JP2016034425A patent/JP6435283B2/ja active Active
-
2017
- 2017-10-12 JP JP2017198263A patent/JP6425785B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3238781B1 (en) | 2019-07-31 |
| EP2568986A1 (en) | 2013-03-20 |
| US9610294B2 (en) | 2017-04-04 |
| JP6148175B2 (ja) | 2017-06-14 |
| JP6435283B2 (ja) | 2018-12-05 |
| EP2977084A1 (en) | 2016-01-27 |
| IL222482A0 (en) | 2012-12-31 |
| JP2016138116A (ja) | 2016-08-04 |
| JP2018039824A (ja) | 2018-03-15 |
| US8957052B2 (en) | 2015-02-17 |
| EP3238781A1 (en) | 2017-11-01 |
| JP2013528596A (ja) | 2013-07-11 |
| CA2796307A1 (en) | 2011-11-17 |
| JP6425785B2 (ja) | 2018-11-21 |
| ES2641144T3 (es) | 2017-11-07 |
| EP2977084B1 (en) | 2017-07-05 |
| US20130131024A1 (en) | 2013-05-23 |
| WO2011141456A1 (en) | 2011-11-17 |
| EP2568986B1 (en) | 2016-01-13 |
| US20150216879A1 (en) | 2015-08-06 |
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