ES2566934T3 - Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina - Google Patents

Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina Download PDF

Info

Publication number
ES2566934T3
ES2566934T3 ES11718122.2T ES11718122T ES2566934T3 ES 2566934 T3 ES2566934 T3 ES 2566934T3 ES 11718122 T ES11718122 T ES 11718122T ES 2566934 T3 ES2566934 T3 ES 2566934T3
Authority
ES
Spain
Prior art keywords
treatment
under
retina
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11718122.2T
Other languages
English (en)
Inventor
Francine Behar-Cohen
Nicolette Farman
Frédéric Jaissier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Descartes
Original Assignee
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Descartes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Assistance Publique Hopitaux de Paris APHP, Institut National de la Sante et de la Recherche Medicale INSERM, Universite Paris Descartes filed Critical Assistance Publique Hopitaux de Paris APHP
Application granted granted Critical
Publication of ES2566934T3 publication Critical patent/ES2566934T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts or implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un antagonista del receptor de mineralocorticoides (RM) o un inhibidor de la expresión génica del receptor de mineralocorticoides, para su uso en el tratamiento de la acumulación de líquido en y/o bajo la retina asociada con coriorretinitis serosa central.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10
imagen11
imagen12
imagen13
imagen14
imagen15
imagen16
imagen17
imagen18
imagen19
imagen20
imagen21
imagen22
imagen23

Claims (1)

  1. imagen1
ES11718122.2T 2010-05-10 2011-05-10 Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina Active ES2566934T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US359075P 2002-02-21
EP10305493 2010-05-10
EP10305493 2010-05-10
US35907510P 2010-06-28 2010-06-28
US35957510P 2010-06-29 2010-06-29
US359575P 2010-06-29
PCT/EP2011/057497 WO2011141456A1 (en) 2010-05-10 2011-05-10 Methods and compositions for the treatment of fluid accumulation in and/ or under the retina

Publications (1)

Publication Number Publication Date
ES2566934T3 true ES2566934T3 (es) 2016-04-18

Family

ID=42289485

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11718122.2T Active ES2566934T3 (es) 2010-05-10 2011-05-10 Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina
ES15183988.3T Active ES2641144T3 (es) 2010-05-10 2011-05-10 Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15183988.3T Active ES2641144T3 (es) 2010-05-10 2011-05-10 Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina

Country Status (7)

Country Link
US (2) US8957052B2 (es)
EP (3) EP2568986B1 (es)
JP (3) JP6148175B2 (es)
CA (1) CA2796307A1 (es)
ES (2) ES2566934T3 (es)
IL (1) IL222482A0 (es)
WO (1) WO2011141456A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2566934T3 (es) 2010-05-10 2016-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina
WO2014202744A1 (en) 2013-06-21 2014-12-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning
WO2016141182A1 (en) 2015-03-03 2016-09-09 Yee Richard W Compositions and methods for treating ocular diseases
WO2017064121A1 (en) * 2015-10-13 2017-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013012A (en) 1960-12-22 1961-12-12 Searle & Co Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones
US3257390A (en) 1963-06-12 1966-06-21 Merck & Co Inc Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents
DE2652761C2 (de) 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
FI77669C (fi) 1983-04-13 1989-04-10 Ciba Geigy Ag 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
DE3506100A1 (de) 1985-02-18 1986-08-21 Schering AG, 1000 Berlin und 4709 Bergkamen 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5981744A (en) 1995-12-11 1999-11-09 G. D. Searle And Co. Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
PT944644E (pt) 1996-12-11 2003-02-28 Searle & Co Processos para a preparacao de esteroides 9,11-epoxi e intermediarios uteis para esse efeito
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6566131B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of Smad6 expression
US6410323B1 (en) 1999-08-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of human Rho family gene expression
US6107091A (en) 1998-12-03 2000-08-22 Isis Pharmaceuticals Inc. Antisense inhibition of G-alpha-16 expression
US5981732A (en) 1998-12-04 1999-11-09 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-13 expression
US6046321A (en) 1999-04-09 2000-04-04 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-i1 expression
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
MXPA01008056A (es) 1999-12-08 2003-07-21 Pharmacia Corp Forma cristalina de eplerenona que exhibe velocidad de disolucion intensificada.
EA008449B1 (ru) 1999-12-08 2007-06-29 Фармация Корпорейшн Кристаллическая форма эплеренона
EP1272630A2 (en) 2000-03-16 2003-01-08 Genetica, Inc. Methods and compositions for rna interference
US6365354B1 (en) 2000-07-31 2002-04-02 Isis Pharmaceuticals, Inc. Antisense modulation of lysophospholipase I expression
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression
CA2469616A1 (en) * 2001-12-12 2003-06-19 James W. Aiken Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
WO2003078394A1 (en) 2002-03-15 2003-09-25 Eli Lilly And Company Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators
TW200400816A (en) 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
WO2004028477A2 (en) * 2002-09-29 2004-04-08 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US20050013845A1 (en) * 2002-11-12 2005-01-20 Warren Stephen L. Adhesive bioerodible ocular drug delivery system
CN1742007A (zh) 2003-01-22 2006-03-01 伊莱利利公司 甾族激素核受体的吲哚衍生物调控剂
WO2004069181A2 (en) * 2003-02-03 2004-08-19 Pharmacia Corporation Composition for the treatment of intraocular pressure
WO2004073608A2 (en) * 2003-02-20 2004-09-02 Alcon, Inc. Formulations of glucocorticoids to treat pathologic ocular angiogenesis
WO2004073607A2 (en) * 2003-02-20 2004-09-02 Alcon, Inc. Use of steroids to treat ocular disorders
CN1918151A (zh) 2003-12-19 2007-02-21 伊莱利利公司 三环甾类激素核受体调节剂
RU2363497C2 (ru) * 2003-12-24 2009-08-10 Новартис Аг Фармацевтические композиции
WO2005079781A1 (en) * 2004-02-25 2005-09-01 La Trobe University Therapeutic and/or prophylactic method
JP2007230869A (ja) 2004-04-05 2007-09-13 Takeda Chem Ind Ltd アルドステロン受容体拮抗剤
PL1755616T3 (pl) * 2004-04-08 2014-10-31 Eye Co Pty Ltd Leczenie mineralokortykoidami retinopatii wysiękowej
US8119154B2 (en) * 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
WO2006010142A2 (en) 2004-07-14 2006-01-26 Ligand Pharmaceuticals, Inc. Mineralocorticoid receptor modulator compounds, processes for their preparation, and their use
CA2573426C (en) 2004-07-30 2015-11-17 Exelixis, Inc. Pyrrole derivatives as pharmaceutical agents
JP5123668B2 (ja) 2005-01-10 2013-01-23 エグゼリクシス, インコーポレイテッド 医薬品としての複素環カルボキサミド化合物
EP1844768A1 (en) 2005-01-19 2007-10-17 Dainippon Sumitomo Pharma Co., Ltd. Aromatic sulfone compound as aldosterone receptor modulator
US20090082321A1 (en) * 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
JP4273235B2 (ja) * 2006-06-01 2009-06-03 国立大学法人 新潟大学 アクアポリン4阻害薬
DK2089367T3 (da) 2006-10-31 2012-02-06 Pfizer Prod Inc Pyrazolinforbindelser som mineralocorticoidreceptor-antagonister
TWI431010B (zh) 2007-12-19 2014-03-21 Lilly Co Eli 礦皮質素受體拮抗劑及使用方法
ES2566934T3 (es) 2010-05-10 2016-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina

Also Published As

Publication number Publication date
JP6435283B2 (ja) 2018-12-05
EP3238781A1 (en) 2017-11-01
JP2013528596A (ja) 2013-07-11
US20130131024A1 (en) 2013-05-23
EP2977084B1 (en) 2017-07-05
JP6425785B2 (ja) 2018-11-21
ES2641144T3 (es) 2017-11-07
EP3238781B1 (en) 2019-07-31
JP2016138116A (ja) 2016-08-04
WO2011141456A1 (en) 2011-11-17
IL222482A0 (en) 2012-12-31
EP2977084A1 (en) 2016-01-27
EP2568986B1 (en) 2016-01-13
US20150216879A1 (en) 2015-08-06
JP6148175B2 (ja) 2017-06-14
US9610294B2 (en) 2017-04-04
CA2796307A1 (en) 2011-11-17
JP2018039824A (ja) 2018-03-15
EP2568986A1 (en) 2013-03-20
US8957052B2 (en) 2015-02-17

Similar Documents

Publication Publication Date Title
MX380810B (es) Sondas para la proyección de imagen de la proteína huntingtina.
LT4303583T (lt) Csf1r inhibitoriai, skirti panaudoti gydant tenosinovinius gigantinių ląstelių navikus
CL2010001483A1 (es) Compuestos derivados de 5-fenil-1h-piridin-2-ona y 6-fenil-2h-piridazin-3-ona, inhibidores de tirosina-quinasa (btk); composicion farmaceutica que comprende a dichos compuestos y su uso para el tratamiento de un estado patologico inflamatorio y/o autoinmune.
CL2012003053A1 (es) Combinacion farmaceutica que comprende un agonista del receptor glp-1 y linagliptin, inhibidor dpp-4; uso de la combinacion farmaceutica para el tratamiento de la diabetes tipo 2 y de la obesidad.
CL2017000654A1 (es) Indazoles sustituidos con bencilo como inhibidores de bub1.
CL2014001639A1 (es) Uso simultaneo, separado o secuencial de un agonista de ppar gamma seleccionado del grupo de glitazonas con un activador de nrf2 aislado seleccionado de un grupo especifico o una composicion que lo comprende, para el tratamiento de un trastorno autoinmune y/o inflamatorio; composicion farmaceutica que comprende a dicho agonista de ppar gamma y al activador de nrf2; y kit que la comprende.
CL2015000294A1 (es) Combinaciones farmaceuticas que comprenden un inhibidor de b-raf, un inhibidor del receptor del factor de crecimiento epidermico y opcionalmente un inhibidor pi3halpha y uso en el tratamiento de una enfermedad proliferativa.
MX2014005800A (es) Mutaciones del receptor notch humano y su uso.
UY34200A (es) 3-(fluorovinil)pirazoles y su uso
MX2015000008A (es) Uso de marcadores en el diagnostico y tratamiento de cancer de prostata.
MX383202B (es) Sondas para la proyección de imagen de la proteína huntingtina.
CR20160061A (es) Formulación estable líquida de etelcalcetide (amg 461)
EP3607327A4 (en) SERVICE POINT TEST CARTRIDGE
UY33856A (es) ?gen y variaciones asociadas con el fenotipo bm1, marcadores moleculares y su uso?.
MX386798B (es) Sondas para la proyección de imagen de la proteína huntingtina.
MX382156B (es) Sondas para formar imagenes de proteina de huntingtina.
ES2566934T3 (es) Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina
UY34590A (es) Fenilimidazopirazoles sustituidos y su uso
ES2641554T3 (es) Kit de piezas para colocación de anclaje quirúrgico
MX2016014558A (es) Extinguidores de fluorescencia "cosmic quenchers".
MX2017014857A (es) Metodos para diagnosticar y evaluar tratamiento para sindrome de cushing.
ES2586116T3 (es) Procedimiento y composición para el tratamiento, la prevención y el diagnóstico de cáncer que contiene células madre de cáncer o derivados de las mismas
ES2664171T3 (es) Aditivo retardador del fraguado y plastificante para el hormigón
ES2611776T3 (es) Uso de sales de tungsteno (VI) para el tratamiento de la esterilidad femenina en mamíferos no diabéticos
EP3606579A4 (en) READY-TO-USE INJECTOR WITH INDICATOR