ES2570756T3 - Derivados pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa - Google Patents

Derivados pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa

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Publication number
ES2570756T3
ES2570756T3 ES10725144T ES10725144T ES2570756T3 ES 2570756 T3 ES2570756 T3 ES 2570756T3 ES 10725144 T ES10725144 T ES 10725144T ES 10725144 T ES10725144 T ES 10725144T ES 2570756 T3 ES2570756 T3 ES 2570756T3
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Spain
Prior art keywords
con
alkyl
hydrogen
preparation
kinase inhibitors
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ES10725144T
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English (en)
Inventor
Chiara Marchionni
Fabio Zuccotto
Alessandra Badari
Mauro Angiolini
Davide Carenzi
Marina Caldarelli
Maurizio Pulici
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Nerviano Medical Sciences SRL
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Nerviano Medical Sciences SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuesto de fórmula (I)**Fórmula** donde R1 es hidrógeno;**Fórmula** R2 es R2', donde R2' es ; R3 es NH2, donde L2 es CH2CH2, CH>=CH o C≡C; A es un enlace directo, O, OCH2, OCO, CON(Y), CON(Y)O, CON(Y)N(Y),CON(Y)SO2, N(Y), N(Y)CO, N(Y)SO2-, N(Y)CON(Y), N(Y)CSN(Y), N(Y)CON(Y)N(Y), N(Y)COO, N(Y)CON(Y)SO2 o N(Y)SO2N(Y); Y es hidrógeno o un alquilo (C1-C3) lineal o ramificado opcionalmente sustituido; R5 es hidrógeno o un grupo opcionalmente sustituido seleccionado entre alquilo (C1-C8) lineal o ramificado, alquenilo (C2-C8), alquinilo (C2-C8), cicloalquilo (C3-C8), heterociclilo, arilo y heteroarilo; R6 se selecciona entre hidrógeno, halógeno, trifluorometilo, alquilo (C1-C3) y alcoxi (C1-C3); R4 un grupo opcionalmente sustituido seleccionado entre alquilo (C1-C6) lineal o ramificado, alquenilo (C2-C6), alquinilo (C2-C6), cicloalquilo (C3-C6) y heterociclilo; y sales farmacéuticamente aceptables.
ES10725144T 2009-06-15 2010-06-11 Derivados pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa Active ES2570756T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09162719 2009-06-15
PCT/EP2010/058223 WO2010145998A1 (en) 2009-06-15 2010-06-11 Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors

Publications (1)

Publication Number Publication Date
ES2570756T3 true ES2570756T3 (es) 2016-05-20

Family

ID=42320051

Family Applications (2)

Application Number Title Priority Date Filing Date
ES16151574.7T Active ES2679379T3 (es) 2009-06-15 2010-06-11 Derivados de pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa
ES10725144T Active ES2570756T3 (es) 2009-06-15 2010-06-11 Derivados pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES16151574.7T Active ES2679379T3 (es) 2009-06-15 2010-06-11 Derivados de pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa

Country Status (5)

Country Link
US (2) US8546413B2 (es)
EP (2) EP3045457B1 (es)
JP (1) JP5789602B2 (es)
ES (2) ES2679379T3 (es)
WO (1) WO2010145998A1 (es)

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US11007194B2 (en) 2011-11-11 2021-05-18 Array Biopharma Inc. Method of treating a proliferative disease
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Also Published As

Publication number Publication date
US8546413B2 (en) 2013-10-01
US8969366B2 (en) 2015-03-03
JP2012530099A (ja) 2012-11-29
US20120178770A1 (en) 2012-07-12
EP3045457A1 (en) 2016-07-20
EP2443117B1 (en) 2016-03-23
JP5789602B2 (ja) 2015-10-07
EP3045457B1 (en) 2018-05-09
ES2679379T3 (es) 2018-08-24
WO2010145998A1 (en) 2010-12-23
US20130345245A1 (en) 2013-12-26
EP2443117A1 (en) 2012-04-25

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