ES2571043T3 - Preparación de dihidropiridinas - Google Patents

Preparación de dihidropiridinas

Info

Publication number
ES2571043T3
ES2571043T3 ES10162298T ES10162298T ES2571043T3 ES 2571043 T3 ES2571043 T3 ES 2571043T3 ES 10162298 T ES10162298 T ES 10162298T ES 10162298 T ES10162298 T ES 10162298T ES 2571043 T3 ES2571043 T3 ES 2571043T3
Authority
ES
Spain
Prior art keywords
formula
compound
preparation
organic solvent
dihydropyridine preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10162298T
Other languages
English (en)
Inventor
Newadkar Ravindranath Vishnu
Joshi Anil Puruschottam
Singh Santosh Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuraxpharm Pharmaceuticals SL
Original Assignee
Laboratorios Lesvi SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Lesvi SL filed Critical Laboratorios Lesvi SL
Application granted granted Critical
Publication of ES2571043T3 publication Critical patent/ES2571043T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un proceso para la preparación de butirato de clevidipina que comprende la etapa: (i) hacer reaccionar un compuesto de fórmula (I): **Fórmula** con 3-amino-crotonato de metilo para obtener butirato de clevidipina, en el que la etapa (i) se realiza en presencia de al menos un disolvente orgánico o una mezcla de disolventes que comprende un disolvente orgánico; y en el que el compuesto de fórmula (I) se prepara mediante la esterificación de un compuesto de fórmula (II) o una sal del mismo: **Fórmula** con un compuesto de fórmula L-CH2-OCO-n-Pr, en la que L es un grupo saliente.
ES10162298T 2010-05-07 2010-05-07 Preparación de dihidropiridinas Active ES2571043T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10162298.3A EP2386544B1 (en) 2010-05-07 2010-05-07 Preparation of dihydropyridines

Publications (1)

Publication Number Publication Date
ES2571043T3 true ES2571043T3 (es) 2016-05-23

Family

ID=42734845

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10162298T Active ES2571043T3 (es) 2010-05-07 2010-05-07 Preparación de dihidropiridinas

Country Status (2)

Country Link
EP (2) EP2386544B1 (es)
ES (1) ES2571043T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2623039C2 (ru) * 2011-04-01 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Дигидропиридины (клевидипин) кратковременного действия для применения в восстановлении после инсульта
CN103242220B (zh) * 2012-02-08 2016-03-09 上海医药工业研究院 丁酸氯维地平的制备方法
CN103373956B (zh) * 2012-04-23 2015-07-01 黑龙江省格润药业有限责任公司 一种制备丁酸氯维地平的方法
CN103450076A (zh) * 2013-09-13 2013-12-18 朱从敏 一种制备丁酸氯维地平的方法
CN104072404A (zh) * 2014-06-06 2014-10-01 北京哈三联科技有限责任公司 一种丁酸氯维地平的制备方法
CN105198797B (zh) * 2015-11-12 2017-12-08 华仁药业股份有限公司 丁酸氯维地平的纯化方法
CN108752263B (zh) * 2018-06-08 2021-10-26 迪嘉药业集团有限公司 一种高纯度硝苯地平结晶的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9303657D0 (sv) 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
SE9804002D0 (sv) 1998-11-23 1998-11-23 Astra Ab New manufacturing process

Also Published As

Publication number Publication date
EP3020704A3 (en) 2016-11-09
EP2386544B1 (en) 2016-02-10
EP3020704A2 (en) 2016-05-18
EP2386544A1 (en) 2011-11-16

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