ES2574606T3 - Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma - Google Patents

Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma Download PDF

Info

Publication number
ES2574606T3
ES2574606T3 ES10192000.7T ES10192000T ES2574606T3 ES 2574606 T3 ES2574606 T3 ES 2574606T3 ES 10192000 T ES10192000 T ES 10192000T ES 2574606 T3 ES2574606 T3 ES 2574606T3
Authority
ES
Spain
Prior art keywords
ethyl acetate
hexane
fraction
eluted
fractions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10192000.7T
Other languages
English (en)
Spanish (es)
Inventor
Chiang Been-Huang
Lin Yu-Wei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Taiwan University
Original Assignee
National Taiwan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Taiwan University filed Critical National Taiwan University
Application granted granted Critical
Publication of ES2574606T3 publication Critical patent/ES2574606T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES10192000.7T 2009-11-26 2010-11-22 Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma Active ES2574606T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TW98140278 2009-11-26
TW098140278 2009-11-26

Publications (1)

Publication Number Publication Date
ES2574606T3 true ES2574606T3 (es) 2016-06-21

Family

ID=43618265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10192000.7T Active ES2574606T3 (es) 2009-11-26 2010-11-22 Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma

Country Status (7)

Country Link
US (2) US20110123562A1 (pl)
EP (1) EP2329816B1 (pl)
JP (1) JP5752925B2 (pl)
ES (1) ES2574606T3 (pl)
MY (1) MY161596A (pl)
PL (1) PL2329816T3 (pl)
TW (1) TWI421085B (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2329816B1 (en) 2009-11-26 2016-04-13 National Taiwan University An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof
US8309611B2 (en) * 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
CN103796647A (zh) * 2011-06-10 2014-05-14 国鼎生物科技股份有限公司 用于治疗脑癌的方法和组合物
TWI484954B (zh) * 2011-10-11 2015-05-21 New Bellus Entpr Co Ltd 用於治療癌症之醫藥組合物
CN103083364A (zh) * 2011-11-04 2013-05-08 丽丰实业股份有限公司 用于治疗癌症的药物组合物
TWI425948B (zh) 2012-01-20 2014-02-11 優生生物科技股份有限公司 Compositions for the inhibition or killing of Porphyromonas gingivalis and their use for the alleviation or treatment of periodontal disease and other diseases
SE1350211A1 (sv) 2012-02-23 2013-08-24 Golden Biotechnology Corp Metoder och kompositioner för behandling av cancermetastaser
TWI597061B (zh) 2013-02-20 2017-09-01 國鼎生物科技股份有限公司 治療白血病之方法及組成物
TWI583376B (zh) * 2013-03-20 2017-05-21 曾卉菱 Compounds isolated from Antelroxicus and their use
CN104115669B (zh) * 2013-04-27 2016-11-02 富裔实业股份有限公司 牛樟芝培养方法及牛樟芝酒萃物的制备方法
TWI555529B (zh) 2014-06-20 2016-11-01 富裔實業股份有限公司 中草藥萃取物用於製備肝癌藥物之用途
JP6034834B2 (ja) * 2014-07-03 2016-11-30 康力生技股▲分▼有限公司 抗子宮筋腫用の漢方薬草合成物およびその漢方薬草抽出物により製造された抗子宮筋腫薬物の製造方法
JP6593856B2 (ja) * 2014-09-03 2019-10-23 台灣利得生物科技股▲ふん▼有限公司 抗肺癌細胞転移用組成物およびその製造方法
DE102014113861B4 (de) 2014-09-24 2024-01-04 Taiwan Leader Biotech Corp. Bioaktive Komponente zur Verwendung bei der Bekämpfung der Metastasierung eines Lungentumors
TWI551291B (zh) * 2015-04-29 2016-10-01 葡萄王生技股份有限公司 一種具降低癌細胞抗藥性之樟芝菌絲體萃取物及其醫藥或食品組合物
CN106176827B (zh) * 2015-04-29 2020-04-14 葡萄王生技股份有限公司 降低癌细胞抗药性的樟芝菌丝体萃取物及其活性物质和组合物
CN110337991A (zh) * 2019-06-19 2019-10-18 三生源生物科技(天津)有限公司 一种基于牛樟芝提取物的肿瘤细胞抑制剂的制备及应用
CN110305918A (zh) * 2019-06-19 2019-10-08 北京化工大学 一种牛樟芝发酵耦合萃取生产4-Acetylantroquinonol B的方法
CN113960204A (zh) * 2021-10-23 2022-01-21 哈尔滨工业大学 一种红松松塔抗肝细胞癌化合物筛选方法
CN115323027B (zh) * 2022-09-07 2024-08-06 福建农林大学 一种生物活性次级代谢产物的制备方法和应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106750A (en) * 1988-08-30 1992-04-21 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
US5445951A (en) * 1993-02-02 1995-08-29 Mcneil-Ppc, Inc. Regioselective enzymatic deacylation of sucrose esters in anhydrous organic media
EP1181938B1 (en) * 1993-04-23 2007-11-14 Wyeth Rapamycin conjugates and antibodies
TWI226370B (en) * 2000-02-17 2005-01-11 Food Industry Res & Dev Inst Isolate of Antrodia camphorata, process for producing a culture of the same and product obtained thereby
CN1192098C (zh) * 2000-11-13 2005-03-09 葡萄王企业股份有限公司 樟芝菌丝体生物活性物质其制备法及含其组成物
CN1386545A (zh) * 2001-05-18 2002-12-25 葡萄王企业股份有限公司 樟芝保肝制剂
TWI241344B (en) * 2002-03-29 2005-10-11 Food Industry Res & Dev Inst Processes for producing an antrodia camphorata culture having pharmacological activity, processes for obtaining a pharmacologically active composition from a culture of A camphorata, products produced thereby and pharmaceutical compositions of cancer...
JP5403844B2 (ja) * 2004-03-02 2014-01-29 善笙生物科技股▲分▼有限公司 AntrodiaCamphorataの菌糸体から得た新規な混合物及び化合物、並びにその使用
US7109232B2 (en) * 2004-03-08 2006-09-19 Simpson Biotech Co., Ltd. Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity
ATE513823T1 (de) * 2004-08-17 2011-07-15 Simpson Biotech Co Ltd Mischung und verbindungen von mycelien von antrodia camphorata und deren verwendung
TW200638867A (en) * 2005-05-06 2006-11-16 Golden Biotechnology Corp Incubation and application methods for the culture of antrodia camphorata
US20070116787A1 (en) * 2005-11-21 2007-05-24 Chih-Jung Yao Cancer treatment
TW200810770A (en) * 2006-08-17 2008-03-01 Kang Jiann Biotech Co Ltd Novel diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
US7601854B2 (en) * 2006-10-25 2009-10-13 Kang Jian Biotech Corp., Ltd. Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
TW200819125A (en) * 2006-10-31 2008-05-01 Golden Biotechnology Corp Application of Antrodia camphorate extract capable of inhibiting growth of tumor cells
EP2094651A1 (en) * 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
TW200829234A (en) * 2007-01-08 2008-07-16 Golden Biotechnology Corp Antrodia camphorata isophorone extract
TWI394573B (zh) * 2007-06-14 2013-05-01 國鼎生物科技股份有限公司 Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for Liver Protection
TWI394575B (zh) * 2007-07-09 2013-05-01 Golden Biotechnology Corp Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus
TW200918498A (en) * 2007-10-19 2009-05-01 Golden Biotechnology Corp Novel compound isolated from Antrodia camphorate extracts
US8772329B2 (en) * 2008-01-28 2014-07-08 Simpson Biotech Co., Ltd. Compounds from mycelium of Antrodia cinnamomea and use thereof
TW201000112A (en) * 2008-06-18 2010-01-01 Mackay Memorial Hospital Use of dehydrosulphurenic acid for inhibiting the growth of cancer cells
US7932285B2 (en) * 2008-11-21 2011-04-26 Well Shine Biotechnology Development Co., Ltd. Compounds from Antrodia camphorata
TWI389699B (zh) * 2009-02-13 2013-03-21 高雄醫學大學 用於誘導細胞凋亡之樟芝子實體乙醇萃取物及其製備方法
TW201102075A (en) * 2009-07-09 2011-01-16 Golden Biotechnology Corp Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of pancreatic cancer
EP2329816B1 (en) 2009-11-26 2016-04-13 National Taiwan University An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof

Also Published As

Publication number Publication date
MY161596A (en) 2017-04-28
TWI421085B (zh) 2014-01-01
US20110123562A1 (en) 2011-05-26
US9950021B2 (en) 2018-04-24
JP5752925B2 (ja) 2015-07-22
EP2329816B1 (en) 2016-04-13
EP2329816A1 (en) 2011-06-08
PL2329816T3 (pl) 2016-10-31
TW201200144A (en) 2012-01-01
JP2011111457A (ja) 2011-06-09
US20130129773A1 (en) 2013-05-23

Similar Documents

Publication Publication Date Title
EP2329816B1 (en) An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof
Żołnierczyk et al. Isoxanthohumol—Biologically active hop flavonoid
Heng et al. Analysis of the bioactive components of Sapindus saponins
CN114524825B (zh) 牛尾蒿内酯a-t及其药物组合物和其制备方法与应用
Li et al. Lignans from the heartwood of Streblus asper and their inhibiting activities to hepatitis B virus
CN101904968A (zh) 重楼薯蓣类皂苷的制备方法及其抗肿瘤药物制剂
CN103936590A (zh) 大戟属中的二萜类化合物及其药物组合物和其在制药中的应用
CN102443613B (zh) 牛樟芝抗癌活性物质、制备方法及其用途
Schmid et al. Quantitative mapping of flavor and pharmacologically active compounds in European licorice roots (Glycyrrhiza glabra L.) in response to growth conditions and arbuscular mycorrhiza symbiosis
CN100413868C (zh) 分离自藤黄树脂并具有抑制肿瘤/癌细胞生长活性的化合物以及包含其的药物组合物
CN108125993B (zh) 一种能逆转肿瘤多药耐药性的茯苓提取物的制备
CN111548327B (zh) 降碳贝壳杉烷型二萜及其制备方法和在制备抗肿瘤药物中的用途
CN106083882A (zh) 驱虫斑鸠菊中的倍半萜二聚体类化合物及制备方法和用途
CN113999245B (zh) 具有抗胰腺癌活性的天然化合物及其分离方法及应用
CN105079011A (zh) 一种具有抗肿瘤作用的药物的制备和应用
CN103610682A (zh) 3α-羟基-30-齐墩果-12,20(29)-二烯-28-酸的制备方法和在制备抗肿瘤药物中的应用
CN115558011A (zh) 一种蒽酮类化合物及其制备方法和用途
CN107674054A (zh) 一类新骨架杂萜化合物,其制备方法、药物组合物和抗肿瘤应用
CN107722096A (zh) 一种具有抗肿瘤作用的甾体类天然药物及其制备方法和用途
CN115490660B (zh) 南牡蒿内酯a-d及其药物组合物和其应用
CN117304032B (zh) 断节参中一种甾体皂苷元化合物及其制备方法与应用
CN115477678B (zh) 一种三萜二糖苷化合物的制备方法和在制备抗肿瘤药物中的应用
CN101463060B (zh) 通关藤提取物
CN108948040A (zh) 一种烟管头草中提取的吉玛烷型倍半萜化合物及其应用
CN111217886B (zh) 乌苏烷型三萜皂苷类化合物及其制备方法和应用