ES2574606T3 - Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma - Google Patents
Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma Download PDFInfo
- Publication number
- ES2574606T3 ES2574606T3 ES10192000.7T ES10192000T ES2574606T3 ES 2574606 T3 ES2574606 T3 ES 2574606T3 ES 10192000 T ES10192000 T ES 10192000T ES 2574606 T3 ES2574606 T3 ES 2574606T3
- Authority
- ES
- Spain
- Prior art keywords
- ethyl acetate
- hexane
- fraction
- eluted
- fractions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C*(CC(CC(*)=C)*O1)CC1=N Chemical compound C*(CC(CC(*)=C)*O1)CC1=N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW98140278 | 2009-11-26 | ||
| TW098140278 | 2009-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2574606T3 true ES2574606T3 (es) | 2016-06-21 |
Family
ID=43618265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10192000.7T Active ES2574606T3 (es) | 2009-11-26 | 2010-11-22 | Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20110123562A1 (pl) |
| EP (1) | EP2329816B1 (pl) |
| JP (1) | JP5752925B2 (pl) |
| ES (1) | ES2574606T3 (pl) |
| MY (1) | MY161596A (pl) |
| PL (1) | PL2329816T3 (pl) |
| TW (1) | TWI421085B (pl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2329816B1 (en) | 2009-11-26 | 2016-04-13 | National Taiwan University | An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof |
| US8309611B2 (en) * | 2010-09-20 | 2012-11-13 | Golden Biotechnology Corporation | Methods and compositions for treating lung cancer |
| CN103796647A (zh) * | 2011-06-10 | 2014-05-14 | 国鼎生物科技股份有限公司 | 用于治疗脑癌的方法和组合物 |
| TWI484954B (zh) * | 2011-10-11 | 2015-05-21 | New Bellus Entpr Co Ltd | 用於治療癌症之醫藥組合物 |
| CN103083364A (zh) * | 2011-11-04 | 2013-05-08 | 丽丰实业股份有限公司 | 用于治疗癌症的药物组合物 |
| TWI425948B (zh) | 2012-01-20 | 2014-02-11 | 優生生物科技股份有限公司 | Compositions for the inhibition or killing of Porphyromonas gingivalis and their use for the alleviation or treatment of periodontal disease and other diseases |
| SE1350211A1 (sv) | 2012-02-23 | 2013-08-24 | Golden Biotechnology Corp | Metoder och kompositioner för behandling av cancermetastaser |
| TWI597061B (zh) | 2013-02-20 | 2017-09-01 | 國鼎生物科技股份有限公司 | 治療白血病之方法及組成物 |
| TWI583376B (zh) * | 2013-03-20 | 2017-05-21 | 曾卉菱 | Compounds isolated from Antelroxicus and their use |
| CN104115669B (zh) * | 2013-04-27 | 2016-11-02 | 富裔实业股份有限公司 | 牛樟芝培养方法及牛樟芝酒萃物的制备方法 |
| TWI555529B (zh) | 2014-06-20 | 2016-11-01 | 富裔實業股份有限公司 | 中草藥萃取物用於製備肝癌藥物之用途 |
| JP6034834B2 (ja) * | 2014-07-03 | 2016-11-30 | 康力生技股▲分▼有限公司 | 抗子宮筋腫用の漢方薬草合成物およびその漢方薬草抽出物により製造された抗子宮筋腫薬物の製造方法 |
| JP6593856B2 (ja) * | 2014-09-03 | 2019-10-23 | 台灣利得生物科技股▲ふん▼有限公司 | 抗肺癌細胞転移用組成物およびその製造方法 |
| DE102014113861B4 (de) | 2014-09-24 | 2024-01-04 | Taiwan Leader Biotech Corp. | Bioaktive Komponente zur Verwendung bei der Bekämpfung der Metastasierung eines Lungentumors |
| TWI551291B (zh) * | 2015-04-29 | 2016-10-01 | 葡萄王生技股份有限公司 | 一種具降低癌細胞抗藥性之樟芝菌絲體萃取物及其醫藥或食品組合物 |
| CN106176827B (zh) * | 2015-04-29 | 2020-04-14 | 葡萄王生技股份有限公司 | 降低癌细胞抗药性的樟芝菌丝体萃取物及其活性物质和组合物 |
| CN110337991A (zh) * | 2019-06-19 | 2019-10-18 | 三生源生物科技(天津)有限公司 | 一种基于牛樟芝提取物的肿瘤细胞抑制剂的制备及应用 |
| CN110305918A (zh) * | 2019-06-19 | 2019-10-08 | 北京化工大学 | 一种牛樟芝发酵耦合萃取生产4-Acetylantroquinonol B的方法 |
| CN113960204A (zh) * | 2021-10-23 | 2022-01-21 | 哈尔滨工业大学 | 一种红松松塔抗肝细胞癌化合物筛选方法 |
| CN115323027B (zh) * | 2022-09-07 | 2024-08-06 | 福建农林大学 | 一种生物活性次级代谢产物的制备方法和应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106750A (en) * | 1988-08-30 | 1992-04-21 | G. D. Searle & Co. | Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents |
| US5445951A (en) * | 1993-02-02 | 1995-08-29 | Mcneil-Ppc, Inc. | Regioselective enzymatic deacylation of sucrose esters in anhydrous organic media |
| EP1181938B1 (en) * | 1993-04-23 | 2007-11-14 | Wyeth | Rapamycin conjugates and antibodies |
| TWI226370B (en) * | 2000-02-17 | 2005-01-11 | Food Industry Res & Dev Inst | Isolate of Antrodia camphorata, process for producing a culture of the same and product obtained thereby |
| CN1192098C (zh) * | 2000-11-13 | 2005-03-09 | 葡萄王企业股份有限公司 | 樟芝菌丝体生物活性物质其制备法及含其组成物 |
| CN1386545A (zh) * | 2001-05-18 | 2002-12-25 | 葡萄王企业股份有限公司 | 樟芝保肝制剂 |
| TWI241344B (en) * | 2002-03-29 | 2005-10-11 | Food Industry Res & Dev Inst | Processes for producing an antrodia camphorata culture having pharmacological activity, processes for obtaining a pharmacologically active composition from a culture of A camphorata, products produced thereby and pharmaceutical compositions of cancer... |
| JP5403844B2 (ja) * | 2004-03-02 | 2014-01-29 | 善笙生物科技股▲分▼有限公司 | AntrodiaCamphorataの菌糸体から得た新規な混合物及び化合物、並びにその使用 |
| US7109232B2 (en) * | 2004-03-08 | 2006-09-19 | Simpson Biotech Co., Ltd. | Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity |
| ATE513823T1 (de) * | 2004-08-17 | 2011-07-15 | Simpson Biotech Co Ltd | Mischung und verbindungen von mycelien von antrodia camphorata und deren verwendung |
| TW200638867A (en) * | 2005-05-06 | 2006-11-16 | Golden Biotechnology Corp | Incubation and application methods for the culture of antrodia camphorata |
| US20070116787A1 (en) * | 2005-11-21 | 2007-05-24 | Chih-Jung Yao | Cancer treatment |
| TW200810770A (en) * | 2006-08-17 | 2008-03-01 | Kang Jiann Biotech Co Ltd | Novel diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof |
| US7601854B2 (en) * | 2006-10-25 | 2009-10-13 | Kang Jian Biotech Corp., Ltd. | Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof |
| TW200819125A (en) * | 2006-10-31 | 2008-05-01 | Golden Biotechnology Corp | Application of Antrodia camphorate extract capable of inhibiting growth of tumor cells |
| EP2094651A1 (en) * | 2006-11-17 | 2009-09-02 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| TW200829234A (en) * | 2007-01-08 | 2008-07-16 | Golden Biotechnology Corp | Antrodia camphorata isophorone extract |
| TWI394573B (zh) * | 2007-06-14 | 2013-05-01 | 國鼎生物科技股份有限公司 | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for Liver Protection |
| TWI394575B (zh) * | 2007-07-09 | 2013-05-01 | Golden Biotechnology Corp | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus |
| TW200918498A (en) * | 2007-10-19 | 2009-05-01 | Golden Biotechnology Corp | Novel compound isolated from Antrodia camphorate extracts |
| US8772329B2 (en) * | 2008-01-28 | 2014-07-08 | Simpson Biotech Co., Ltd. | Compounds from mycelium of Antrodia cinnamomea and use thereof |
| TW201000112A (en) * | 2008-06-18 | 2010-01-01 | Mackay Memorial Hospital | Use of dehydrosulphurenic acid for inhibiting the growth of cancer cells |
| US7932285B2 (en) * | 2008-11-21 | 2011-04-26 | Well Shine Biotechnology Development Co., Ltd. | Compounds from Antrodia camphorata |
| TWI389699B (zh) * | 2009-02-13 | 2013-03-21 | 高雄醫學大學 | 用於誘導細胞凋亡之樟芝子實體乙醇萃取物及其製備方法 |
| TW201102075A (en) * | 2009-07-09 | 2011-01-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of pancreatic cancer |
| EP2329816B1 (en) | 2009-11-26 | 2016-04-13 | National Taiwan University | An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof |
-
2010
- 2010-11-22 EP EP10192000.7A patent/EP2329816B1/en active Active
- 2010-11-22 ES ES10192000.7T patent/ES2574606T3/es active Active
- 2010-11-22 PL PL10192000.7T patent/PL2329816T3/pl unknown
- 2010-11-24 US US12/954,112 patent/US20110123562A1/en not_active Abandoned
- 2010-11-25 MY MYPI2010005559A patent/MY161596A/en unknown
- 2010-11-25 TW TW099140707A patent/TWI421085B/zh active
- 2010-11-25 JP JP2010262373A patent/JP5752925B2/ja active Active
-
2013
- 2013-01-16 US US13/743,130 patent/US9950021B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MY161596A (en) | 2017-04-28 |
| TWI421085B (zh) | 2014-01-01 |
| US20110123562A1 (en) | 2011-05-26 |
| US9950021B2 (en) | 2018-04-24 |
| JP5752925B2 (ja) | 2015-07-22 |
| EP2329816B1 (en) | 2016-04-13 |
| EP2329816A1 (en) | 2011-06-08 |
| PL2329816T3 (pl) | 2016-10-31 |
| TW201200144A (en) | 2012-01-01 |
| JP2011111457A (ja) | 2011-06-09 |
| US20130129773A1 (en) | 2013-05-23 |
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