ES2623982T3 - Compuestos heterocíclicos de unión a receptor de quimiocina con eficacia potenciada - Google Patents

Compuestos heterocíclicos de unión a receptor de quimiocina con eficacia potenciada Download PDF

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Publication number
ES2623982T3
ES2623982T3 ES02805977T ES02805977T ES2623982T3 ES 2623982 T3 ES2623982 T3 ES 2623982T3 ES 02805977 T ES02805977 T ES 02805977T ES 02805977 T ES02805977 T ES 02805977T ES 2623982 T3 ES2623982 T3 ES 2623982T3
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chemiokin
potentiated
union
receptor
effectiveness
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Gary J. Bridger
Renato T. Skerlj
Al Kaller
Curtis Harwig
David Bogucki
Trevor Wilson
Jason Crawford
Ernest J. Mceachern
Bem Atsma
Siquiao Nan
Yuanxi Zhou
Dominique Schols
Christopher Dennis Smith
Rosaria Maria Di Fluri
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Genzyme Corp
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Genzyme Corp
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Un compuesto de la fórmula **Fórmula** o una sal farmacéuticamente aceptable del mismo; e incluyendo cualquiera de las formas estereoisoméricas del mismo; en la que n4 es 2-6; cada R1 es independientemente H, halo, alquilo (C1-10), alcoxi (C1-10), o CF3; R3 es H, alquilo (C1-10), alquenilo (C2-10), arilalquilo (aril "C"5-12-alquilo-C1-6), o arilo ("C"5-12); cada R4 es independientemente H o alquilo (C1-10), o los dos grupos R4 pueden tomarse junto con el anillo al que están unidos para formar un anillo fenilo; y cada R6 es independientemente H, arilalquilo (aril "C"5-12-alquilo-C1-6), arilacilo (arilacilo "C"5-12), o arilsulfonilo (arilsulfonilo "C"5-12), en los que los restos arilo ("C"5-12) de los mismos contienen opcionalmente uno o más átomos de nitrógeno.
ES02805977T 2001-12-21 2002-12-23 Compuestos heterocíclicos de unión a receptor de quimiocina con eficacia potenciada Expired - Lifetime ES2623982T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34271601P 2001-12-21 2001-12-21
US35082202P 2002-01-17 2002-01-17
PCT/US2002/041407 WO2003055876A1 (en) 2001-12-21 2002-12-23 Chemokine receptor binding heterocyclic compounds with enhanced efficacy

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ES2623982T3 true ES2623982T3 (es) 2017-07-12

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US (2) US20030220341A1 (es)
EP (1) EP1465889B1 (es)
JP (1) JP4556020B2 (es)
KR (1) KR20040068339A (es)
CN (2) CN102153540A (es)
AU (1) AU2002357379A1 (es)
BR (1) BRPI0215050B8 (es)
CA (1) CA2467718C (es)
ES (1) ES2623982T3 (es)
HU (1) HUP0402458A2 (es)
IL (2) IL161784A0 (es)
MX (1) MXPA04006136A (es)
NO (1) NO20042578L (es)
NZ (1) NZ533542A (es)
PL (1) PL369856A1 (es)
RU (1) RU2325387C2 (es)
WO (1) WO2003055876A1 (es)

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