ES263122A1 - A procedure for the manufacture of derivatives of 1,4-benzodiazepinas (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the manufacture of derivatives of 1,4-benzodiazepinas (Machine-translation by Google Translate, not legally binding)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of ES263122A1publicationCriticalpatent/ES263122A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A process for the manufacture of 14-benzodiazepine derivatives which comprises when treating a benzodiazepine derivative of the general formula wherein R 1 and R3 represent hydrogen or alkyl R2 represents hydrogen, alkyl, alkoxy, trifluoromethyl or halogen and R4 represents hydrogen or an acyl group while the nucleus designated by I is unsubstituted, monosubstituted with trifluoromethyl, or mono- or bisubstituted with alkyl, alkoxy, alkylthio, hydroxyalkylthio, halogen, nitro, amino, alkylsulfinyl, alkylsulfonyl, hydroxy or acylamino, or a corresponding 4-deoxy compound with an acidic agent any product can then be nitrated, the nitro groups can be reduced to amino groups and the latter can be acylated. (Machine-translation by Google Translate, not legally binding)
ES263122A1959-12-101960-12-09A procedure for the manufacture of derivatives of 1,4-benzodiazepinas (Machine-translation by Google Translate, not legally binding)
ExpiredES263122A1
(en)
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