ES2633726T3 - Ácidos grasos para utilizar como medicamento - Google Patents
Ácidos grasos para utilizar como medicamento Download PDFInfo
- Publication number
- ES2633726T3 ES2633726T3 ES09823196.2T ES09823196T ES2633726T3 ES 2633726 T3 ES2633726 T3 ES 2633726T3 ES 09823196 T ES09823196 T ES 09823196T ES 2633726 T3 ES2633726 T3 ES 2633726T3
- Authority
- ES
- Spain
- Prior art keywords
- fatty acids
- medicine
- laxatives
- free fatty
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000003814 drug Substances 0.000 title abstract description 4
- 235000014113 dietary fatty acids Nutrition 0.000 title description 4
- 239000000194 fatty acid Substances 0.000 title description 4
- 229930195729 fatty acid Natural products 0.000 title description 4
- 150000004665 fatty acids Chemical class 0.000 title description 3
- 230000013872 defecation Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 235000021588 free fatty acids Nutrition 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000008141 laxative Substances 0.000 description 10
- 229940125722 laxative agent Drugs 0.000 description 8
- 210000001072 colon Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 230000002475 laxative effect Effects 0.000 description 3
- WGFOBBZOWHGYQH-MXHNKVEKSA-N lubiprostone Chemical compound O1[C@](C(F)(F)CCCC)(O)CC[C@@H]2[C@@H](CCCCCCC(O)=O)C(=O)C[C@H]21 WGFOBBZOWHGYQH-MXHNKVEKSA-N 0.000 description 3
- 229960000345 lubiprostone Drugs 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 2
- 229960003656 ricinoleic acid Drugs 0.000 description 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 108010062745 Chloride Channels Proteins 0.000 description 1
- 102000011045 Chloride Channels Human genes 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 244000134552 Plantago ovata Species 0.000 description 1
- 235000003421 Plantago ovata Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000009223 Psyllium Substances 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241001672648 Vieira Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- -1 bicyclic fatty acid Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 229940018602 docusate Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940079360 enema for constipation Drugs 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 150000003165 prostaglandin E1 derivatives Chemical class 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Ácido graso libre o mezcla de ácidos grasos libres para utilizar como medicamento para inducir el proceso de defecación mediante administración rectal, que comprenden uno o más ácidos grasos libres saturados o insaturados con una longitud de la cadena de carbonos en el intervalo de C4 a C36.
Description
Ácidos grasos para utilizar como medicamento
[0001] Los laxantes se utilizan para tratar el estreñimiento, es decir, la ausencia de defecación regular, la acumulación de heces en el colon y/o el paso de pequeñas cantidades de heces duras y secas. A las personas que están estreñidas les puede resultar difícil y doloroso tener una evacuación intestinal. Los laxantes también se utilizan 10 para limpiar el intestino inferior antes de una proctoscopia, rectoscopia, colonoscopia, obtención de imágenes de rayos x del colon o un procedimiento de diagnóstico similar. Existen varios tipos de laxantes, véase la visión general en la tabla 1. Los laxantes pueden producir efectos secundarios, pero por lo general no son graves. Los estimulantes e irritantes son más propensos que otros tipos de laxantes a causar efectos secundarios, tales como malestar abdominal, desmayos y calambres. Los laxantes pueden ser para la administración oral, por ejemplo comprimidos,
15 cápsulas y líquidos, o para la administración rectal, por ejemplo, supositorios y enemas. Los laxantes administrados oralmente pueden reducir la biodisponibilidad de fármacos y nutrientes.
[0002] El aceite de ricino es un laxante bien conocido, una dosis de adulto terapéutica habitual para el efecto laxante es de 15 a 60 ml, administrados por vía oral. Aproximadamente el 90% del contenido de ácidos grasos en el aceite 20 de ricino es el triglicérido formado de ácido ricinoleico (ácido 12-hidroxi-9-cis-octadecenoico), un ácido graso monoinsaturado, que es el componente activo del aceite de ricino, actúa como laxante por estimulación de la secreción de fluidos y electrolitos en el intestino delgado. Se liberan una o dos copiosas heces semifluidas de 2 a 6 horas desde la administración. El ácido ricinoleico es eficaz para prevenir el crecimiento de numerosas especies de virus, bacterias, levaduras y mohos, y posee cierto efecto anti-inflamatorio (Vieira et al 2000; Burdock et al.,
25 2006). Los ácidos grasos de cadena corta, tales como ácido láctico, acético, butírico y propiónico, pueden estimular la motilidad del colon y mediante el aumento de la presión osmótica (es decir, agentes hiperosmóticos, Tabla 1).
[0003] La lubiprostona (ácido difluoropentil-2-hidroxi-6-oxooctahidrociclopenta-heptanoico) es un ácido graso bicíclico derivado de un metabolito de la prostaglandina E1. Después de la administración oral, la lubiprostona activa
30 canales de cloruro específicos (canales CIC-2) en el tracto gastro-intestinal para estimular la secreción del fluido intestinal, aumentar el tránsito de GI, y mejorar los síntomas del estreñimiento (BE Lacy 2008). Por lo tanto, la lubiprostona tiene un efecto específico del receptor.
Tabla 1, Tipos de laxantes 35
- Clase
- Sitio de acción Inicio de acción Mecanismo de acción Ejemplos
- Agentes productores de volumen
- Intestino delgado y grueso 12-72 horas aumentar el volumen de las heces (retener más agua) y ablandarán las Psyllium, metilcelulosa, fibras dietéticas
- heces y estimularán la motilidad intestinal
- Ablandadores de
- Intestino delgado y 12-72 horas Mantener agua y Docusate (un
- heces y
- grueso grasas en las heces, tensioactivo)
- tensioactivos
- facilitando el
- movimiento
- Solución salina
- Intestino delgado y grueso 0,5-6 horas Retener agua en el lumne intestinal, aumentando la presión intraluminal conduciendo a hidróxido de magnesio, sulfato de magnesio, fosfato de sodio
- heces más blandas
- Lubricantes y emolientes
- Colon 6-8 horas hacer que las heces sean resbaladizas Aceite mineral
- de manera que se deslicen a través del
- intestino más
- fácilmente. Retrasa
- la absorción de agua
- Agentes
- Colon 0,5 horas Actuar mediante el Sorbitol, lactulosa,
- hiperosmóticos
- efecto osmótico que polietilenglicol,
- retiene el agua en el
- supositorios de
- intestino
- glicerina
- Estimulantes e
- Colon 6-10 horas Estimular la acción comprimidos de
2
Claims (1)
-
imagen1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11009308P | 2008-10-31 | 2008-10-31 | |
| US110093P | 2008-10-31 | ||
| US17414409P | 2009-04-30 | 2009-04-30 | |
| US174144P | 2009-04-30 | ||
| PCT/IS2009/000012 WO2010049954A1 (en) | 2008-10-31 | 2009-10-30 | Fatty acids for use as a medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2633726T3 true ES2633726T3 (es) | 2017-09-25 |
Family
ID=42128346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09823196.2T Active ES2633726T3 (es) | 2008-10-31 | 2009-10-30 | Ácidos grasos para utilizar como medicamento |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8372425B2 (es) |
| EP (1) | EP2349250B1 (es) |
| JP (1) | JP6113954B2 (es) |
| CN (1) | CN102245176B (es) |
| AU (1) | AU2009309237B2 (es) |
| CA (1) | CA2742227C (es) |
| DK (1) | DK2349250T3 (es) |
| ES (1) | ES2633726T3 (es) |
| NZ (1) | NZ593186A (es) |
| PL (1) | PL2349250T3 (es) |
| PT (1) | PT2349250T (es) |
| WO (1) | WO2010049954A1 (es) |
| ZA (1) | ZA201104036B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010002242A1 (en) | 2008-07-02 | 2010-01-07 | N.V. Nutricia | Nutritional composition for improving muscle function and daily activity |
| CA2766799A1 (en) * | 2009-06-26 | 2010-12-29 | Eric Kuhrts | Water-soluble dietary fatty acids |
| AU2010363574B2 (en) * | 2010-11-02 | 2016-10-13 | Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited | Uses of unsaturated fatty acids for inhibiting virus replication and /or infection |
| MX2013010076A (es) * | 2011-03-03 | 2014-04-07 | Tersus Pharmaceuticals Llc | Composiciones y metodos que comprenden c16:1n7 palmitoleato. |
| WO2013035113A1 (en) | 2011-09-06 | 2013-03-14 | Lipid Pharmaceuticals Ehf. | Coated suppositories |
| UA114615C2 (uk) | 2012-01-06 | 2017-07-10 | Омтера Фармасьютікалз, Інк. | Збагачена дпк композиція омега-3 поліненасичених жирних кислот у формі вільної кислоти |
| HK1206248A1 (en) | 2012-05-07 | 2016-01-08 | Omthera Pharmaceuticals Inc. | Compositions of statins and omega-3 fatty acids |
| ITMI20130354A1 (it) * | 2013-03-08 | 2014-09-09 | Again Life Italia Srl | Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie. |
| US8728546B1 (en) * | 2013-03-15 | 2014-05-20 | Swing Aerobics Licensing, Inc. | Medicament for treatment of cancer, cardiovascular diseases and inflammation |
| ES2978914T3 (es) | 2014-07-02 | 2024-09-23 | Nissui Corp | Método para producir ácidos grasos libres insaturados monovalentes derivados de productos marinos o ésteres de alcohol inferior de los mismos |
| WO2016043684A1 (en) * | 2014-09-18 | 2016-03-24 | Ciftci Ihsan Hakki | Use of aqueous extract of triticum vulgare in the treatment of hemorrhoid |
| US10772343B2 (en) | 2014-11-19 | 2020-09-15 | Kansas State University Research Foundation | Chemical mitigants in animal feed and feed ingredients |
| US12064455B2 (en) | 2020-03-18 | 2024-08-20 | Lipid Pharmaceuticals Ehf | Free fatty acids and methods of manufacture and use for treating coronavirus and other viral respiratory infections |
| WO2022105987A1 (de) * | 2020-11-17 | 2022-05-27 | Wacker Chemie Ag | Cyclodextrin enthaltende formulierungen zur verbesserung der wirksamkeit von fettsäuren als nicht-selektive herbizide |
| WO2022156882A1 (de) * | 2021-01-19 | 2022-07-28 | Wacker Chemie Ag | Cyclodextrin und fettsäuren enthaltende formulierungen zur kontrolle und abwehr von insekten mit verbesserter wirksamkeit |
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-
2009
- 2009-10-30 PT PT98231962T patent/PT2349250T/pt unknown
- 2009-10-30 US US12/609,845 patent/US8372425B2/en not_active Expired - Fee Related
- 2009-10-30 WO PCT/IS2009/000012 patent/WO2010049954A1/en not_active Ceased
- 2009-10-30 AU AU2009309237A patent/AU2009309237B2/en not_active Ceased
- 2009-10-30 JP JP2011533936A patent/JP6113954B2/ja not_active Expired - Fee Related
- 2009-10-30 PL PL09823196T patent/PL2349250T3/pl unknown
- 2009-10-30 EP EP09823196.2A patent/EP2349250B1/en active Active
- 2009-10-30 DK DK09823196.2T patent/DK2349250T3/en active
- 2009-10-30 ES ES09823196.2T patent/ES2633726T3/es active Active
- 2009-10-30 CN CN200980149999.3A patent/CN102245176B/zh not_active Expired - Fee Related
- 2009-10-30 CA CA2742227A patent/CA2742227C/en not_active Expired - Fee Related
- 2009-10-30 NZ NZ593186A patent/NZ593186A/xx not_active IP Right Cessation
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2011
- 2011-05-31 ZA ZA2011/04036A patent/ZA201104036B/en unknown
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2013
- 2013-01-10 US US13/737,992 patent/US9072714B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100113387A1 (en) | 2010-05-06 |
| ZA201104036B (en) | 2012-03-28 |
| CN102245176A (zh) | 2011-11-16 |
| EP2349250A1 (en) | 2011-08-03 |
| CA2742227C (en) | 2017-01-24 |
| DK2349250T3 (en) | 2017-07-03 |
| JP2012507505A (ja) | 2012-03-29 |
| NZ593186A (en) | 2013-02-22 |
| US20130137771A1 (en) | 2013-05-30 |
| EP2349250A4 (en) | 2012-05-23 |
| CN102245176B (zh) | 2015-05-27 |
| EP2349250B1 (en) | 2017-04-19 |
| US9072714B2 (en) | 2015-07-07 |
| AU2009309237A1 (en) | 2011-06-23 |
| PL2349250T3 (pl) | 2017-09-29 |
| AU2009309237B2 (en) | 2016-02-25 |
| JP6113954B2 (ja) | 2017-04-12 |
| PT2349250T (pt) | 2017-07-25 |
| WO2010049954A1 (en) | 2010-05-06 |
| US8372425B2 (en) | 2013-02-12 |
| CA2742227A1 (en) | 2010-05-06 |
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