ES2636441T8 - Un procedimiento novedoso para la síntesis de polifenoles - Google Patents

Un procedimiento novedoso para la síntesis de polifenoles Download PDF

Info

Publication number
ES2636441T8
ES2636441T8 ES12739384.1T ES12739384T ES2636441T8 ES 2636441 T8 ES2636441 T8 ES 2636441T8 ES 12739384 T ES12739384 T ES 12739384T ES 2636441 T8 ES2636441 T8 ES 2636441T8
Authority
ES
Spain
Prior art keywords
polyphenols
synthesis
novel procedure
novel
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12739384.1T
Other languages
English (en)
Other versions
ES2636441T3 (es
Inventor
Sundeep Dugar
Dinesh MAHAJAN
Pantelis Peter Giannousis
Vijay Singh
Kamal Kishore KAPOOR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sphaera Pharma Pte Ltd
Original Assignee
Sphaera Pharma Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sphaera Pharma Pte Ltd filed Critical Sphaera Pharma Pte Ltd
Application granted granted Critical
Publication of ES2636441T3 publication Critical patent/ES2636441T3/es
Publication of ES2636441T8 publication Critical patent/ES2636441T8/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES12739384.1T 2011-01-27 2012-01-24 Un procedimiento novedoso para la síntesis de polifenoles Active ES2636441T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
INDE01962011 2011-01-27
IN196DE2011 2011-01-27
PCT/IN2012/000052 WO2012101652A2 (en) 2011-01-27 2012-01-24 A novel process for synthesis of polyphenols

Publications (2)

Publication Number Publication Date
ES2636441T3 ES2636441T3 (es) 2017-10-05
ES2636441T8 true ES2636441T8 (es) 2018-12-14

Family

ID=46581222

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12739384.1T Active ES2636441T3 (es) 2011-01-27 2012-01-24 Un procedimiento novedoso para la síntesis de polifenoles

Country Status (7)

Country Link
US (1) US9428482B2 (es)
EP (1) EP2668176B1 (es)
JP (1) JP5890846B2 (es)
CN (1) CN103582635B (es)
ES (1) ES2636441T3 (es)
TW (1) TWI697489B (es)
WO (1) WO2012101652A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9556140B2 (en) 2013-01-26 2017-01-31 Sphaera Pharma Pvt. Ltd. Approach for synthesis of catechins
CN105283179A (zh) * 2013-04-04 2016-01-27 斯法尔制药私人有限公司 表儿茶素及相关多酚的新类似物
US10618933B2 (en) 2014-07-23 2020-04-14 Epirium Bio Inc. Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof
US10898465B2 (en) 2016-06-21 2021-01-26 Epirium Bio Inc. Utility of (+) epicatechin and their analogs
CN105949161B (zh) * 2016-06-28 2018-05-15 温州大学 一种3-芳巯基黄酮化合物的制备方法
CN106946835B (zh) * 2017-04-25 2019-03-01 广州科技职业技术学院 橙皮素酯化物及其制备方法和应用
WO2019044672A1 (ja) * 2017-08-28 2019-03-07 株式会社Nbcメッシュテック ポリフェノールの製造方法
CA3117466A1 (en) 2018-10-24 2020-04-30 Epirium Bio Inc. Co-crystals comprising epicatechin and a carboxy-n-heterocyclic co-crystal former

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122608B (en) * 1982-06-01 1985-10-02 Zyma Sa (+)-cyanidan-3-ol derivatives
EP0445819B1 (en) * 1990-03-08 2001-08-22 Fuji Photo Film Co., Ltd. Positive type photoresist composition
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
EP1602652A1 (en) * 2003-03-03 2005-12-07 San-Ei Gen F.F.I., Inc. Adiponectin expression promoter
JP5339664B2 (ja) * 2004-02-13 2013-11-13 花王株式会社 Ampk活性化剤
JP2006083105A (ja) * 2004-09-16 2006-03-30 Ito En Ltd 血液流動性改善剤および飲食物
EP1896443A1 (en) * 2005-06-29 2008-03-12 Mars, Incorporated Preparation of (+)-catechin, (-)-epicatechin, (-)-catechin, (+)-epicatechin, and their 5,7,3',4'-tetra-o-benzyl analogues
US20100204204A1 (en) * 2007-06-06 2010-08-12 University Of South Florida Nutraceutical co-crystal compositions
JP5382676B2 (ja) * 2007-12-07 2014-01-08 国立大学法人名古屋大学 アントシアニジン類の製造方法

Also Published As

Publication number Publication date
TW201309662A (zh) 2013-03-01
WO2012101652A3 (en) 2012-12-27
ES2636441T3 (es) 2017-10-05
US20140031421A1 (en) 2014-01-30
EP2668176A4 (en) 2014-08-27
EP2668176A2 (en) 2013-12-04
JP2014509312A (ja) 2014-04-17
WO2012101652A2 (en) 2012-08-02
CN103582635A (zh) 2014-02-12
CN103582635B (zh) 2019-02-19
JP5890846B2 (ja) 2016-03-22
TWI697489B (zh) 2020-07-01
US9428482B2 (en) 2016-08-30
EP2668176B1 (en) 2017-05-17

Similar Documents

Publication Publication Date Title
ES2603028T8 (es) Procedimiento para la preparación de (Z)-alfa-fluoro-beta-amino-acrilaldehídos sustituidos
PT2740287T (pt) Característica melhorada para cobertura exterior-interior
LT2895484T (lt) Gliukozilceramido sintazės inhibitoriai
BR112014003878A2 (pt) síntese de r-bifenilalaninol
CO6910197A2 (es) Compuestos novedosos
BR112013018875A2 (pt) métodos e composições para a preparação de noribogaína a partir de voacangina
BR112013023526A2 (pt) produto fibroso para a fabricação de tal produto fibroso
ES2547827T8 (es) Procedimiento para la purificación de la micafungina
BR112013024413A2 (pt) compostos e métodos para a preparação de diarilpropanos
EP2691361A4 (en) SYNTHESIS OF DIAZIDEN
ES2641042T8 (es) Procedimiento para la fabricación de un fármaco proteínico
BR112013012094A2 (pt) método para a purifação de misturas
BR112013031218A2 (pt) protetores solares
BR112012001731A2 (pt) Processo para a preparação de 1-benzil-3-hidroximetil-1h-indazol
BR112014010327A2 (pt) processo para a preparação de compostos
CL2014002825A1 (es) Procesos para la preparación de un compuesto de 1-aril-5-alquil pirazol
BRPI1010841A2 (pt) método para a fabricação de fluoroalquilnitrilas
BR112013014581A2 (pt) método para a fabricação de um diorgano-di-halossilano
BR112013012096A2 (pt) método para a purifação de misturas
BR112013031107A2 (pt) protetores solares
BR112015009720A2 (pt) método para a preparação de um composto de fórmula (i) e intermediários de síntese.
BR112013022508A2 (pt) novos compostos de azaespirodecanona
BR112014008575A2 (pt) processo para a preparação de ditina-tetracarboximidas
DK2477971T3 (da) Fremgangsmåde til syntese af 5-amino-1-phenyl-3-cyan-4-triflourmethylsulfinylpyrazol
EP2804607A4 (en) SYNTHESIS OF RALTEGRAVIR